2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt NF-κB Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation
  3. JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species
  4. Pentagalloylglucose

Pentagalloylglucose  (Synonyms: Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose)

目录号: HY-N0527 纯度: 99.77%
COA 产品使用指南

摩尔计算器

Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 是一种口服有效的没食子单宁化合物，也是凋亡 (apoptosis) 和自噬 (autophagy) 诱导剂。Pentagalloylglucose 通过 GSK3β/β-catenin 途径诱导细胞凋亡自噬。Pentagalloylglucose 具有抗氧化、抗诱变、抗炎、抗惊厥、心脏保护、抗过敏、降胆甾醇血症和抗肿瘤活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pentagalloylglucose Chemical Structure

Pentagalloylglucose Chemical Structure

CAS No. : 14937-32-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥828
In-stock
1 mg ￥251
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5 mg ￥550
In-stock
10 mg ￥800
In-stock
25 mg ￥1520
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50 mg ￥2363
In-stock
100 mg ￥3538
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Customer Review

Other Forms of Pentagalloylglucose:

Pentagalloylglucose 相关抗体

Top Publications Citing Use of Products

    Pentagalloylglucose purchased from MCE. Usage Cited in: Gastroenterology. 2023 Jun;164(7):1232-1247.  [Abstract]

    In human PC organoids, Pentagalloylglucose (PGG; 100 nM) upregulates p53, decreases RRM1 and RRM2 levels, and aggravates gemcitabine-induced replication stress.

    Pentagalloylglucose purchased from MCE. Usage Cited in: Viruses. 2018 Apr 17;10(4). pii: E201.  [Abstract]

    After incubation with PGG and IPS, RABV is inoculated with BHK-21 cells for 48 h, and the expression level of viral P is analyzed by Western blotting.

    查看 JAK 亚型特异性产品:

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities[1][2][3].
    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A549 ED50
    > 10 μg/mL
    Compound: 10
    Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay
    Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay
    		[PMID: 1431932]
    HCT-116 IC50
    1.61 μM
    Compound: PGG
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability by MTT assay
    		[PMID: 29778287]
    HCT-8 ED50
    > 10 μg/mL
    Compound: 10
    Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay
    Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay
    		[PMID: 1431932]
    HeLa IC50
    356.3 μM
    Compound: 8
    Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
    		[PMID: 24613627]
    HepG2 IC50
    92.4 μM
    Compound: 8
    Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
    		[PMID: 24613627]
    HT-29 IC50
    28 μg/mL
    Compound: PGG
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
    		[PMID: 22216935]
    HT-29 IC50
    34 μg/mL
    Compound: PGG
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay in presence of H2O2 scavenger catalase
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay in presence of H2O2 scavenger catalase
    		[PMID: 22216935]
    HT-29 IC50
    4.46 μM
    Compound: PGG
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by MTT assay
    		[PMID: 29778287]
    KB ED50
    > 10 μg/mL
    Compound: 10
    Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay
    Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay
    		[PMID: 1431932]
    MDA-MB-231 IC50
    9.12 μM
    Compound: 5
    Cytotoxicity against human MDA-MB-231 cells expressing CD73 assessed as reduction in cell viability by CCK8 assay
    Cytotoxicity against human MDA-MB-231 cells expressing CD73 assessed as reduction in cell viability by CCK8 assay
    		[PMID: 33359608]
    MIA PaCa-2 IC50
    72.59 μM
    Compound: 5
    Cytotoxicity against human MIA PaCa-2 cells expressing CD73 assessed as reduction in cell viability by CCK8 assay
    Cytotoxicity against human MIA PaCa-2 cells expressing CD73 assessed as reduction in cell viability by CCK8 assay
    		[PMID: 33359608]
    NCM460 IC50
    23 μg/mL
    Compound: PGG
    Antiproliferative activity against human NCM460 cells after 72 hrs by MTT assay
    Antiproliferative activity against human NCM460 cells after 72 hrs by MTT assay
    		[PMID: 22216935]
    TE-671 ED50
    > 10 μg/mL
    Compound: 10
    Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay
    Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay
    		[PMID: 1431932]
    体外研究
    (In Vitro)

    Pentagalloylglucose (1 μM, 5 天) 抑制乳腺癌细胞和髓母细胞瘤细胞的增殖和存活，IC50 分别为 3.24 μM 和 1.47 μM[1]。
    Pentagalloylglucose (10-20 μM, 24 h) 通过激活系膜细胞中的 Nrf2/HO-1 和抑制 JAK2/STAT3 途径减少 AGE 诱导的炎症[2]。
    Pentagalloylglucose (40 μM, 24 h) 通过 GSK3β/β-catenin 途径抑制人鼻咽癌细胞的生长迁移，并阻滞细胞周期，诱导细胞凋亡自噬[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Pentagalloylglucose 相关抗体:

    Cell Viability Assay[1].

    Cell Line: MDA-MB-231, DAOY, PC-3, SK-HEP-1 cells
    Concentration: 1 μM
    Incubation Time: 5 days
    Result: Inhibited cell viability.

    Western Blot Analysis[2].

    Cell Line: Mouse mesangial cells (MES cells)
    Concentration: 10-20 μM
    Incubation Time: 24 h
    Result: Increased expression of Nrf2 protein.

    Cell Migration Assay [3].

    Cell Line: CNE1, CNE2 cells
    Concentration: 40 μM
    Incubation Time: 24 h
    Result: Inhibited cell migration.
    体内研究
    (In Vivo)

    Pentagalloylglucose (10 mg/kg, 每周三天, 静脉注射) 通过破坏 MDA-MB-231 异种移植裸鼠中的 PALB2-BRCA2 相互作用来增强肿瘤对 PARP 抑制剂和放疗的敏感性[1]。
    Pentagalloylglucose (10, 20mg/kg, 两天一次, 腹腔注射) 在 CNE2 细胞异种移植裸鼠模型中减少肿瘤肺转移并具有抗肿瘤活性[3]。
    Pentagalloylglucose (5, 10 mg/kg, 7 天, 腹腔注射) 对大鼠脑缺血再灌注损伤具有改善作用[4]。
    Pentagalloylglucose (10 mg/kg, 28 天, 口服) 通过免疫抑制活性增加卵清蛋白致敏小鼠的 T 调节细胞群并抑制 IgE 的产生[5]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: MDA-MB-231 xenograft and DAOY xenograft female BALB/c nude mice[1].
    Dosage: 10 mg/kg
    Administration: Intravenous injection (i.v.); 3 days per week; 5 weeks
    Result: Delayed the tumor growth.
    Animal Model: CNE2 cell xenograft nude mouse model[3].
    Dosage: 10, 20 mg/kg
    Administration: Intraperitoneal injection (i.p.); once every two days; 26 days
    Result: Suppressed tumor growth.
    Animal Model: male wistar albino rat[4].
    Dosage: 5, 10 mg/kg
    Administration: Intraperitoneal injection (i.p.); once daily; 7 days
    Result: Reduced vascular congestion and inflammatory changes.
    Animal Model: male BALB/C mice[5].
    Dosage: 10 mg/kg
    Administration: Oral gavage (p.o.); once daily; 28 days
    Result: Increased the proportion of CD4FoxP3 Treg cells.
    分子量

    940.68

    Formula

    C41H32O26
    CAS 号
    性状

    固体

    颜色

    White to light yellow

    中文名称

    1,2,3,4,6-O-没食子酰葡萄糖
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 100 mg/mL (106.31 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    H2O 中的溶解度 : 6 mg/mL (6.38 mM; 超声加热助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.0631 mL 5.3153 mL 10.6306 mL
    5 mM 0.2126 mL 1.0631 mL 2.1261 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    请根据您的 实验动物和给药方式 选择适当的溶解方案。

    以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
    以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 方案 一

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (2.66 mM); 澄清溶液

      此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

      生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
    • 方案 二

      请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (2.66 mM); 澄清溶液

      此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

      2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： PBS

      Solubility: 1.43 mg/mL (1.52 mM); 澄清溶液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    请输入您的动物体内配方组成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
    方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
    计算结果
    工作液所需浓度 : mg/mL
    储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
    您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
    动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
    连续给药周期超过半月以上，请谨慎选择该方案。
    请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
    纯度 & 产品资料

    纯度: 99.77%

    COA (301 KB) HNMR (353 KB) LCMS (93 KB)

    产品使用指南 (1538 KB)
    参考文献

    Pentagalloylglucose 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 1.0631 mL 5.3153 mL 10.6306 mL 26.5765 mL
    5 mM 0.2126 mL 1.0631 mL 2.1261 mL 5.3153 mL
    DMSO 10 mM 0.1063 mL 0.5315 mL 1.0631 mL 2.6577 mL
    15 mM 0.0709 mL 0.3544 mL 0.7087 mL 1.7718 mL
    20 mM 0.0532 mL 0.2658 mL 0.5315 mL 1.3288 mL
    25 mM 0.0425 mL 0.2126 mL 0.4252 mL 1.0631 mL
    30 mM 0.0354 mL 0.1772 mL 0.3544 mL 0.8859 mL
    40 mM 0.0266 mL 0.1329 mL 0.2658 mL 0.6644 mL
    50 mM 0.0213 mL 0.1063 mL 0.2126 mL 0.5315 mL
    60 mM 0.0177 mL 0.0886 mL 0.1772 mL 0.4429 mL
    80 mM 0.0133 mL 0.0664 mL 0.1329 mL 0.3322 mL
    100 mM 0.0106 mL 0.0532 mL 0.1063 mL 0.2658 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pentagalloylglucose14937-32-7Penta-O-galloyl-β-D-glucose 1,2,3,4,6-Pentagalloyl glucose1,2,3,4,6-O-没食子酰葡萄糖JAKKeap1-Nrf2Apoptosisβ-cateninReactive Oxygen SpeciesJanus kinaseBeta cateninantioxidantanti-inflammatoryMDA-MB-231MES cellInhibitorinhibitorinhibit

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