1. Gene
  2. DPP4 - dipeptidyl peptidase 4 Gene

DPP4 - dipeptidyl peptidase 4 Gene

中文名称:二肽基肽酶 4

种属: Homo sapiens

同用名: CD26; ADABP; ADCP2; DPPIV; TP103

基因 ID: 1803 | 基因类型: protein coding

关于 DPP4

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,992,245-162,074,215 (from NCBI)

This gene has 23 transcripts (splice variants), 286 orthologues and 6 paralogues. Biased expression in small intestine (RPKM 70.7), placenta (RPKM 57.1) and 13 other tissues.

功能概要

DPP4 基因编码二肽基肽酶 4,它与腺苷脱氨酶复合蛋白 2 和 T 细胞活化抗原 CD26 相同。它是一种内在的 II 型跨膜糖蛋白和丝氨酸外肽酶,可从多肽的 N 末端切割 X-脯氨酸二肽。二肽基肽酶 4 高度参与葡萄糖和胰岛素代谢,以及免疫调节。这种蛋白质被证明是中东呼吸综合征冠状病毒 (MERS-CoV) 的功能性受体,蛋白质模型表明它可能与 SARS-CoV-2 (导致 COVID-19 的病毒) 发挥相似的作用。[RefSeq 提供,2020 年 4 月]

The DPP4 gene encodes Dipeptidyl Peptidase 4, which is identical to Adenosine Deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl Peptidase 4 is highly involved in glucose and Insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]

DPP4 基因产物(8)

mRNA Protein Name
NM_001935.4 NP_001926.2 dipeptidyl peptidase 4 isoform 1
NR_166823.1
NM_001379605.1 NP_001366534.1 dipeptidyl peptidase 4 isoform 3
NM_001379604.1 NP_001366533.1 dipeptidyl peptidase 4 isoform 2
NR_166825.1
NM_001379606.1 NP_001366535.1 dipeptidyl peptidase 4 isoform 4
NR_166824.1
NR_166822.1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemorepellent activity IDA
IDA: 通过直接分析推断
23677473 GOA
enables chemorepellent activity IMP
IMP: 通过突变表型推断
23677473 GOA
enables dipeptidyl-peptidase activity IDA
IDA: 通过直接分析推断
10593948 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22001206 GOA
enables protease binding IPI
IPI: 通过物理相互作用推断
16651416 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7594462 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
14684150 GOA
enables serine-type endopeptidase activity EXP
EXP: 通过实验结果推断
8100523 GOA
enables serine-type peptidase activity IDA
IDA: 通过直接分析推断
14684150 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
10900005 GOA
enables virus receptor activity IDA
IDA: 通过直接分析推断
23486063 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell activation IDA
IDA: 通过直接分析推断
7594462 GOA
involved in T cell costimulation IDA
IDA: 通过直接分析推断
10900005 GOA
involved in endothelial cell migration IDA
IDA: 通过直接分析推断
16651416 GOA
involved in negative regulation of extracellular matrix disassembly IDA
IDA: 通过直接分析推断
16651416 GOA
involved in negative regulation of neutrophil chemotaxis IMP
IMP: 通过突变表型推断
23677473 GOA
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
17549790 GOA
involved in proteolysis IDA
IDA: 通过直接分析推断
27198182 GOA
involved in regulation of cell-cell adhesion mediated by integrin IDA
IDA: 通过直接分析推断
11772392 GOA
involved in response to hypoxia IDA
IDA: 通过直接分析推断
16670267 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
15052268 GOA
located in cell surface IDA
IDA: 通过直接分析推断
7594462 GOA
located in endocytic vesicle IDA
IDA: 通过直接分析推断
10900005 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
16651416 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
16670267 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DPP4 蛋白结构

DPPIV_N

DPPIV_N: Dipeptidyl peptidase IV (DPP IV) N-terminal region (108 - 478)

Peptidase_S9

Peptidase_S9: Prolyl oligopeptidase family (561 - 764)

  • 0
  • 200
  • 400
  • 600
  • 766 a.a.
蛋白主名 其他名称

dipeptidyl peptidase 4

ADCP-2

DPP IV

Gly-Pro naphthylamidase

Post-proline dipeptidyl aminopeptidase IV

T-cell activation antigen CD26

Xaa-Pro-dipeptidylaminopeptidase

adenosine deaminase complexing protein 2

dipeptidyl peptidase IV

dipeptidylpeptidase 4

dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)

DPP4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DPP4 P27487 CXCL2 Homo sapiens P19875
Protease Assay
21314817
种属内
DPP4 P27487 CXCL2 Homo sapiens P19875
Enzymatic Study
18275857
种属间
DPP4 P27487 S Human MERS coronavirus A0A2R4KP93
Filter Binding
29669833
种属间
DPP4 P27487 S Human MERS coronavirus A0A2R4KP93
Alpha-Screen
29669833
种属间
DPP4 P27487 S Human MERS coronavirus R9UQ53
Comigration in SDS
23835475
种属间
DPP4 P27487 S Human MERS coronavirus R9UQ53
GMS
23835475
种属间
DPP4 P27487 S Human MERS coronavirus R9UQ53
X-Ray Diffraction
23835475
种属内
DPP4 P27487 CXCL10 Homo sapiens P02778
Enzymatic Study
18275857
种属内
DPP4 P27487 CXCL11 Homo sapiens O14625
Protease Assay
21314817
种属内
DPP4 P27487 CCL11 Homo sapiens P51671
Enzymatic Study
18275857
种属内
DPP4 P27487 CXCL10 Homo sapiens P02778
Protease Assay
21314817
种属内
DPP4 P27487 DPP4 Homo sapiens P27487
CD
22001206
种属内
DPP4 P27487 VIP Homo sapiens P01282
Protease Assay
21314817
种属内
DPP4 P27487 GCG Homo sapiens P01275
Protease Assay
21314817
种属内
DPP4 P27487 S Middle East respiratory syndrome-related coronavirus K9N5Q8
SPR
32275855
种属内
DPP4 P27487 S Middle East respiratory syndrome-related coronavirus K9N5Q8
Filter Binding
29669833
种属内
DPP4 P27487 S Middle East respiratory syndrome-related coronavirus K9N5Q8
Alpha-Screen
29669833
种属内
DPP4 P27487 S Middle East respiratory syndrome-related coronavirus K9N5Q8
FACS
32275855
种属内
DPP4 P27487 S Middle East respiratory syndrome-related coronavirus K9N5Q8
Confocal
32275855
种属内
DPP4 P27487 S Middle East respiratory syndrome-related coronavirus K9N5Q8
FACS
32203189
种属间
DPP4 P27487 ADA Bos taurus P56658
SPR
22001206
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DPP4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70017 CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, His) P27487 (N29-P766) ≥95%
HY-P72975 CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293) P27487 (N29-P766) ≥95%
HY-P72976 CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, Fc) P27487 (N29-P766) ≥95%

关联疾病

疾病名称 别名
Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection

Hypoglycemia

Hypoglycaemia

Low Blood Sugar

Hypoglycaemia Nos

Spontaneous Hypoglycaemia

Nondiabetic Hypoglycaemia

Hypoglycaemic Disorder Nos

Hypoglycaemic Syndrome

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia

Pancreatic Colloid Cystadenoma

Mucinous Cystadenoma Of Pancreas

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency Disease

Primary Immunodeficiency

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Sezary'S Disease

Sezary Syndrome

Sézary Syndrome

Sezary'S Lymphoma

Sezary Disease

Sezary Erythroderma

Sezary Lymphoma

Diabetes Mellitus, Ketosis-Prone

Diabetic Ketoacidosis

KPD

Diabetes Mellitus, Ketosis-Prone, Susceptibility To

Ketosis-Prone Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetic Ketoacidosis Nos

Dka - [Diabetic Ketoacidosis] Nos

Dka - [Diabetic Ketoacidosis] Without Coma

Dka - [Diabetic Ketoacidosis] With Coma

Residual Stage Of Open Angle Glaucoma

Open-Angle Glaucoma Residual Stage

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

Cutaneous T-Cell Lymphoma

Cutaneous T Cell Lymphoma

Lymphoma, T-Cell, Cutaneous

Ctcl

Lymphoma T-Cell Cutaneous

Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Fatty Liver Disease

Alcoholic Fatty Liver

Fatty Liver

Fatty Liver, Alcoholic

Fatty Change Of Liver

Hepatic Lipidosis

Steatosis Of Liver

Fatty Liver Alcoholic

Steatohepatitis

Etoh Fatty Liver

Etoh Fatty Liver Metamorphosis

Fatty Etoh Liver Necrosis

Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]

Squamous Cell Bile Duct Carcinoma

Bile Duct Squamous Cell Carcinoma

Coronavirus Infectious Disease
Vulvovaginitis

Vulvo-Vaginitis

Glucose Intolerance

Glucose: Intolerance

Glucose: Malabsorption

Malabsorption Of Glucose

Impaired Glucose Tolerance

Hyperinsulinism

Hyperinsulinemia

Autoimmune Disease Of Endocrine System
Acquired Metabolic Disease
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To

ANON

Anorexia Nervosa, Susceptibility To, 1

An

Anorexia Nervosa 1

An - [Anorexia Nervosa]

Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder

Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Follicular Adenoma

Follicular Adenoma Of The Thyroid Gland

Thyroid Follicular Adenoma

Adenoma Follicular

Follicular Thyroid Adenoma

Thyroid Gland Follicular Adenoma

Bullous Pemphigoid

Benign Pemphigus

Senile Dermatitis Herpetiformis

Old Age Pemphigus

Parapemphigus

Pemphigoid

Pemphigoid Bullous

Pemphigoid, Bullous

Balanitis
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

Intermediate Coronary Syndrome

Unstable Angina

Angina At Rest

Anginal Chest Pain At Rest

Impending Infarction

Preinfarction Angina

Worsening Angina

Angina, Unstable

Myocardial Preinfarction Syndrome

Angina Unstable

Crescendo Angina

Angina Decubitus

Acute Coronary Insufficiency

Unstable Angina Pectoris

Preinfarctional Angina Pectoris

Worsening Effort Angina

Preinfarction Syndrome

Unstable Angina Pectoris Syndrome

Unstable Anginal Attack

Unstable Cardiac Angina

Unstable Chest Angina

Unstable Heart Angina

De Novo Effort Angina Pectoris

Crescendo Angina Pectoris

Ua - [Unstable Angina]

Psoriasis
Lymphoblastic Lymphoma

Lymphoma, Lymphoblastic

Lymphoma Lymphoblastic

Precursor Cell Lymphoblastic Lymphoma

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency

LEPD

Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency

Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction

Leptin

Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Carbohydrate Metabolic Disorder

Inborn Errors Of Carbohydrate Metabolism

Disorder Of Carbohydrate Metabolism

Carbohydrate Metabolism, Inborn Errors

Disorder Of Carbohydrate Transport And Metabolism

Inborn Carbohydrate Metabolism Disorder

Inborn Carbohydrate Metabolic Disorder

Carbohydrate Metabolism Disorder

Carbohydrate Metabolism Disorders

Disorders Of Carbohydrate Metabolism

Congenital Disorders Of Carbohydrate Metabolism

Inherited Disorders Of Carbohydrate Metabolism

Autonomic Neuropathy

Diabetic Autonomic Neuropathy

Diabetic Autonomic Neuropathy

Diabetic Neuropathies

Hypoglycemic Coma
Glucose Metabolism Disease

Glucose Metabolism Disorders

Disorder Of Glucose Metabolism

Diabetes Mellitus

Diabetes

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Urinary Tract Infection

Urinary Tract Infections

Uti

Urinary Tract Infection Nos

Uti - [Urinary Tract Infection]

Uti Nos - [Urinary Tract Infection Nos]

Urosepsis Nos

E Coli Uti

E Coli Urinary Tract Infection

Escherichia Coli Uti

Inherited Metabolic Disorder

Inborn Errors Of Metabolism

Inborn Metabolism Disorder

Metabolic Hereditary Disorder

Inborn Error Of Metabolism

Inborn Metabolic Disorder

Metabolism, Inborn Errors

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Mycosis Fungoides

Mycosis Fungoides Lymphoma

Alibert-Bazin Syndrome

Granuloma Fungoides

Classic Mycosis Fungoides

Mycosis Fungoides, Alibert-Bazin Type

Adenosquamous Bile Duct Carcinoma

Bile Duct Adenosquamous Carcinoma

Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Balanoposthitis

Balanitis Due To Infection

Angioedema

Angioneurotic Oedema

Quincke'S Edema

Angioneurotic Edema

Giant Urticaria

Prediabetes Syndrome

Impaired Glucose Tolerance

Prediabetes

Prediabetic State

IGT

Igt - [Impaired Glucose Tolerance]

Impaired Glucose Tolerance With Unspecified Complication

Impaired Glucose Tolerance Without Complication

Abnormal Glucose Tolerance

Peripheral Artery Disease

Peripheral Arterial Disease

Peripheral Arterial Diseases

Hyperglycemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DPP4 RGD RGD:2515
Bos taurus DPP4 VGNC VGNC:106715
Canis familiaris DPP4 VGNC VGNC:40074
Felis catus DPP4 VGNC VGNC:61604
Mus musculus DPP4 MGD MGI:94919
Macaca mulatta DPP4 VGNC VGNC:71979
Macaca fascicularis DPP4 NCBI NCBI:102133935
Others DPP4 NCBI