1. Gene
  2. GABARAPL1 - GABA type A receptor associated protein like 1 Gene

GABARAPL1 - GABA type A receptor associated protein like 1 Gene

中文名称:GABA A 型受体相关蛋白样 1

种属: Homo sapiens

同用名: ATG8; GEC1; APG8L; ATG8B; ATG8L; APG8-LIKE

基因 ID: 23710 | 基因类型: protein coding

关于 GABARAPL1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,212,877-10,223,128 (from NCBI)

This gene has 19 transcripts (splice variants), 202 orthologues and 6 paralogues. Broad expression in brain (RPKM 136.2), kidney (RPKM 101.2) and 23 other tissues.

功能概要

启用 Tat 蛋白结合活性和泛素蛋白连接酶结合活性。预计参与自噬体组装;线粒体自噬;和细胞对氮饥饿的反应。位于自噬体中。与线粒体共定位。 [由基因组资源联盟提供,2022 年 4 月]

Enables Tat protein binding activity and ubiquitin protein Ligase binding activity. Predicted to be involved in autophagosome assembly; Autophagy of mitochondrion; and cellular response to nitrogen starvation. Located in autophagosome. Colocalizes with mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

GABARAPL1 基因产物(2)

mRNA Protein Name
NM_001363598.2 NP_001350527.1 gamma-aminobutyric acid receptor-associated protein-like 1 isoform 1
NM_031412.4 NP_113600.1 gamma-aminobutyric acid receptor-associated protein-like 1 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Tat protein binding IPI
IPI: 通过物理相互作用推断
22354992 GOA
enables phospholipid binding IDA
IDA: 通过直接分析推断
20404487 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9892355 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
25127057 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in autophagosome IDA
IDA: 通过直接分析推断
15292400 GOA
colocalizes with mitochondrion IGI
IGI: 通过遗传相互作用推断
20200478 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GABARAPL1 蛋白结构

Atg8

Atg8: Autophagy protein Atg8 ubiquitin like (14 - 116)

  • 0
  • 100
  • 117 a.a.
蛋白主名 其他名称

gamma-aminobutyric acid receptor-associated protein-like 1

GABA(A) receptor-associated protein-like 1

GABARAPL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GABARAPL1 Q9H0R8 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
种属内
GABARAPL1 Q9H0R8 RETREG3 Homo sapiens Q86VR2
Y2H Array
25416956
种属内
GABARAPL1 Q9H0R8 RETREG3 Homo sapiens Q86VR2
Y2H Array
29892012
种属内
GABARAPL1 Q9H0R8 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 RETREG3 Homo sapiens Q86VR2
Validated Y2H
25416956
种属内
GABARAPL1 Q9H0R8 TBC1D5 Homo sapiens B9A6K1
Validated Y2H
25416956
种属内
GABARAPL1 Q9H0R8 AHNAK2 Homo sapiens Q8IVF2-2
Validated Y2H
25416956
种属内
GABARAPL1 Q9H0R8 NEK9 Homo sapiens Q8TD19
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 TBC1D15 Homo sapiens Q8TC07
Pull Down
20562859
种属内
GABARAPL1 Q9H0R8 OSBPL3 Homo sapiens Q9H4L5
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 OSBPL3 Homo sapiens Q9H4L5
Validated Y2H
32296183
种属内
GABARAPL1 Q9H0R8 OSBPL3 Homo sapiens Q9H4L5
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 STRN3 Homo sapiens Q13033-2
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 STRN3 Homo sapiens Q13033-2
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 STRN3 Homo sapiens Q13033-2
BioID
34524948
种属内
GABARAPL1 Q9H0R8 RABGAP1 Homo sapiens Q9Y3P9
Pull Down
20562859
种属内
GABARAPL1 Q9H0R8 RABGAP1 Homo sapiens Q9Y3P9
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 UMAD1 Homo sapiens C9J7I0
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 UMAD1 Homo sapiens C9J7I0
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 BSCL2 Homo sapiens J3KQ12
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 BSCL2 Homo sapiens J3KQ12
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 CLINT1 Homo sapiens Q14677
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 TBC1D25 Homo sapiens Q3MII6
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 TBC1D25 Homo sapiens Q3MII6
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 SCYL3 Homo sapiens Q8IZE3-2
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 SCYL3 Homo sapiens Q8IZE3-2
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 SCYL3 Homo sapiens Q8IZE3-2
BioID
34524948
种属内
GABARAPL1 Q9H0R8 NEDD4 Homo sapiens P46934-3
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 NEDD4 Homo sapiens P46934-3
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
种属内
GABARAPL1 Q9H0R8 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 NFIA Homo sapiens Q12857-2
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 NFIA Homo sapiens Q12857-2
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 TMEM131 Homo sapiens Q0P631
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 TMEM131 Homo sapiens Q0P631
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 PTPRR Homo sapiens Q15256-5
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 PTPRR Homo sapiens Q15256-5
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 ATG2A Homo sapiens Q2TAZ0
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 ATG2A Homo sapiens Q2TAZ0
Pull Down
20562859
种属内
GABARAPL1 Q9H0R8 KBTBD6 Homo sapiens Q86V97
Pull Down
20562859
种属内
GABARAPL1 Q9H0R8 KBTBD6 Homo sapiens Q86V97
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 KBTBD6 Homo sapiens Q86V97
Pull Down
25684205
种属内
GABARAPL1 Q9H0R8 KBTBD6 Homo sapiens Q86V97
Confocal
25684205
种属内
GABARAPL1 Q9H0R8 ATG101 Homo sapiens Q9BSB4
BioID
34524948
种属内
GABARAPL1 Q9H0R8 DNAAF4 Homo sapiens Q8WXU2
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 FNIP1 Homo sapiens Q8TF40
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 TECPR2 Homo sapiens O15040
Pull Down
20562859
种属内
GABARAPL1 Q9H0R8 NSMAF Homo sapiens Q92636
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 STBD1 Homo sapiens O95210
BioID
34524948
种属内
GABARAPL1 Q9H0R8 STBD1 Homo sapiens O95210
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 TBC1D2B Homo sapiens Q9UPU7
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 ATG4A Homo sapiens Q8WYN0
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 ATG4A Homo sapiens Q8WYN0
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 ATG4A Homo sapiens Q8WYN0
Validated Y2H
25416956
种属内
GABARAPL1 Q9H0R8 ATG4A Homo sapiens Q8WYN0
Validated Y2H
32296183
种属内
GABARAPL1 Q9H0R8 ATG4A Homo sapiens Q8WYN0
Y2H Array
25416956
种属内
GABARAPL1 Q9H0R8 SQSTM1 Homo sapiens Q13501
Phage Display
39009827
种属内
GABARAPL1 Q9H0R8 SQSTM1 Homo sapiens Q13501
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 SQSTM1 Homo sapiens Q13501
FPS
39009827
种属内
GABARAPL1 Q9H0R8 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 SQSTM1 Homo sapiens Q13501
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 SQSTM1 Homo sapiens Q13501
Phage Display
37219487
种属内
GABARAPL1 Q9H0R8 NIPSNAP2 Homo sapiens O75323
Pull Down
20562859
种属内
GABARAPL1 Q9H0R8 NIPSNAP2 Homo sapiens O75323
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 DYNLL1 Homo sapiens P63167
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 DYNLL1 Homo sapiens P63167
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 SAFB2 Homo sapiens Q14151
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 SAFB2 Homo sapiens Q14151
Pull Down
20562859
种属内
GABARAPL1 Q9H0R8 IPO5 Homo sapiens O00410
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 HADHB Homo sapiens P55084
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 RCN2 Homo sapiens Q14257
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 RCN2 Homo sapiens Q14257
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 RCN2 Homo sapiens Q14257
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 HADHA Homo sapiens P40939
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 TNIP1 Homo sapiens Q15025
Y2H Array
25416956
种属内
GABARAPL1 Q9H0R8 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 TNIP1 Homo sapiens Q15025
Y2H Array
31515488
种属内
GABARAPL1 Q9H0R8 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
25416956
种属内
GABARAPL1 Q9H0R8 KBTBD7 Homo sapiens Q8WVZ9
Y2H Prey Pooling
25416956
种属内
GABARAPL1 Q9H0R8 KBTBD7 Homo sapiens Q8WVZ9
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 KBTBD7 Homo sapiens Q8WVZ9
Y2H Array
25416956
种属内
GABARAPL1 Q9H0R8 KBTBD7 Homo sapiens Q8WVZ9
Pull Down
25684205
种属内
GABARAPL1 Q9H0R8 PRKAR1A Homo sapiens P10644
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 PSMB4 Homo sapiens P28070
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 PSMB4 Homo sapiens P28070
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 ATG4B Homo sapiens Q9Y4P1
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 ATG4B Homo sapiens Q9Y4P1
Validated Y2H
32296183
种属内
GABARAPL1 Q9H0R8 ATG4B Homo sapiens Q9Y4P1
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 ATG4B Homo sapiens Q9Y4P1
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 BSDC1 Homo sapiens Q9NW68
Validated Y2H
32296183
种属内
GABARAPL1 Q9H0R8 BSDC1 Homo sapiens Q9NW68
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 BSDC1 Homo sapiens Q9NW68
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 ZBTB22 Homo sapiens O15209
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 ZBTB22 Homo sapiens O15209
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 NEDD4 Homo sapiens P46934
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
种属内
GABARAPL1 Q9H0R8 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
种属内
GABARAPL1 Q9H0R8 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 KXD1 Homo sapiens Q9BQD3
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 KXD1 Homo sapiens Q9BQD3
Y2H
21516116
种属内
GABARAPL1 Q9H0R8 KXD1 Homo sapiens Q9BQD3
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 PBXIP1 Homo sapiens Q96AQ6
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 PBXIP1 Homo sapiens Q96AQ6
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 THAP7 Homo sapiens Q9BT49
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 THAP7 Homo sapiens Q9BT49
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 TBC1D5 Homo sapiens Q92609
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 TBC1D5 Homo sapiens Q92609
BioID
34524948
种属内
GABARAPL1 Q9H0R8 TBC1D5 Homo sapiens Q92609
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 NBR1 Homo sapiens Q14596
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 NBR1 Homo sapiens Q14596
Pull Down
19250911
种属内
GABARAPL1 Q9H0R8 UBA5 Homo sapiens Q9GZZ9
Pull Down
20562859
种属内
GABARAPL1 Q9H0R8 CALCOCO1 Homo sapiens Q9P1Z2
Validated Y2H
32296183
种属内
GABARAPL1 Q9H0R8 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 NCOA7 Homo sapiens Q8NI08
BioID
34524948
种属内
GABARAPL1 Q9H0R8 NCOA7 Homo sapiens Q8NI08
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 BNIP3L Homo sapiens O60238
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 BNIP3L Homo sapiens O60238
Y2H Array
32296183
种属内
GABARAPL1 Q9H0R8 MLX Homo sapiens Q9UH92-3
Validated Y2H
32296183
种属内
GABARAPL1 Q9H0R8 ULK1 Homo sapiens O75385
BioID
34524948
种属内
GABARAPL1 Q9H0R8 OPRK1 Homo sapiens P41145
Y2H
16431922
种属内
GABARAPL1 Q9H0R8 OPRK1 Homo sapiens P41145
Pull Down
16431922
种属内
GABARAPL1 Q9H0R8 ATG7 Homo sapiens O95352
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 ATG3 Homo sapiens Q9NT62
Anti Tag CoIP
20562859
种属内
GABARAPL1 Q9H0R8 STK3 Homo sapiens Q13188
Pull Down
20562859
种属内
GABARAPL1 Q9H0R8 TP53INP1 Homo sapiens Q96A56
Y2H Prey Pooling
32296183
种属内
GABARAPL1 Q9H0R8 TP53INP1 Homo sapiens Q96A56
MAPPIT
32296183
种属内
GABARAPL1 Q9H0R8 TP53INP1 Homo sapiens Q96A56
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GABARAPL1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70913 GABARAPL1/GEC-1 Protein, Human (His) Q9H0R8 (M1-K117) ≥95%

关联疾病

疾病名称 别名
Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis

Acanthamoeba Encephalitis

Acanthamoeba Granulomatous Encephalitis

Granulomatous Amebic Encephalitis Due To Acanthamoeba

Primary Amebic Meningoencephalitis

Pam

Naegleria Fowleri Infection

Meningoencephalitis Caused By Naegleria Fowleri

Primary Amoebic Meningoencephalitis

Warburg Micro Syndrome 3

WARBM3

Micro Syndrome 3

Warburg Micro Syndrome 2

WARBM2

Micro Syndrome 2

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GABARAPL1 VGNC VGNC:99929
Mus musculus GABARAPL1 MGD MGI:1914980
Canis familiaris GABARAPL1 VGNC VGNC:57447
Rattus norvegicus GABARAPL1 RGD RGD:1596143
Felis catus GABARAPL1 VGNC VGNC:84022
Bos taurus GABARAPL1 VGNC VGNC:56201
Others GABARAPL1 NCBI