2. Gene
  3. Ager - advanced glycosylation end product-specific receptor Gene

Ager - advanced glycosylation end product-specific receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: RAGE

基因 ID: 11596 | 基因类型: protein coding

关于 Ager

功能概要

Enables S100 protein binding activity; advanced glycation end-product binding activity; and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of long-term synaptic potentiation; and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of advanced glycation end-product receptor activity; and positive regulation of macromolecule metabolic process. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ager 基因产物(4)

mRNA Protein Name
NM_001271422.1 NP_001258351.1 advanced glycosylation end product-specific receptor isoform b precursor
NM_001271423.1 NP_001258352.1 advanced glycosylation end product-specific receptor isoform c precursor
NM_001271424.1 NP_001258353.1 advanced glycosylation end product-specific receptor isoform d
NM_007425.3 NP_031451.2 advanced glycosylation end product-specific receptor isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables S100 protein binding IPI
IPI: 通过物理相互作用推断
18606705 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10399917 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within astrocyte development IMP
IMP: 通过突变表型推断
22577135 MGI
involved in cellular response to amyloid-beta IMP
IMP: 通过突变表型推断
19221410 MGI
acts upstream of or within induction of positive chemotaxis IMP
IMP: 通过突变表型推断
14744997 MGI
acts upstream of or within inflammatory response IGI
IGI: 通过遗传相互作用推断
21148126 MGI
involved in microglial cell activation IGI
IGI: 通过遗传相互作用推断
22406537 MGI
involved in negative regulation of blood circulation IGI
IGI: 通过遗传相互作用推断
12808450 MGI
involved in negative regulation of long-term synaptic potentiation IGI
IGI: 通过遗传相互作用推断
18367618 MGI
acts upstream of or within positive regulation of JUN kinase activity IMP
IMP: 通过突变表型推断
18323529 MGI
involved in positive regulation of chemokine production IGI
IGI: 通过遗传相互作用推断
22406537 MGI
involved in positive regulation of endothelin production IGI
IGI: 通过遗传相互作用推断
12808450 MGI
involved in positive regulation of interleukin-1 beta production IGI
IGI: 通过遗传相互作用推断
22406537 MGI
involved in positive regulation of interleukin-6 production IGI
IGI: 通过遗传相互作用推断
22406537 MGI
acts upstream of or within positive regulation of monocyte chemotactic protein-1 production IGI
IGI: 通过遗传相互作用推断
24995813 MGI
involved in positive regulation of tumor necrosis factor production IGI
IGI: 通过遗传相互作用推断
22406537 MGI
acts upstream of or within protein localization to membrane IMP
IMP: 通过突变表型推断
18323529 MGI
acts upstream of or within regulation of DNA binding IMP
IMP: 通过突变表型推断
18323529 MGI
involved in regulation of inflammatory response IDA
IDA: 通过直接分析推断
10399917 MGI
involved in regulation of long-term synaptic potentiation IMP
IMP: 通过突变表型推断
19221410 MGI
involved in regulation of p38MAPK cascade IGI
IGI: 通过遗传相互作用推断
18367618 MGI
involved in response to amyloid-beta IGI
IGI: 通过遗传相互作用推断
18367618 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
18323529 MGI
involved in transcytosis IGI
IGI: 通过遗传相互作用推断
22406537 MGI
involved in transcytosis IMP
IMP: 通过突变表型推断
12808450 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

advanced glycosylation end product-specific receptor

advanced glycation end-products receptor

receptor for advanced glycosylation end products

Ager 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Ager Q62151 Prkcz Mus musculus Q02956
Anti Bait CoIP
21829704
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Ager 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74425 AGER Protein, Mouse (HEK293, His) Q62151-1/NP_031451.2 (Q24-A342) ≥95%

相关产品

Approval
生物活性分子 (8)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0146 Verteporfin 99.58% 是
HY-16561 Resveratrol 99.94% 是
HY-113416 Dehydroepiandrosterone sulfate 99.28% 否
HY-B0167A Sodium Salicylate 99.93% 是
HY-147080 Avacincaptad pegol sodium Inhibitor 98.53% 否
HY-109561 Pegaptanib sodium Inhibitor 98.09% 否
HY-14892 Gemigliptin Inhibitor / 否
HY-B0146R Verteporfin (Standard) / 否
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-108801 Aflibercept Inhibitor 97.90% 否
HY-P99116 Faricimab Inhibitor 97.97% 否
Clinical Phase
生物活性分子 (31)
目录号 产品名 作用方式
纯度 Phase
HY-I0626 Cytosine 99.99% Phase 4
HY-W013494 L-Carnosine 99.94% Phase 3
HY-106024B Alagebrium chloride Inhibitor 99.93% Phase 3
HY-19720A Emixustat hydrochloride 99.29% Phase 3
HY-B1745 Pyridoxylamine 99.91% Phase 3
HY-19720 Emixustat Inhibitor 98.00% Phase 3
HY-16467 Squalamine lactate Inhibitor 98.27% Phase 3
HY-116098 Anecortave desacetate 98.36% Phase 3
HY-153484 Bevasiranib Inhibitor / Phase 3
HY-153484A Bevasiranib sodium Inhibitor / Phase 3
HY-112499 Menaquinone-7 ≥98.0% Phase 2
HY-128973 Pyropheophorbide-a ≥98.0% Phase 2
HY-P3204 POT-4 Inhibitor 99.64% Phase 2
HY-128850 N-Acetyl-D-mannosamine ≥98.0% Phase 2
HY-10186 TG 100801 Inhibitor 98.61% Phase 2
HY-136788 ALK4290 Inhibitor 99.79% Phase 2
HY-112499R Menaquinone-7 (Standard) / Phase 2
HY-P1930 Risuteganib Inhibitor / Phase 2
HY-P3204A POT-4 TFA Inhibitor / Phase 2
HY-P5285 Lunasin Inhibitor / Phase 2
HY-W250163 NAD+ lithium / Phase 2
HY-10187 TG 100801 Hydrochloride Inhibitor / Phase 2
HY-14564 GTS-21 Agonist / Phase 2
HY-N0088 Apocynin Inhibitor 99.96% Phase 1
HY-N0160 Kinetin 99.47% Phase 1
HY-136093A Lixumistat acetate Activator 99.88% Phase 1
HY-W050154 Kojic acid Inhibitor 99.99% Phase 1
HY-N1420 Rhamnose ≥98.0% Phase 1
HY-136093 Lixumistat hydrochloride Activator / Phase 1
HY-16387 PF 00337210 Inhibitor / Phase 1
HY-19692 Itasetron Antagonist / Phase 1
抗体抑制剂 (4)
目录号 产品名 作用方式
纯度 Phase
HY-108801A Aflibercept (VEGF Trap) Inhibitor 97.66% Phase 4
HY-P99298 Lampalizumab Inhibitor 99.46% Phase 3
HY-P99576 Tarcocimab Inhibitor 98.35% Phase 3
HY-P99629 Galegenimab Inhibitor 99.91% Phase 2
Pre-clinical Phase
生物活性分子 (186)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0664 Aucubin Inhibitor 99.49% 否
HY-131042 NNMTi Inhibitor 99.80% 否
HY-N1485 Cycloastragenol Activator ≥98.0% 否
HY-126255 SBI-797812 Activator 99.74% 否
HY-N0033 Poliumoside Inhibitor 99.80% 否
HY-N0568 Madecassoside 99.58% 否
HY-147313 TH10785 Activator 99.93% 否
HY-N0295 Protocatechualdehyde Inhibitor 99.98% 否
HY-129460 XJB-5-131 Inhibitor 99.9% 否
HY-147059 Dieckol 99.81% 否
HY-103157 PD146176 99.16% 否
HY-11068 SB 239063 Inhibitor 99.61% 否
HY-120912 Gingerenone A Activator 99.70% 否
HY-150069 UBX1325 99.16% 否
HY-129380 Fructosyl-lysine ≥95.0% 否
HY-110195 Smurf1-IN-A01 99.81% 否
HY-137817 BCH001 Inhibitor 98.83% 否
HY-16561R Resveratrol (Standard) 99.73% 否
HY-N2292 Kinsenoside 99.91% 否
HY-P1149A Epitalon TFA Activator 99.62% 否
HY-N0012 Glycitin Inhibitor 99.84% 否
HY-P1928 Humanin Inhibitor 99.83% 否
HY-W013573 S-Allyl-L-cysteine Inducer 98.64% 否
HY-402361 TERT activator-1 99.50% 否
HY-N2485 4'-Methoxyresveratrol 99.48% 否
HY-N5135 Liriopesides B 99.85% 否
HY-P3252A Pegcetacoplan acetate Inhibitor 98.72% 否
HY-107811 Harmol 99.77% 否
HY-15114 S 17092 Inhibitor 98.42% 否
HY-P1149 Epitalon Activator 99.50% 是
HY-14892A Gemigliptin tartrate Inhibitor 98.17% 否
HY-129566 Withanolide B Activator ≥99.0% 否
HY-B1745A Pyridoxylamine dihydrochloride 99.93% 否
HY-N6818 5,​7,​4'-​Trimethoxyflavone 99.65% 否
HY-N7690 3,5,7,3′,4′-Pentamethoxyflavone Inhibitor 99.15% 否
HY-106353 Smilagenin Agonist ≥98.0% 是
HY-113303 FAPy-adenine 99.95% 否
HY-128463 N-tert-Butyl-α-phenylnitrone Inhibitor 99.94% 否
HY-76383 LR-90 Inhibitor 99.59% 否
HY-N1517 Ganoderic acid C2 99.30% 否
HY-N4089 Quercetin 3-gentiobioside Inhibitor 99.92% 否
HY-N6588 3,4,5-Tricaffeoylquinic acid Inhibitor 98.71% 否
HY-133968 24-Methylenecholesterol Activator 99.48% 否
HY-101528 IDRA 21 Modulator 99.33% 否
HY-129380A Fructosyl-lysine dihydrochloride ≥95.0% 否
HY-N4170 Chebulic acid 98.77% 否
HY-P5904 Caveolin-1 (82-101) amide (human, mouse, rat) Inhibitor 98.48% 否
HY-15289 Ciproxifan maleate Antagonist 99.75% 否
HY-B1340 Carbadox Inhibitor ≥98.0% 否
HY-N2278 Kushenol A Inhibitor 99.84% 否
HY-159062 Goji Extract Activator / 否
HY-16561S Resveratrol-d4 ≥99.0% 否
HY-B1169 Timonacic ≥98.0% 否
HY-156781 Sirtuin-1 inhibitor 1 Inhibitor 98.09% 否
HY-110291 A-971432 Agonist ≥99.0% 否
HY-147108 Mitochondria degrader-1 Inducer 95.10% 否
HY-N7628 Cassiaside C 99.90% 否
HY-W286743 Nε-(Carboxymethyl)-L-lysine 99.70% 否
HY-114653 SRPIN803 Inhibitor 99.17% 否
HY-132126 SPHINX Inhibitor 99.87% 否
HY-133859 M084 Inhibitor / 否
HY-154847 WM-662 Inhibitor 99.48% 否
HY-N3127 Orobol Inhibitor 99.28% 否
HY-P0064 Palmitoyl Tetrapeptide-3 Inhibitor 99.20% 否
HY-P1930A Risuteganib hydrochloride Inhibitor 98.54% 否
HY-N2550A (+)-Coclaurine hydrochloride 99.09% 否
HY-N9347 Stepharine Inhibitor ≥98.0% 否
HY-P2096 Hexapeptide-11 Inhibitor 99.52% 否
HY-117924 AUTEN-67 Inducer ≥92.0% 否
HY-W013494S L-Carnosine-d4 99.00% 否
HY-W337672 H-Pro-Hyp-OH ≥99.0% 否
HY-11053 S 24795 Agonist 99.66% 否
HY-124609 CAD031 Inhibitor 99.39% 否
HY-126487A H-Arg-Lys-OH TFA 99.86% 否
HY-145486 1-Arachidonoyl-sn-glycerol 3-phosphate ammonium / 否
HY-153917 CRT0063465 Ligand 99.59% 否
HY-15492 AG-13958 Inhibitor 99.71% 否
HY-163690 HTRA1-IN-1 Inhibitor / 否
HY-65008 N-Demethylricinine 99.84% 否
HY-I0626S2 Cytosine-d2 99.69% 否
HY-N12486A (3S,8R,9R)-Isofalcarintriol / 否
HY-N2284 Sophoflavescenol Inhibitor 98.15% 否
HY-N2947 Boeravinone B Inhibitor ≥97.0% 否
HY-N3757 (+)-Dihydrorobinetin ≥98.0% 否
HY-N7426 3-Deoxyglucosone / 否
HY-P10409 SHLP2 99.18% 否
HY-P2663 Acetyl tetrapeptide-2 99.70% 否
HY-Q49697 Sirtuin modulator 3 Modulator 99.32% 否
HY-164159 α-Glucosylrutin Inhibitor / 否
HY-158821 ISTH0036 / 否
HY-158821A ISTH0036 sodium / 否
HY-N6818R 5,​7,​4'-​Trimethoxyflavone (Standard) / 否
HY-43515 ESI1 / 否
HY-107652 AF-DX 384 Antagonist / 否
HY-113033A Pentosidine TFA / 否
HY-116780A Prothipendyl hydrochloride Inhibitor / 否
HY-124223 AF-DX 384 methanesulfonate Antagonist / 否
HY-128135 MHY 553 Agonist / 否
HY-128463S N-tert-Butyl-α-phenylnitrone-d14 / 否
HY-133804 Arteanoflavone Inhibitor / 否
HY-133968S1 24-Methylenecholesterol-13C Activator / 否
HY-136788A ALK4290 dihydrochloride Inhibitor / 否
HY-138830A (S,S)-TAK-418 / 否
HY-139464 Q134R 99.55% 否
HY-142025 Daumone / 否
HY-142778 Lp-PLA2-IN-10 / 否
HY-14567A Ciproxifan hydrochloride Antagonist / 否
HY-148322 Sirtuin modulator 5 Modulator / 否
HY-151487 CypD-IN-3 Inhibitor / 否
HY-151488 CypD-IN-4 Inhibitor / 否
HY-151489 CypE-IN-1 Inhibitor / 否
HY-151546 MRS4596 Antagonist / 否
HY-151547 MRS4719 Antagonist / 否
HY-153183 Lp-PLA2-IN-12 Inhibitor / 否
HY-153560 Lp-PLA2-IN-14 Inhibitor / 否
HY-15492A AG-13958 (mono(hydrochloride)) Inhibitor / 否
HY-155138 GLS1 Inhibitor-7 Inhibitor / 否
HY-155988 Sirtuin modulator 6 Modulator / 否
HY-156023 Sirtuin modulator 7 Modulator 99.28% 否
HY-157421 Nampt activator-4 Modulator / 否
HY-159007 BD-AcAc2 / 否
HY-159925 QKY-613 Activator / 否
HY-161088 Anti-aging agent 1 / 否
HY-162269 Nampt activator-5 Activator / 否
HY-162515 8-OAc / 否
HY-162866 CXM102 Activator / 否
HY-162904 BPU17 / 否
HY-162968 MRTF-A-IN-1 Inhibitor / 否
HY-162969 MRTF-A-IN-2 Inhibitor / 否
HY-163403 VEGFR-2-IN-43 Inhibitor / 否
HY-16561G Resveratrol (GMP) / 否
HY-16561S1 Resveratrol-13C6 / 否
HY-167740 Glycerophosphoinositol (lysine) / 否
HY-168336 E0924G Activator / 否
HY-169085 LRAT-IN-1 / 否
HY-169204 Mito-fisetin mF3 Inhibitor / 否
HY-169265 BRD-K20733377 Inhibitor / 否
HY-169266 BRD-K56819078 Inhibitor / 否
HY-66018 Palmitoyl tripeptide-5 biTFA / 否
HY-B0801AS Fexofenadine-d10 hydrochloride Inhibitor / 否
HY-B1340S Carbadox-d3 Inhibitor / 否
HY-E70022 D-Mannose isomerase (PsMaSeAF) / 否
HY-E70410 NAD Synthetase / 否
HY-I0626S Cytosine-2,4-13C2-1,3-15N2 / 否
HY-I0626S1 Cytosine-13C,15N2 / 否
HY-N1097 Venoterpine / 否
HY-N1190 DL-Syringaresinol Inhibitor / 否
HY-N12653 Exserohilone Inhibitor / 否
HY-N13380 6′‐O‐Galloylsalidroside / 否
HY-N15152 Isoaesculioside D / 否
HY-N1517A (Rac)-Ganoderic acid C2 Inhibitor / 否
HY-N2550 (+)-Coclaurine / 否
HY-N3612 Communic acid Inhibitor / 否
HY-N6883 6-Methoxytricin Inhibitor / 否
HY-N8375 Sieboldin Inhibitor / 否
HY-P0095 Acetyl tetrapeptide-5 Inhibitor 98.05% 否
HY-P0104 Palmitoyl tripeptide-38 Inhibitor / 否
HY-P10140 JNK-IN-15, Cell-Permeable Inhibitor / 否
HY-P10141 JNK-IN-15, Cell-Permeable, Negative Control Inhibitor / 否
HY-P10611 [D-Ser14]-Humanin / 否
HY-P4308 Z-Pro-Pro-aldehyde-dimethyl acetal Inhibitor / 否
HY-P5233 Acetyltetrapeptide 11 Inhibitor / 否
HY-RS00444 AGER Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W127725 Thymolphthalexon tetrasodium / 否
HY-W127738 6-O-Stearoyl-L-ascorbic acid / 否
HY-107758 Y-29794 oxalate Inhibitor / 否
HY-113033 Pentosidine / 否
HY-113127 L-Tryptophanamide / 否
HY-123754 AGN-201904 Inhibitor / 否
HY-123904 UoS12258 Activator / 否
HY-130221 (25S)-Δ7-Dafachronic acid / 否
HY-131528 Tenilsetam / 否
HY-145545 1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE / 否
HY-14567 Ciproxifan Antagonist / 否
HY-149708 UCM-13207 Inhibitor / 否
HY-154951 Oct4 inducer-2 Inducer / 否
HY-164066 Sodium Acetylated Hyaluronate / 否
HY-N12071 Lucidin-ω-Me ether / 否
HY-N12486 Isofalcarintriol / 否
HY-N13232 Grape Skin Extract / 否
HY-N13299 Glucoberteroin / 否
HY-N15147 Panax saponin C Activator / 否
HY-N8380 (-)-Latifolin / 否
HY-W268155 3,4'-Dihydroxypropiophenone / 否
HY-W701069 Isomyosmine / 否
HY-W747597 Ganglioside GD1b Disodium Salt (Bovine Brain) / 否
抗体抑制剂 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P9951A Ranibizumab (anti-VEGF) Inhibitor 98.08% 否
HY-P99905 Efdamrofusp alfa / 否
HY-P99402 Rinucumab Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ager NCBI NCBI:177
Macaca fascicularis Ager NCBI NCBI:102121124
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