Brd4 - bromodomain containing 4 Gene

中文名称：含溴结构域 4

种属: Rattus norvegicus

关于 Brd4

功能概要

预计该基因编码的蛋白可启动多种功能，包括 P-TEFb 复合物结合活性；组蛋白结合活性；和蛋白丝氨酸/苏氨酸激酶活性。预计参与多个过程，包括组蛋白 H3-K36 三甲基化的正调控；调节细胞内信号转导； RNA 聚合酶 II 对转录的调控。预计在几个过程的上游或内部起作用，包括组蛋白乙酰化；内细胞团细胞增殖；和有丝分裂细胞周期的 G2/M 转换的正调节。预测位于浓缩的核染色体和核质中。预计是细胞周期蛋白/CDK 阳性转录延伸因子复合物的一部分。预计在染色质和细胞核中有活性。该基因的人类直系同源物与结肠癌和特发性肺纤维化有关。与人类 BRD4 同源（含 4 的溴结构域）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including P-TEFb complex binding activity; histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of histone H3-K36 trimethylation; regulation of intracellular signal transduction; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including histone acetylation; inner cell mass cell proliferation; and positive regulation of G2/M transition of mitotic cell cycle. Predicted to be located in condensed nuclear chromosome and nucleoplasm. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in colon Cancer and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4). [provided by Alliance of Genome Resources, Apr 2022]