1. Gene
  2. Mmp9 - matrix metallopeptidase 9 Gene

Mmp9 - matrix metallopeptidase 9 Gene

中文名称:基质金属肽酶 9

种属: Rattus norvegicus

基因 ID: 81687 | 基因类型: protein coding

关于 Mmp9

Primary_assembly 3: 153,683,858-153,692,120 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 216 orthologues, 23 paralogues and is associated with 259 phenotypes. Biased expression in Thymus (RPKM 39.9), Kidney (RPKM 35.9) and 6 other tissues.

功能概要

该基因编码的蛋白可启动纤连蛋白结合活性和金属肽酶活性。参与多个过程,包括细胞对细胞基质粘附的反应;对细胞因子刺激的细胞反应;和细胞对铁 (III) 离子的反应。位于细胞外空间。部分含蛋白质复合物。用于研究动脉疾病(多种);脑缺血(多发);充血性心力衰竭;肾小球硬化;和肺部疾病(多种)。多种疾病的生物标志物,包括动脉疾病(多种);脑部疾病(多种);慢性阻塞性肺病(多发性);糖代谢疾病(多种);和肾脏疾病(多种)。该基因的人类直系同源基因与多种疾病有关,包括唐氏综合症;无牙症;动脉疾病(多发性);自身免疫性疾病(多种);和慢性阻塞性肺病(多发性)。与人 MMP9(基质金属肽酶 9)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Located in extracellular space. Part of protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9). [provided by Alliance of Genome Resources, Apr 2022]

Mmp9 基因产物(1)

mRNA Protein Name
NM_031055.2 NP_112317.2 matrix metalloproteinase-9 precursor

Mmp9 蛋白结构

PG_binding_1

PG_binding_1: pfam01471 (40 - 94)

Peptidase_M10

Peptidase_M10: pfam00413 (115 - 444)

FN2

FN2: smart00059 (223 - 271)

FN2

FN2: smart00059 (281 - 329)

FN2

FN2: smart00059 (340 - 388)

PT

PT: cl04822 (457 - 488)

PT

PT: pfam04886 (474 - 509)

HX

HX: cd00094 (516 - 706)

  • 0
  • 200
  • 400
  • 600
  • 708 a.a.
蛋白主名 其他名称

matrix metalloproteinase-9

92 kDa gelatinase

92-kDa type IV collagenase

GELB

MMP-9

gelatinase B

matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)

重组 Mmp9 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73301 MMP-9 Protein, Rat (HEK293, His) EDL96479.1 (A20-P708) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp9 NCBI NCBI:4318