2. Gene
  3. Th - tyrosine hydroxylase Gene

Th - tyrosine hydroxylase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 21823 | 基因类型: protein coding

关于 Th

功能概要

Predicted to enable several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in eye development and visual perception. Acts upstream of or within several processes, including dopamine biosynthetic process from tyrosine; dopaminergic synaptic transmission; and learning or memory. Located in several cellular components, including axon; perikaryon; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Th 基因产物(1)

mRNA Protein Name
NM_009377.2 NP_033403.1 tyrosine 3-monooxygenase
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
7715703 MGI
acts upstream of or within dopamine biosynthetic process from tyrosine IDA
IDA: 通过直接分析推断
9520487 MGI
acts upstream of or within dopamine biosynthetic process from tyrosine IMP
IMP: 通过突变表型推断
7592982 MGI
acts upstream of or within eating behavior IGI
IGI: 通过遗传相互作用推断
10802666 MGI
acts upstream of or within eating behavior IMP
IMP: 通过突变表型推断
11430814 MGI
involved in embryonic camera-type eye morphogenesis IMP
IMP: 通过突变表型推断
16445854 MGI
involved in eye photoreceptor cell development IMP
IMP: 通过突变表型推断
16445854 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
7715703 MGI
involved in hyaloid vascular plexus regression IMP
IMP: 通过突变表型推断
30936473 MGI
acts upstream of or within learning IMP
IMP: 通过突变表型推断
14684249 MGI
acts upstream of or within locomotory behavior IGI
IGI: 通过遗传相互作用推断
12538862 MGI
acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
11430814 MGI
acts upstream of or within mating behavior IMP
IMP: 通过突变表型推断
9829800 MGI
acts upstream of or within memory IMP
IMP: 通过突变表型推断
14684249 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: 通过突变表型推断
7592982 MGI
acts upstream of or within synaptic transmission, dopaminergic IMP
IMP: 通过突变表型推断
12604788 MGI
involved in visual perception IMP
IMP: 通过突变表型推断
16445854 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
15814794 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
10707987 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
12074840 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15643613 MGI
located in perikaryon IDA
IDA: 通过直接分析推断
10350535 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
30936473 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine 3-monooxygenase

tyrosine 3-hydroxylase

重组 Th 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73563 Tyrosine Hydroxylase Protein, Mouse (sf9, His) P24529 (P2-S498) ≥95%

相关产品

Approval
生物活性分子 (8)
目录号 产品名 作用方式
纯度 是否罕见病
HY-N0394 L-Cystine ≥98.0% 否
HY-107916 Thyrotropin / 否
HY-B0976 Fenoterol Agonist 99.08% 否
HY-B0976A Fenoterol hydrobromide Agonist 99.90% 否
HY-109520 Glatiramer acetate ≥98.0% 否
HY-17002 Suplatast (Tosilate) Inhibitor 98.33% 否
HY-B0976AR Fenoterol hydrobromide (Standard) Agonist / 否
HY-N7454 Anhydroerythromycin A Inhibitor / 否
抗体抑制剂 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99025 Lebrikizumab Inhibitor 99.90% 否
HY-P99396 Spesolimab Inhibitor 99.10% 否
HY-P99256 Tildrakizumab Antagonist 99.46% 否
Clinical Phase
生物活性分子 (13)
目录号 产品名 作用方式
纯度 Phase
HY-10535 Evofosfamide Inducer ≥98.0% Phase 3
HY-148074 Zelnecirnon Inhibitor 99.84% Phase 2
HY-N0095 (S)-10-Hydroxycamptothecin 99.38% Phase 2
HY-124573 OBI-3424 99.23% Phase 2
HY-15342 Timapiprant Antagonist 99.48% Phase 2
HY-118250 GSK2245035 99.85% Phase 2
HY-17632 Tarloxotinib bromide Inhibitor 99.26% Phase 2
HY-15342A Timapiprant sodium Inhibitor 99.61% Phase 2
HY-114141 BI-671800 Antagonist 99.36% Phase 2
HY-103637A Vimirogant hydrochloride Inhibitor 98.39% Phase 2
HY-12284 NVP-QAV680 Antagonist / Phase 2
HY-103637 Vimirogant Inhibitor / Phase 2
HY-150298 Soquelitinib Inhibitor 99.71% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P990090 Rademikibart Inhibitor 98.69% Phase 3
Pre-clinical Phase
生物活性分子 (165)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153808 Complete Freund's adjuvant (CFA) / 否
HY-15826 SGC-CBP30 Inhibitor 99.83% 否
HY-101092 QS-21 Activator 99.67% 否
HY-125801 3-Oxo-5β-cholanoic acid Inhibitor 99.37% 否
HY-116961 TH1020 99.60% 否
HY-12776 GSK805 Inhibitor 98.01% 否
HY-126360 Oxazolone ≥98.0% 否
HY-125276 TH5487 Inhibitor 98.76% 否
HY-123604 TH1834 99.60% 否
HY-147313 TH10785 Activator 99.93% 否
HY-134771 YM-341619 Inhibitor 99.06% 否
HY-106224B Orexin A (human, rat, mouse) (acetate) Agonist 99.93% 否
HY-111818 TH34 Inhibitor 99.52% 否
HY-N2279 Kurarinone 99.47% 否
HY-108522 PA452 Antagonist ≥99.0% 否
HY-122818 bpV(phen) trihydrate ≥98.0% 否
HY-12814 TH588 Inhibitor 99.20% 否
HY-123604A TH1834 dihydrochloride 99.68% 否
HY-122630 TH-257 Inhibitor 98.01% 否
HY-W011220 Ciglitazone Agonist 98.89% 否
HY-17442 Azathramycin Inhibitor 99.85% 否
HY-16965 TH287 Inhibitor 98.29% 否
HY-G0017 N-Desmethyl imatinib 99.16% 否
HY-P3993A (Gly14)-Humanin (human) (acetate) Inhibitor 99.86% 否
HY-155950 TH9619 99.33% 否
HY-101392 Harmane Inhibitor 99.91% 否
HY-120000 MS402 Inhibitor 99.62% 否
HY-N0592A Demethyleneberberine chloride 98.93% 否
HY-N4084 Thonningianin A Inducer 99.73% 否
HY-150168 TH-Z145 Inhibitor 95.50% 否
HY-125209 TH5427 99.92% 否
HY-P1907 Human Papillomavirus (HPV) E7 protein (49-57) 98.92% 否
HY-138113 Pyrrothiogatain 96.77% 否
HY-145848 ERRγ agonist-1 Agonist 98.70% 否
HY-150167 TH-Z93 Inhibitor 99.00% 否
HY-100750 Norverapamil hydrochloride Inhibitor 99.80% 否
HY-135909 TH1217 Modulator 99.73% 否
HY-139780 JNJ-61803534 Inhibitor 99.88% 否
HY-144200 CCR8 antagonist 2 Antagonist 99.71% 否
HY-W677684 Nurr1 agonist 2 Agonist 99.27% 否
HY-153808B Complete Freund's adjuvant (CFA, 1 mg/ml) / 否
HY-N6636 Valencene Inhibitor ≥70.0% 否
HY-P1252 Parathyroid Hormone (1-34), bovine Agonist 99.04% 否
HY-W010520 Methylisothiazolinone 99.37% 否
HY-123468 HA-1004 Inhibitor 99.03% 否
HY-125390 SM-360320 Agonist 98.07% 否
HY-151539 TH470 Inhibitor 99.57% 否
HY-161296 TH6342 Inhibitor 98.90% 否
HY-16668 Tyrphostin A1 Inhibitor 98.96% 否
HY-142938 RORγt agonist 3 Agonist 98.12% 否
HY-91018 Trimethyl[3-(trimethoxysilyl)propyl]ammonium (chloride), 50% in methanol / 否
HY-W019901 Anhydrous calcium sulfate (with indicator, 4 mesh) ≥99.0% 否
HY-120574 TH1338 Inhibitor 98.77% 否
HY-120785 SR1555 Antagonist 99.69% 否
HY-130353 Desethylamiodarone hydrochloride ≥99.0% 否
HY-136065 bpV(phen) ≥98.0% 否
HY-B0976AS Fenoterol-d6 hydrobromide Agonist 95.32% 否
HY-N0592 Demethyleneberberine ≥98.0% 否
HY-W338247 Imidaclothiz 98.04% 否
HY-113238F FITC-Lithocholic acid 3-sulfate 90.01% 否
HY-W763582 GelMA, 30% methacrylation / 否
HY-131272 Febuxostat dicarboxylic acid impurity 98.76% 否
HY-138115 7ß,27-Dihydroxycholesterol Activator ≥99.0% 否
HY-145809 FASN-IN-5 Inhibitor 99.81% 否
HY-146243 TH-Z835 99.58% 否
HY-158694A TLR7 agonist 20 hydrochloride Agonist 99.86% 否
HY-159102 PVP-037.2 Agonist / 否
HY-N10534 Lewis X trisaccharide Inhibitor ≥99.0% 否
HY-N7501 Isoformononetin Inhibitor 99.60% 否
HY-P5333A Aβ1-14-εK-KKK-MvF5 Th acetate Inhibitor 99.93% 否
HY-W002291 p-Fluoro-L-phenylalanine 99.91% 否
HY-128353 ROR agonist-1 Antagonist / 否
HY-159507 Brezivaptan / 否
HY-125209A TH5427 hydrochloride Inhibitor / 否
HY-126252 A-9758 Inhibitor / 否
HY-130243 RORγt Inverse agonist 6 Antagonist 98.97% 否
HY-142806 RORγt inverse agonist 26 / 否
HY-160040A Cobitolimod sodium Agonist / 否
HY-130353S Desethyl Amiodarone-d4 hydrochloride / 否
HY-100801 L-threo-3-Hydroxyaspartic acid 98.80% 否
HY-110295 SPL-334 Inhibitor / 否
HY-112348 HA-1004 hydrochloride Inhibitor / 否
HY-116890 CRTh2 antagonist 4 / 否
HY-118250A GSK2245035 maleate / 否
HY-120225 NJK14047 Inhibitor / 否
HY-120785A SR1555 hydrochloride Antagonist / 否
HY-125693 L685818 Inhibitor / 否
HY-126037 (±)-ML 209 Antagonist 99.87% 否
HY-130353R Desethylamiodarone hydrochloride (Standard) / 否
HY-131279 Olmesartan ethyl ester / 否
HY-132828 Odatroltide Inhibitor / 否
HY-132851 Corixetan / 否
HY-135101 Methotrexate γ-Methyl Ester / 否
HY-135773 CRTh2 antagonist 3 / 否
HY-135810S Cletoquine-d4 Inhibitor / 否
HY-135810S1 Cletoquine-d4-1 Inhibitor / 否
HY-135843 TH-263 / 否
HY-137292 PTB7-Th / 否
HY-139193 TH1760 / 否
HY-142703 RORγt inverse agonist 28 Inhibitor / 否
HY-142937 RORγt agonist 2 Agonist / 否
HY-143885 JAK1/TYK2-IN-3 Inhibitor / 否
HY-145491 Resolvin D5 / 否
HY-145577 Lafadofensine / 否
HY-149029 TH-6 95.00% 否
HY-153662 TH-Z816 Inhibitor / 否
HY-153663 TH-Z827 Inhibitor / 否
HY-155219 TH9028 Inhibitor / 否
HY-155487 JTE-151 Inhibitor / 否
HY-155505 AHR agonist 4 Agonist / 否
HY-155680 BET BD2-IN-1 Inhibitor / 否
HY-157020 UniPR1449 Antagonist / 否
HY-157918 Carboxy-EG6-hexadecanethiol / 否
HY-157921 Amino-EG6-undecanethiol hydrochloride / 否
HY-158217 GelMA, 30% methacrylation, Green Fluorescent / 否
HY-158217A GelMA, 60% methacrylation, Green Fluorescent / 否
HY-158217B GelMA, 90% methacrylation, Green Fluorescent / 否
HY-158218 GelMA, 30% methacrylation, Red Fluorescent / 否
HY-158694 TLR7 agonist 20 Agonist / 否
HY-159183 THP-NCS / 否
HY-159184 THP-Mal / 否
HY-160040 Cobitolimod Agonist / 否
HY-161255 3,4-DAA Inhibitor / 否
HY-162490 TF-S14 Inhibitor / 否
HY-162727 GCS-12 / 否
HY-163704 KRN7000 analog 1 / 否
HY-163801 Nurr1 agonist 9 Agonist / 否
HY-164454 AJI-100 Inhibitor / 否
HY-164455 AJI-214 Inhibitor / 否
HY-166863 L-erythro-Sphingosine(synthetic) / 否
HY-167571 12:0 Diether PC / 否
HY-167692 JI069 / 否
HY-B0432AS3 Propafenone-d5 (hydrochloride)(Ethyl) Inhibitor / 否
HY-D1527 N-(3-Fluoranthenyl)maleimide / 否
HY-E70084 Tth DNA polymerase / 否
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin / 否
HY-N6636R Valencene (Standard) Inhibitor / 否
HY-N7501S Isoformononetin-d3 98.64% 否
HY-N7512 Asimilobine / 否
HY-P1052 Myelin Basic Protein(87-99) / 否
HY-P1252A Parathyroid Hormone (1-34), bovine TFA Agonist / 否
HY-P3993 (Gly14)-Humanin (human) Inhibitor / 否
HY-P4790 Acetyl-Exenatide Inhibitor / 否
HY-RS14467 TH Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W010520R Methylisothiazolinone (Standard) / 否
HY-W013718 TTHA / 否
HY-W018829 10-Undecenal 97.96% 否
HY-W019901D Anhydrous calcium sulfate (with indicator, 10-20 mesh) / 否
HY-W282259 PTH-tyrosine / 否
HY-W763582A GelMA, 60% methacrylation / 否
HY-112863 RORγt inhibitor 3 Inhibitor / 否
HY-118428 Fluenetil / 否
HY-122349 Lotrifen / 否
HY-123568 PBI-1393 / 否
HY-12814A TH588 hydrochloride Inhibitor / 否
HY-138143 N-(p-Tosyl)-GPR-pNA acetate / 否
HY-16965A TH287 hydrochloride Inhibitor / 否
HY-N3548 Catalpalactone Inhibitor / 否
HY-P10463 ssK36 Inhibitor / 否
HY-W019901C Anhydrous calcium sulfate (with indicator, 8 mesh) / 否
HY-W098047 Dimethyl octadecanedioate / 否
HY-W140401 Dimethyl nonanedioate / 否
HY-W763582B GelMA, 90% methacrylation / 否
HY-11054 TH-237A 98.55% 否
HY-101871 Trehalose 6-behenate / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Th NCBI NCBI:7054
Canis familiaris Th NCBI NCBI:403444
Felis catus Th NCBI NCBI:101090720
Macaca fascicularis Th NCBI NCBI:102134074
Canis lupus familiaris Th NCBI
Susscrofa domestica Th NCBI
Leporidae Th NCBI
Rattus norvegicus Th NCBI NCBI:25085
Macaca mulatta Th NCBI NCBI:721137
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