2. Gene
  3. CDK4 - cyclin-dependent kinase 4 Gene

CDK4 - cyclin-dependent kinase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 4

种属: Rattus norvegicus

基因 ID: 94201 | 基因类型: protein coding

关于 CDK4

Primary_assembly 7: 62,883,105-62,942,403 forward strand.mRatBN7.2:CM026980.1

This gene has 4 transcripts (splice variants), 229 orthologues, 24 paralogues and is associated with 48 phenotypes. Biased expression in Thymus (RPKM 573.2), Adrenal (RPKM 371.5) and 9 other tissues.

功能概要

该基因编码的蛋白可启动细胞周期蛋白结合活性和细胞周期蛋白依赖性蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括细胞大小的正调节；对高氧反应；和对睾丸激素的反应。位于细胞质的细胞核和核周区。胰腺癌生物标志物；前列腺肥大;和膀胱癌。该基因的人类直系同源物与多种疾病有关，包括癌（多种）；家族性黑色素瘤；胶质母细胞瘤;肥胖;和 2 型糖尿病。与人 CDK4（细胞周期蛋白依赖性激酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell size; response to hyperoxia; and response to testosterone. Located in nucleus and perinuclear region of cytoplasm. Biomarker of pancreatic cancer; prostatic hypertrophy; and urinary bladder Cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

CDK4 基因产物(2)

mRNA Protein Name
NM_053593.3 NP_446045.1 cyclin-dependent kinase 4 isoform 1
NM_001402395.1 NP_001389324.1 cyclin-dependent kinase 4 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cyclin binding IPI
IPI: 通过物理相互作用推断
15809057 RGD
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12163013 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
8651753 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
16534847 RGD
involved in cellular response to polyamine macromolecule IEP
IEP: 通过表达模式推断
21737690 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
11598123 RGD
involved in lens development in camera-type eye IEP
IEP: 通过表达模式推断
10620399 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
18353414 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17635516 RGD
involved in positive regulation of cell size IMP
IMP: 通过突变表型推断
12163013 RGD
involved in positive regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
21737690 RGD
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
12163013 RGD
involved in response to hyperoxia IEP
IEP: 通过表达模式推断
18082050 RGD
involved in response to testosterone IDA
IDA: 通过直接分析推断
17962342 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
17343987 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18353414 RGD
located in nucleus IDA
IDA: 通过直接分析推断
18353414 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15161838 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cyclin-dependent kinase 4

PSK-J3

cell division protein kinase 4

相关产品

Approval
生物活性分子 (14)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50767 Palbociclib Inhibitor 99.94% 否
HY-16297A Abemaciclib Inhibitor 99.97% 是
HY-15777 Ribociclib Inhibitor 99.94% 否
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% 否
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% 是
HY-A0065 Palbociclib isethionate Inhibitor 99.99% 否
HY-50767C Palbociclib hydrochloride Inhibitor 99.93% 否
HY-15777A Ribociclib hydrochloride Inhibitor 99.95% 否
HY-15777B Ribociclib succinate Inhibitor 99.93% 否
HY-101467A Trilaciclib hydrochloride Inhibitor 99.69% 否
HY-114338 Dalpiciclib Inhibitor 99.70% 否
HY-15777C Ribociclib succinate hydrate Inhibitor 99.96% 否
HY-50767D Palbociclib orotate Inhibitor / 否
HY-50767B Palbociclib dihydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (26)
目录号 产品名 作用方式
纯度 Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.74% Phase 4
HY-114338A Dalpiciclib hydrochloride Inhibitor 98.22% Phase 3
HY-112272 Lerociclib Inhibitor 98.35% Phase 3
HY-10005 Flavopiridol Inhibitor 99.73% Phase 2
HY-101563 GSK3326595 99.83% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-10006 Flavopiridol Hydrochloride Inhibitor 99.73% Phase 2
HY-10424 Milciclib Inhibitor 99.90% Phase 2
HY-12624 Narazaciclib Inhibitor 99.12% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-16559 Riviciclib hydrochloride 98.89% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Phase 2
HY-103712 Samuraciclib Inhibitor / Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.54% Phase 1
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-111361 FN-1501 Inhibitor 99.08% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
HY-50940A AT7519 TFA Inhibitor 96.62% Phase 1
Pre-clinical Phase
生物活性分子 (102)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103248 Toyocamycin Inhibitor 99.78% 否
HY-10329 JNJ-7706621 Inhibitor 99.91% 否
HY-15339 CVT-313 Inhibitor 99.90% 否
HY-11009 CGP60474 Inhibitor 99.23% 否
HY-116035 Nimbolide Inhibitor 99.79% 否
HY-136252 BSJ-04-132 Inhibitor 99.07% 否
HY-114177 Ebvaciclib Inhibitor 99.98% 否
HY-136250 BSJ-03-204 Inhibitor 99.76% 否
HY-13914 Roniciclib Inhibitor 98.09% 否
HY-15275 BMS-265246 Inhibitor 98.92% 否
HY-10014 R547 Inhibitor 99.57% 否
HY-138946 XY028-140 Inhibitor 98.52% 否
HY-15878 LDC000067 Inhibitor 99.00% 否
HY-18299A Purvalanol A Inhibitor 98.30% 否
HY-12445 Asnuciclib Inhibitor 99.76% 否
HY-128669 Abemaciclib metabolite M2 Inhibitor 99.94% 否
HY-18629 SU9516 Inhibitor 99.81% 否
HY-13266A BS-181 hydrochloride Inhibitor 99.80% 否
HY-119940 MC180295 Inhibitor 98.89% 否
HY-126534A Abemaciclib metabolite M18 hydrochloride Inhibitor 98.01% 否
HY-129336 Abemaciclib metabolite M20 Inhibitor 96.02% 否
HY-129180 XY028-133 Inhibitor 98.62% 否
HY-15569 NU6102 Inhibitor 99.23% 否
HY-147007 β-catenin-IN-3 Inhibitor 96.58% 否
HY-50767S Palbociclib-d8 Inhibitor 99.84% 否
HY-15889 AMG 925 Inhibitor 98.20% 否
HY-148062 RSS0680 98.03% 否
HY-122609 XO44 99.38% 否
HY-107419 NU6140 Inhibitor 99.07% 否
HY-114339 CDK4/6-IN-2 Inhibitor 99.82% 否
HY-126251 CDK9-IN-7 Inhibitor 98.05% 否
HY-112243A Cimpuciclib tosylate Inhibitor 99.16% 否
HY-142076 CDK4/6-IN-15 Inhibitor 99.32% 否
HY-103380 NSC 625987 Inhibitor 98.58% 否
HY-148061 DB1113 99.28% 否
HY-153556 GW297361 Inhibitor 98.13% 否
HY-111207 CA224 Inhibitor 99.94% 否
HY-100429 CAN508 Inhibitor 99.59% 否
HY-148365 NecroIr1 Inhibitor 98.02% 否
HY-112822 ON-013100 Inhibitor 98.66% 否
HY-152263 HEMTAC CDK4/6 degrader 1 Inhibitor 98.18% 否
HY-100624 Ryuvidine Inhibitor 99.40% 否
HY-163786 PROTAC CDK4/6 degrader 1 Degrader 98.88% 否
HY-148366 NecroIr2 Inhibitor 98.99% 否
HY-112346 RGB-286147 Inhibitor 98.60% 否
HY-136726 CGP-82996 Inhibitor 98.12% 否
HY-13266 BS-181 Inhibitor 98.10% 否
HY-15889A AMG 925 (HCl) Inhibitor / 否
HY-148214 CDK2/4/6-IN-2 Inhibitor / 否
HY-168664 CPD-39 Degrader / 否
HY-126534 Abemaciclib metabolite M18 Inhibitor / 否
HY-129336S Abemaciclib metabolite M20-d8 Inhibitor 97.01% 否
HY-123045 PNU-292137 Inhibitor / 否
HY-112243 Cimpuciclib Inhibitor / 否
HY-126244 CDK4/6-IN-3 Inhibitor / 否
HY-112418 CDK4/6-IN-18 Inhibitor / 否
HY-155602 CDK2-IN-18 Inhibitor / 否
HY-115908 ZDLD13 Inhibitor / 否
HY-163640 CDK4 degrader 1 Degrader / 否
HY-143257 CDK4/6-IN-7 Inhibitor / 否
HY-172128 NUAK1-IN-2 Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-147409 Ulecaciclib Inhibitor / 否
HY-168444 CDK4/6-IN-23 Inhibitor / 否
HY-151898 CDK4/6-IN-14 Inhibitor / 否
HY-170992 Autophagy agonist-1 Inhibitor / 否
HY-115942 Anticancer agent 29 Inhibitor / 否
HY-164376 CDK4/6-IN-21 Inhibitor / 否
HY-153336 CDK-IN-12 Inhibitor / 否
HY-115993 CDK4/6-IN-10 Inhibitor / 否
HY-159155 CDK2/4-IN-1 Inhibitor / 否
HY-162619 CDK9-IN-33 Inhibitor / 否
HY-163787 YY173 Inhibitor / 否
HY-163856 CDK7-IN-30 Inhibitor / 否
HY-115904 FLT3/CDK4-IN-1 Inhibitor / 否
HY-153088 CDK4/6-IN-16 Inhibitor / 否
HY-172198 GSK3-IN-10 Inhibitor / 否
HY-143258 CDK4/6-IN-8 Inhibitor / 否
HY-151071 TMX-3013 Inhibitor / 否
HY-146213 CDK4/6-IN-12 Inhibitor / 否
HY-168660 CPD-10 Degrader / 否
HY-168996 LA-CB1 Degrader / 否
HY-160941 CDK2-IN-29 Inhibitor / 否
HY-155787 SHR5428 Inhibitor / 否
HY-164906 TMX-2138 Degrader / 否
HY-123034 CDKI-83 Inhibitor / 否
HY-146253 CDK1/2/4-IN-1 Inhibitor / 否
HY-164376A CDK4/6-IN-21 maleate Inhibitor / 否
HY-115992 CDK4/6-IN-9 Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-148213 CDK2/4/6-IN-1 Inhibitor / 否
HY-162530 CDK4/6-IN-20 Inhibitor / 否
HY-141685 3-Methylthienyl-carbonyl-JNJ-7706621 Inhibitor / 否
HY-162529 CDK4/6-IN-19 Inhibitor / 否
HY-170815 CDK4/9-IN-1 Inhibitor / 否
HY-172127 NUAK1-IN-1 Inhibitor / 否
HY-150609 SHP2/CDK4-IN-1 Inhibitor / 否
HY-115909 ZDLD20 Inhibitor 99.84% 否
HY-170651 CDK4/6/HDAC-IN-1 Inhibitor / 否
HY-151069 TMX-2039 Inhibitor / 否
HY-112450 Olomoucine II Inhibitor / 否
HY-111932 Indirubin-5-sulfonate Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens CDK4 NCBI NCBI:1019
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