2. Gene
  3. Hdac3 - histone deacetylase 3 Gene

Hdac3 - histone deacetylase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 3

种属: Mus musculus

基因 ID: 15183 | 基因类型: protein coding

关于 Hdac3

Chromosome 18: 38,068,897-38,088,069 reverse strand.GRCm39:CM001011.3

This gene has 6 transcripts (splice variants), 155 orthologues, 10 paralogues and is associated with 7 phenotypes. Ubiquitous expression in CNS E14 (RPKM 54.1), limb E14.5 (RPKM 54.1) and 28 other tissues.

功能概要

该基因编码的蛋白可启动染色质 DNA 结合活性和蛋白质脱乙酰酶活性。参与多个过程，包括基因表达的昼夜节律调节；冷诱导产热的正调节；和蛋白质泛素化的正调控。作用于多个过程的上游或内部，包括组蛋白 H4-K12 去乙酰化；心肌细胞分化的负调节；和转录调控，DNA 模板化。位于细胞质和细胞核中。以多种结构表达，包括消化系统；脑;早孕;胚胎间充质；和感觉器官。用于研究子宫内膜异位症。该基因的人类直系同源物与肺非小细胞癌有关。与人类 HDAC3（组蛋白脱乙酰酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin DNA binding activity and protein deacetylase activity. Involved in several processes, including circadian regulation of gene expression; positive regulation of cold-induced thermogenesis; and positive regulation of protein ubiquitination. Acts upstream of or within several processes, including histone H4-K12 deacetylation; negative regulation of cardiac muscle cell differentiation; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study endometriosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Apr 2022]

Hdac3 基因产物(1)

mRNA Protein Name
NM_010411.2 NP_034541.2 histone deacetylase 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
14980219 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
18458156 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
15832170 MGI
enables histone deacetylase activity IDA
IDA: 通过直接分析推断
17464331 MGI
enables histone deacetylase activity IMP
IMP: 通过突变表型推断
15832170 MGI
enables histone decrotonylase activity IDA
IDA: 通过直接分析推断
30279482 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11641275 MGI
enables protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
17158926 MGI
enables transcription factor binding IDA
IDA: 通过直接分析推断
17158926 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within circadian regulation of gene expression IGI
IGI: 通过遗传相互作用推断
19037247 MGI
involved in circadian regulation of gene expression IMP
IMP: 通过突变表型推断
26776516 MGI
involved in cornified envelope assembly IMP
IMP: 通过突变表型推断
32467224 MGI
involved in epidermis development IMP
IMP: 通过突变表型推断
32467224 MGI
involved in establishment of skin barrier IMP
IMP: 通过突变表型推断
32467224 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
32467224 MGI
involved in in utero embryonic development IMP
IMP: 通过突变表型推断
32467224 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
24565863 MGI
acts upstream of or within negative regulation of cardiac muscle cell differentiation IMP
IMP: 通过突变表型推断
24565863 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17158926 MGI
acts upstream of or within neural precursor cell proliferation IDA
IDA: 通过直接分析推断
25556659 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
28614293 MGI
involved in positive regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
26776516 MGI
involved in random inactivation of X chromosome IMP
IMP: 通过突变表型推断
25915022 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
26776516 MGI
acts upstream of or within regulation of mitotic cell cycle IDA
IDA: 通过直接分析推断
10542131 MGI
acts upstream of or within regulation of multicellular organism growth IGI
IGI: 通过遗传相互作用推断
19037247 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
19463978 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in chromatin IDA
IDA: 通过直接分析推断
25556659 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
17158926 MGI
located in nucleus IDA
IDA: 通过直接分析推断
17158926 MGI
is active in nucleus IPI
IPI: 通过物理相互作用推断
32467224 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Hdac3 蛋白结构

HDAC3

HDAC3: cd10005 (2 - 382)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
蛋白主名 其他名称

histone deacetylase 3

HD3

HDAC3 splicing HDAC3alpha

HDAC3 splicing HDAC3beta

HDAC3 splicing HDAC3delta

HDAC3 splicing HDAC3gamma

protein deacetylase HDAC3

protein deacylase HDAC3

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10221 Vorinostat Inhibitor 99.95% 是
HY-109015 Tucidinostat Inhibitor 98.60% 否
HY-12164 Mocetinostat Inhibitor 99.43% 是
HY-13322 Pracinostat Inhibitor 99.82% 是
HY-B0494 Bufexamac Inhibitor ≥98.0% 否
Clinical Phase
生物活性分子 (18)
目录号 产品名 作用方式
纯度 Phase
HY-12163 Entinostat Inhibitor 99.82% Phase 3
HY-50934 Tacedinaline Inhibitor 99.32% Phase 3
HY-10990 Abexinostat Inhibitor 98.63% Phase 3
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-100748 Zabadinostat Inhibitor 99.81% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-14718 Resminostat Inhibitor 99.84% Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
Pre-clinical Phase
生物活性分子 (104)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13909 RGFP966 Inhibitor 99.81% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-18613 CAY10603 Inhibitor ≥98.0% 否
HY-19327 ACY-738 Inhibitor 99.92% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-16425 RG2833 Inhibitor 99.86% 否
HY-19618 BRD3308 Inhibitor 98.82% 否
HY-100719 BRD-6929 Inhibitor 99.04% 否
HY-104008 ACY-957 Inhibitor 99.66% 否
HY-115475 SW-100 Inhibitor 99.59% 否
HY-119939 CHDI-390576 Inhibitor 98.07% 否
HY-111400 SR-4370 Inhibitor 99.95% 否
HY-N0071 Crotonoside Inhibitor 99.64% 否
HY-153358 TNG260 Inhibitor 99.91% 否
HY-19328 ACY-775 Inhibitor 99.69% 否
HY-18976 UF010 99.84% 否
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% 否
HY-100871 WT-161 Inhibitor 98.36% 否
HY-W009776 Suberoyl bis-hydroxamic acid Inhibitor ≥98.0% 否
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% 否
HY-18712 BG45 Inhibitor 99.96% 否
HY-19747 HPOB Inhibitor 99.80% 否
HY-116818 Crebinostat Inhibitor 99.79% 否
HY-13267 Droxinostat Inhibitor 98.91% 否
HY-119017 SB-429201 Inhibitor 98.99% 否
HY-100384 NKL 22 Inhibitor 97.27% 否
HY-146346 HD-TAC7 Inhibitor 98.75% 否
HY-110280 MC1742 Inhibitor 99.20% 否
HY-102083 BRD4884 Inhibitor ≥99.0% 否
HY-114483 AES-135 Inhibitor 98.21% 否
HY-124053 BRD2492 Inhibitor 99.18% 否
HY-138831 AES-350 Inhibitor 99.30% 否
HY-131708A FNDR-20123 Inhibitor 98.08% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-164233 YX968 Inhibitor / 否
HY-152174 HDAC-IN-52 Inhibitor 99.46% 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-151464 SHP2/HDAC-IN-1 Inhibitor / 否
HY-131708 FNDR-20123 free base Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-150109 Purinostat mesylate Inhibitor / 否
HY-159171 sEH/HDAC6-IN-2 Inhibitor / 否
HY-144293 HDAC-IN-31 Inhibitor / 否
HY-154855 HDAC-IN-56 Inhibitor / 否
HY-149669 PH14 Inhibitor 99.29% 否
HY-152225 MC2625 Inhibitor / 否
HY-144297 HDAC1-IN-3 Inhibitor / 否
HY-144292 HDAC-IN-30 Inhibitor / 否
HY-151896 HDAC6-IN-14 Inhibitor / 否
HY-152173 HDAC-IN-51 Inhibitor / 否
HY-163282 NB512 Inhibitor / 否
HY-168650 ROCK/HDAC-IN-1 Inhibitor / 否
HY-162487 HDAC-IN-72 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-159172 HDAC3-IN-4 Inhibitor / 否
HY-149029 TH-6 Inhibitor 95.00% 否
HY-146750 HDAC-IN-37 Inhibitor / 否
HY-151443 HDAC-IN-47 Inhibitor / 否
HY-147966 HDAC-IN-43 Inhibitor / 否
HY-151261 HDAC6-IN-13 Inhibitor 98.08% 否
HY-163430 HDAC-IN-71 Inhibitor / 否
HY-162658 Leuxinostat Inhibitor / 否
HY-146351 HDAC-IN-38 Inhibitor / 否
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% 否
HY-161783 HDAC6-IN-45 Inhibitor / 否
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / 否
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / 否
HY-117374 HDAC3-IN-1 Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-168287 HDAC3/8 ligand-1 / 否
HY-153583 HDAC8-IN-4 Inhibitor / 否
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-156027 SIRT6-IN-3 Inhibitor / 否
HY-147934 HDAC8-IN-3 Inhibitor / 否
HY-161778 ZG-126 Inhibitor / 否
HY-161154 HDAC3-IN-3 Inhibitor / 否
HY-163207 sEH/HDAC6-IN-1 Inhibitor / 否
HY-144654 HDAC/Top-IN-1 Inhibitor / 否
HY-144395 HDAC6-IN-4 Inhibitor / 否
HY-169226 HDAC6-IN-51 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-143877 NN-390 Inhibitor / 否
HY-163834 HDAC6-IN-47 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-162910 HDAC-IN-79 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-151897 HDAC-IN-49 Inhibitor / 否
HY-147840 HDAC-IN-41 Inhibitor / 否
HY-109015S Tucidinostat-d4 Inhibitor / 否
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / 否
HY-147731 HDAC6-IN-9 Inhibitor / 否
HY-163894 HDAC6-IN-48 Inhibitor / 否
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / 否
HY-150577 HDAC-IN-45 Inhibitor / 否
HY-133147 HDAC3/6-IN-2 Inhibitor / 否
HY-162769 HDAC3-IN-5 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否
HY-145852 Top/HDAC-IN-2 Inhibitor / 否
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / 否
HY-146392 HDAC-IN-39 Inhibitor / 否
HY-151569 SAHA-OH Inhibitor / 否
HY-19754 CRA-026440 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hdac3 NCBI NCBI:8841
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