2. Gene
  3. Myc - MYC proto-oncogene, bHLH transcription factor Gene

Myc - MYC proto-oncogene, bHLH transcription factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：MYC 原癌基因，bHLH 转录因子

种属: Rattus norvegicus

同用名: mMyc; c-myc; RNCMYC

基因 ID: 24577 | 基因类型: protein coding

关于 Myc

Primary_assembly 7: 93,593,705-93,598,630 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 217 orthologues, 4 paralogues and is associated with 102 phenotypes. Biased expression in Spleen (RPKM 98.), Thymus (RPKM 64.5) and 9 other tissues.

功能概要

该基因编码的蛋白质是一种多功能的核磷蛋白，在细胞周期进程、细胞凋亡和细胞转化中发挥作用。它作为调节特定靶基因转录的转录因子发挥作用。该基因的突变、过表达、重排和易位与人类的多种造血肿瘤、白血病和淋巴瘤（包括伯基特淋巴瘤）有关。有证据表明，从上游框内非 AUG (CUG) 和下游 AUG 起始位点开始的替代翻译会导致在人和小鼠中产生具有不同 N 末端的两种亚型。大鼠 mRNA 在 AUG 起始位点的上游也有一个类似的 CUG，表明它也可能产生两种 Myc 蛋白。 [RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, Apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Rat mRNA also has a similarly placed CUG upstream of the AUG start site, suggesting that it may also produce two Myc proteins. [provided by RefSeq, Jul 2008]

Myc 基因产物(1)

mRNA Protein Name
NM_012603.2 NP_036735.2 myc proto-oncogene protein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
11799123 RGD
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
15139290 RGD
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
17341548 RGD
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
15139290 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17334388 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
17341548 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15139290 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA-templated transcription IDA
IDA: 通过直接分析推断
15139290 RGD
involved in DNA-templated transcription initiation IDA
IDA: 通过直接分析推断
3306601 RGD
involved in G0 to G1 transition IEP
IEP: 通过表达模式推断
23119170 RGD
involved in amino acid transport IMP
IMP: 通过突变表型推断
22842522 RGD
involved in cellular response to angiotensin IEP
IEP: 通过表达模式推断
17886230 RGD
involved in cellular response to arsenite(3-) IEP
IEP: 通过表达模式推断
9848127 RGD
involved in cellular response to carbohydrate stimulus IEP
IEP: 通过表达模式推断
20694826 RGD
involved in cellular response to cycloheximide IEP
IEP: 通过表达模式推断
11550711 RGD
involved in cellular response to cytokine stimulus IEP
IEP: 通过表达模式推断
11687580 RGD
involved in cellular response to dimethyl sulfoxide IEP
IEP: 通过表达模式推断
12873812 RGD
involved in cellular response to endothelin IEP
IEP: 通过表达模式推断
16365184 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: 通过表达模式推断
7524476 RGD
involved in cellular response to estrogen stimulus IEP
IEP: 通过表达模式推断
21980073 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: 通过表达模式推断
7524476 RGD
involved in cellular response to growth hormone stimulus IEP
IEP: 通过表达模式推断
11550711 RGD
involved in cellular response to hydrostatic pressure IEP
IEP: 通过表达模式推断
22644739 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
2200903 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
22706317 RGD
involved in cellular response to lectin IEP
IEP: 通过表达模式推断
2200903 RGD
involved in cellular response to organic cyclic compound IEP
IEP: 通过表达模式推断
21980073 RGD
involved in cellular response to phorbol 13-acetate 12-myristate IEP
IEP: 通过表达模式推断
2200903 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: 通过表达模式推断
7524476 RGD
involved in cellular response to prolactin IEP
IEP: 通过表达模式推断
9296381 RGD
involved in cellular response to putrescine IEP
IEP: 通过表达模式推断
8048943 RGD
involved in cellular response to retinoic acid IEP
IEP: 通过表达模式推断
12873812 RGD
involved in cellular response to testosterone stimulus IEP
IEP: 通过表达模式推断
7721656 RGD
involved in cellular response to type II interferon IEP
IEP: 通过表达模式推断
7524476 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17886230 RGD
involved in glucose metabolic process IMP
IMP: 通过突变表型推断
12480946 RGD
involved in hypothalamus development IEP
IEP: 通过表达模式推断
23291449 RGD
involved in in utero embryonic development IEP
IEP: 通过表达模式推断
23077551 RGD
involved in inner mitochondrial membrane organization IMP
IMP: 通过突变表型推断
22629444 RGD
involved in lactic acid secretion IMP
IMP: 通过突变表型推断
22842522 RGD
involved in liver regeneration IEP
IEP: 通过表达模式推断
3335218 RGD
involved in myoblast proliferation IEP
IEP: 通过表达模式推断
2425941 RGD
involved in negative regulation of D-glucose import IMP
IMP: 通过突变表型推断
22842522 RGD
involved in negative regulation of epithelial cell apoptotic process IMP
IMP: 通过突变表型推断
22100782 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
23349663 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
9924025 RGD
involved in ovarian follicle development IEP
IEP: 通过表达模式推断
9071960 RGD
involved in positive regulation of ATP biosynthetic process IMP
IMP: 通过突变表型推断
22629444 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18818310 RGD
involved in positive regulation of cell cycle IMP
IMP: 通过突变表型推断
22210745 RGD
involved in positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
21980073 RGD
involved in positive regulation of cellular respiration IMP
IMP: 通过突变表型推断
22842522 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
22842522 RGD
involved in positive regulation of glial cell proliferation IMP
IMP: 通过突变表型推断
9316053 RGD
involved in positive regulation of glycolytic process IMP
IMP: 通过突变表型推断
22842522 RGD
involved in positive regulation of mitochondrial membrane potential IMP
IMP: 通过突变表型推断
22629444 RGD
involved in positive regulation of oxidative phosphorylation IMP
IMP: 通过突变表型推断
18414044 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
8421701 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
8113414 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
12480946 RGD
involved in pyruvate transport IMP
IMP: 通过突变表型推断
22842522 RGD
involved in re-entry into mitotic cell cycle IMP
IMP: 通过突变表型推断
18414044 RGD
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11799123 RGD
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
17341548 RGD
involved in regulation of mitotic cell cycle IMP
IMP: 通过突变表型推断
12070150 RGD
involved in regulation of oxidative phosphorylation IMP
IMP: 通过突变表型推断
22629444 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
23027806 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
12370848 RGD
involved in response to human chorionic gonadotropin IEP
IEP: 通过表达模式推断
9071960 RGD
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15139290 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Myc 蛋白结构

Myc_N

Myc_N: pfam01056 (15 - 358)

bHLHzip_c-Myc

bHLHzip_c-Myc: cd11458 (364 - 447)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
蛋白主名 其他名称

myc proto-oncogene protein

Avian myelocytomatosis viral (v-myc) oncogene homolog

myelocytomatosis oncogene

myelocytomatosis viral oncogene homolog

proto-oncogene c-Myc

transcription factor p64

v-myc avian myelocytomatosis viral oncogene homolog

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-N7454 Anhydroerythromycin A Inhibitor / 否
HY-17381A Idarubicin / 否
Clinical Phase
生物活性分子 (9)
目录号 产品名 作用方式
纯度 Phase
HY-111784 Inobrodib Inhibitor 99.94% Phase 2
HY-153356 MRT-2359 Inducer 99.98% Phase 2
HY-13241 Ralimetinib dimesylate 99.91% Phase 2
HY-109050 Alobresib Inhibitor 98.04% Phase 2
HY-100653 AZD5153 99.20% Phase 2
HY-13241A Ralimetinib Inhibitor / Phase 2
HY-16291 APTO-253 98.86% Phase 1
HY-136938 NEO2734 Inhibitor 99.63% Phase 1
HY-145898 WBC100 Inhibitor ≥95.0% Phase 1
Pre-clinical Phase
生物活性分子 (155)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12702 10058-F4 Inhibitor 99.77% 否
HY-80013 THZ1 Inhibitor 99.84% 否
HY-107738 Guggulsterone 99.95% 否
HY-134582 dCBP-1 Inhibitor 99.44% 否
HY-112929 DT-061 Activator 99.95% 否
HY-19735 KJ Pyr 9 Inhibitor 99.62% 否
HY-139330 MGH-CP1 Inducer 99.21% 否
HY-124675 MYCMI-6 98.14% 否
HY-139361 Sulfopin Inhibitor 99.69% 否
HY-126477 NNK 99.98% 否
HY-134761 EN4 Inhibitor 97.05% 否
HY-12863 Pelabresib Inhibitor 99.95% 否
HY-N0330 Momordin Ic 99.71% 否
HY-100996 10074-G5 Inhibitor 98.11% 否
HY-N2068 Didymin Inducer 99.96% 否
HY-123954 BTX-A51 98.58% 否
HY-100669 Mycro 3 Inhibitor 98.11% 否
HY-129600 MYCi361 Inhibitor 99.85% 否
HY-124447 BTYNB Inhibitor ≥98.0% 否
HY-80013A THZ1 Hydrochloride Inhibitor 98.61% 否
HY-112296 T025 98.84% 否
HY-122683 sAJM589 Inhibitor 98.34% 否
HY-114208A BI-9321 trihydrochloride Antagonist 98.40% 否
HY-145669 DIF-3 98.07% 否
HY-133121 WDR5-IN-1 ≥98.0% 否
HY-N0704 Agrimol B 99.75% 否
HY-103038 ML327 Inhibitor 98.06% 否
HY-117203A CDK12-IN-E9 Inhibitor 99.97% 否
HY-12703 KSI-3716 Inhibitor 98.94% 否
HY-129937A GNE-987 Inhibitor 99.91% 否
HY-N2534 Karanjin 99.75% 否
HY-120028 GNE-207 Inhibitor 97.02% 否
HY-13250 Silvestrol aglycone Inhibitor 99.84% 否
HY-19759 SRT 2183 98.17% 否
HY-17442 Azathramycin Inhibitor 99.85% 否
HY-135691 hnRNPK-IN-1 ≥97.0% 否
HY-149230 USP28-IN-4 Inhibitor 99.35% 否
HY-153713 MYC-RIBOTAC 98.05% 否
HY-N3005 Britannin 99.93% 否
HY-N6747 Stauprimide Inhibitor 99.45% 否
HY-114189 GW284543 Inhibitor 99.94% 否
HY-112316 BAY1238097 Inhibitor 99.02% 否
HY-123955 Casein Kinase inhibitor A86 99.26% 否
HY-N8146 Bruceantinol Inhibitor 98.89% 否
HY-124811 IRES-C11 Inhibitor 99.03% 否
HY-162318A MYC degrader 1 TFA Degrader 99.36% 否
HY-144878 VPC-70619 Inhibitor ≥99.0% 否
HY-111411 IZCZ-3 Inhibitor 98.13% 否
HY-133131 PROTAC BRD4 Degrader-1 Inhibitor 99.12% 否
HY-125236 BET-IN-19 Inhibitor 99.74% 否
HY-148836 c-Myc inhibitor 6 Inhibitor 98.04% 否
HY-149209 LL-K8-22 99.76% 否
HY-150259 MDEG-541 Degrader 98.05% 否
HY-153728 WM-586 Inhibitor 98.74% 否
HY-112799 DK419 Inhibitor 99.88% 否
HY-134333 ICCB280 Activator 99.43% 否
HY-148450 eIF4A3-IN-16 Inhibitor 98.37% 否
HY-121418 Lusianthridin Inhibitor ≥98.0% 否
HY-134975 NY2267 Inhibitor 98.53% 否
HY-148446 eIF4A3-IN-12 Inhibitor 99.70% 否
HY-148452 eIF4A3-IN-18 Inhibitor 99.58% 否
HY-149229 USP28-IN-3 Inhibitor 98.26% 否
HY-149873 Anticancer agent 126 Inhibitor ≥98.0% 否
HY-154847 WM-662 Inhibitor 99.48% 否
HY-160409 TopBP1-IN-1 Inhibitor / 否
HY-163828 PPA24 98.09% 否
HY-162318 MYC degrader 1 Degrader 99.61% 否
HY-124129 10074-A4 Inhibitor 98.03% 否
HY-125365 Rifamycin S 98.82% 否
HY-148444 eIF4A3-IN-10 Inhibitor 97.87% 否
HY-N10790 RA-V 99.63% 否
HY-112316A (R)-BAY1238097 99.07% 否
HY-119271 CMLD010509 / 否
HY-101280 LB-60-OF61 Inhibitor 99.25% 否
HY-111522 RK-9123016 Inhibitor 99.02% 否
HY-112929B (1S,2S,3R)-DT-061 99.73% 否
HY-147291 VPC-70063 99.92% 否
HY-147651 β-catenin-IN-4 Inhibitor 99.84% 否
HY-147973 IZTZ-1 / 否
HY-148443 eIF4A3-IN-9 Inhibitor 99.71% 否
HY-148445 eIF4A3-IN-11 Inhibitor 99.24% 否
HY-148447 eIF4A3-IN-13 Inhibitor 99.92% 否
HY-148448 eIF4A3-IN-14 Inhibitor 99.81% 否
HY-148449 eIF4A3-IN-15 Inhibitor / 否
HY-148451 eIF4A3-IN-17 Inhibitor 99.56% 否
HY-162470 DBPR728 Inhibitor 98.11% 否
HY-W011616 Cardionogen 1 Inhibitor 99.21% 否
HY-101280A LB-60-OF61 hydrochloride Inhibitor / 否
HY-111537 rel-AZ5576 / 否
HY-104072 BRD4-IN-3 Inhibitor / 否
HY-114189A GW284543 hydrochloride Inhibitor / 否
HY-114208 BI-9321 Antagonist / 否
HY-115832 Ap44mSe / 否
HY-121444 MYRA-A / 否
HY-121917 Ro 31-7837 / 否
HY-125636 Mycro1 / 否
HY-125978 JY-3-094 Inhibitor / 否
HY-126979 Mycro2 / 否
HY-128761 CBP/p300-IN-2 Inhibitor / 否
HY-129937 (S)-GNE-987 Inhibitor / 否
HY-131203 PROTAC BRD4 Degrader-6 / 否
HY-136794 SB-284851-BT Inhibitor / 否
HY-139885 c-Myc inhibitor 4 Inhibitor / 否
HY-141666 MYC-IN-2 Inhibitor / 否
HY-143235 BRD4 Inhibitor-15 / 否
HY-143471 WNY0824 / 否
HY-145843 c-Myc inhibitor 5 Inhibitor / 否
HY-146445 P300 bromodomain-IN-1 Inhibitor / 否
HY-147261 B026 Inhibitor / 否
HY-148837 c-Myc inhibitor 7 / 否
HY-148838 c-Myc inhibitor 8 Inhibitor / 否
HY-148839 c-Myc inhibitor 9 Inhibitor / 否
HY-149228 USP28-IN-2 Inhibitor / 否
HY-149495 CP-07 Degrader / 否
HY-149513 EP12 / 否
HY-149735 BET-IN-20 / 否
HY-150683 NC-III-49-1 Inhibitor / 否
HY-150684 GXH-II-052 Inhibitor / 否
HY-151471 Anticancer agent 84 Inhibitor / 否
HY-15163A Zotiraciclib hydrochloride Inhibitor / 否
HY-151884 FUBP1-IN-2 Inhibitor / 否
HY-152471 Eleven-Nineteen-Leukemia Protein IN-3 Inhibitor / 否
HY-153996 CT1113 Inhibitor / 否
HY-154839 c-Myc inhibitor 10 Inhibitor / 否
HY-155153 CDK9-IN-24 / 否
HY-155507 c-Myc inhibitor 11 Inhibitor / 否
HY-155508 c-Myc inhibitor 12 Inhibitor / 否
HY-156084 LL-K9-3 / 否
HY-156673 m-Se3 Inhibitor / 否
HY-158062 LC-1-40 / 否
HY-160549 c-Myc inhibitor 14 Inhibitor / 否
HY-160689 GW694590A Inhibitor / 否
HY-161127 NT-B2R Inhibitor / 否
HY-161826 Antitumor agent-174 Inhibitor / 否
HY-162294 c-Myc inhibitor 13 Inhibitor / 否
HY-162460 ERK1/2 inhibitor 10 Inhibitor / 否
HY-162469 6K465 Inhibitor / 否
HY-162686 MYC-IN-3 Inhibitor / 否
HY-162796 TS-2 / 否
HY-16291A APTO-253 hydrochloride Inhibitor / 否
HY-163108 ATAD2-IN-1 / 否
HY-163679 PROTAC ERα Degrader-9 / 否
HY-163774 WDR5-MYC-IN-1 Inhibitor / 否
HY-169348 β-catenin-IN-8 Inhibitor / 否
HY-169378 CSI86 Degrader / 否
HY-N11576 Secalonic acid D / 否
HY-RS08877 MYC Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08878 Myc Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08879 Myc Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-120750 A 62176 hydrochloride / 否
HY-125090 PHA-680626 / 否
HY-130369 NSC10010 hydrochloride / 否
HY-149451 SYHA1815 Inhibitor / 否
HY-168684 E3 Ligase Ligand-linker Conjugate 136 / 否
HY-W806047 BRD4 Inhibitor-37 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Myc NCBI NCBI:4609
Macaca fascicularis Myc NCBI NCBI:102127966
Mus musculus Myc NCBI NCBI:17869
Susscrofa domestica Myc NCBI
Leporidae Myc NCBI
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