1. Gene
  2. UBE2K - ubiquitin conjugating enzyme E2 K Gene

UBE2K - ubiquitin conjugating enzyme E2 K Gene

中文名称:泛素结合酶 E2 K

种属: Homo sapiens

同用名: LIG; HIP2; HYPG; UBC1; E2-25K

基因 ID: 3093 | 基因类型: protein coding

关于 UBE2K

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:39,698,136-39,782,792 (from NCBI)

This gene has 7 transcripts (splice variants), 282 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 24.1), thyroid (RPKM 17.9) and 25 other tissues.

功能概要

该基因编码的蛋白质属于泛素结合酶家族。这种蛋白质与无名指蛋白相互作用,它可以泛素化亨廷顿氏病的基因产物亨廷顿蛋白。这种蛋白质的已知功能包括在扩展的聚谷氨酰胺蛋白的聚集体形成中发挥作用,在多聚谷氨酰胺疾病中抑制细胞凋亡,在新合成的 MHC I 类重链从内质网脱位中发挥作用,并参与泡沫细胞形成。已经为该基因鉴定了编码不同亚型的多个转录物变体。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene belongs to the ubiquitin-conjugating Enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate Huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of Apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

UBE2K 基因产物(6)

mRNA Protein Name
NM_001111112.2 NP_001104582.1 ubiquitin-conjugating enzyme E2 K isoform 2
NM_001111113.2 NP_001104583.1 ubiquitin-conjugating enzyme E2 K isoform 3
NM_001312646.2 NP_001299575.1 ubiquitin-conjugating enzyme E2 K isoform 4
NM_001312647.2 NP_001299576.1 ubiquitin-conjugating enzyme E2 K isoform 5 precursor
NM_001312648.2 NP_001299577.1 ubiquitin-conjugating enzyme E2 K isoform 5 precursor
NM_005339.5 NP_005330.1 ubiquitin-conjugating enzyme E2 K isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17500595 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
16714285 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
20061386 GOA
enables ubiquitin-ubiquitin ligase activity IDA
IDA: 通过直接分析推断
17873885 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UBE2K 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (8 - 147)

UBA

UBA: UBA/TS-N domain (162 - 197)

  • 0
  • 100
  • 200 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 K

E2 ubiquitin-conjugating enzyme K

UBE2K 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UBE2K P61086 MID2 Homo sapiens Q9UJV3-2 32296183
种属内
UBE2K P61086 MID2 Homo sapiens Q9UJV3-2 32296183
种属内
UBE2K P61086 MID2 Homo sapiens Q9UJV3-2 32296183
种属内
UBE2K P61086 TSN Homo sapiens Q15631 32296183
种属内
UBE2K P61086 TSN Homo sapiens Q15631 32296183
种属内
UBE2K P61086 TSN Homo sapiens Q15631 32296183
种属内
UBE2K P61086 RNF167 Homo sapiens Q9H6Y7 32814053
种属内
UBE2K P61086 RNF167 Homo sapiens Q9H6Y7 32814053
种属内
UBE2K P61086 RNF167 Homo sapiens Q9H6Y7 32814053
种属内
UBE2K P61086 ZFTRAF1 Homo sapiens P0DTL6 33961781
种属内
UBE2K P61086 ZFTRAF1 Homo sapiens P0DTL6 28514442
种属内
UBE2K P61086 TRIM39 Homo sapiens Q9HCM9-2 32296183
种属内
UBE2K P61086 TRIM39 Homo sapiens Q9HCM9-2 32296183
种属内
UBE2K P61086 TRIM39 Homo sapiens Q9HCM9-2 32296183
种属内
UBE2K P61086 FAM163A Homo sapiens Q96GL9 32814053
种属内
UBE2K P61086 FAM163A Homo sapiens Q96GL9 32814053
种属内
UBE2K P61086 FAM163A Homo sapiens Q96GL9 32814053
种属内
UBE2K P61086 TRIM5 Homo sapiens Q9C035-3 32296183
种属内
UBE2K P61086 TRIM5 Homo sapiens Q9C035-3 32296183
种属内
UBE2K P61086 TRIM5 Homo sapiens Q9C035-3 32296183
种属内
UBE2K P61086 CAMK2A Homo sapiens Q9UQM7 32814053
种属内
UBE2K P61086 CAMK2A Homo sapiens Q9UQM7 32814053
种属内
UBE2K P61086 CAMK2A Homo sapiens Q9UQM7 32814053
种属内
UBE2K P61086 KRIT1 Homo sapiens O00522 32296183
种属内
UBE2K P61086 KRIT1 Homo sapiens O00522 32296183
种属内
UBE2K P61086 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
UBE2K P61086 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
UBE2K P61086 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
UBE2K P61086 TRIM35 Homo sapiens Q9UPQ4-2 32296183
种属内
UBE2K P61086 TRIM35 Homo sapiens Q9UPQ4-2 32296183
种属内
UBE2K P61086 TRIM35 Homo sapiens Q9UPQ4-2 32296183
种属内
UBE2K P61086 ADAL Homo sapiens Q6DHV7-2 32814053
种属内
UBE2K P61086 ADAL Homo sapiens Q6DHV7-2 32814053
种属内
UBE2K P61086 ADAL Homo sapiens Q6DHV7-2 32814053
种属内
UBE2K P61086 GLIPR1L2 Homo sapiens Q4G1C9-2 32814053
种属内
UBE2K P61086 GLIPR1L2 Homo sapiens Q4G1C9-2 32814053
种属内
UBE2K P61086 GLIPR1L2 Homo sapiens Q4G1C9-2 32814053
种属内
UBE2K P61086 RNF182 Homo sapiens Q8N6D2 32296183
种属内
UBE2K P61086 RNF182 Homo sapiens Q8N6D2 32296183
种属内
UBE2K P61086 RNF182 Homo sapiens Q8N6D2 32296183
种属内
UBE2K P61086 BFAR Homo sapiens Q9NZS9 32296183
种属内
UBE2K P61086 BFAR Homo sapiens Q9NZS9 32296183
种属内
UBE2K P61086 BFAR Homo sapiens Q9NZS9 32296183
种属内
UBE2K P61086 RNF166 Homo sapiens Q96A37 32296183
种属内
UBE2K P61086 RNF166 Homo sapiens Q96A37 32296183
种属内
UBE2K P61086 RNF166 Homo sapiens Q96A37 32296183
种属内
UBE2K P61086 SPSB2 Homo sapiens Q99619 32814053
种属内
UBE2K P61086 SPSB2 Homo sapiens Q99619 32814053
种属内
UBE2K P61086 SPSB2 Homo sapiens Q99619 32814053
种属内
UBE2K P61086 RNF185 Homo sapiens Q96GF1 32296183
种属内
UBE2K P61086 RNF185 Homo sapiens Q96GF1 32296183
种属内
UBE2K P61086 RNF185 Homo sapiens Q96GF1 32296183
种属内
UBE2K P61086 DTX3 Homo sapiens Q8N9I9 25416956
种属内
UBE2K P61086 DTX3 Homo sapiens Q8N9I9 32296183
种属内
UBE2K P61086 DTX3 Homo sapiens Q8N9I9 32296183
种属内
UBE2K P61086 DTX3 Homo sapiens Q8N9I9 32296183
种属内
UBE2K P61086 DTX3 Homo sapiens Q8N9I9 25416956
种属内
UBE2K P61086 MID1 Homo sapiens O15344 32296183
种属内
UBE2K P61086 MID1 Homo sapiens O15344 32296183
种属内
UBE2K P61086 MARCHF3 Homo sapiens Q86UD3 32814053
种属内
UBE2K P61086 MARCHF3 Homo sapiens Q86UD3 32814053
种属内
UBE2K P61086 MARCHF3 Homo sapiens Q86UD3 32814053
种属内
UBE2K P61086 MIPOL1 Homo sapiens Q8TD10 32296183
种属内
UBE2K P61086 MIPOL1 Homo sapiens Q8TD10 25416956
种属内
UBE2K P61086 MIPOL1 Homo sapiens Q8TD10 32296183
种属内
UBE2K P61086 MIPOL1 Homo sapiens Q8TD10 32296183
种属内
UBE2K P61086 SPSB1 Homo sapiens Q96BD6 32814053
种属内
UBE2K P61086 SPSB1 Homo sapiens Q96BD6 32814053
种属内
UBE2K P61086 SPSB1 Homo sapiens Q96BD6 32814053
种属内
UBE2K P61086 REL Homo sapiens Q04864 25416956
种属内
UBE2K P61086 REL Homo sapiens Q04864 25416956
种属内
UBE2K P61086 RNF5 Homo sapiens Q99942 32296183
种属内
UBE2K P61086 RNF5 Homo sapiens Q99942 25416956
种属内
UBE2K P61086 RNF5 Homo sapiens Q99942 32296183
种属内
UBE2K P61086 RNF5 Homo sapiens Q99942 32296183
种属内
UBE2K P61086 GNB2 Homo sapiens P62879 32814053
种属内
UBE2K P61086 GNB2 Homo sapiens P62879 32814053
种属内
UBE2K P61086 GNB2 Homo sapiens P62879 32814053
种属内
UBE2K P61086 EXOSC7 Homo sapiens Q15024 32296183
种属内
UBE2K P61086 EXOSC7 Homo sapiens Q15024 32296183
种属内
UBE2K P61086 EXOSC7 Homo sapiens Q15024 32296183
种属内
UBE2K P61086 DXO Homo sapiens O77932 32814053
种属内
UBE2K P61086 DXO Homo sapiens O77932 32814053
种属内
UBE2K P61086 DXO Homo sapiens O77932 32814053
种属内
UBE2K P61086 VPS11 Homo sapiens Q9H270 32814053
种属内
UBE2K P61086 VPS11 Homo sapiens Q9H270 32814053
种属内
UBE2K P61086 VPS11 Homo sapiens Q9H270 32814053
种属内
UBE2K P61086 CCNC Homo sapiens P24863 32296183
种属内
UBE2K P61086 CCNC Homo sapiens P24863 32296183
种属内
UBE2K P61086 TP53BP1 Homo sapiens Q12888 32814053
种属内
UBE2K P61086 TP53BP1 Homo sapiens Q12888 32814053
种属内
UBE2K P61086 TP53BP1 Homo sapiens Q12888 32814053
种属内
UBE2K P61086 HTT Homo sapiens P42858
Y2H
17500595
种属内
UBE2K P61086 CCNB1 Homo sapiens P14635 20965177
种属内
UBE2K P61086 DDIT4 Homo sapiens Q9NX09 32814053
种属内
UBE2K P61086 DDIT4 Homo sapiens Q9NX09 32814053
种属内
UBE2K P61086 DDIT4 Homo sapiens Q9NX09 32814053
种属内
UBE2K P61086 LAMTOR1 Homo sapiens Q6IAA8 32814053
种属内
UBE2K P61086 LAMTOR1 Homo sapiens Q6IAA8 32814053
种属内
UBE2K P61086 LAMTOR1 Homo sapiens Q6IAA8 32814053
种属内
UBE2K P61086 NEDD8 Homo sapiens Q15843 32814053
种属内
UBE2K P61086 NEDD8 Homo sapiens Q15843 32814053
种属内
UBE2K P61086 NEDD8 Homo sapiens Q15843 32814053
种属内
UBE2K P61086 TRIM27 Homo sapiens P14373 32296183
种属内
UBE2K P61086 TRIM27 Homo sapiens P14373 32296183
种属内
UBE2K P61086 TRIM27 Homo sapiens P14373 27107012
种属内
UBE2K P61086 TRIM27 Homo sapiens P14373 27107012
种属内
UBE2K P61086 TRIM27 Homo sapiens P14373
Y2H
27107012
种属内
UBE2K P61086 WFS1 Homo sapiens O76024 32814053
种属内
UBE2K P61086 WFS1 Homo sapiens O76024 32814053
种属内
UBE2K P61086 WFS1 Homo sapiens O76024 32814053
种属内
UBE2K P61086 SDCBP Homo sapiens O00560 32296183
种属内
UBE2K P61086 SDCBP Homo sapiens O00560 32296183
种属内
UBE2K P61086 TRIM39 Homo sapiens Q9HCM9 25416956
种属内
UBE2K P61086 TRIM39 Homo sapiens Q9HCM9 25416956
种属内
UBE2K P61086 RNF183 Homo sapiens Q96D59 32296183
种属内
UBE2K P61086 RNF183 Homo sapiens Q96D59 32296183
种属内
UBE2K P61086 RNF183 Homo sapiens Q96D59 32296183
种属内
UBE2K P61086 CIAO2B Homo sapiens Q9Y3D0 32814053
种属内
UBE2K P61086 CIAO2B Homo sapiens Q9Y3D0 32814053
种属内
UBE2K P61086 CIAO2B Homo sapiens Q9Y3D0 32814053
种属内
UBE2K P61086 SIAH1 Homo sapiens Q8IUQ4 25416956
种属内
UBE2K P61086 SIAH1 Homo sapiens Q8IUQ4 25416956
种属内
UBE2K P61086 PAX6 Homo sapiens P26367 32296183
种属内
UBE2K P61086 PAX6 Homo sapiens P26367 32296183
种属内
UBE2K P61086 TRIM31 Homo sapiens Q9BZY9 32296183
种属内
UBE2K P61086 TRIM31 Homo sapiens Q9BZY9 32296183
种属内
UBE2K P61086 TRIM31 Homo sapiens Q9BZY9 32296183
种属内
UBE2K P61086 DDI1 Homo sapiens Q8WTU0 25416956
种属内
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 32296183
种属内
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 25416956
种属内
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 32296183
种属内
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 33961781
种属内
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 25416956
种属内
UBE2K P61086 RNF138 Homo sapiens Q8WVD3
TAP
27173435
种属内
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 32296183
种属内
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 25416956
种属内
UBE2K P61086 RING1 Homo sapiens Q06587 32814053
种属内
UBE2K P61086 RING1 Homo sapiens Q06587 32814053
种属内
UBE2K P61086 RING1 Homo sapiens Q06587 32296183
种属内
UBE2K P61086 RING1 Homo sapiens Q06587 32296183
种属内
UBE2K P61086 RING1 Homo sapiens Q06587 32814053
种属内
UBE2K P61086 RING1 Homo sapiens Q06587 32296183
种属内
UBE2K P61086 PICK1 Homo sapiens Q9NRD5 32296183
种属内
UBE2K P61086 PICK1 Homo sapiens Q9NRD5 32296183
种属内
UBE2K P61086 PICK1 Homo sapiens Q9NRD5 32296183
种属内
UBE2K P61086 MARCHF7 Homo sapiens Q9H992 32296183
种属内
UBE2K P61086 MARCHF7 Homo sapiens Q9H992 32296183
种属内
UBE2K P61086 MARCHF7 Homo sapiens Q9H992 32296183
种属内
UBE2K P61086 TCAP Homo sapiens O15273 32814053
种属内
UBE2K P61086 TCAP Homo sapiens O15273 32814053
种属内
UBE2K P61086 TCAP Homo sapiens O15273 32814053
种属内
UBE2K P61086 TRIM50 Homo sapiens Q86XT4 32296183
种属内
UBE2K P61086 TRIM50 Homo sapiens Q86XT4 32296183
种属内
UBE2K P61086 TRIM50 Homo sapiens Q86XT4 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBE2K 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71405 UBE2K Protein, Human (GST) P61086-1 (M1-N200) ≥95%

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements, And Impaired Language

Chromosome 5q14.3 Deletion Syndrome

5q14.3 Microdeletion Syndrome

Mental Retardation, Autosomal Dominant 20

NEDHSIL

Autosomal Dominant Mental Retardation 20

Mrd20

Del(5)(Q14.3)

Monosomy 5q14.3

Intellectual Disability, Autosomal Dominant 20

Mental Retardation, Autosomal Dominant 20, Formerly

Mrd20, Formerly

Mental Retardation, Stereotypic Movements, Epilepsy, And/Or Cerebral Malformations

5q14.3 Deletion Syndrome

Autosomal Dominant Intellectual Disability 20

Mental Retardation, Autosomal Dominant, Type 20

Liddle Syndrome 1

Liddle Syndrome

Pseudoaldosteronism

Liddle'S Syndrome

LIDLS1

Lidls

Pseudohyperaldosteronism

Pseudoprimary Hyperaldosteronism

Pseudohyperaldosteronism Type 1

Liddles Syndrome

Uterine Adnexa Cancer
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1

Hypophosphatemic Nephrolithiasis/Osteoporosis 1

NPHLOP1

Nephrolithiasis-Osteoporosis, Hypophosphatemic, 1

Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 1

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Cortical Dysplasia, Complex, With Other Brain Malformations 6

Complex Cortical Dysplasia With Other Brain Malformations 6

CDCBM6

Cdcbm56

Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6

Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus UBE2K RGD RGD:1311626
Bos taurus UBE2K VGNC VGNC:36587
Macaca mulatta UBE2K VGNC VGNC:79957
Mus musculus UBE2K MGD MGI:1858216
Felis catus UBE2K VGNC VGNC:80098
Canis familiaris UBE2K VGNC VGNC:48057
Others UBE2K NCBI