1. Gene
  2. Acly - ATP citrate lyase Gene

Acly - ATP citrate lyase Gene

中文名称:ATP柠檬酸裂解酶

种属: Rattus norvegicus

同用名: ACL; Clatp

基因 ID: 24159 | 基因类型: protein coding

关于 Acly

Primary_assembly 10: 85,412,049-85,463,320 reverse strand.mRatBN7.2:CM026983.1

This gene has 5 transcripts (splice variants), 283 orthologues and is associated with 3 phenotypes. Biased expression in Adrenal (RPKM 1293.6), Liver (RPKM 156.3) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 柠檬酸合酶活性。参与乙酰辅酶A代谢过程;柠檬酸代谢过程;和脂肪酸的生物合成过程。预计位于核质和质膜中。预计在胞质溶胶中有活性。与人类 ACLY(ATP 柠檬酸裂解酶)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables ATP citrate synthase activity. Involved in acetyl-CoA metabolic process; citrate metabolic process; and fatty acid biosynthetic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human ACLY (ATP Citrate Lyase). [provided by Alliance of Genome Resources, Apr 2022]

Acly 基因产物(2)

mRNA Protein Name
NM_016987.2 NP_058683.2 ATP-citrate synthase isoform 1
NM_001111095.1 NP_001104565.1 ATP-citrate synthase isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP citrate synthase activity IDA
IDA: 通过直接分析推断
2295639 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acetyl-CoA metabolic process IDA
IDA: 通过直接分析推断
18062843 RGD
involved in citrate metabolic process IDA
IDA: 通过直接分析推断
18062843 RGD
involved in fatty acid biosynthetic process IDA
IDA: 通过直接分析推断
11735100 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Acly 蛋白结构

PLN02235

PLN02235: cl42902 (0 - 418)

PLN02522

PLN02522: cl31895 (488 - 1093)

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  • 1101 a.a.
蛋白主名 其他名称

ATP-citrate synthase

ATP-citrate (pro-S-)-lyase

citrate cleavage enzyme

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acly NCBI NCBI:47