Honokiol (Synonyms: 和厚朴酚; NSC 293100)

目录号: HY-N0003 纯度: 99.85%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Honokiol是一种具有生物活性的双酚类植物化学物质，靶向多种信号分子，具有有效的抗氧化，抗炎，抗血管生成和抗癌活性。它抑制 Akt 的活化。Honokiol 能透过血脑屏障。

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Honokiol Chemical Structure

CAS No. : 35354-74-6

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥500	In-stock
5 mg	￥281	In-stock
10 mg	￥450	In-stock
50 mg	￥550	In-stock
100 mg	￥770	In-stock
200 mg	￥990	In-stock
500 mg		询价
1 g		询价

or 大包装询价

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Customer Review

Other Forms of Honokiol:

Honokiol (Standard) 询价

MCE 顾客使用本产品发表的 45 篇科研文献

: Honokiol purchased from MCE. Usage Cited in: Exp Anim. 2023 Mar 2. [Abstract]; IF staining assays demonstrates that Honokiol (5 mg/kg; i.p.; single) elevates the expression of SIRT3 in the lung tissues of APE (acute pulmonary embolism) rats.

: Honokiol purchased from MCE. Usage Cited in: Int J Biol Macromol. 2020 Mar 15;147:79-88. [Abstract]; Effect of GFP-A and Honokiol (activator of ERK1/2) (10 μmol/L) on the protein expression of NF-κB p65 in HT-29 cells. Cells were treated with 180 μg/mL GFP-A in the presence or absence of Honokiol for different durations of time. The expression of protein was analyzed by western blot. β-Actin was used as an equal loading control.

Honokiol 相关产品

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier^[1]^[2]^[3]^[4].

IC₅₀ & Target^[4]

ERK1

ERK2

Autophagy

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A2780	IC₅₀	30.5 μM Compound: Honokiol	Antiproliferative activity against human A2780 cells after 24 hrs by MTT assay Antiproliferative activity against human A2780 cells after 24 hrs by MTT assay	[PMID: 31278004]
A2780	IC₅₀	30.5 μM Compound: 1	Antiproliferative activity against cisplatin-sensitive human A2780 cells by MTT assay Antiproliferative activity against cisplatin-sensitive human A2780 cells by MTT assay	[PMID: 19589678]
A2780	IC₅₀	31.58 μM Compound: HN; 2a	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
A2780	IC₅₀	41.2 μM Compound: 1	Antiproliferative activity against cisplatin-resistant human A2780 cells by MTT assay Antiproliferative activity against cisplatin-resistant human A2780 cells by MTT assay	[PMID: 19589678]
A549	IC₅₀	> 5 μg/mL Compound: 6	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 17918910]
A549	IC₅₀	12.51 μM Compound: Honokiol	Cytotoxicity against human A549 cells after 24 hrs by MTS assay Cytotoxicity against human A549 cells after 24 hrs by MTS assay	[PMID: 22533983]
A549	IC₅₀	29.7 μM Compound: Honokiol	Antiproliferative activity against human A549 cells by MTT assay Antiproliferative activity against human A549 cells by MTT assay	[PMID: 31278004]
A549	IC₅₀	34.1 μM Compound: Honokiol	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 31278004]
A549	IC₅₀	35 μM Compound: Honokiol	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 21853991]
A549	IC₅₀	35 μM Compound: 1	Antiproliferative activity against human A549 cells by MTT assay Antiproliferative activity against human A549 cells by MTT assay	[PMID: 19589678]
A549	IC₅₀	35.31 μM Compound: 1; HK	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30006164]
A549	IC₅₀	35.41 μM Compound: Honokiol	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 31278004]
A549	IC₅₀	38.04 μM Compound: HN; 2a	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
A549	IC₅₀	7.75 μM Compound: Honokiol	Cytotoxicity against human A549 cells after 72 hrs by MTS assay Cytotoxicity against human A549 cells after 72 hrs by MTS assay	[PMID: 22533983]
BV-2	IC₅₀	17 μM Compound: 1	Anti-inflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay Anti-inflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay	[PMID: 30472026]
CHO	EC₅₀	> 10 μM Compound: 1	Agonist activity at recombinant human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 5 mins by cAMP-competition binding assay Agonist activity at recombinant human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 5 mins by cAMP-competition binding assay	[PMID: 24900561]
CNE2Z	IC₅₀	31.27 μM Compound: Honokiol	Antiproliferative activity against human CNE2Z cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human CNE2Z cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 31831382]
HCC827	IC₅₀	33.88 μM Compound: 1; HK	Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay	[PMID: 30006164]
HCT-116	IC₅₀	19.05 μM Compound: Honokiol	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 31278004]
HCT-116	IC₅₀	47.65 μM Compound: 35	Antitumor activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antitumor activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 36332549]
HEK293	ED₅₀	11.8 μM Compound: Honokiol	Agonist activity at human RXR-alpha expressed in HEK293 cells coexpressing with pCMX-beta-gal after 24 to 48 hrs by luciferase reporter gene assay Agonist activity at human RXR-alpha expressed in HEK293 cells coexpressing with pCMX-beta-gal after 24 to 48 hrs by luciferase reporter gene assay	[PMID: 24959987]
HEK293	EC₅₀	11.8 μM Compound: 1	Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay	[PMID: 20695472]
HEK293	IC₅₀	40 μM Compound: Ho	Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 2 days by MTT assay Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 2 days by MTT assay	[PMID: 30733086]
HEK293	IC₅₀	9.3 μg/mL Compound: Honokiol	Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 27259399]
HeLa	IC₅₀	> 5 μg/mL Compound: 6	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 17918910]
HepG2	IC₅₀	16.5 μM Compound: Honokiol	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 21853991]
HepG2	IC₅₀	23.85 μM Compound: HN; 2a	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
HepG2	IC₅₀	32.9 μM Compound: Honokiol	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 31278004]
HepG2	IC₅₀	33.88 μM Compound: Honokiol	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 31278004]
HepG2	IC₅₀	34.3 μM Compound: Honokiol	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 31278004]
HT-29	IC₅₀	13.24 μM Compound: Honokiol	Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay	[PMID: 22533983]
HT-29	IC₅₀	23.05 μM Compound: Honokiol	Cytotoxicity against human HT-29 cells after 24 hrs by MTS assay Cytotoxicity against human HT-29 cells after 24 hrs by MTS assay	[PMID: 22533983]
HT-29	IC₅₀	25 μM Compound: Ho	Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 2 days by MTT assay Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 2 days by MTT assay	[PMID: 30733086]
HT-29	IC₅₀	31.58 μM Compound: HN; 2a	Antiproliferative activity against human HT29 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HT29 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
HT-29	IC₅₀	6.1 μg/mL Compound: Honokiol	Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 27259399]
Huh-7	IC₅₀	58.5 μM Compound: Honokiol	Cytotoxicity against human Huh7.5 cells after 72 hrs Cytotoxicity against human Huh7.5 cells after 72 hrs	[PMID: 24400834]
HUVEC	IC₅₀	52.6 μM Compound: Honokiol	Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay	[PMID: 21853991]
I10	IC₅₀	31.11 μM Compound: Honokiol	Antiproliferative activity against mouse I10 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against mouse I10 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 31831382]
K562	IC₅₀	> 5 μg/mL Compound: 6	Cytotoxicity against human K562 cells by MTT assay Cytotoxicity against human K562 cells by MTT assay	[PMID: 17918910]
K562	IC₅₀	21.1 μM Compound: 1	Antiproliferative activity against human K562 cells by MTT assay Antiproliferative activity against human K562 cells by MTT assay	[PMID: 19589678]
K562	IC₅₀	22.1 μM Compound: Honokiol	Antiproliferative activity against human K562 cells after 24 hrs by MTT assay Antiproliferative activity against human K562 cells after 24 hrs by MTT assay	[PMID: 31278004]
K562	IC₅₀	23.91 μM Compound: Honokiol	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 31278004]
K562	IC₅₀	28.4 μM Compound: Honokiol	Antiproliferative activity against human K562 cells by MTT assay Antiproliferative activity against human K562 cells by MTT assay	[PMID: 31278004]
L02	IC₅₀	25.49 μM Compound: HN; 2a	Antiproliferative activity against human L02 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human L02 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
Lewis lung carcinoma cell line	IC₅₀	65.4 μM Compound: Honokiol	Antiproliferative activity against mouse LL/2 cells after 24 hrs by MTT assay Antiproliferative activity against mouse LL/2 cells after 24 hrs by MTT assay	[PMID: 21853991]
MCF7	IC₅₀	35 μM Compound: Ho	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 2 days by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 2 days by MTT assay	[PMID: 30733086]
MCF7	IC₅₀	41.8 μM Compound: Honokiol	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 31831382]
MCF7	IC₅₀	5 μg/mL Compound: Honokiol	Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 27259399]
MDA-MB-231	IC₅₀	44.89 μM Compound: Honokiol	Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay	[PMID: 34605238]
NCI-H1650	IC₅₀	37.35 μM Compound: 1; HK	Antiproliferative activity against human NCI-H1650 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1650 cells after 72 hrs by MTT assay	[PMID: 30006164]
NCI-H1975	IC₅₀	30.2 μM Compound: Honokiol	Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay	[PMID: 31278004]
NCI-H1975	IC₅₀	30.2 μM Compound: 1; HK	Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay	[PMID: 30006164]
NCI-H358	IC₅₀	31.57 μM Compound: 1; HK	Antiproliferative activity against human NCI-H358 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H358 cells after 72 hrs by MTT assay	[PMID: 30006164]
NCI-H441	IC₅₀	33.32 μM Compound: 1; HK	Antiproliferative activity against human H441 cells after 72 hrs by MTT assay Antiproliferative activity against human H441 cells after 72 hrs by MTT assay	[PMID: 30006164]
NCI-H460	IC₅₀	38.46 μM Compound: 1; HK	Antiproliferative activity against human H460 cells after 72 hrs by MTT assay Antiproliferative activity against human H460 cells after 72 hrs by MTT assay	[PMID: 30006164]
Oocyte	EC₅₀	23.4 μM Compound: Hon, HK	Modulation of GABA Aalpha5beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha5beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	36.2 μM Compound: Hon, HK	Modulation of GABA alpha1beta2gamma2s receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA alpha1beta2gamma2s receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	39.3 μM Compound: Hon, HK	Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	46.4 μM Compound: Hon, HK	Modulation of GABA Aalpha2beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha2beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	52.4 μM Compound: Hon, HK	Modulation of GABA Aalpha3beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha3beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	57 μM Compound: Hon, HK	Modulation of GABA Aalpha1beta1 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha1beta1 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	59.6 μM Compound: Hon, HK	Modulation of GABA Aalpha1beta3 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha1beta3 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
PANC-1	IC₅₀	31.24 μM Compound: HN; 2a	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
PC-3	IC₅₀	29.03 μM Compound: HN; 2a	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
PC-9	IC₅₀	36.72 μM Compound: 1; HK	Antiproliferative activity against human PC9 cells after 72 hrs by MTT assay Antiproliferative activity against human PC9 cells after 72 hrs by MTT assay	[PMID: 30006164]
Platelet	IC₅₀	0.6 μM Compound: 2	Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry	[PMID: 32463237]
RKO	IC₅₀	11.42 μM Compound: 35	Antitumor activity against human RKO cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antitumor activity against human RKO cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 36332549]
SW480	IC₅₀	15.14 μM Compound: 35	Antitumor activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antitumor activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 36332549]
UACC-903	IC₅₀	5.1 μM Compound: Honokiol	Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay	[PMID: 22533983]
UACC-903	IC₅₀	7.45 μM Compound: Honokiol	Cytotoxicity against human UACC-903 cells after 24 hrs by MTS assay Cytotoxicity against human UACC-903 cells after 24 hrs by MTS assay	[PMID: 22533983]
Vero	EC₅₀	6.5 μM Compound: 18	Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA	[PMID: 17663539]
Vero	CC₅₀	88.9 μM Compound: 18	Cytotoxicity against Vero E6 cells by MTT assay Cytotoxicity against Vero E6 cells by MTT assay	[PMID: 17663539]

体外研究
(In Vitro)

Honokiol (0、12.5、25 和 50 μM) 抑制 GBM 细胞的生长并诱导细胞凋亡，对 30 μM DBTRG-05MG 细胞的 IC₅₀ 约为。Honokiol 诱导的 GBM 细胞凋亡与 Rb 蛋白的下调和 PARP 和 Bcl-x (S/L) 的裂解有关。Honokiol (50 μM) 增加 GBM 细胞中自噬标记物的水平^[1]。
Honokiol 具有抗癌作用，对MDA-MB-231、MDA-MB-468、MDA-MB-453细胞系的IC₅₀值为16.99 ± 1.28 μM，15.94 ±分别为 2.35 μM 和 20.11 ±3.13 μM。Honokiol (3，10 μM) 在克隆形成试验中对球体数量和球体大小产生显著抑制作用^[2]。
Honokiol (0.1-1.0 μM) 特异性抑制由胶原蛋白刺激的洗涤过的人血小板聚集，但不抑制其他激动剂刺激的血小板聚集。honokiol (0.6 和 1.0 μM) 可以浓度依赖性地抑制洗涤过的人血小板中胶原诱导的 ATP 释放反应。Honokiol 可特异性抑制惊厥素刺激的血小板聚集和 Lyn、PLCγ2 和 PKC 的磷酸化。Honokiol (5，10 μM) 显著抑制惊厥素刺激的 MAPK 和 Akt 激活^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Honokiol-NM (40 mg/kg，po) 产生优异的抗癌作用，PCNA、Cyclin D1 和 cleaved caspase 3 表达在该处理组中显著改变 2.12、1.92 和 1.68 倍^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

266.33

Formula

C₁₈H₁₈O₂

CAS 号

35354-74-6

性状

固体

颜色

White to off-white

中文名称

和厚朴酚

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 50 mg/mL (187.74 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7547 mL	18.7737 mL	37.5474 mL
5 mM	0.7509 mL	3.7547 mL	7.5095 mL
10 mM	0.3755 mL	1.8774 mL	3.7547 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.39 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.39 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.39 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： Corn Oil
Solubility: 16.67 mg/mL (62.59 mM); 澄清溶液; 超声助溶

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.90%

选择批次：

Data Sheet (654 KB) SDS (620 KB)

COA (288 KB) HNMR (197 KB) LCMS (482 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Chang KH, et al. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett. 2013 Nov;6(5):1435-1438. [Content Brief]

[2]. Godugu C, et al. Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC). Colloids Surf B Biointerfaces. 2017 Jan 23;153:208-219 [Content Brief]

[3]. Lee TY, et al. Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Sci Rep. 2017 Jan 5;7:40002 [Content Brief]

[4]. Zhai H, et al. Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2). Eur J Pharmacol. 2005 Jun 1;516(2):112-7. [Content Brief]

Cell Assay ^[2]	In cytotoxicity assays, 10,000 cells/well are added to 96 wells plates and incubated overnight, thereafter cells are treated with different concentrations of Honokiol dissolved in dimethylsulphoxide (DMSO). Since Honokiol is not soluble in aqueous solvents, for in vitro studies Honokiol is dissolved in DMSO. To study the possible effect of DMSO on cells, solvent (DMSO) control is used at highest concentration of <0.1%. After 72 h treatment, cells are fixed and cell viability is measured by crystal violet staining (0.05%). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[2]	For anticancer in vivo studies, the MDA-MB-231 cells (2 million) are injected into mammary fat tissue. Two weeks after the tumor cell injections, palpable tumors are observed in mammary tissues, which is an indication of tumor formation. Then drug treatment either in free form or in nanomicellar forms is given orally at the dose of 40 and 80 mg/kg daily. The drug treatment is continued for 4 weeks, and the tumor volumes and body weights are recorded weekly. After 4 weeks of treatment, animals are sacrificed; final tumor volumes and weights are measured. These tumors are used for western blot and immunohistochemical analysis. For western blot experiments, tumor tissues are stored at −80°C till the analysis is done. For IHC, tumors are fixed in formal saline. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Chang KH, et al. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett. 2013 Nov;6(5):1435-1438. [Content Brief] [2]. Godugu C, et al. Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC). Colloids Surf B Biointerfaces. 2017 Jan 23;153:208-219 [Content Brief] [3]. Lee TY, et al. Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Sci Rep. 2017 Jan 5;7:40002 [Content Brief] [4]. Zhai H, et al. Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2). Eur J Pharmacol. 2005 Jun 1;516(2):112-7. [Content Brief]

Honokiol 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7547 mL	18.7737 mL	37.5474 mL	93.8685 mL
	5 mM	0.7509 mL	3.7547 mL	7.5095 mL	18.7737 mL
	10 mM	0.3755 mL	1.8774 mL	3.7547 mL	9.3869 mL
	15 mM	0.2503 mL	1.2516 mL	2.5032 mL	6.2579 mL
	20 mM	0.1877 mL	0.9387 mL	1.8774 mL	4.6934 mL
	25 mM	0.1502 mL	0.7509 mL	1.5019 mL	3.7547 mL
	30 mM	0.1252 mL	0.6258 mL	1.2516 mL	3.1290 mL
	40 mM	0.0939 mL	0.4693 mL	0.9387 mL	2.3467 mL
	50 mM	0.0751 mL	0.3755 mL	0.7509 mL	1.8774 mL
	60 mM	0.0626 mL	0.3129 mL	0.6258 mL	1.5645 mL
	80 mM	0.0469 mL	0.2347 mL	0.4693 mL	1.1734 mL
	100 mM	0.0375 mL	0.1877 mL	0.3755 mL	0.9387 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Honokiol35354-74-6NSC 293100和厚朴酚NSC293100NSC-293100AktAutophagyHCVERKPKBProtein kinase BHepatitis C virusExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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Honokiol (Synonyms: 和厚朴酚; NSC 293100)

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Honokiol (Synonyms: 和厚朴酚; NSC 293100)

Customer Review

Other Forms of Honokiol:

Honokiol 相关抗体

MCE 顾客使用本产品发表的 45 篇科研文献

Honokiol 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 Akt 亚型特异性产品:

查看 ERK 亚型特异性产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

Honokiol 相关抗体:

摩尔计算器

稀释计算器

Honokiol 相关分类

完整储备液配制表

Keywords:

您最近查看的产品:

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