2. Gene
  3. Cdk1 - cyclin-dependent kinase 1 Gene

Cdk1 - cyclin-dependent kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 1

种属: Rattus norvegicus

同用名: Cdc2; Cdc2a

基因 ID: 54237 | 基因类型: protein coding

关于 Cdk1

Biased expression in Thymus (RPKM 28.3), Spleen (RPKM 193.1) and 8 other tissues.

功能概要

该基因编码的蛋白可启动细胞周期蛋白结合活性；细胞周期蛋白依赖性蛋白丝氨酸/苏氨酸激酶活性；和组蛋白激酶活性。参与多个过程，包括高尔基体分解；蛋白质输入细胞核的正调节；和心室心肌细胞的发育。在基因表达的负调控上游或负调控中起作用。位于细胞质和细胞核中。肝细胞癌的生物标志物。该基因与乳腺癌相关的人类直向同源基因；宫颈癌;和膀胱癌。与人 CDK1（细胞周期蛋白依赖性激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and histone kinase activity. Involved in several processes, including Golgi disassembly; positive regulation of protein import into nucleus; and ventricular cardiac muscle cell development. Acts upstream of or within negative regulation of gene expression. Located in cytoplasm and nucleus. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder Cancer. Orthologous to human CDK1 (cyclin dependent kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdk1 基因产物(1)

mRNA Protein Name
NM_019296.2 NP_062169.1 cyclin-dependent kinase 1

Cdk1 蛋白结构

STKc_CDK1_euk

STKc_CDK1_euk: cd07861 (2 - 286)

  • 0
  • 100
  • 200
  • 297 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 1

Cell division cycle control protein 2

cell division control protein 2 homolog

cell division cycle 2 homolog A

cell division cycle 2, G1 to S and G2 to M

cell division protein kinase 1

p34 protein kinase

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16297A Abemaciclib Inhibitor 99.94% 是
HY-10492 Dinaciclib Inhibitor 99.36% 是
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% 是
HY-B0263 Thiabendazole Inhibitor 99.77% 否
Clinical Phase
生物活性分子 (26)
目录号 产品名 作用方式
纯度 Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.74% Phase 4
HY-10005 Flavopiridol Inhibitor 99.73% Phase 2
HY-30237 (R)-Roscovitine Inhibitor 99.84% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-10006 Flavopiridol Hydrochloride Inhibitor 99.73% Phase 2
HY-13914 Roniciclib Inhibitor 98.09% Phase 2
HY-10424 Milciclib Inhibitor 99.90% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-16559 Riviciclib hydrochloride 98.89% Phase 2
HY-103712B Samuraciclib hydrochloride hydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-137432A Avotaciclib trihydrochloride Inhibitor 99.75% Phase 2
HY-137432 Avotaciclib Inhibitor 99.72% Phase 2
HY-112272 Lerociclib Inhibitor 98.35% Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.54% Phase 1
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-10032 PF 477736 Inhibitor 99.21% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-12871B Atuveciclib Inhibitor 99.80% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
Pre-clinical Phase
生物活性分子 (83)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12529 Ro-3306 Inhibitor 98.68% 否
HY-12302 Kenpaullone Inhibitor 98.20% 否
HY-10329 JNJ-7706621 Inhibitor 99.91% 否
HY-124719 hSMG-1 inhibitor 11j Inhibitor 99.82% 否
HY-15339 CVT-313 Inhibitor 99.90% 否
HY-15154 NG 52 Inhibitor 99.97% 否
HY-18340 (R)​-​CR8 Inhibitor 99.61% 否
HY-11009 CGP60474 Inhibitor 99.23% 否
HY-N0417 Cucurbitacin E Inhibitor 99.92% 否
HY-124760 hSMG-1 inhibitor 11e Inhibitor 99.81% 否
HY-15878 LDC000067 Inhibitor 98.00% 否
HY-18299A Purvalanol A Inhibitor 98.30% 否
HY-10014 R547 Inhibitor 99.57% 否
HY-12445 Asnuciclib Inhibitor 99.76% 否
HY-13266A BS-181 hydrochloride Inhibitor 99.80% 否
HY-13461A PHA-767491 hydrochloride Inhibitor 98.06% 否
HY-15275 BMS-265246 Inhibitor 98.92% 否
HY-18629 SU9516 Inhibitor 99.81% 否
HY-18340A (R)-CR8 trihydrochloride Inhibitor 98.95% 否
HY-18299 Purvalanol B Inhibitor ≥97.0% 否
HY-12280 THZ2 Inhibitor 99.03% 否
HY-X0150 JSH-150 Inhibitor 98.36% 否
HY-117535 CDK2-IN-4 Inhibitor 98.07% 否
HY-129478 TC11 Activator 98.04% 否
HY-119940 MC180295 Inhibitor 98.89% 否
HY-15569 NU6102 Inhibitor 99.23% 否
HY-108359 Alsterpaullone Inhibitor 99.85% 否
HY-148062 RSS0680 98.03% 否
HY-103647 K00546 Inhibitor 98.08% 否
HY-15889 AMG 925 Inhibitor 98.20% 否
HY-107419 NU6140 Inhibitor 99.07% 否
HY-103221 MeBIO Inhibitor ≥98.0% 否
HY-15241 NVP-LCQ195 Inhibitor 98.81% 否
HY-19316 NU2058 Inhibitor 99.66% 否
HY-112463 CDK1-IN-2 Inhibitor 97.17% 否
HY-139980 CDK9-IN-13 Inhibitor 99.22% 否
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% 否
HY-111237 Butyrolactone I Inhibitor 98.03% 否
HY-153556 GW297361 Inhibitor 98.13% 否
HY-N5072 Desmethylglycitein Inhibitor 98.98% 否
HY-100429 CAN508 Inhibitor 99.59% 否
HY-112462 Cdk1/2 Inhibitor III Inhibitor 99.69% 否
HY-111930 5-Iodo-indirubin-3'-monoxime Inhibitor 99.50% 否
HY-13816 NU6027 Inhibitor 99.04% 否
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% 否
HY-112346 RGB-286147 Inhibitor 98.60% 否
HY-115924 CDK1-IN-1 Inhibitor 99.33% 否
HY-103383 (R)-DRF053 dihydrochloride Inhibitor 99.30% 否
HY-13266 BS-181 Inhibitor 98.10% 否
HY-14372 BS-194 Inhibitor 99.36% 否
HY-X0009A JSH-009 dimaleate Inhibitor / 否
HY-136726 CGP-82996 Inhibitor 98.12% 否
HY-114903 (E/Z)-BIO-acetoxime Inhibitor / 否
HY-103381 NSC693868 Inhibitor ≥99.0% 否
HY-15889A AMG 925 HCl Inhibitor / 否
HY-13461 PHA-767491 Inhibitor / 否
HY-151409 CDK1-IN-5 Inhibitor / 否
HY-151407 CDK1-IN-3 Inhibitor / 否
HY-103712 Samuraciclib Inhibitor / 否
HY-126244 CDK4/6-IN-3 Inhibitor / 否
HY-112336 Aloisine RP106 Inhibitor / 否
HY-123034 CDKI-83 Inhibitor / 否
HY-151898 CDK4/6-IN-14 Inhibitor / 否
HY-115942 Anticancer agent 29 Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-151878 CDK7-IN-20 Inhibitor / 否
HY-161826 Antitumor agent-174 Inhibitor / 否
HY-112363 Aloisine A Inhibitor / 否
HY-147901 KDM1/CDK1-IN-1 Inhibitor / 否
HY-155787 SHR5428 Inhibitor / 否
HY-141685 3-Methylthienyl-carbonyl-JNJ-7706621 Inhibitor / 否
HY-151408 CDK1-IN-4 Inhibitor / 否
HY-163856 CDK7-IN-30 Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-123369 BMI-1026 Inhibitor / 否
HY-147646 CDK1/Cyc B-IN-1 Inhibitor 98.47% 否
HY-146253 CDK1/2/4-IN-1 Inhibitor / 否
HY-160643 CDK2-IN-27 Inhibitor / 否
HY-112403 (S)-Roscovitine Inhibitor / 否
HY-123045 PNU-292137 Inhibitor / 否
HY-112450 Olomoucine II Inhibitor / 否
HY-111932 Indirubin-5-sulfonate Inhibitor / 否
HY-111931 Indirubin-3'-monoxime-5-sulphonic acid Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk1 NCBI NCBI:983
Mus musculus Cdk1 NCBI NCBI:12534
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