2. NF-κB Apoptosis
  3. NF-κB Apoptosis
  4. NF-κB-IN-4

NF-κB-IN-4 (化合物 17) 是一种有效的可透过血脑屏障的 NF-κB 通路抑制剂。NF-κB-IN-4 表现出潜在的低毒性抗神经炎症活性。NF-κB-IN-4 可阻断 IκBα 的激活和磷酸化，降低 NLRP3 的表达，从而抑制 NF-κB 的激活。NF-κB-IN-4 可用于神经炎症相关疾病的研究。

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NF-κB-IN-4 Chemical Structure

NF-κB-IN-4 Chemical Structure

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1241
In-stock
1 mg ￥795
In-stock
5 mg ￥1750
In-stock
10 mg ￥2800
In-stock
25 mg ￥5600
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

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Customer Review

NF-κB-IN-4 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NF-κB-IN-4 (compound 17) is a potent and BBB-penetrated NF-κB pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research[1].

体外研究
(In Vitro)

NF-κB-IN-4 (compound 17) (0-10 μM, 24 h) shows high anti-inflammatory activity[1].
NF-κB-IN-4 (0-5 μM, 24 h) significantly decreases the LPS-induced p-IκBα expression levels, significantly inhibits the phosphorylation of IκBα and the expression of three proteins (NLRP3, ASC and caspase-1) in BV2 cells[1].
NF-κB-IN-4 (0-5 μM, 24 h) induces LPS-induced apoptosis in BV2 cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NF-κB-IN-4 相关抗体:

Cell Cytotoxicity Assay

Cell Line: BV2 microglia cells[1]
Concentration: 0, 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Showed high anti-inflammatory activity, with the survival rate of BV2 microglia cells of 97.4%, inhibition rates against TNF-α and IL-6 release of 60.8% and 80.2%, respectively.

Western Blot Analysis

Cell Line: BV2 cells[1]
Concentration: 0, 1.25, 2.5, 5 μM
Incubation Time: 24 h
Result: Significantly decreased the LPS-induced p-IκBα expression levels, significantly inhibited the phosphorylation of IκBα and the expression of three proteins (NLRP3, ASC and caspase-1) in BV2 cells.

Apoptosis Analysis

Cell Line: BV2 cells[1]
Concentration: 0, 2.5, 5 μM
Incubation Time: 24 h
Result: Induced LPS-induced apoptosis in BV2 cells in a dose-dependent manner, with the apoptosis rates of 30.7% (2.5 μM) and 13.0% (5 μM), respectively.
分子量

322.34

Formula

C18H15FN4O
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (310.23 mM; ultrasonic and warming and heat to 150°C; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1023 mL 15.5116 mL 31.0231 mL
5 mM 0.6205 mL 3.1023 mL 6.2046 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

NF-κB-IN-4 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1023 mL 15.5116 mL 31.0231 mL 77.5579 mL
5 mM 0.6205 mL 3.1023 mL 6.2046 mL 15.5116 mL
10 mM 0.3102 mL 1.5512 mL 3.1023 mL 7.7558 mL
15 mM 0.2068 mL 1.0341 mL 2.0682 mL 5.1705 mL
20 mM 0.1551 mL 0.7756 mL 1.5512 mL 3.8779 mL
25 mM 0.1241 mL 0.6205 mL 1.2409 mL 3.1023 mL
30 mM 0.1034 mL 0.5171 mL 1.0341 mL 2.5853 mL
40 mM 0.0776 mL 0.3878 mL 0.7756 mL 1.9389 mL
50 mM 0.0620 mL 0.3102 mL 0.6205 mL 1.5512 mL
60 mM 0.0517 mL 0.2585 mL 0.5171 mL 1.2926 mL
80 mM 0.0388 mL 0.1939 mL 0.3878 mL 0.9695 mL
100 mM 0.0310 mL 0.1551 mL 0.3102 mL 0.7756 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-4NF-κBApoptosisNuclear factor-κBNuclear factor-kappaBNeuroinflammationLow toxicityBlood-brain barrierBV2 microglia cellsNeuroprotectiveInhibitorinhibitorinhibit

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