CDK1/Cyc B-IN-1

目录号: HY-147646 纯度: 98.47%: FAQs
Data Sheet SDS COA 产品使用指南技术支持

CDK1/Cyc B-IN-1 (Compound 5) 是一种选择性的 CDK1/Cyc B 复合体抑制剂，IC₅₀ 为 97 nM。CDK1/Cyc B-IN-1 诱导细胞凋亡 (apoptosis) 和 G2/M 细胞期阻滞。CDK1/Cyc B-IN-1 对癌细胞具有广谱的细胞毒性。

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CDK1/Cyc B-IN-1 Chemical Structure

CAS No. : 2459916-56-2

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10 mg	￥1450	In-stock
25 mg	￥2900	In-stock
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CDK1/Cyc B-IN-1 相关产品

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

生物活性
纯度 & 产品资料
参考文献

生物活性

CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC₅₀ of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines^[1].

IC₅₀ & Target

CDK1-Cyclin B

97 nM (IC₅₀)

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
786-0	GI₅₀	4.47 μM Compound: 5	Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
A498	GI₅₀	11.48 μM Compound: 5	Antiproliferative activity against human A498 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human A498 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
A549	GI₅₀	4.47 μM Compound: 5	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
ACHN	GI₅₀	2.09 μM Compound: 5	Antiproliferative activity against human ACHN cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human ACHN cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
BT-549	GI₅₀	2 μM Compound: 5	Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
CAKI-1	GI₅₀	6.17 μM Compound: 5	Antiproliferative activity against human CAKI-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human CAKI-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
CCRF-CEM	GI₅₀	2.69 μM Compound: 5	Antiproliferative activity against human CCRF-CEM cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human CCRF-CEM cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
COLO 205	GI₅₀	3.8 μM Compound: 5	Antiproliferative activity against human COLO 205 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human COLO 205 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
DU-145	GI₅₀	1.86 μM Compound: 5	Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
EKVX	GI₅₀	4.57 μM Compound: 5	Antiproliferative activity against human EKVX cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human EKVX cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HCC 2998	GI₅₀	16.22 μM Compound: 5	Antiproliferative activity against human HCC 2998 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HCC 2998 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HCT-116	GI₅₀	1.82 μM Compound: 5	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HCT-116	IC₅₀	5.34 μM Compound: 5	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32773088]
HCT-15	GI₅₀	1.95 μM Compound: 5	Antiproliferative activity against human HCT-15 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HCT-15 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HL-60(TB)	GI₅₀	1.41 μM Compound: 5	Antiproliferative activity against human HL-60(TB) cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HL-60(TB) cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HOP-62	GI₅₀	2.57 μM Compound: 5	Antiproliferative activity against human HOP-62 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HOP-62 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HOP-92	GI₅₀	2.04 μM Compound: 5	Antiproliferative activity against human HOP-92 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HOP-92 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
Hs-578T	GI₅₀	2.63 μM Compound: 5	Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
HT-29	GI₅₀	2.4 μM Compound: 5	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
IGROV-1	GI₅₀	1.95 μM Compound: 5	Antiproliferative activity against human IGROV-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human IGROV-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
K562	GI₅₀	1.2 μM Compound: 5	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
KM12	GI₅₀	3.31 μM Compound: 5	Antiproliferative activity against human KM12 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human KM12 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
LOX IMVI	GI₅₀	1.7 μM Compound: 5	Antiproliferative activity against human LOX IMVI cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human LOX IMVI cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
M14	GI₅₀	1.86 μM Compound: 5	Antiproliferative activity against human M14 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human M14 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
Malme-3M	GI₅₀	2.24 μM Compound: 5	Antiproliferative activity against human Malme-3M cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human Malme-3M cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
MCF7	GI₅₀	3.63 μM Compound: 5	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
MDA-MB-231	GI₅₀	3.16 μM Compound: 5	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
MDA-MB-435	GI₅₀	2.14 μM Compound: 5	Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
MDA-MB-468	GI₅₀	2 μM Compound: 5	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
MOLT-4	GI₅₀	2.14 μM Compound: 5	Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI/ADR-RES	GI₅₀	13.18 μM Compound: 5	Antiproliferative activity against human NCI/ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI/ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI-H226	GI₅₀	3.24 μM Compound: 5	Antiproliferative activity against human NCI-H226 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-H226 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI-H23	GI₅₀	2.45 μM Compound: 5	Antiproliferative activity against human NCI-H23 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-H23 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI-H322M	GI₅₀	2.51 μM Compound: 5	Antiproliferative activity against human NCI-H322M cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-H322M cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI-H460	GI₅₀	3.09 μM Compound: 5	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
NCI-H522	GI₅₀	1.82 μM Compound: 5	Antiproliferative activity against human NCI-H522 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-H522 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
OVCAR-3	GI₅₀	1.78 μM Compound: 5	Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
OVCAR-4	GI₅₀	4.68 μM Compound: 5	Antiproliferative activity against human OVCAR-4 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human OVCAR-4 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
OVCAR-5	GI₅₀	6.17 μM Compound: 5	Antiproliferative activity against human OVCAR-5 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human OVCAR-5 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
OVCAR-8	GI₅₀	2.69 μM Compound: 5	Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
PC-3	GI₅₀	2.4 μM Compound: 5	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
RPMI-8226	GI₅₀	3.47 μM Compound: 5	Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
RXF 393	GI₅₀	2 μM Compound: 5	Antiproliferative activity against human RXF 393 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human RXF 393 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SF-268	GI₅₀	2.19 μM Compound: 5	Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SF-295	GI₅₀	7.08 μM Compound: 5	Antiproliferative activity against human SF-295 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SF-295 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SF-539	GI₅₀	2.09 μM Compound: 5	Antiproliferative activity against human SF-539 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SF-539 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SK-MEL-2	GI₅₀	2.04 μM Compound: 5	Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SK-MEL-28	GI₅₀	2.19 μM Compound: 5	Antiproliferative activity against human SK-MEL-28 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SK-MEL-28 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SK-OV-3	GI₅₀	14.13 μM Compound: 5	Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SN12C	GI₅₀	2.82 μM Compound: 5	Antiproliferative activity against human SN12C cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SN12C cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SNB-19	GI₅₀	2.4 μM Compound: 5	Antiproliferative activity against human SNB-19 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SNB-19 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SNB-75	GI₅₀	1.95 μM Compound: 5	Antiproliferative activity against human SNB-75 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SNB-75 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SR	GI₅₀	1.41 μM Compound: 5	Antiproliferative activity against human SR cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SR cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
SW-620	GI₅₀	2.57 μM Compound: 5	Antiproliferative activity against human SW-620 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human SW-620 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
T47D	GI₅₀	6.46 μM Compound: 5	Antiproliferative activity against human T47D cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human T47D cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
TK-10	GI₅₀	4.68 μM Compound: 5	Antiproliferative activity against human TK-10 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human TK-10 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
U-251	GI₅₀	1.91 μM Compound: 5	Antiproliferative activity against human U-251 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human U-251 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
UACC-257	GI₅₀	2.34 μM Compound: 5	Antiproliferative activity against human UACC-257 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human UACC-257 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
UACC-62	GI₅₀	2.04 μM Compound: 5	Antiproliferative activity against human UACC-62 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human UACC-62 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
UO-31	GI₅₀	3.63 μM Compound: 5	Antiproliferative activity against human UO-31 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human UO-31 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 32773088]
WI-38	IC₅₀	21.7 μM Compound: 5	Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32773088]

体外研究
(In Vitro)

CDK1/Cyc B-IN-1 (Compound 5) shows cytotoxic activity with IC₅₀ values of 5.33 ± 0.69 µM and 21.69 ± 1.04 µM against HCT-116 and WI-38, respectively^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

353.85

Formula

C₁₄H₁₂ClN₃O₂S₂

CAS 号

2459916-56-2

性状

固体

颜色

Light yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 100 mg/mL (282.61 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8261 mL	14.1303 mL	28.2606 mL
5 mM	0.5652 mL	2.8261 mL	5.6521 mL
10 mM	0.2826 mL	1.4130 mL	2.8261 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.07 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 98.47%

选择批次：

Data Sheet (621 KB) SDS (251 KB)

COA (294 KB) HNMR (158 KB) LCMS (96 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Mohamed SH, et al. An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties. Bioorg Med Chem. 2020 Sep 1;28(17):11563 [Content Brief]

CDK1/Cyc B-IN-1 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8261 mL	14.1303 mL	28.2606 mL	70.6514 mL
	5 mM	0.5652 mL	2.8261 mL	5.6521 mL	14.1303 mL
	10 mM	0.2826 mL	1.4130 mL	2.8261 mL	7.0651 mL
	15 mM	0.1884 mL	0.9420 mL	1.8840 mL	4.7101 mL
	20 mM	0.1413 mL	0.7065 mL	1.4130 mL	3.5326 mL
	25 mM	0.1130 mL	0.5652 mL	1.1304 mL	2.8261 mL
	30 mM	0.0942 mL	0.4710 mL	0.9420 mL	2.3550 mL
	40 mM	0.0707 mL	0.3533 mL	0.7065 mL	1.7663 mL
	50 mM	0.0565 mL	0.2826 mL	0.5652 mL	1.4130 mL
	60 mM	0.0471 mL	0.2355 mL	0.4710 mL	1.1775 mL
	80 mM	0.0353 mL	0.1766 mL	0.3533 mL	0.8831 mL
	100 mM	0.0283 mL	0.1413 mL	0.2826 mL	0.7065 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK1/Cyc B-IN-12459916-56-2CDKApoptosisCyclin dependent kinaseanticancer activityHCT-116WI-38p53BAXcytochrome ccaspases-3caspases-8caspases-9Bcl-2Inhibitorinhibitorinhibit

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CDK1/Cyc B-IN-1

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