BRD4 - bromodomain containing 4 Gene

中文名称：含溴结构域 4

种属: Homo sapiens

同用名: CAP; MCAP; HUNK1; HUNKI

基因 ID: 23476 | 基因类型: protein coding

关于 BRD4

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,235,519-15,332,539 (from NCBI)

This gene has 13 transcripts (splice variants), 66 orthologues, 11 paralogues and is associated with 111 phenotypes. Ubiquitous expression in placenta (RPKM 10.8), testis (RPKM 9.2) and 25 other tissues.

功能概要

该基因编码的蛋白质与小鼠蛋白质 MCAP 同源，后者在有丝分裂期间与染色体相关，并且与人类 RING3 蛋白质 (一种丝氨酸/苏氨酸激酶) 同源。这些蛋白质中的每一个都包含两个溴结构域，这是一个可能参与染色质靶向的保守序列基序。该基因被认为是易位 t (15;19) (q13;p13.1) 的 19 号染色体靶点，它定义了年轻人的上呼吸道癌。已经描述了两种选择性剪接的转录本变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

BRD4 基因产物(11)

mRNA	Protein	Name
NM_001379292.1	NP_001366221.1	bromodomain-containing protein 4 isoform short
NM_001330384.2	NP_001317313.1	bromodomain-containing protein 4 isoform 3
XM_047438543.1	XP_047294499.1	bromodomain-containing protein 4 isoform X4
XM_047438541.1	XP_047294497.1	bromodomain-containing protein 4 isoform X2
XM_047438542.1	XP_047294498.1	bromodomain-containing protein 4 isoform X3
XR_007066712.1
NM_001379291.1	NP_001366220.1	bromodomain-containing protein 4 isoform long
XM_047438544.1	XP_047294500.1	bromodomain-containing protein 4 isoform X4
XM_047438540.1	XP_047294496.1	bromodomain-containing protein 4 isoform X1
NM_058243.3	NP_490597.1	bromodomain-containing protein 4 isoform long
NM_014299.3	NP_055114.1	bromodomain-containing protein 4 isoform short

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables P-TEFb complex binding	IDA IDA: 通过直接分析推断	17690245	GOA
enables RNA polymerase II C-terminal domain binding	IDA IDA: 通过直接分析推断	22509028	GOA
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IMP IMP: 通过突变表型推断	22509028	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	20871596	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	21555454	GOA
enables histone reader activity	IDA IDA: 通过直接分析推断	23086925	GOA
enables lysine-acetylated histone binding	IDA IDA: 通过直接分析推断	20871596	GOA
enables p53 binding	IDA IDA: 通过直接分析推断	23317504	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17023018	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	23086925	GOA
enables transcription coactivator activity	IMP IMP: 通过突变表型推断	21555454	GOA
enables transcription coregulator activity	IMP IMP: 通过突变表型推断	24360279	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IMP IMP: 通过突变表型推断	23728299	GOA
involved in chromatin remodeling	IDA IDA: 通过直接分析推断	23728299	GOA
involved in negative regulation by host of viral transcription	IDA IDA: 通过直接分析推断	17690245	GOA
involved in negative regulation of DNA damage checkpoint	IMP IMP: 通过突变表型推断	23728299	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	21555454	GOA
acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	10938129	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	19103749	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	23086925	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	19103749	GOA
acts upstream of or within positive regulation of transcription elongation by RNA polymerase II	IMP IMP: 通过突变表型推断	18039861	GOA
involved in regulation of inflammatory response	IDA IDA: 通过直接分析推断	19103749	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	18039861	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromosome	IDA IDA: 通过直接分析推断	23728299	GOA
located in condensed nuclear chromosome	IDA IDA: 通过直接分析推断	10938129	GOA
located in nucleus	IDA IDA: 通过直接分析推断	20871596	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BRD4 蛋白结构

Bromodomain

0
300
600
900
1200
1362 a.a.

蛋白主名

其他名称

bromodomain-containing protein 4

chromosome-associated protein

mitotic chromosome-associated protein

BRD4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	BRD4	O60885	E2	Human papillomavirus	P03120	SLC	22761572
种属间	BRD4	O60885	E2	Human papillomavirus	P03120	Anti Tag CoIP	15109495
种属间	BRD4	O60885	E2	Human papillomavirus	P03120	Y2H	18305892
种属内	BRD4	O60885	TWIST1	Homo sapiens	Q15672	NMR	24525235
种属内	BRD4	O60885	NCK1	Homo sapiens	P16333	Peptide Array	17474147
种属内	BRD4	O60885	GRB2	Homo sapiens	P62993	Peptide Array	17474147
种属间	BRD4	O60885	E2	Human papillomavirus	P04015	Affinity Chrom	17023018
种属间	BRD4	O60885	E2	Human papillomavirus	P04015	SLC	22761572
种属间	BRD4	O60885	E2	Human papillomavirus	P06790	SLC	22761572
种属内	BRD4	O60885	RELA	Homo sapiens	Q04206	Anti Bait CoIP	19103749
种属内	BRD4	O60885	RELA	Homo sapiens	Q04206	Pull Down	23686307
种属内	BRD4	O60885	RELA	Homo sapiens	Q04206	NMR	22645123
种属内	BRD4	O60885	RELA	Homo sapiens	Q04206	Anti Bait CoIP	23686307
种属内	BRD4	O60885	RELA	Homo sapiens	Q04206	X-Ray Diffraction	23686307
种属内	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Pull Down	24360279
种属内	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Anti Bait CoIP	24360279
种属内	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Anti Tag CoIP	24360279
种属内	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Y2H	23455924

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 BRD4 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7846	BRD4 Protein, Human (His-Flag)	O60885-1 (E49-E460)	≥95%

BRD4 抗体

目录号	产品名	应用	反应物种
HY-P80976	BRD4 Antibody	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Rhabdomyosarcoma

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Kbg Syndrome

KBGS	Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies
Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies	Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome
Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Desmoplastic/Nodular Medulloblastoma	Medulloblastoma With Extensive Nodularity
Desmoplastic Medulloblastoma	Medulloblastoma, Somatic
Medulloblastoma, Desmoplastic	Brain Medulloblastoma
Cns Pnet	Infratentorial Primitive Neuroectodermal Tumor
Mben	Medulloblastoma Desmoplastic
Neuroectodermal Tumors, Primitive	Medulloblastomas
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Cornelia De Lange Syndrome 1

De Lange Syndrome	CDLS1
Cdl	Cdls
Typus Degenerativus Amstelodamensis	Brachmann-De Lange Syndrome
Bdls	Amstelodamensis Typus Degenerativus
Cornelia De Lange Syndrome, Type 1

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Leukemia, Myeloid, Acute	Acute Myeloid Leukemia, Somatic
Leukemia, Acute Myeloid, Somatic	Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic
Acute Myeloblastic Leukaemia	Acute Myelogenous Leukaemia
Aml - Acute Myeloid Leukemia	Acute Myeloid Leukemia With Cebpa Somatic Mutations
Aml With Cebpa Somatic Mutations	Inherited Acute Myeloid Leukemia
Familial Aml	Inherited Aml
Pure Familial Aml	Pure Familial Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia	Therapy-Related Aml And Myelodysplastic Syndrome
Acute Myeloid Leukemia, Secondary	Acute Non-Lymphoblastic Leukemia
Acute Non-Lymphocytic Leukemia	Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia	Acute Myeloblastic Leukaemia With Multilineage Dysplasia
Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission	Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Ureteral Obstruction

Heterophyiasis

Heterophyes Infectious Disease

Nasal Cavity Cancer

Nasal Cavity Carcinoma	Malignant Neoplasm Of Nasal Cavities
Malignant Tumor Of The Nasal Cavity	Cancer Of Nasal Cavity
Carcinoma Of Nasal Cavity	Malignant Neoplasm Of Nasal Cavity
Neoplasm Of Nasal Cavity

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase

生物活性分子 (2)

目录号	产品名	作用方式	纯度	Phase
HY-111916	ODM-207	Inhibitor	99.58%	Phase 2
HY-112090	ABBV-744	Inhibitor	99.97%	Phase 1

Pre-clinical Phase

生物活性分子 (125)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101838	dBET1	Inhibitor	99.24%	否
HY-100972	ARV-771	Inhibitor	99.87%	否
HY-136570	GSK778	Inhibitor	98.93%	否
HY-12863	Pelabresib	Inhibitor	99.95%	否
HY-122826	ZXH-3-26	Inhibitor	98.90%	否
HY-136571	GSK046	Inhibitor	99.65%	否
HY-100482	CPI-637	Inhibitor	99.94%	否
HY-123941	FKBP12 PROTAC dTAG-7	Inhibitor	99.07%	否
HY-14443	XMD8-92	Inhibitor	99.67%	否
HY-114305	A1874	Inhibitor	99.70%	否
HY-107443	I-BET762 carboxylic acid	Inhibitor	99.55%	否
HY-19999A	PF-CBP1 hydrochloride	Inhibitor	99.99%	否
HY-129937A	GNE-987	Inhibitor	99.91%	否
HY-120028	GNE-207	Inhibitor	97.02%	否
HY-103632	PROTAC BRD9 Degrader-1	Inhibitor	/	否
HY-101519	BETd-260	Inhibitor	99.59%	否
HY-123844	dBET57	Inhibitor	99.94%	否
HY-141438	SIM1	Inhibitor	99.57%	否
HY-110374	NVS-CECR2-1	Inhibitor	99.40%	否
HY-101146	SF2523	Inhibitor	98.25%	否
HY-125232	MS645		≥98.0%	否
HY-114204	GSK8814	Inhibitor	99.60%	否
HY-156828	MMH2	Degrader	98.03%	否
HY-126428	ZL0580	Modulator	99.26%	否
HY-133737	PROTAC BRD4 Degrader-5	Inhibitor	99.93%	否
HY-112429	HJB97	Inhibitor	98.05%	否
HY-138563	GSK973	Inhibitor	99.97%	否
HY-120000	MS402	Inhibitor	99.62%	否
HY-112609	QCA570	Inhibitor	99.95%	否
HY-117491	BRD4 Inhibitor-10	Inhibitor	99.52%	否
HY-111102	FL-411	Inhibitor	99.05%	否
HY-129917	KB02-JQ1	Inhibitor	99.17%	否
HY-136920	CBP/p300-IN-8	Inhibitor	99.94%	否
HY-133131	PROTAC BRD4 Degrader-1	Inhibitor	99.12%	否
HY-130622	LT052	Inhibitor	98.77%	否
HY-114504	RVX-297	Inhibitor	95.00%	否
HY-161515	BRD4/NAMPT-IN-1	Inhibitor	99.45%	否
HY-107442	PROTAC BRD4-binding moiety 1		/	否
HY-112610	CF53	Inhibitor	99.78%	否
HY-148864	JQ1-TCO	Inhibitor	99.95%	否
HY-156827	MMH1	Degrader	98.08%	否
HY-160528	IBG3	Inhibitor	98.53%	否
HY-111502	Y06036	Inhibitor	98.57%	否
HY-101121	NI-42	Inhibitor	99.53%	否
HY-147202	BRD4 Inhibitor-24	Inhibitor	99.27%	否
HY-146208	BRD4 Inhibitor-20	Inhibitor	99.00%	否
HY-112376	MZP-54	Inhibitor	98.16%	否
HY-145260	BRD4/CK2-IN-1	Inhibitor	98.62%	否
HY-158031	PLK1/BRD4-IN-5	Inhibitor	99.55%	否
HY-139148	UMB298	Inhibitor	99.11%	否
HY-129201	ZEN-2759	Inhibitor	99.51%	否
HY-136857	BRD4 degrader-3	Degrader	99.43%	否
HY-145264	OARV-771	Inhibitor	98.33%	否
HY-131061	BET bromodomain inhibitor 1	Inhibitor	99.91%	否
HY-114416	GS-626510	Inhibitor	99.80%	否
HY-111875	SNIPER(BRD)-1	Inhibitor	99.43%	否
HY-142520	I-BET567	Inhibitor	99.49%	否
HY-103297	OXFBD02	Inhibitor	98.04%	否
HY-148864A	(Z)-JQ1-TCO	Inhibitor	99.34%	否
HY-160558	PLK1/BRD4-IN-3	Inhibitor	99.66%	否
HY-160557	PLK1/BRD4-IN-2	Inhibitor	/	否
HY-111503	Y06137	Inhibitor	99.90%	否
HY-132991	ML 2-14	Degrader	99.43%	否
HY-135236	OXFBD04	Inhibitor	98.99%	否
HY-146999	YM458	Inhibitor	99.16%	否
HY-107425A	cis-MZ 1	Degrader	/	否
HY-114407	TD-428	Inhibitor	/	否
HY-163638	BRD4 degrader-1	Degrader	/	否
HY-110215	XD14	Inhibitor	95.02%	否
HY-111977	ZEN-3219	Inhibitor	99.75%	否
HY-161651	BRD4 ligand 6		/	否
HY-100696	PNZ5	Inhibitor	/	否
HY-133136	PROTAC BRD4 Degrader-2	Inhibitor	/	否
HY-146660	BRD4 Inhibitor-18	Inhibitor	/	否
HY-126325	BY27	Inhibitor	/	否
HY-149100	PLK1-IN-6	Inhibitor	/	否
HY-135558	PROTAC BRD4 Degrader-3	Inhibitor	/	否
HY-143235	BRD4 Inhibitor-15	Inhibitor	/	否
HY-169170	PARP1/BRD4-IN-3	Inhibitor	/	否
HY-170390	AB3067	Degrader	/	否
HY-143471	WNY0824	Inhibitor	/	否
HY-170686	BRD4 Inhibitor-38	Inhibitor	/	否
HY-168634	SJ46421	Inhibitor	/	否
HY-143300	BRD4-BD1-IN-2	Inhibitor	/	否
HY-131203	PROTAC BRD4 Degrader-6	Inhibitor	/	否
HY-153945	BET-IN-15	Inhibitor	/	否
HY-152213	BET-IN-13	Inhibitor	/	否
HY-162240	SJH1-51B	Degrader	/	否
HY-132128	BRD4 Inhibitor-12	Inhibitor	/	否
HY-149098	SJ1461	Inhibitor	/	否
HY-161650	PROTAC BRD4 Degrader-26	Degrader	/	否
HY-151972	BRD4 Inhibitor-25	Inhibitor	/	否
HY-163282	NB512	Inhibitor	/	否
HY-163413	BRD4-BD1-IN-3	Inhibitor	/	否
HY-144338	PARP1/BRD4-IN-1	Inhibitor	/	否
HY-149806	Bromodomain IN-2	Inhibitor	/	否
HY-143299	BRD4-BD1-IN-1	Inhibitor	/	否
HY-147375	Bromodomain inhibitor-10	Inhibitor	/	否
HY-142705	BRD4 D1-IN-2	Inhibitor	/	否
HY-169358	L134	Inhibitor	/	否
HY-153519	WWL0245	Inhibitor	/	否
HY-139294	PROTAC BRD4 Degrader-15	Inhibitor	/	否
HY-W265951	3-Methylcarbostyril	Inhibitor	/	否
HY-147374	Bromodomain inhibitor-9	Inhibitor	/	否
HY-150683	NC-III-49-1	Inhibitor	/	否
HY-130612	PROTAC BRD2/BRD4 degrader-1	Inhibitor	/	否
HY-150613	PARP1/BRD4-IN-2	Inhibitor	/	否
HY-157290	HL403	Inhibitor	/	否
HY-157460	BRD4 Inhibitor-29		/	否
HY-150684	GXH-II-052	Inhibitor	/	否
HY-155680	BET BD2-IN-1	Inhibitor	/	否
HY-104072	BRD4-IN-3	Inhibitor	/	否
HY-158331	Gal-ARV-771	Degrader	/	否
HY-129937	(S)-GNE-987	Inhibitor	/	否
HY-160662	BRD4-IN-5	Inhibitor	/	否
HY-143328	PROTAC BRD4 Degrader-17	Degrader	/	否
HY-161368	BRD-SF2	Degrader	/	否
HY-136794	SB-284851-BT	Inhibitor	/	否
HY-163639	BRD4 degrader-2	Inhibitor	/	否
HY-132130	BRD4 Inhibitor-13	Inhibitor	/	否
HY-136570A	GSK778 hydrochloride	Inhibitor	/	否
HY-155222	TW9	Inhibitor	/	否
HY-102044	BET-IN-2	Inhibitor	/	否
HY-111978	ZEN-3862	Inhibitor	98.86%	否
HY-111979	ZEN-3411	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	BRD4	VGNC	VGNC:38520
Macaca mulatta	BRD4	VGNC	VGNC:70301
Felis catus	BRD4	VGNC	VGNC:60168
Bos taurus	BRD4	VGNC	VGNC:26559
Rattus norvegicus	BRD4	RGD	RGD:1307282
Mus musculus	BRD4	MGD	MGI:1888520
Others	BRD4	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.