1. Gene
  2. KIR2DL3 - killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 Gene

KIR2DL3 - killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 Gene

中文名称:杀伤细胞免疫球蛋白样受体,两个 Ig 结构域和长胞质尾 3

种属: Homo sapiens

同用名: p58; NKAT; GL183; NKAT2; CD158b; KIR2DL; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GB

基因 ID: 3804 | 基因类型: protein coding

关于 KIR2DL3

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,738,513-54,753,052 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 56 orthologues and 25 paralogues. Low expression observed in reference dataset.

功能概要

杀伤细胞免疫球蛋白样受体 (KIR) 是由自然杀伤细胞和 T 细胞亚群表达的跨膜糖蛋白。 KIR 基因具有多态性和高度同源性,它们位于 1 Mb 白细胞受体复合体 (LRC) 内染色体 19q13.4 的簇中。 KIR 基因簇的基因含量因单倍型而异,尽管在所有单倍型 (KIR3DL3、KIR3DP1、KIR3DL4、KIR3DL2) 中都发现了几个“框架”基因。 KIR 蛋白根据细胞外免疫球蛋白结构域 (2D 或 3D) 的数量以及它们是否具有长 (L) 或短 (S) 细胞质结构域进行分类。具有长细胞质结构域的 KIR 蛋白通过基于免疫酪氨酸的抑制基序 (ITIM) 在配体结合后转导抑制信号,而具有短细胞质结构域的 KIR 蛋白缺乏 ITIM 基序,而是与 TYRO 蛋白酪氨酸激酶结合蛋白结合以转导激活信号。几种 KIR 蛋白的配体是 HLA I 类分子的子集;因此,KIR 蛋白被认为在免疫反应的调节中起重要作用。[RefSeq 提供,2008 年 7 月]

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

KIR2DL3 基因产物(1)

mRNA Protein Name
NM_015868.3 NP_056952.2 killer cell immunoglobulin-like receptor 2DL3 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8574854 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KIR2DL3 蛋白结构

ig

ig: Immunoglobulin domain (43 - 101)

Ig_2

Ig_2: Immunoglobulin domain (128 - 220)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
蛋白主名 其他名称

killer cell immunoglobulin-like receptor 2DL3

CD158 antigen-like family member B2

KIR2DL3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KIR2DL3 P43628 TTMP Homo sapiens Q5BVD1 32296183
种属内
KIR2DL3 P43628 RTP2 Homo sapiens Q5QGT7 32296183
种属内
KIR2DL3 P43628 NRM Homo sapiens Q8IXM6 32296183
种属内
KIR2DL3 P43628 JAGN1 Homo sapiens Q8N5M9 32296183
种属内
KIR2DL3 P43628 SLC38A7 Homo sapiens Q9NVC3 32296183
种属内
KIR2DL3 P43628 NINJ2 Homo sapiens Q9NZG7 32296183
种属内
KIR2DL3 P43628 CISD2 Homo sapiens Q8N5K1 32296183
种属内
KIR2DL3 P43628 CISD2 Homo sapiens Q8N5K1 32296183
种属内
KIR2DL3 P43628 CISD2 Homo sapiens Q8N5K1 32296183
种属内
KIR2DL3 P43628 HLA-B Homo sapiens P01889 19858347
种属内
KIR2DL3 P43628 HLA-C Homo sapiens P10321 18322206
种属内
KIR2DL3 P43628 HLA-C Homo sapiens P10321 19858347
种属内
KIR2DL3 P43628 ADGRE2 Homo sapiens Q9UHX3 32296183
种属内
KIR2DL3 P43628 GPR108 Homo sapiens Q9NPR9 32296183
种属内
KIR2DL3 P43628 AGTRAP Homo sapiens Q6RW13-2 32296183
种属内
KIR2DL3 P43628 GPX8 Homo sapiens Q8TED1 32296183
种属内
KIR2DL3 P43628 GPX8 Homo sapiens Q8TED1 32296183
种属内
KIR2DL3 P43628 GPX8 Homo sapiens Q8TED1 32296183
种属内
KIR2DL3 P43628 AIG1 Homo sapiens Q9NVV5-2 32296183
种属内
KIR2DL3 P43628 SNORC Homo sapiens Q6UX34 32296183
种属内
KIR2DL3 P43628 KTN1 Homo sapiens Q86UP2-3 32296183
种属内
KIR2DL3 P43628 ANKRD46 Homo sapiens Q86W74-2 32296183
种属内
KIR2DL3 P43628 TMEM97 Homo sapiens Q5BJF2 32296183
种属内
KIR2DL3 P43628 BRICD5 Homo sapiens Q6PL45-2 32296183
种属内
KIR2DL3 P43628 CLDN19 Homo sapiens Q8N6F1-2 32296183
种属内
KIR2DL3 P43628 AQP10 Homo sapiens Q96PS8 32296183
种属内
KIR2DL3 P43628 TMEM243 Homo sapiens Q9BU79 32296183
种属内
KIR2DL3 P43628 ATP6V0E1 Homo sapiens O15342 32296183
种属内
KIR2DL3 P43628 ATP6V0E1 Homo sapiens O15342 32296183
种属内
KIR2DL3 P43628 PLPPR2 Homo sapiens Q96GM1 32296183
种属内
KIR2DL3 P43628 HLA-C Homo sapiens Q53YP1 19858347
种属内
KIR2DL3 P43628 GJA8 Homo sapiens P48165 32296183
种属内
KIR2DL3 P43628 GJA8 Homo sapiens P48165 32296183
种属内
KIR2DL3 P43628 GJA8 Homo sapiens P48165 32296183
种属内
KIR2DL3 P43628 LEUTX Homo sapiens A8MZ59 32296183
种属内
KIR2DL3 P43628 LEUTX Homo sapiens A8MZ59 32296183
种属内
KIR2DL3 P43628 FAM209A Homo sapiens Q5JX71 32296183
种属内
KIR2DL3 P43628 FAM209A Homo sapiens Q5JX71 32296183
种属内
KIR2DL3 P43628 FAM209A Homo sapiens Q5JX71 32296183
种属内
KIR2DL3 P43628 RNF152 Homo sapiens Q8N8N0 32296183
种属内
KIR2DL3 P43628 RNF152 Homo sapiens Q8N8N0 32296183
种属内
KIR2DL3 P43628 RNF152 Homo sapiens Q8N8N0 32296183
种属内
KIR2DL3 P43628 TMEM86B Homo sapiens Q8N661 32296183
种属内
KIR2DL3 P43628 CYBC1 Homo sapiens Q9BQA9 32296183
种属内
KIR2DL3 P43628 OLFM4 Homo sapiens Q6UX06 32296183
种属内
KIR2DL3 P43628 LHFPL5 Homo sapiens Q8TAF8 32296183
种属内
KIR2DL3 P43628 FAM3C Homo sapiens Q92520 32296183
种属内
KIR2DL3 P43628 PTPN11 Homo sapiens Q06124 8648092
种属内
KIR2DL3 P43628 TMEM222 Homo sapiens Q9H0R3 32296183
种属内
KIR2DL3 P43628 CXCL9 Homo sapiens Q07325 32296183
种属内
KIR2DL3 P43628 EMD Homo sapiens P50402 32296183
种属内
KIR2DL3 P43628 CLN6 Homo sapiens Q9NWW5 32296183
种属内
KIR2DL3 P43628 FUNDC2 Homo sapiens Q9BWH2 32296183
种属内
KIR2DL3 P43628 COQ9 Homo sapiens O75208 32296183
种属内
KIR2DL3 P43628 COQ9 Homo sapiens O75208 32296183
种属内
KIR2DL3 P43628 TRAF3IP3 Homo sapiens Q9Y228 32296183
种属内
KIR2DL3 P43628 PTPN6 Homo sapiens P29350 8691154
种属内
KIR2DL3 P43628 PTPN6 Homo sapiens P29350
SPR
8648092
种属内
KIR2DL3 P43628 PTPN6 Homo sapiens P29350 8691154
种属内
KIR2DL3 P43628 PTPN6 Homo sapiens P29350 8574854
种属内
KIR2DL3 P43628 IFITM3 Homo sapiens Q01628 32296183
种属内
KIR2DL3 P43628 INSIG2 Homo sapiens Q9Y5U4 32296183
种属内
KIR2DL3 P43628 BTN2A2 Homo sapiens Q8WVV5 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 KIR2DL3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70354 KIR2DL3 Protein, Human (HEK293, His) P43628-1 (H22-H245) ≥95%
HY-P75901 KIR2DL3 Protein, Human (HEK293, Fc) AAX23102.1 (H22-H245) ≥95%
HY-P78166 KIR2DL3 Protein, Human (Biotinylated, HEK293, His-Avi) P43628-1 (H22-H245) ≥95%
HY-P78474 KIR2DL3 Protein, Human (HEK293, His-Avi) P43628-1 (H22-H245) ≥95%

KIR2DL3 抗体

目录号 产品名 应用 反应物种
HY-P81501 KIR2DL3 Antibody (YA1246) IHC-P Human

关联疾病

疾病名称 别名
Chronic Nk-Cell Lymphocytosis

Nk-Cell Large Granular Lymphocyte Lymphocytosis

Chronic Lymphoproliferative Disorder Of Nk-Cells

Psoriasis
Nk Cell Deficiency
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Amelogenesis Imperfecta, Type Ie

Aih1

Amelogenesis Imperfecta Type 1e

AI1E

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1

Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth

Enamel Hypoplasia, X-Linked

Amelogenesis Imperfecta Type Ie

Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1

Enamel Hypoplasia X-Linked

Amelogenesis Imperfecta, X-Linked 1

Amelogenesis Imperfecta, Type 1e

Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth

X-Linked Amelogenesis Imperfecta 1

X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1

X-Linked Enamel Hypoplasia

Amelogenesis Imperfecta X-Linked 1

Amelogenesis Imperfecta 1e

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e

Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth

Xai

X-Linked Amelogenesis Imperfecta

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma