1. Gene
  2. PARP1 - poly(ADP-ribose) polymerase 1 Gene

PARP1 - poly(ADP-ribose) polymerase 1 Gene

中文名称:聚 (ADP-核糖) 聚合酶 1

种属: Homo sapiens

同用名: PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP

基因 ID: 142 | 基因类型: protein coding

关于 PARP1

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:226,360,691-226,408,093 (from NCBI)

This gene has 26 transcripts (splice variants), 210 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 71.4), appendix (RPKM 40.9) and 25 other tissues.

功能概要

该基因编码染色质相关酶聚 (ADP-核糖基) 转移酶,它通过聚 (ADP-核糖基) 化修饰各种核蛋白。这种修饰依赖于 DNA,参与各种重要细胞过程的调节,如分化、增殖和肿瘤转化,还参与细胞从 DNA 损伤中恢复所涉及的分子事件的调节。此外,这种酶可能是范可尼贫血的突变位点,可能参与了 I 型糖尿病的病理生理过程。[RefSeq 提供,2008 年 7 月]

This gene encodes a chromatin-associated Enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this Enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

PARP1 基因产物(1)

mRNA Protein Name
NM_001618.4 NP_001609.2 poly [ADP-ribose] polymerase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
21233213 GOA
enables NAD DNA ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
27471034 GOA
enables NAD+-histone H2BS6 serine ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
34874266 GOA
enables NAD+-histone H3S10 serine ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
34874266 GOA
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
7852410 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
7852410 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
IMP: 通过突变表型推断
22504299 GOA
enables NAD+-protein-aspartate ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
19764761 GOA
enables NAD+-protein-glutamate ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
19764761 GOA
enables NAD+-protein-histidine ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
35393539 GOA
enables NAD+-protein-serine ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
28190768 GOA
enables NAD+-protein-tyrosine ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
29954836 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
19303849 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
30675909 GOA
enables damaged DNA binding IDA
IDA: 通过直接分析推断
22683995 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
23382074 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
14734561 GOA
enables nucleosome binding IDA
IDA: 通过直接分析推断
15607977 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7596430 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
22683995 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
17177976 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
18055453 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ATP generation from poly-ADP-D-ribose IDA
IDA: 通过直接分析推断
27257257 GOA
involved in DNA ADP-ribosylation IDA
IDA: 通过直接分析推断
27471034 GOA
involved in DNA damage response IDA
IDA: 通过直接分析推断
22683995 GOA
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
24550317 GOA
involved in DNA damage response IMP
IMP: 通过突变表型推断
24289924 GOA
involved in DNA repair IDA
IDA: 通过直接分析推断
30104678 GOA
involved in apoptotic process IDA
IDA: 通过直接分析推断
15565177 GOA
involved in cellular response to UV IMP
IMP: 通过突变表型推断
24289924 GOA
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
19303849 GOA
acts upstream of or within cellular response to oxidative stress IMP
IMP: 通过突变表型推断
25378300 GOA
involved in double-strand break repair IDA
IDA: 通过直接分析推断
24906880 GOA
involved in double-strand break repair IMP
IMP: 通过突变表型推断
23230272 GOA
acts upstream of or within mitochondrial DNA metabolic process IMP
IMP: 通过突变表型推断
25378300 GOA
acts upstream of or within mitochondrial DNA repair IMP
IMP: 通过突变表型推断
25378300 GOA
acts upstream of or within mitochondrion organization IMP
IMP: 通过突变表型推断
25378300 GOA
involved in negative regulation of ATP biosynthetic process IMP
IMP: 通过突变表型推断
24289924 GOA
involved in negative regulation of cGAS/STING signaling pathway IDA
IDA: 通过直接分析推断
35460603 GOA
involved in negative regulation of innate immune response IDA
IDA: 通过直接分析推断
35460603 GOA
involved in negative regulation of innate immune response IMP
IMP: 通过突变表型推断
32844745 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15607977 GOA
involved in negative regulation of transcription elongation by RNA polymerase II IDA
IDA: 通过直接分析推断
35393539 GOA
involved in positive regulation of DNA-templated transcription, elongation IDA
IDA: 通过直接分析推断
27256882 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
22464733 GOA
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
26344098 GOA
involved in positive regulation of single strand break repair IGI
IGI: 通过遗传相互作用推断
28002403 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11112786 GOA
involved in protein auto-ADP-ribosylation IDA
IDA: 通过直接分析推断
15607977 GOA
involved in protein localization to chromatin IDA
IDA: 通过直接分析推断
34874266 GOA
acts upstream of or within protein modification process IMP
IMP: 通过突变表型推断
25378300 GOA
involved in protein poly-ADP-ribosylation IDA
IDA: 通过直接分析推断
15674325 GOA
involved in regulation of base-excision repair IDA
IDA: 通过直接分析推断
34102106 GOA
involved in regulation of catalytic activity IDA
IDA: 通过直接分析推断
25749521 GOA
acts upstream of or within regulation of protein localization IMP
IMP: 通过突变表型推断
24550317 GOA
involved in replication fork reversal IDA
IDA: 通过直接分析推断
33412112 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
30675909 GOA
is active in cytosol IDA
IDA: 通过直接分析推断
35460603 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
25378300 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
9518481 GOA
is active in nuclear replication fork IDA
IDA: 通过直接分析推断
33412112 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
9518481 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
22464733 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17177976 GOA
part of protein-DNA complex IDA
IDA: 通过直接分析推断
22504299 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
22504299 GOA
is active in site of DNA damage IDA
IDA: 通过直接分析推断
22683995 GOA
located in site of DNA damage IMP
IMP: 通过突变表型推断
27248496 GOA
is active in site of double-strand break IDA
IDA: 通过直接分析推断
29234005 GOA
located in site of double-strand break IDA
IDA: 通过直接分析推断
26344098 GOA
part of transcription regulator complex IDA
IDA: 通过直接分析推断
19303849 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PARP1 蛋白结构

zf-PARP

zf-PARP: Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region (12 - 89)

zf-PARP

zf-PARP: Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region (116 - 199)

PADR1

PADR1: PADR1 (NUC008) domain (279 - 332)

BRCT

BRCT: BRCA1 C Terminus (BRCT) domain (388 - 461)

WGR

WGR: WGR domain (550 - 629)

PARP_reg

PARP_reg: Poly(ADP-ribose) polymerase, regulatory domain (662 - 795)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (797 - 1007)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1014 a.a.
蛋白主名 其他名称

poly [ADP-ribose] polymerase 1

ADP-ribosyltransferase (NAD+

poly (ADP-ribose) polymerase)

ADP-ribosyltransferase NAD(+)

ADP-ribosyltransferase diphtheria toxin-like 1

DNA ADP-ribosyltransferase PARP1

NAD(+) ADP-ribosyltransferase 1

poly (ADP-ribose) polymerase family, member 1

poly(ADP-ribose) synthetase

poly(ADP-ribosyl)transferase

poly[ADP-ribose] synthase 1

protein poly-ADP-ribosyltransferase PARP1

PARP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PARP1 P09874 SNAI1 Homo sapiens O95863
Anti Bait CoIP
21577210
种属内
PARP1 P09874 SNAI1 Homo sapiens O95863
Confocal
21577210
种属内
PARP1 P09874 RECQL Homo sapiens P46063
Anti Tag CoIP
35271311
种属内
PARP1 P09874 XRCC5 Homo sapiens P13010
Anti Bait CoIP
17283121
种属内
PARP1 P09874 XRCC5 Homo sapiens P13010
Anti Tag CoIP
14734561
种属内
PARP1 P09874 XRCC5 Homo sapiens P13010
Enzymatic Study
14734561
种属内
PARP1 P09874 XRCC6 Homo sapiens P12956
Anti Bait CoIP
17283121
种属内
PARP1 P09874 XRCC5 Homo sapiens P13010
Anti Bait CoIP
20085707
种属内
PARP1 P09874 XRCC6 Homo sapiens P12956
Anti Tag CoIP
35271311
种属内
PARP1 P09874 XRCC6 Homo sapiens P12956
Enzymatic Study
14734561
种属内
PARP1 P09874 XRCC6 Homo sapiens P12956
Anti Tag CoIP
14734561
种属内
PARP1 P09874 XRCC6 Homo sapiens P12956
GMS
14734561
种属内
PARP1 P09874 XRCC5 Homo sapiens P13010
Anti Bait CoIP
21575865
种属内
PARP1 P09874 XRCC5 Homo sapiens P13010
Anti Tag CoIP
35271311
种属内
PARP1 P09874 TP53 Homo sapiens P04637
Anti Bait CoIP
15044383
种属内
PARP1 P09874 TP53 Homo sapiens P04637
Anti Bait CoIP
14627987
种属内
PARP1 P09874 WRN Homo sapiens Q14191
Anti Bait CoIP
14596914
种属内
PARP1 P09874 WRN Homo sapiens Q14191
Anti Tag CoIP
14734561
种属内
PARP1 P09874 WRN Homo sapiens Q14191
GMS
14734561
种属内
PARP1 P09874 EP400 Homo sapiens Q96L91
Anti Tag CoIP
35271311
种属内
PARP1 P09874 E2F1 Homo sapiens Q01094
Anti Bait CoIP
14627987
种属内
PARP1 P09874 E2F1 Homo sapiens Q01094
Anti Bait CoIP
20133863
种属内
PARP1 P09874 PIAS4 Homo sapiens Q8N2W9
Pull Down
19779455
种属内
PARP1 P09874 PIAS4 Homo sapiens Q8N2W9
Anti Tag CoIP
19779455
种属内
PARP1 P09874 CASP3 Homo sapiens P42574
Protease Assay
17167422
种属内
PARP1 P09874 RRP1B Homo sapiens Q14684-1
Anti Tag CoIP
19710015
种属内
PARP1 P09874 RRP1B Homo sapiens Q14684-1
Confocal
19710015
种属间
PARP1 P09874 Snai1 Mus musculus Q02085
ADP Ribosylase
21577210
种属内
PARP1 P09874 RNF146 Homo sapiens Q9NTX7
Anti Tag CoIP
35271311
种属内
PARP1 P09874 RNF146 Homo sapiens Q9NTX7
Anti Tag CoIP
21799911
种属内
PARP1 P09874 NFIC Homo sapiens P08651
Anti Tag CoIP
35271311
种属内
PARP1 P09874 ERG Homo sapiens P11308
CH-IP
21575865
种属内
PARP1 P09874 ERG Homo sapiens P11308
Anti Bait CoIP
21575865
种属内
PARP1 P09874 SUMO1 Homo sapiens P63165
Anti Bait CoIP
19779455
种属内
PARP1 P09874 APTX Homo sapiens Q7Z2E3
Anti Tag CoIP
35271311
种属内
PARP1 P09874 APTX Homo sapiens Q7Z2E3
Anti Bait CoIP
15044383
种属内
PARP1 P09874 APTX Homo sapiens Q7Z2E3
Anti Tag CoIP
15555565
种属内
PARP1 P09874 APTX Homo sapiens Q7Z2E3
Y2H
15555565
种属内
PARP1 P09874 OARD1 Homo sapiens Q9Y530
Crosslink
23481255
种属内
PARP1 P09874 OARD1 Homo sapiens Q9Y530
Enzymatic Study
23481255
种属内
PARP1 P09874 XRCC1 Homo sapiens P18887
Anti Bait CoIP
15044383
种属内
PARP1 P09874 XRCC1 Homo sapiens P18887
Anti Tag CoIP
18971944
种属内
PARP1 P09874 XRCC1 Homo sapiens P18887
Anti Tag CoIP
35271311
种属内
PARP1 P09874 XRCC1 Homo sapiens P18887
Anti Bait CoIP
24778456
种属内
PARP1 P09874 ZNF423 Homo sapiens Q2M1K9
Anti Tag CoIP
22863007
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PARP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74652 PARP1 Protein, Human (sf9, His) P09874 (M1-W1014) ≥95%

关联疾病

疾病名称 别名
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

Primitive Neuroectodermal Tumor

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Ewing Family Of Tumors

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities

Cervical Adenocarcinoma

Adenocarcinoma Cervix Uteri

Adenocarcinoma Of Cervix

Adenocarcinoma Of The Uterine Cervix

Adenocarcinoma Of The Cervix Uteri

Oligospermia
Pellagra

Niacin Deficiency

Niacin-Tryptophan Deficiency

Pellagroid Syndrome

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

Lymphangioleiomyomatosis

Lymphangiomyomatosis

LAM

Lung Lymphangioleiomyomatosis

Pulmonary Lymphangioleiomyomatosis

Lymphangioleiomyomatosis, Somatic

Lymphangio-Myomatosis

Diphtheria

Corynebacterium Infections

Corynebacterium Infection

Diphtherial Infection

Infection Due To Corynebacterium Diphtheriae

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc

Osebold-Remondini Syndrome

Brachydactyly Type A6

Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

Bda6

Brachydactyly, Type A6

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Aplastic Anemia

Aplastic Anemia, Susceptibility To

Anemia Aplastic

Idiopathic Aplastic Anemia

Secondary Aplastic Anemia

Idiopathic Bone Marrow Failure

Aplastic Anemia Idiopathic

AA

Anemia, Aplastic

Aplastic Anemia, Idiopathic

Erythroid Aplasia

Aa - [Aplastic Anaemia]

Haematopoietic Aplasia

Aleukia Haemorrhagica

Anaemia Due To Decreased Red Cell Production

Aplasia Bone Marrow

Aplastic Bone Marrow

Hypoplastic Anaemia Nos

Myeloid Bone Marrow Aplasia

Pancytopenia

Panhaematopenia

Hypoproliferative Anaemia

Medullary Hypoplasia

Red Blood Cells Hypoplastic Anaemia

Panmyelophthisis

Panhemocytopenia

Refractive Hypoproliferative Anaemia

Toxic Anaemia

Toxic Aplastic Anaemia

Aplastic Anaemia Due To Toxic Cause

Idiopathic Aplastic Anaemia Nos

Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma

Ataxia-Telangiectasia

Ataxia Telangiectasia

Louis-Bar Syndrome

AT

At1

Ataxia-Telangiectasia Syndrome

Ataxia - Telangiectasia Variant

Boder-Sedgwick Syndrome

Louis Bar Syndrome

Cerebello-Oculocutaneous Telangiectasia

Immunodeficiency With Ataxia Telangiectasia

A-T

Ataxia Telangiectasia Syndrome

Atm

Telangiectasia, Cerebello-Oculocutaneous

Ataxia-Telangiectasia Variant

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Rhabdomyosarcoma
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Osteonecrosis Of The Jaw
Aging
Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea

Glioblastoma Classical Subtype
Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Head And Neck Cancer

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Cancer, Head/Neck

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos

Reticulosarcoma

Histiocytic Lymphoma

Large-Cell Lymphomas

Lymphoma, Large-Cell

Lymphoma Large Cell

Diffuse Large B-Cell Lymphoma

Histiocytic Sarcoma

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx

Npc

Nasopharyngeal Cancer

Nasopharyngeal Carcinoma 1

Nasopharynx Carcinoma

Nasopharyngeal Neoplasms

Npca

Carcinoma Of Nasopharynx

Malignant Nasopharyngeal Tumor

Nasopharynx Cancer

Squamous Cell Carcinoma Of The Nasopharynx

Nasopharyngeal Neoplasm

Cancer Of Nasopharynx

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

De Sanctis-Cacchione Syndrome

Xp

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Xeroderma Pigmentosum, Complementation Group A

Xeroderma Pigmentosum Group A

Xp1

Xeroderma Pigmentosum, Group A

XPA

Xeroderma Pigmentosum I

Xeroderma Pigmentosum Complementation Group A

Xp Group A

Xp, Group A

Xeroderma Pigmentosum 1

Xeroderma Pigmentosum, Type 1

XP-A

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Diabetes Mellitus

Diabetes

Myeloma, Multiple

Multiple Myeloma

Kahler Disease

Myelomatosis

Plasma Cell Myeloma

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler'S Disease

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Werner Syndrome

Werner'S Syndrome

WRN

Adult Progeria

Ws

Adult Premature Ageing Syndrome

Adult Premature Aging Syndrome

Werners Syndrome

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Fallopian Tube Carcinoma

Fallopian Tube Cancer

Cancer Of The Fallopian Tube

Carcinoma Of Fallopian Tube

Neoplasm Of Fallopian Tube

Fallopian Tube Neoplasms

Fallopian Tube Ca

Fallopian Tube Neoplasm

Malignant Neoplasm Of Uterine Tube

Malignant Tumor Of Fallopian Tube

Malignant Tumour Of Fallopian Tube

Tumor Of The Fallopian Tube

Tumor, Fallopian Tube, Malignant

Malignant Tumor Of Fallopian Tubes

Cancer Of Fallopian Tubes

Malignant Tubal Tumor

Tubal Cancer

Malignant Neoplasm Of Fallopian Tube

Primary Malignant Neoplasm Of Fallopian Tube

Cancer Of The Oviduct

Neuroma
Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Sporadic Breast Cancer

Sporadic Breast Carcinoma

Dyslexia
Osteogenic Sarcoma

Osteosarcoma

OSRC

Osteosarcoma, Somatic

Neoplasms, Bone Tissue

Bone Tissue Neoplasm

Osteoid Sarcoma

Skeletal Sarcoma

Osteosarcoma Of Bone

Bone Sarcoma

Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PARP1 VGNC VGNC:100025
Rattus norvegicus PARP1 RGD RGD:2053
Canis familiaris PARP1 VGNC VGNC:53874
Mus musculus PARP1 MGD MGI:1340806
Felis catus PARP1 VGNC VGNC:107909
Others PARP1 NCBI