2. Gene
  3. Hdac2 - histone deacetylase 2 Gene

Hdac2 - histone deacetylase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 2

种属: Mus musculus

同用名: YAF1; Yy1bp; mRPD3; D10Wsu179e

基因 ID: 15182 | 基因类型: protein coding

关于 Hdac2

Chromosome 10: 36,850,540-36,877,885 forward strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 205 orthologues, 10 paralogues and is associated with 43 phenotypes. Broad expression in CNS E11.5 (RPKM 72.6), CNS E14 (RPKM 53.5) and 19 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合活性； Krueppel 相关框域绑定活动；和转录辅阻遏物结合活性。参与多个过程，包括动物器官发育；组蛋白去乙酰化；和基因表达的调控。作用于多个过程的上游或内部，包括组蛋白修饰；神经系统发育；和信号转导的调节。位于异染色质；核;和复制叉。 RNA 聚合酶 II 转录抑制复合物的一部分。以多种结构表达，包括消化系统；脑;早孕;泌尿生殖系统；和感觉器官。该基因的人类直系同源物与胃癌有关。与人类 HDAC2（组蛋白脱乙酰酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA binding activity; Krueppel-associated box domain binding activity; and transcription corepressor binding activity. Involved in several processes, including animal organ development; histone deacetylation; and regulation of gene expression. Acts upstream of or within several processes, including histone modification; nervous system development; and regulation of signal transduction. Located in heterochromatin; nucleus; and replication fork. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in stomach Cancer. Orthologous to human HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hdac2 基因产物(1)

mRNA Protein Name
NM_008229.2 NP_032255.2 histone deacetylase 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
33795231 MGI
enables Krueppel-associated box domain binding IPI
IPI: 通过物理相互作用推断
21177534 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
24137001 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
18458156 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
17392792 MGI
enables enzyme binding IPI
IPI: 通过物理相互作用推断
20972425 MGI
enables histone H4K16 deacetylase activity IMP
IMP: 通过突变表型推断
23516383 MGI
enables histone deacetylase activity IDA
IDA: 通过直接分析推断
12975471 MGI
enables histone deacetylase activity IGI
IGI: 通过遗传相互作用推断
12975471 MGI
enables histone decrotonylase activity IDA
IDA: 通过直接分析推断
30279482 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10888872 MGI
enables protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
18754010 MGI
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
12007404 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cardiac muscle cell development IMP
IMP: 通过突变表型推断
17322895 MGI
acts upstream of cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
17322895 MGI
acts upstream of or within cellular response to trichostatin A IDA
IDA: 通过直接分析推断
24137001 MGI
involved in circadian regulation of gene expression IDA
IDA: 通过直接分析推断
15226430 MGI
involved in dendrite development IMP
IMP: 通过突变表型推断
18754010 MGI
involved in embryonic digit morphogenesis IGI
IGI: 通过遗传相互作用推断
21093383 MGI
involved in epidermal cell differentiation IGI
IGI: 通过遗传相互作用推断
21093383 MGI
involved in eyelid development in camera-type eye IGI
IGI: 通过遗传相互作用推断
21093383 MGI
involved in fungiform papilla formation IGI
IGI: 通过遗传相互作用推断
21093383 MGI
involved in hair follicle placode formation IGI
IGI: 通过遗传相互作用推断
21093383 MGI
acts upstream of or within hippocampus development IGI
IGI: 通过遗传相互作用推断
19380719 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18754010 MGI
involved in negative regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
21093383 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
19503085 MGI
acts upstream of or within negative regulation of cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
17322895 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
21093383 MGI
involved in negative regulation of miRNA transcription IGI
IGI: 通过遗传相互作用推断
24675724 MGI
involved in negative regulation of miRNA transcription IMP
IMP: 通过突变表型推断
24675724 MGI
involved in negative regulation of neuron projection development IDA
IDA: 通过直接分析推断
18754010 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
10431247 MGI
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
21093383 MGI
acts upstream of or within neuron differentiation IGI
IGI: 通过遗传相互作用推断
19380719 MGI
involved in odontogenesis of dentin-containing tooth IGI
IGI: 通过遗传相互作用推断
21093383 MGI
acts upstream of oligodendrocyte differentiation IGI
IGI: 通过遗传相互作用推断
19503085 MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
20833366 MGI
involved in positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
21093383 MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation IGI
IGI: 通过遗传相互作用推断
19503085 MGI
involved in protein deacetylation IDA
IDA: 通过直接分析推断
18754010 MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
17322895 MGI
acts upstream of or within regulation of protein deacetylation IGI
IGI: 通过遗传相互作用推断
20833366 MGI
acts upstream of or within regulation of sarcomere organization IMP
IMP: 通过突变表型推断
17322895 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription repressor complex IDA
IDA: 通过直接分析推断
12007404 MGI
located in chromatin IDA
IDA: 通过直接分析推断
12007404 MGI
located in heterochromatin IDA
IDA: 通过直接分析推断
14519686 MGI
located in nucleus IDA
IDA: 通过直接分析推断
20720167 MGI
located in replication fork IDA
IDA: 通过直接分析推断
10888872 MGI
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
17182846 MGI
part of transcription repressor complex IPI
IPI: 通过物理相互作用推断
17182846 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Hdac2 蛋白结构

HDAC2

HDAC2: cd10011 (8 - 373)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
蛋白主名 其他名称

histone deacetylase 2

HD2

YY1 transcription factor-binding protein

protein deacylase HDAC2

相关产品

Approval
生物活性分子 (8)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10221 Vorinostat Inhibitor 99.95% 是
HY-10585 Valproic acid Inhibitor 98.88% 否
HY-15149 Romidepsin Inhibitor 99.98% 否
HY-109015 Tucidinostat Inhibitor 98.60% 否
HY-10585A Valproic acid sodium Inhibitor 98.14% 否
HY-12164 Mocetinostat Inhibitor 99.43% 是
HY-13322 Pracinostat Inhibitor 99.82% 是
HY-10585B Valproic acid (sodium)(2:1) Inhibitor / 否
Clinical Phase
生物活性分子 (17)
目录号 产品名 作用方式
纯度 Phase
HY-12163 Entinostat Inhibitor 99.82% Phase 3
HY-50934 Tacedinaline Inhibitor 99.32% Phase 3
HY-10990 Abexinostat Inhibitor 98.63% Phase 3
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-100748 Zabadinostat Inhibitor 99.81% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
HY-124295 MPT0E028 Inhibitor 99.63% Phase 1
Pre-clinical Phase
生物活性分子 (107)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18998 LMK-235 Inhibitor 99.61% 否
HY-N0931 Santacruzamate A Inhibitor 99.04% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-18613 CAY10603 Inhibitor ≥98.0% 否
HY-19327 ACY-738 Inhibitor 99.92% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-19618 BRD3308 Inhibitor 98.82% 否
HY-100719 BRD-6929 Inhibitor 99.04% 否
HY-104008 ACY-957 Inhibitor 99.66% 否
HY-115475 SW-100 Inhibitor 99.59% 否
HY-111400 SR-4370 Inhibitor 99.95% 否
HY-19328 ACY-775 Inhibitor 99.69% 否
HY-18976 UF010 99.84% 否
HY-100871 WT-161 Inhibitor 98.36% 否
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% 否
HY-18712 BG45 Inhibitor 99.96% 否
HY-19747 HPOB Inhibitor 99.80% 否
HY-116818 Crebinostat Inhibitor 99.79% 否
HY-117709 BRD6688 Inhibitor 98.90% 否
HY-10585R Valproic acid (Standard) Inhibitor / 否
HY-18700 BRD73954 Inhibitor ≥98.0% 否
HY-100384 NKL 22 Inhibitor 97.27% 否
HY-117583 cis-BG47 Inhibitor 98.02% 否
HY-146346 HD-TAC7 Inhibitor 98.75% 否
HY-110280 MC1742 Inhibitor 99.20% 否
HY-146153 HDAC-IN-40 Inhibitor 98.71% 否
HY-102083 BRD4884 Inhibitor ≥99.0% 否
HY-124053 BRD2492 Inhibitor 99.18% 否
HY-131708A FNDR-20123 Inhibitor 98.08% 否
HY-156422 KPZ560 Inhibitor / 否
HY-157388 CARM1/HDAC2-IN-1 Inhibitor / 否
HY-152174 HDAC-IN-52 Inhibitor 99.46% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-151464 SHP2/HDAC-IN-1 Inhibitor / 否
HY-128582 PI3K/HDAC-IN-1 Inhibitor / 否
HY-131708 FNDR-20123 free base Inhibitor / 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / 否
HY-150109 Purinostat mesylate Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-161778 ZG-126 Inhibitor / 否
HY-133147 HDAC3/6-IN-2 Inhibitor / 否
HY-146392 HDAC-IN-39 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-149946 HDAC-IN-57 Inhibitor / 否
HY-151897 HDAC-IN-49 Inhibitor / 否
HY-152173 HDAC-IN-51 Inhibitor / 否
HY-151261 HDAC6-IN-13 Inhibitor 98.08% 否
HY-115941 HDAC-IN-9 Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-145852 Top/HDAC-IN-2 Inhibitor / 否
HY-162769 HDAC3-IN-5 Inhibitor / 否
HY-169226 HDAC6-IN-51 Inhibitor / 否
HY-146159 PI3K/HDAC-IN-2 Inhibitor / 否
HY-144654 HDAC/Top-IN-1 Inhibitor / 否
HY-147934 HDAC8-IN-3 Inhibitor / 否
HY-154855 HDAC-IN-56 Inhibitor / 否
HY-163207 sEH/HDAC6-IN-1 Inhibitor / 否
HY-162910 HDAC-IN-79 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-144332 PHD2/HDACs-IN-1 Inhibitor / 否
HY-163834 HDAC6-IN-47 Inhibitor / 否
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / 否
HY-151896 HDAC6-IN-14 Inhibitor / 否
HY-109015S Tucidinostat-d4 Inhibitor / 否
HY-150577 HDAC-IN-45 Inhibitor / 否
HY-151248 HDAC2-IN-1 Inhibitor / 否
HY-162630 HDAC6-IN-44 Inhibitor / 否
HY-149721 HDAC4-IN-1 Inhibitor / 否
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / 否
HY-149029 TH-6 Inhibitor 95.00% 否
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / 否
HY-163282 NB512 Inhibitor / 否
HY-125645 M122 Inhibitor / 否
HY-144395 HDAC6-IN-4 Inhibitor / 否
HY-151569 SAHA-OH Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-152146 HDAC-IN-50 Inhibitor / 否
HY-157481 HDAC1-IN-6 Inhibitor / 否
HY-161783 HDAC6-IN-45 Inhibitor / 否
HY-144293 HDAC-IN-31 Inhibitor / 否
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / 否
HY-147840 HDAC-IN-41 Inhibitor / 否
HY-159171 sEH/HDAC6-IN-2 Inhibitor / 否
HY-144297 HDAC1-IN-3 Inhibitor / 否
HY-161667 GSK-3β/HDAC-IN-1 Inhibitor / 否
HY-144292 HDAC-IN-30 Inhibitor / 否
HY-162487 HDAC-IN-72 Inhibitor / 否
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / 否
HY-163430 HDAC-IN-71 Inhibitor / 否
HY-10585G Valproic acid (GMP) Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-146351 HDAC-IN-38 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-161524 HDAC6-IN-43 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-151443 HDAC-IN-47 Inhibitor / 否
HY-162955 LSD1/HDAC-IN-1 Inhibitor / 否
HY-143877 NN-390 Inhibitor / 否
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% 否
HY-157740 XSJ-10 Inhibitor / 否
HY-147966 HDAC-IN-43 Inhibitor / 否
HY-168650 ROCK/HDAC-IN-1 Inhibitor / 否
HY-117374 HDAC3-IN-1 Inhibitor / 否
HY-117583A BG47 Inhibitor / 否
HY-19754 CRA-026440 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hdac2 NCBI NCBI:3066
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