Jak2 - Janus kinase 2 Gene

中文名称：两面神激酶 2

种属: Mus musculus

同用名: Fd17

关于 Jak2

功能概要

该基因编码的蛋白可启动白细胞介素 12 受体结合活性和蛋白酪氨酸激酶活性。参与多个过程，包括造血；大分子代谢过程的正向调控；和信号转导的调节。作用于多个过程的上游或内部，包括细胞表面受体信号通路；细胞对脂质的反应；和细胞凋亡过程的调节。位于小窝和核内。以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；肝脏和胆道系统；和肌肉骨骼系统。用于研究原发性血小板增多症；骨髓纤维化;骨髓增生性肿瘤；和真性红细胞增多症。该基因的人类直系同源基因与多种疾病有关，包括胃肠系统癌症（多种）；血液系统癌症（多发性）；肝血管疾病（多发性）；炎症性肠病（多发性）；和肺非小细胞癌（多发性）。与人类 JAK2（Janus 激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables interleukin-12 receptor binding activity and protein tyrosine kinase activity. Involved in several processes, including hemopoiesis; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to lipid; and regulation of apoptotic process. Located in caveola and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and musculoskeletal system. Used to study essential thrombocythemia; myelofibrosis; myeloproliferative neoplasm; and polycythemia vera. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Apr 2022]