1. Gene
  2. Mmp9 - matrix metallopeptidase 9 Gene

Mmp9 - matrix metallopeptidase 9 Gene

中文名称:基质金属肽酶 9

种属: Rattus norvegicus

基因 ID: 81687 | 基因类型: protein coding

关于 Mmp9

Primary_assembly 3: 153,683,858-153,692,120 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 216 orthologues, 23 paralogues and is associated with 259 phenotypes. Biased expression in Thymus (RPKM 39.9), Kidney (RPKM 35.9) and 6 other tissues.

功能概要

该基因编码的蛋白可启动纤连蛋白结合活性和金属肽酶活性。参与多个过程,包括细胞对细胞基质粘附的反应;对细胞因子刺激的细胞反应;和细胞对铁 (III) 离子的反应。位于细胞外空间。部分含蛋白质复合物。用于研究动脉疾病(多种);脑缺血(多发);充血性心力衰竭;肾小球硬化;和肺部疾病(多种)。多种疾病的生物标志物,包括动脉疾病(多种);脑部疾病(多种);慢性阻塞性肺病(多发性);糖代谢疾病(多种);和肾脏疾病(多种)。该基因的人类直系同源基因与多种疾病有关,包括唐氏综合症;无牙症;动脉疾病(多发性);自身免疫性疾病(多种);和慢性阻塞性肺病(多发性)。与人 MMP9(基质金属肽酶 9)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Located in extracellular space. Part of protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9). [provided by Alliance of Genome Resources, Apr 2022]

Mmp9 基因产物(1)

mRNA Protein Name
NM_031055.2 NP_112317.2 matrix metalloproteinase-9 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fibronectin binding IPI
IPI: 通过物理相互作用推断
18039280 RGD
enables metallopeptidase activity IDA
IDA: 通过直接分析推断
11826121 RGD
enables peptidase activity IDA
IDA: 通过直接分析推断
8531210 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17148685 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
9732233 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to cell-matrix adhesion IEP
IEP: 通过表达模式推断
20218972 RGD
involved in cellular response to cell-matrix adhesion IMP
IMP: 通过突变表型推断
12963432 RGD
involved in cellular response to cytokine stimulus IEP
IEP: 通过表达模式推断
19909738 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
16046515 RGD
involved in cellular response to iron(III) ion IEP
IEP: 通过表达模式推断
21683124 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
21683124 RGD
involved in cellular response to low-density lipoprotein particle stimulus IEP
IEP: 通过表达模式推断
19554388 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
22410640 RGD
involved in collagen catabolic process IDA
IDA: 通过直接分析推断
22410640 RGD
involved in heart development IDA
IDA: 通过直接分析推断
12061388 RGD
involved in kidney development IEP
IEP: 通过表达模式推断
9733107 RGD
involved in macrophage chemotaxis IDA
IDA: 通过直接分析推断
20110414 RGD
involved in modification of synaptic structure, modulating synaptic transmission EXP
EXP: 通过实验结果推断
19047646 RGD
involved in modification of synaptic structure, modulating synaptic transmission IDA
IDA: 通过直接分析推断
19047646 RGD
involved in negative regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
22490164 RGD
involved in ossification IEP
IEP: 通过表达模式推断
15883642 RGD
involved in parturition IEP
IEP: 通过表达模式推断
7492685 RGD
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
19948826 RGD
involved in positive regulation of leukocyte migration IDA
IDA: 通过直接分析推断
16698855 RGD
involved in positive regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
17493927 RGD
involved in protein catabolic process IDA
IDA: 通过直接分析推断
11788364 RGD
involved in proteolysis IDA
IDA: 通过直接分析推断
20110414 RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping IDA
IDA: 通过直接分析推断
19420267 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
19889233 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
17603938 RGD
involved in response to high light intensity IEP
IEP: 通过表达模式推断
17854381 RGD
involved in response to hyperoxia IEP
IEP: 通过表达模式推断
19099751 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
17289933 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
17452115 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
17158349 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
19879865 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
17650800 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
17114644 RGD
involved in response to oxidative stress IDA
IDA: 通过直接分析推断
15642321 RGD
involved in response to retinoic acid IEP
IEP: 通过表达模式推断
19099751 RGD
involved in response to tumor necrosis factor IEP
IEP: 通过表达模式推断
17704356 RGD
involved in response to vitamin A IEP
IEP: 通过表达模式推断
17164434 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
16846501 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17603938 RGD
involved in tissue remodeling IDA
IDA: 通过直接分析推断
16740171 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse EXP
EXP: 通过实验结果推断
19047646 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
19047646 RGD
is active in extracellular matrix of synaptic cleft IDA
IDA: 通过直接分析推断
18332222 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
17603938 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
18332222 RGD
is active in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
18332222 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
16935996 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Mmp9 蛋白结构

PG_binding_1

PG_binding_1: pfam01471 (40 - 94)

Peptidase_M10

Peptidase_M10: pfam00413 (115 - 444)

FN2

FN2: smart00059 (223 - 271)

FN2

FN2: smart00059 (281 - 329)

FN2

FN2: smart00059 (340 - 388)

PT

PT: cl04822 (457 - 488)

PT

PT: pfam04886 (474 - 509)

HX

HX: cd00094 (516 - 706)

  • 0
  • 200
  • 400
  • 600
  • 708 a.a.
蛋白主名 其他名称

matrix metalloproteinase-9

92 kDa gelatinase

92-kDa type IV collagenase

GELB

MMP-9

gelatinase B

matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)

重组 Mmp9 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73301 MMP-9 Protein, Rat (HEK293, His) EDL96479.1 (A20-P708) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp9 NCBI NCBI:4318