Myc - myelocytomatosis oncogene Gene

中文名称：骨髓细胞瘤癌基因

种属: Mus musculus

同用名: Myc2; Nird; Niard; bHLHe39

关于 Myc

功能概要

该基因编码的蛋白质是一种多功能的核磷蛋白，在细胞周期进程、细胞凋亡和细胞转化中发挥作用。它作为调节特定靶基因转录的转录因子发挥作用。该基因的突变、过表达、重排和易位与人类的多种造血肿瘤、白血病和淋巴瘤（包括伯基特淋巴瘤）有关。有证据表明，从上游框内非 AUG (CUG) 和下游 AUG 起始位点开始的替代翻译会导致在人和小鼠中产生具有不同 N 末端的两种亚型。在压力条件下，例如高细胞密度和甲硫氨酸剥夺，非 AUG 启动蛋白的合成会显着增加，表明它在逆境中的重要性。可变剪接导致多个转录本变体。 [RefSeq 提供，2010 年 4 月]

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, Apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]