1. Gene
  2. BTK - Bruton tyrosine kinase Gene

BTK - Bruton tyrosine kinase Gene

中文名称:布鲁顿酪氨酸激酶

种属: Homo sapiens

同用名: AT; ATK; BPK; XLA; IMD1; AGMX1; IGHD3; PSCTK1

基因 ID: 695 | 基因类型: protein coding

关于 BTK

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:101,349,450-101,390,796 (from NCBI)

This gene has 31 transcripts (splice variants), 206 orthologues, 32 paralogues and is associated with 78 phenotypes. Biased expression in lymph node (RPKM 25.2), spleen (RPKM 18.4) and 13 other tissues.

功能概要

由该基因编码的蛋白质在 B 细胞发育中起着至关重要的作用。该基因的突变会导致 1 型 X 连锁无丙种球蛋白血症,这是一种免疫缺陷,其特征是不能产生成熟的 B 淋巴细胞,并且与 Ig 重链重排失败有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2013 年 12 月]

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

BTK 基因产物(3)

mRNA Protein Name
NM_000061.3 NP_000052.1 tyrosine-protein kinase BTK isoform 1
NM_001287345.2 NP_001274274.1 tyrosine-protein kinase BTK isoform 2
NM_001287344.2 NP_001274273.1 tyrosine-protein kinase BTK isoform 3

BTK 蛋白结构

PH

PH: PH domain (5 - 132)

BTK

BTK: BTK motif (140 - 169)

SH3_1

SH3_1: SH3 domain (220 - 266)

SH2

SH2: SH2 domain (281 - 362)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (402 - 650)

  • 0
  • 200
  • 400
  • 600
  • 659 a.a.
蛋白主名 其他名称

tyrosine-protein kinase BTK

B-cell progenitor kinase

Bruton agammaglobulinemia tyrosine kinase

Bruton's tyrosine kinase

agammaglobulinaemia tyrosine kinase

dominant-negative kinase-deficient Brutons tyrosine kinase

重组 BTK 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72048 BTK Protein, Human (Sf9, His) Q06187 (M1-S659) ≥95%
HY-P700598 BTK Protein, Human (P. pastoris, His) Q06187 (M1-S659) ≥95%

关联疾病

疾病名称 别名
Marginal Zone B-Cell Lymphoma

Marginal Zone Lymphoma

Mzl

Mucosa-Associated Lymphoid Tissue Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstrom Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstrom'S Macroglobulinaemia

Waldenstrom'S Syndrome

Waldenström Macroglobulinemia

Waldenstrom'S Macroglobulinemia

Wm

Waldenström'S Macroglobulinemia

Malignant Lymphoma - Lymphoplasmacytic

Cd40 Ligand Deficiency

X-Linked Hyper Igm Syndrome

Hyperimmunoglobulin M Syndrome

Higm1

Hyper-Igm Syndrome Type 1

X-Linked Hyper-Igm Syndrome

Xhigm

Higmx-1

X-Linked Hyper-Igm Immunodeficiency

Hyper-Igm Syndrome 1

Immunodeficiency With Hyper-Igm, Type 1

Hyper-Igm Syndrome Due To Cd40 Ligand Deficiency

Hyper-Igm Syndrome Due To Cd40l Deficiency

Hyper-Igm Immunodeficiency Syndrome

Hyper-Igm Immunodeficiency Syndrome, Type 1

X-Linked Recessive Disease
Transient Hypogammaglobulinemia Of Infancy

Immunoglobulin Maturational Delay

Thi - [Transient Hypogammaglobulinaemia Of Infancy]

Immunodeficiency 7

Tcr-Alpha-Beta-Positive T-Cell Deficiency

IMD7

T-Cell Receptor-Alpha/Beta Deficiency

Immunodeficiency 7, Tcr-Alpha/Beta Deficient

Tcr-Alpha/Beta Deficiency

Tcr-Alpha-Beta+ T-Cell Deficiency

T-Cell Receptor Alpha/Beta Deficiency

Isolated Growth Hormone Deficiency Type Iii

Congenital Ighd Type Iii

Congenital Isolated Gh Deficiency Type Iii

Congenital Isolated Growth Hormone Deficiency Type Iii

Fleisher Syndrome

Growth Hormone Deficiency With Hypogammaglobulinemia

Ighd Iii

X-Linked Ighd

X-Linked Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 3

X-Linked Agammaglobulinemia And Isolated Growth Hormone Deficiency

X-Linked Hypogammaglobulinemia And Isolated Growth Hormone Deficiency

Agammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked

Hypogammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked

Ighd3

Growth Hormone Deficiency, Isolated, Type Iii )

Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws

Selective Immunoglobulin Deficiency Disease
X-Linked Monogenic Disease
Agammaglobulinemia 1, Autosomal Recessive

AGM1

Agammaglobulinemia 1

Autosomal Recessive Agammaglobulinemia 1

Agammaglobulinemia, Autosomal Recessive, Due To Ighm Defect

Agammaglobulinemia Autosomal Recessive Due To Ighm Defect

Agammaglobulinemia, Type 1, Autosomal Recessive )

Congenital Hypogammaglobulinemia

Congenital Hypogammaglobulinaemia

Bn2 Diffuse Large B-Cell Lymphoma

Bn2 Dlbcl

Doid:0081064

Agammaglobulinemia

Hypogammaglobulinemia

Ighm

Mu Heavy Chain Deficiency

Mu-Heavy Chain Disease

Mu-Hcd

Mu-Chain Disease

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Immunodeficiency 45

IMD45

Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia

Omenn Syndrome

Histiocytic Medullary Reticulosis

Severe Combined Immunodeficiency With Hypereosinophilia

Combined Immunodeficiency With Hypereosinophilia

Reticuloendotheliosis, Familial, With Eosinophilia

Reticuloendotheliosis Familial With Eosinophilia

Familial Reticuloendotheliosis

Omenn'S Syndrome

OS

Malignant Histiocytosis

Pneumocystosis

Pneumocystis Jirovecii Pneumonia

Pneumocystis Carinii Pneumonia

Pneumocystis Pneumonia

Pulmonary Pneumocystosis

PCP

Pneumocystosis Pneumonia

Pneumonia Pneumocystis Carinii

Pneumonia, Pneumocystis

Pneumocystis Jiroveci Pneumonia

Lymphopenia

Lymphocytopenia

Diffuse Large B-Cell Lymphoma

Dlbcl

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Large B-Cell Diffuse Lymphoma

Lymphoma, Large B-Cell, Diffuse

Dlbcl - [Diffuse Large B-Cell Lymphoma]

Diffuse Large Beta Cell Lymphoma

B Cell Deficiency

Immunoglobulin Heavy Chain Deficiency

B Cell Deficiencies

Immunoglobulin Heavy Chain Deletion

Humoral Immune Defect

Central Nervous System Hematologic Cancer

Cns Hematopoietic Tumor

Hematopoietic Neoplasm Of Central Nervous System

Central Nervous System Hematopoietic Neoplasm

Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Acquired Hypogammaglobulinemia

Common Variable Immune Deficiency

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Tibial Nerve Palsy
Immunodeficiency With Hyper-Igm, Type 1

Immunodeficiency, X-Linked, With Hyper-Igm

Hyper Igm Syndrome

HIGM1

Xhim

Hyper-Igm Syndrome

Higm

Hyper-Igm Syndrome 1

Immunodeficiency 3

Imd3

Immunodeficiency With Hyper-Igm

Immunodeficiency With Hyper Igm Type 1

Ihis

X-Linked Hyper Igm Syndrome

Hyper-Igm Immunodeficiency, X-Linked

Hyper Igm Immunodeficiency, X-Linked

Hyper Igm Syndrome 1

X-Linked Immunodeficiency With Hyper-Igm 1

Immunodeficiency, With Hyper Igm

Immunodeficiency, With Hyper Igm, Type 1

Hyper-Igm Immunodeficiency Syndrome, Type 1

Hyperimmunoglobulin M Syndrome

Testicular Lymphoma

Malignant Lymphoma Of Testis

Lymphoma Of The Testis

Wiskott-Aldrich Syndrome

WAS

Eczema-Thrombocytopenia-Immunodeficiency Syndrome

Immunodeficiency 2

Aldrich Syndrome

Imd2

Wiskott-Aldrich Syndrome 1

Was1

Wiskott Syndrome

Wiskott Aldrich Syndrome

Eczema Thrombocytopenia Immunodeficiency Syndrome

Imd 2

Refractory Plasma Cell Neoplasm
Lambda 5 Deficiency
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Transient Hypogammaglobulinemia
Immunodeficiency 46

Tfrc-Related Combined Immunodeficiency

IMD46

Cid Due To Tfrc Deficiency

Combined Immunodeficiency Due To Tfrc Deficiency

Hairy Cell Leukemia

Hcl-V

Hairy Cell Leukemia Variant

Hairy Cell Leukaemia Variant

Hcl

Leukemic Reticuloendotheliosis

Leukemic Reticuloendotheliosis Variant

Prolymphocytic Variant Of Hcl

Prolymphocytic Variant Of Hairy Cell Leukemia

Leukemia Hairy Cell

Leukemia, Hairy Cell

Leukaemic Reticuloendotheliosis

Lre - [Leukemic Reticuloendotheliosis]

Hairy-Cell Leukaemia, Nos

Hcl - [Hairy Cell Leukaemia]

Hairy-Cell Leukaemia Without Mention Of Remission

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency Disease

Primary Immunodeficiency

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Plasma Protein Metabolism Disease
Anemia, Autoimmune Hemolytic

Autoimmune Hemolytic Anemia

Idiopathic Autoimmune Hemolytic Anemia

Immuno-Hemolytic Anemia

Anemia, Hemolytic, Autoimmune

Autoimmune Haemolytic Anaemia

Autoimmune Hemolytic Anaemia

Acquired Autoimmune Hemolytic Anemia

Anemia Hemolytic Autoimmune

Familial Auto-Immune Hemolytic Anemia

Aha

Aiha

Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia

IGHD3

Ighd Iii

Fleisher Syndrome

Growth Hormone Deficiency With Hypogammaglobulinemia, X-Linked

Hypogammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked

Agammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked

Short Stature Due To Isolated Growth Hormone Deficiency With X-Linked Hypogammaglobulinemia

Growth Hormone Deficiency, Isolated, 3, With Agammaglobulinemia

Agammaglobulinemia And Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 3

X-Linked Hypogammaglobulinemia And Isolated Growth Hormone Deficiency

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia

Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder

Ecthyma
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Aneurysm, Intracranial Berry, 12

ANIB12

Intracranial Berry Aneurysm 12

N1 Diffuse Large B-Cell Lymphoma

N1 Dlbcl

Doid:0081067

Paralytic Poliomyelitis

Poliomyelitis, Paralytic

Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma

Mcd Diffuse Large B-Cell Lymphoma

Mcd Dlbcl

Doid:0081066

Mohr-Tranebjaerg Syndrome

Deafness-Dystonia-Optic Neuronopathy Syndrome

Jensen Syndrome

Deafness Dystonia Syndrome

MTS

Dds

Deafness-Dystonia-Optic Atrophy Syndrome

Deafness Syndrome, Progressive, With Blindness, Dystonia, Fractures, And Mental Deficiency

Opticoacoustic Nerve Atrophy With Dementia

Dystonia-Deafness Syndrome

Ddp

Ddon Syndrome

Mohr-Tranebjærg Syndrome

Deafness Dystonia Optic Atrophy Syndrome

Deafness Dystonia Optic Neuronopathy Syndrome

Dystonia Deafness Syndrome

Ddon

Deafness - Dystonia - Optic Neuronopathy Syndrome

Deafness-Dystonia-Optic Neuronopathy Syndrome

Hearing Loss-Dystonia-Optic Neuronopathy Syndrome

Dfn-1

X-Linked Progressive Deafness Type 1

Panniculitis

Nodular Panniculitis

Agammaglobulinemia, X-Linked

X-Linked Agammaglobulinemia

XLA

Bruton Type Agammaglobulinemia

Bruton'S Agammaglobulinemia

Bruton-Type Agammaglobulinemia

Agmx1

Imd1

Agammaglobulinemia, X-Linked 1

Btk-Deficiency

Agammaglobulinemia

Hypogammaglobulinemia

Agammaglobulinemia, X-Linked, Type 1

Immunodeficiency 1

Bruton Agammaglobulinemia Tyrosine Kinase Deficiency

Bruton'S Agammaglobulinaemia

Bruton'S Sex-Linked Agammaglobulinemia

Bruton'S Type Agammaglobulinemia

Btk Deficiency

Agammaglobulinemia, Btk

Agammaglobulinemia, Bruton Tyrosine Kinase

Congenital Agammaglobulinemia

Immunodeficiency Type 1

X-Linked Agammaglobulinemia Type 1

Mast-Cell Leukemia

Mast Cell Leukemia

Leukemia, Mast-Cell

Leukemia Mast Cell

Mast Cell Leukaemia Nos

Mast Cell Leukaemia Without Mention Of Remission

Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked

Lymphoplasmacytic Lymphoma

Waldenstrom Macroglobulinemia

Malignant Lymphoma - Lymphoplasmacytic

Waldenström Macroglobulinaemia

Waldenström Macroglobulinaemia Without Mention Of Remission

Idiopathic Macroglobulinaemia

Primary Macroglobulinaemia

Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Dlbcl Abc Type

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Central Nervous System Lymphoma

Microglioma

Primary Cns Lymphoma

Cns Lymphoma

Primary Central Nervous System Lymphoma

Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia

Richter'S Syndrome

Richter Syndrome

Richter Transformation

Poliomyelitis

Infantile Paralysis

Polio

Conjunctivitis

Madras Eye

Adenoviral Conjunctivitis

Acute Adenoviral Follicular Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Swimming-Pool Conjunctivitis

Inflammation Of Conjunctiva

Ophthalmia

Acute Conjunctivitis

Eye Catarrh

Catarrhal Ophthalmia

Koch-Weeks Conjunctivitis

Pyoderma
Immunoglobulin A Deficiency 1

Immunoglobulin A Deficiency

Selective Iga Deficiency Disease

IGAD1

Selective Immunoglobulin A Deficiency

Immunoglobulin A, Selective Deficiency Of

Iga, Selective Deficiency Of

Gamma-A-Globulin, Selective Deficiency Of

Selective Iga Immunodeficiency

Selective Iga Deficiency

Iga Deficiency Selective

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Cll/Sll

B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Icdo:9823/3

Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission

Small Cell B-Cell Lymphoma

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma

Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris BTK VGNC VGNC:38560
Macaca mulatta BTK VGNC VGNC:82111
Felis catus BTK VGNC VGNC:82460
Rattus norvegicus BTK RGD RGD:1359683
Mus musculus BTK MGD MGI:88216
Bos taurus BTK VGNC VGNC:26601
Others BTK NCBI