Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum.
The basic requirements for the compounds that are supposed to penetrate the blood-brain barrier are somewhat different from those for the majority of drug discovery projects. Alongside the known problem with delivery of the large and non-polar compounds and their penetrability through the cell membrane, the other issue arises as well: small and polar compounds are not able to pass the Blood-Brain Barrier. Chemspace CNS-focused library comprises quite small, non-polar compounds that are also free from PAINS/toxic fragments and aggregators.
Protein-protein interactions (PPIs) play a key role in nearly every biological function and are a promising new class of biological targets for therapeutic intervention. This is a collection of 2,906 diverse compounds designed for discovery of PPI modulators.
The Chinese National Compound Library (CNCL) composes 1.4 million compounds possessing diversified structures. Coupled with this library will be advanced sample handling, information management and quality control systems. Most compounds in the library are drug-like, conforming to “Lipinski’s Rule of Five”, such as MW < 500, logP < 5, Hydrogen Bond Donors < 5.
ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks.
Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.
Discovery Diversity Sets (DDS) are high-quality compound libraries focused on novel chemotypes and non-trivial structures. Discovery Diversity Set 10 compose of 10 highly diverse compounds produced only within last three years. The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because they are based on diverse novel scaffolds and latest building blocks. The hits discovered are expected to easily yield lead compounds.
Discovery Diversity Sets (DDS) are high-quality compound libraries focused on novel chemotypes and non-trivial structures. Discovery Diversity Set 50 compose of 50,240 highly diverse compounds produced only within last three years. The two sets do not overlap and deliver a total of 60 thousand compounds. The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because they are based on diverse novel scaffolds and latest building blocks. The hits discovered are expected to easily yield lead compounds.
MCE 3D 多样片段库由 5,400 个非平面片段分子组成（平均 Fsp3 值为 0.58），超过4,700个片段至少包含一个手性中心。本库设计的关键元素是 3D 结构、多样性、生物反应性等。另，库中化合物在保证高sp3中心和 3D 结构优势的同时，还有效提高了片段潜在生物活性，为基于片段的药物发现提供了更高的片段命中优化概率，增加了找到创新命中的可能性。
放射性疾病是人体受各种电离辐射后发生的各种类型和不同程度的损伤 (或疾病) 的总称。即使是少量的电离辐射也会使机体产生自由基和活性氧，引起氧化应激，导致 DNA 损伤和染色体畸变。抗辐射药物又称辐射防护药，是用于预防/保护非肿瘤细胞免受辐射有害影响的化合物。抗辐射药物可预防放射性物质对人体的损伤，减轻各种放射性疾病的临床症状。此外，抗辐射药物还被常运用于癌症放射治疗中,保护正常细胞不受损伤。而理想的抗辐射药物应当在保护正常细胞的前提下，不影响肿瘤细胞对放射治疗的敏感性。
糖尿病是以长期高血糖为特征的代谢疾病。主要有两种类型：I 型糖尿病（T1D）和 II 型糖尿病（T2D）。I 型糖尿病又称为青少年糖尿病或胰岛素依赖型糖尿病，是以胰腺中 β 细胞破坏，不能产生胰岛素为特征；而 II 型糖尿病又称为非胰岛素依赖性糖尿病，其特征为胰岛素分泌进行性障碍，靶组织对分泌的胰岛素敏感性降低，其中 II 型糖尿病是糖尿病中的主要形式。所有类型的糖尿病都可能导致身体许多部位出现并发症，并增加过早死亡的风险，可能的并发症包括肾功能衰竭、截肢、视力丧失和神经损伤等。
Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum.
Growth factor-like peptide; Leader protein; Non-structural protein 10; Non-structural protein 2; Non-structural protein 3; Non-structural protein 4; Non-structural protein 6; Non-structural protein 7; Non-structural protein 8; Non-structural protein 9; Papain-like proteinase; p65 homolog
TCPTP 是一种非受体酪氨酸特异性磷酸酶，可严格调节影响造血、炎症、细胞增殖和葡萄糖稳态的各种激酶（INSR、EGFR、JAK、Src）。在免疫系统中，TCPTP 调节 T 细胞受体信号传导并抑制细胞因子途径（IL2、干扰素）。TCPTP Protein, Human (sf9) 是重组的 TCPTP 蛋白，由 Sf9 insect cells 表达，不带标签, with residual Gly-Pro in N-terminal (not related to functional changes)。
EDNRB/内皮素 R B 型蛋白是内皮素 1、2 和 3 的非特异性受体，通过 G 蛋白激活磷脂酰肌醇-钙第二信使系统。这一机制强调了其在介导内皮素神经肽引发的细胞反应中的关键作用，强调了 EDNRB 在转导各种生理过程信号中的多功能性。EDNRB/Endothelin R Type B Protein, Human (HEK293, His) 是重组的 EDNRB/内皮素 R B 型蛋白，由 HEK293 表达，带有 C-His 标签。
EDNRB/内皮素 R B 型蛋白是内皮素 1、2 和 3 的非特异性受体，通过 G 蛋白激活磷脂酰肌醇-钙第二信使系统。这一机制强调了其在介导内皮素神经肽引发的细胞反应中的关键作用，强调了 EDNRB 在转导各种生理过程信号中的多功能性。EDNRB/Endothelin R Type B Protein, Human (HEK293, Fc) 是重组的 EDNRB/B 型内皮素 R 蛋白，由 HEK293 表达，带有 C-mFc 标签。EDNRB/Endothelin R Type B Protein, Human (HEK293, Fc) 全长 75 个氨基酸，分子量分别约为 ~47.5 & 43.7 kDa。
EDNRB/内皮素 R B 型蛋白是内皮素 1、2 和 3 的非特异性受体，通过 G 蛋白激活磷脂酰肌醇-钙第二信使系统。这一机制强调了其在介导内皮素神经肽引发的细胞反应中的关键作用，强调了 EDNRB 在转导各种生理过程信号中的多功能性。EDNRB/Endothelin R Type B Protein, Human (Cell-Free, His) 是重组的 EDNRB/内皮素 R B 型蛋白，由 E. coli Cell-free 表达，带有 C-10*His 标签。EDNRB/Endothelin R Type B Protein, Human (Cell-Free, His) 全长 416 个氨基酸，分子量为 50.3 kDa。
Linker for Activation of T-Cells Family Member 2; Linker for Activation of B-Cells; Membrane-Associated Adapter Molecule; Non-T-Cell Activation Linker; Williams-Beuren Syndrome Chromosomal Region 15 Protein; Williams-Beuren Syndrome Chromosomal Region 5 Protei
Glutamate carboxypeptidase II type Non peptidase homologue; Inactive N acetylated alpha linked acidic dipeptidase like protein 2; Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2; N acetylated alpha linked acidic dipeptidase like 2; NAALADase L2; NAALADL 2; NAALADL2
ATP synthase alpha chain; ATP synthase alpha chain; mitochondrial; ATP synthase subunit alpha; ATP synthase subunit alpha mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit 1; cardiac muscle; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; 1; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 1; cardiac muscle; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 2; Non-cardiac muscle-like 2; ATP sythase F1 ATPase; alpha subunit; ATP5A; Atp5a1; ATP5AL2; ATPA_HUMAN; ATPM; Epididymis secretory sperm binding protein Li 123m; hATP1; HEL-S-123m; MC5DN4; mitochondrial; Mitochondrial ATP synthetase; Mitochondrial ATP synthetase oligomycin resistant; Modifier of Min 2; Modifier of Min 2 mouse homolog; Modifier of Min 2; mouse; homolog of; MOM2; OMR; ORM; OTTHUMP00000163475
SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
WB, IHC-P, IP
Human, Rat
alpha Synuclein Antibody (YA2073) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2073), targeting alpha Synuclein, with a predicted molecular weight of 14 kDa (observed band size: 18 kDa). alpha Synuclein Antibody (YA2073) can be used for WB, IHC-P, IP experiment in human, rat background.
SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
WB, ICC/IF
Human, Mouse, Rat
Phospho-alpha Synuclein (Ser129) Antibody (YA1484) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1484), targeting Phospho-alpha Synuclein (Ser129), with a predicted molecular weight of 14 kDa. Phospho-alpha Synuclein (Ser129) Antibody (YA1484) can be used for WB, ICC/IF experiment in human, mouse, rat background.
CD66c; CEACAM6; CEAL; NCA; Non specific cross reacting antigen; Normal cross reacting antigen
WB, IHC-P, ICC/IF, IP
Human, Mouse, Rat
CEACAM6 Antibody (YA3351) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3351), targeting CEACAM6, with a predicted molecular weight of 37 kDa (observed band size: 37 kDa). CEACAM6 Antibody (YA3351) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.
NEAS Antibody (YA1355) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1355), targeting NEAS, with a predicted molecular weight of 285 kDa (observed band size: 285 kDa). NEAS Antibody (YA1355) can be used for WB, ICC/IF experiment in human, mouse, rat background.
alpha Fodrin Antibody (YA3347) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3347), targeting alpha Fodrin, with a predicted molecular weight of 285 kDa (observed band size: 150,285 kDa). alpha Fodrin Antibody (YA3347) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.
Cofilin Antibody (YA2822) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2822), targeting Cofilin, with a predicted molecular weight of 19 kDa (observed band size: 19 kDa). Cofilin Antibody (YA2822) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.
Endothelin B receptor; ET-B; ET-BR; Endothelin receptor Non-selective type
WB, IP
Human
Endothelin Receptor B Antibody (YA3255) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3255), targeting Endothelin Receptor B, with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). Endothelin Receptor B Antibody (YA3255) can be used for WB, IP experiment in human background.
Cofilin 1 Antibody (YA1311) is a non-conjugated IgG antibody, targeting Cofilin 1, with a predicted molecular weight of 19 kDa (observed band size: 19 kDa). Cofilin 1 Antibody (YA1311) can be used for WB, IF-Cell, FC experiment in Human, Mouse, Rat, Monkey background.
CD209; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing Non-integrin 1; DC-SIGN; DC-SIGN1; CD209
WB
Human
CD209 Antibody (YA3359) is a biotin-conjugated non-conjugated IgG antibody, targeting CD209, with a predicted molecular weight of 46 kDa (observed band size: 50 kDa). CD209 Antibody (YA3359) can be used for WB experiment in human background.
Cernunno; Nhej1; Non homologous end joining factor 1; Protein cernunnos; XLF; XRCC4 like factor
WB, IHC-P, ICC/IF, FC
Human, Mouse, Rat
XLF Antibody (YA2300) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2300), targeting XLF, with a predicted molecular weight of 33 kDa (observed band size: 39 kDa). XLF Antibody (YA2300) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.
PSMD14 Antibody (YA2250) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2250), targeting PSMD14, with a predicted molecular weight of 35 kDa (observed band size: 35 kDa). PSMD14 Antibody (YA2250) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.
MYLK Antibody (YA3133) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3133), targeting MYLK, with a predicted molecular weight of 211 kDa. MYLK Antibody (YA3133) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.
alpha Actinin 4 Antibody (YA2062) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2062), targeting alpha Actinin 4, with a predicted molecular weight of 105 kDa (observed band size: 105 kDa). alpha Actinin 4 Antibody (YA2062) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.
PTP1B Antibody (YA1776) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1776), targeting PTP1B, with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). PTP1B Antibody (YA1776) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.
Phospho-PTP1B (Ser352) Antibody (YA1027) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1027), targeting Phospho-PTP1B (Ser352), with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). Phospho-PTP1B (Ser352) Antibody (YA1027) can be used for WB, ICC/IF, IP experiment in human background.
Phospho-PTP1B (Ser378) Antibody (YA1028) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1028), targeting Phospho-PTP1B (Ser378), with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). Phospho-PTP1B (Ser378) Antibody (YA1028) can be used for WB, IHC-P experiment in human background.
SHP1 Antibody (YA1044) is a mouse-derived non-conjugated IgG2a antibody (Clone NO.: YA1044), targeting SHP1, with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). SHP1 Antibody (YA1044) can be used for WB, IP experiment in human background.
SHP1 Antibody (YA1045) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1045), targeting SHP1, with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). SHP1 Antibody (YA1045) can be used for WB, IHC-P experiment in human background.
SHP2 Antibody (YA1643) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1643), targeting SHP2, with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). SHP2 Antibody (YA1643) can be used for WB, IHC-P, IP experiment in human background.
PYK2 Antibody (YA682) is a non-conjugated and Mouse origined monoclonal antibody about 116 kDa, targeting to PYK2 (4B4). It can be used for WB,IHC-P assays with tag free, in the background of Human.
SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; Tyrosine-protein phosphatase Non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibito
WB, FC
Human
SIRP alpha Antibody (YA1361) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1361), targeting SIRP alpha. SIRP alpha Antibody (YA1361) can be used for FC,WB experiment in human background.
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