2. Gene
  3. ALK - ALK receptor tyrosine kinase Gene

ALK - ALK receptor tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ALK 受体酪氨酸激酶

种属: Rattus norvegicus

基因 ID: 266802 | 基因类型: protein coding

关于 ALK

Primary_assembly 6: 22,880,625-23,598,034 forward strand.mRatBN7.2:CM026979.1

This gene has 1 transcript (splice variant), 195 orthologues, 54 paralogues and is associated with 20 phenotypes. Biased expression in Brain (RPKM 8.9), Spleen (RPKM 2.9) and 4 other tissues.

功能概要

预测该基因编码的蛋白可实现相同的蛋白结合活性和跨膜受体蛋白酪氨酸激酶活性。参与神经系统发育。预测位于质膜中。预计是受体复合体的一部分。预计是质膜的组成部分。与人类 ALK（ALK 受体酪氨酸激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable identical protein binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in nervous system development. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Orthologous to human ALK (ALK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

ALK 基因产物(1)

mRNA Protein Name
NM_001169101.3 NP_001162572.1 ALK tyrosine kinase receptor precursor

ALK 蛋白结构

MAM

MAM: cl27660 (269 - 427)

MAM

MAM: pfam00629 (483 - 638)

PTKc_ALK_LTK

PTKc_ALK_LTK: cd05036 (1112 - 1388)

PRK12323

PRK12323: cl36108 (1406 - 1575)

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  • 1617 a.a.
蛋白主名 其他名称

ALK tyrosine kinase receptor

ALK tyrosine kinase receptor-like

anaplastic lymphoma kinase

anaplastic lymphoma receptor tyrosine kinase

相关产品

Approval
生物活性分子 (17)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50878 Crizotinib 99.97% 是
HY-12215 Lorlatinib 99.92% 是
HY-15656 Ceritinib Inhibitor 99.98% 是
HY-12678 Entrectinib 99.79% 是
HY-13011 Alectinib Inhibitor 99.78% 是
HY-12857 Brigatinib Inhibitor 99.98% 是
HY-103022 Repotrectinib Inhibitor 99.90% 否
HY-15656A Ceritinib dihydrochloride Inhibitor 99.57% 是
HY-13011A Alectinib Hydrochloride Inhibitor 99.92% 是
HY-50878A Crizotinib hydrochloride 99.86% 是
HY-103714A Ensartinib dihydrochloride Inhibitor 99.51% 否
HY-145574 Iruplinalkib Inhibitor 99.29% 否
HY-100375 Diroximel fumarate Activator 99.90% 是
HY-103714 Ensartinib Inhibitor 99.93% 否
HY-123689 Samidorphan 99.04% 否
HY-12215R Lorlatinib (Standard) 99.92% 否
HY-50878B Crizotinib acetate Inhibitor / 否
Clinical Phase
生物活性分子 (13)
目录号 产品名 作用方式
纯度 Phase
HY-16590 X-376 Inhibitor 98.10% Phase 3
HY-19928 Vactosertib Inhibitor 99.58% Phase 2
HY-139279 Zotizalkib Inhibitor 98.02% Phase 2
HY-103021 LY3200882 Inhibitor 99.86% Phase 2
HY-109084 Conteltinib Inhibitor 99.0% Phase 2
HY-109179 Itacnosertib Inhibitor 99.06% Phase 2
HY-17603 Belizatinib Inhibitor 99.64% Phase 2
HY-136788 ALK4290 Inhibitor 99.79% Phase 2
HY-15841 CEP-37440 Inhibitor 99.91% Phase 1
HY-155163 APG-2449 Inhibitor 98.93% Phase 1
HY-135366 HPN-01 Inhibitor 98.61% Phase 1
HY-13326 ASP3026 99.88% Phase 1
HY-142287 Con B-1 Inhibitor / Phase 1
抗体抑制剂 (3)
目录号 产品名 作用方式
纯度 Phase
HY-P99353 Ascrinvacumab Inhibitor 97.45% Phase 2
HY-P99752 Nemvaleukin alfa 99.50% Phase 2
HY-P990022 Prafnosbart Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (215)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10431 SB-431542 Inhibitor 99.85% 否
HY-13418A Dorsomorphin Inhibitor 99.91% 否
HY-10432 A 83-01 Inhibitor 99.41% 否
HY-13418 Dorsomorphin dihydrochloride Inhibitor 99.91% 否
HY-12071 LDN193189 Inhibitor 99.48% 否
HY-13012 RepSox Inhibitor 99.92% 否
HY-12273 DMH-1 Inhibitor 99.95% 否
HY-12043 SB 525334 Inhibitor 99.97% 否
HY-131442 Alkyne-phenol 99.45% 否
HY-12071A LDN193189 Tetrahydrochloride Inhibitor 99.86% 否
HY-10432A A 83-01 sodium Inhibitor 98.43% 否
HY-12071B LDN-193189 dihydrochloride Inhibitor 99.75% 否
HY-13521 SB-505124 Inhibitor 99.99% 否
HY-W040304 Alkynyl Palmitic Acid ≥97.0% 否
HY-10192 NVP-TAE 684 99.27% 否
HY-13227 SD-208 Inhibitor 99.87% 否
HY-16712 LDN-214117 Inhibitor 99.92% 否
HY-10326 GW788388 Inhibitor 99.92% 否
HY-15897 LDN-212854 Inhibitor 99.70% 否
HY-112155 MS4078 Inhibitor 99.72% 否
HY-13020 GSK1838705A Inhibitor 99.21% 否
HY-12274 ML347 Inhibitor 99.94% 否
HY-12953 R-268712 Inhibitor 99.88% 否
HY-15609 AZD-3463 99.58% 否
HY-12278 K02288 Inhibitor 99.73% 否
HY-19928A Vactosertib Hydrochloride Inhibitor 99.22% 是
HY-153386 CPD-1224 Inhibitor 99.24% 否
HY-111482 SM 16 Inhibitor 99.82% 否
HY-19628 OD36 Inhibitor 98.70% 否
HY-123919 TL13-112 Inhibitor 98.15% 否
HY-18758 IN-1130 Inhibitor 99.93% 否
HY-13012G RepSox (GMP) Inhibitor / 否
HY-144043 ALK5-IN-8 Inhibitor 98.06% 否
HY-156467 Neladalkib 99.90% 否
HY-13464 ALK-IN-1 Inhibitor 99.94% 否
HY-18766 EW-7195 Inhibitor 99.20% 否
HY-118528A TP0427736 hydrochloride Inhibitor 99.22% 否
HY-122856 AZ12601011 Inhibitor 99.88% 否
HY-145608 Zilurgisertib Inhibitor 99.77% 否
HY-78349 A 77-01 Inhibitor 99.92% 否
HY-12678S1 Entrectinib-d8 99.82% 否
HY-148234 M4K2234 Inhibitor 98.71% 否
HY-150169 THRX-144644 Inhibitor 99.90% 否
HY-19990 ALK kinase inhibitor-1 Inhibitor 99.87% 否
HY-10431R SB-431542 (Standard) Inhibitor / 否
HY-12331 KRCA-0008 96.19% 否
HY-18030A CEP-28122 mesylate salt Inhibitor 99.08% 否
HY-112815 ALK2-IN-2 Inhibitor 99.93% 否
HY-147219A SIAIS164018 hydrochloride 99.84% 否
HY-152845 Ficonalkib Inhibitor 98.55% 否
HY-136773A KER047 succinate Inhibitor 98.93% 否
HY-15801 HG-14-10-04 Inhibitor 99.09% 否
HY-160506 PRO-6E 99.85% 否
HY-50878S Crizotinib-d5 99.60% 否
HY-122582 TL13-12 Inhibitor 98.06% 否
HY-10432G A 83-01 (GMP) Inhibitor / 否
HY-117887 Fidrisertib Inhibitor 96.11% 否
HY-160520 ALK-IN-28 Inhibitor 99.30% 否
HY-13521A SB-505124 hydrochloride Inhibitor 99.34% 否
HY-125851 TP-008 Inhibitor 99.42% 否
HY-112156 MS4077 Inhibitor 99.66% 否
HY-10327 GW-6604 Inhibitor ≥98.0% 否
HY-109179A Itacnosertib (hydrocholide) Inhibitor 99.43% 否
HY-15358 ALK inhibitor 2 Inhibitor 99.57% 否
HY-156467A Neladalkib TFA / 否
HY-136773 KER047 Inhibitor 99.35% 否
HY-12273R DMH-1 (Standard) Inhibitor / 否
HY-151289 ALK5-IN-34 Inhibitor 98.21% 否
HY-15357 ALK inhibitor 1 Inhibitor 99.62% 否
HY-N4126 6-Demethoxytangeretin Inhibitor 99.37% 否
HY-112801 F-1 Inhibitor 98.03% 否
HY-109084A Conteltinib tetrahydrochloride Inhibitor / 否
HY-13783 BIBF0775 Inhibitor 99.53% 否
HY-163807 22-SLF Degrader / 否
HY-N4107 Phyllanthin Inhibitor 99.96% 否
HY-111752 EML4-ALK kinase inhibitor 1 Inhibitor 98.02% 否
HY-112140 JH-VIII-157-02 Inhibitor 99.67% 否
HY-147219 SIAIS164018 / 否
HY-12678S Entrectinib-d4 Inhibitor / 否
HY-135887 ZX-29 99.52% 否
HY-136194 TL13-22 Inhibitor 99.71% 否
HY-15656S Ceritinib-d7 Inhibitor 98.00% 否
HY-E70357 Alkaline Phosphatase (ALP), Human Placental / 否
HY-123689S Samidorphan-d4 / 否
HY-123689S1 Samidorphan-d5 Antagonist / 否
HY-13956S1 Pioglitazone-d4 (alkyl) 98.55% 否
HY-RS00598 ALK Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-18030 CEP-28122 Inhibitor / 否
HY-128569 ALK-IN-5 Inhibitor / 否
HY-128596 ALK-IN-6 Inhibitor / 否
HY-129171 TGFBR1-IN-1 Inhibitor / 否
HY-132229 LPM4870108 Inhibitor / 否
HY-135509 Lorlatinib acetate / 否
HY-159147 SIA​​IS039 / 否
HY-131909 CJ-2360 Inhibitor / 否
HY-10432R A 83-01 (Standard) Inhibitor / 否
HY-108230 ALK-IN-12 Inhibitor / 否
HY-110347 Mps1-IN-1 dihydrochloride Inhibitor / 否
HY-112877 ALK-5-IN-1 Inhibitor / 否
HY-120387 SMU-B Inhibitor / 否
HY-120663 KRCA-0713 Inhibitor / 否
HY-12215S2 Deulorlatinib / 否
HY-12857S Brigatinib-13C6 Inhibitor / 否
HY-12973 ALK-IN-13 Inhibitor / 否
HY-13011S Alectinib-d8 Inhibitor / 否
HY-13011S1 Alectinib-d6 Inhibitor / 否
HY-130794 ALK/ROS1-IN-1 Inhibitor / 否
HY-131244 ALK-IN-9 Inhibitor / 否
HY-136195 TL13-110 Inhibitor / 否
HY-136788A ALK4290 dihydrochloride Inhibitor / 否
HY-137918 TGF-βRI inhibitor 3 Inhibitor / 否
HY-142949 ALK5-IN-7 Inhibitor / 否
HY-142950 ALK5-IN-6 Inhibitor / 否
HY-143557 Trk-IN-7 Inhibitor / 否
HY-144423 Trk-IN-10 Inhibitor / 否
HY-144437 ALK5-IN-9 Inhibitor / 否
HY-144732 TRK/ALK-IN-1 Inhibitor / 否
HY-145855 J-1063 Inhibitor / 否
HY-146022 SIAIS117 Inhibitor / 否
HY-146408 ALK-IN-21 Inhibitor / 否
HY-146694 RIPK2-IN-1 Inhibitor / 否
HY-146780 TGFβRI-IN-4 Inhibitor / 否
HY-147206 Biotin-PEG-Alk (MW 600) / 否
HY-147206A Biotin-PEG-Alk (MW 1000) / 否
HY-147206B Biotin-PEG-Alk (MW 2000) / 否
HY-147206C Biotin-PEG-Alk (MW 3400) / 否
HY-147206D Biotin-PEG-Alk (MW 5000) / 否
HY-147206E Biotin-PEG-Alk (MW 10000) / 否
HY-147206F Biotin-PEG-Alk (MW 20000) / 否
HY-147833 ALK-IN-22 / 否
HY-148246 MU1700 Inhibitor / 否
HY-149403 J-1048 Inhibitor / 否
HY-151155 ALK-IN-23 Inhibitor / 否
HY-151233 ALK5-IN-10 Inhibitor / 否
HY-151270 ALK5-IN-25 Inhibitor / 否
HY-151272 ALK5-IN-26 Inhibitor / 否
HY-151273 ALK5-IN-27 Inhibitor / 否
HY-151275 ALK5-IN-28 Inhibitor / 否
HY-151277 ALK5-IN-29 Inhibitor / 否
HY-151279 ALK5-IN-30 Inhibitor / 否
HY-151281 ALK5-IN-31 Inhibitor / 否
HY-151282 ALK5-IN-32 Inhibitor / 否
HY-151283 ALK5-IN-33 Inhibitor / 否
HY-153246 ALK2-IN-5 Inhibitor / 否
HY-155227 ALK/EGFR-IN-1 / 否
HY-155227A ALK/EGFR-IN-2 Inhibitor / 否
HY-155227B ALK/EGFR-IN-3 Inhibitor / 否
HY-155227S ALK/EGFR-IN-1-d5 / 否
HY-155939 M4K2163 dihydrochloride Inhibitor / 否
HY-156432 ALK-IN-26 99.87% 否
HY-156470 Multi-kinase-IN-6 / 否
HY-157391 ALK/ROS1-IN-3 Inhibitor / 否
HY-159952 ALK5-IN-84 Inhibitor / 否
HY-160237 HYL001 Inhibitor / 否
HY-161350 ALK/HDAC-IN-1 Inhibitor / 否
HY-161376 M4K2281 Inhibitor / 否
HY-161377 M4K2306 Inhibitor / 否
HY-161662 ALK5-IN-80 Inhibitor / 否
HY-161749 PROTAC ALK degrader-1 Degrader / 否
HY-161750 PROTAC ALK degrader-2 Degrader / 否
HY-161910 SH-E4A-66 Inhibitor / 否
HY-163429 J-1149 Inhibitor / 否
HY-163507 ALK5-IN-79 Inhibitor / 否
HY-164397 XMU-MP-5 / 否
HY-167388 PLLA5000-PEG5000-ALK / 否
HY-167389 PLLA5000-PEG3000-ALK / 否
HY-167390 PLLA5000-PEG2000-ALK / 否
HY-167391 PLLA5000-PEG1000-ALK / 否
HY-167392 PLLA4000-PEG5000-ALK / 否
HY-167393 PLLA4000-PEG3000-ALK / 否
HY-167394 PLLA4000-PEG2000-ALK / 否
HY-167395 PLLA4000-PEG1000-ALK / 否
HY-167396 PLLA3000-PEG5000-ALK / 否
HY-167397 PLLA3000-PEG3000-ALK / 否
HY-167398 PLLA3000-PEG2000-ALK / 否
HY-167399 PLLA3000-PEG1000-ALK / 否
HY-167400 PLLA2000-PEG5000-ALK / 否
HY-167401 PLLA2000-PEG3000-ALK / 否
HY-167402 PLLA2000-PEG2000-ALK / 否
HY-167403 PLLA2000-PEG1000-ALK / 否
HY-167404 PLLA1000-PEG5000-ALK / 否
HY-167405 PLLA1000-PEG3000-ALK / 否
HY-167406 PLLA1000-PEG2000-ALK / 否
HY-167407 PLLA1000-PEG1000-ALK / 否
HY-167408 PLLA10000-PEG5000-ALK / 否
HY-167409 PLLA10000-PEG3000-ALK / 否
HY-167410 PLLA10000-PEG2000-ALK / 否
HY-167864 M4K2308 Inhibitor / 否
HY-168513 ALK-IN-29 Inhibitor / 否
HY-168551 PROTAC ALK degrader-3 Degrader / 否
HY-168552 3-Hydroxyazetidine-Cyclohexanol / 否
HY-168553 3-Hydroxyazetidine-Cyclohexanol-5-Aminothalidomide / 否
HY-168607 ALK5-IN-83 Inhibitor / 否
HY-169482 ALK protein ligand-1 Inhibitor / 否
HY-170418 ALK/ROS1-IN-5 / 否
HY-170592 dALK-3 Degrader / 否
HY-170928 DA-0157 Inhibitor / 否
HY-19628A OD36 hydrochloride Inhibitor / 否
HY-50878AS Crizotinib-d9 hydrochloride / 否
HY-E70034 Galactokinase (BiGalK) / 否
HY-N0679S Retinyl acetate-d3 / 否
HY-RS00599 Alk Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00600 ALK Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W707119 RepSox hydrochloride Inhibitor / 否
HY-118528 TP0427736 Inhibitor / 否
HY-14243 CEP-14083 Inhibitor / 否
HY-158905 MTDB-Alkyne Degrader / 否
HY-160172 ALK/ROS1-IN-4 Inhibitor / 否
HY-160172A ALK/ROS1-IN-4 hydrate Inhibitor / 否
HY-162902 ALK5-IN-82 Inhibitor / 否
HY-168163 CDK12/13 ligand 1 Degrader / 否
HY-169481 AP-1 Degrader / 否
HY-18030B CEP-28122 mesylate hydrochloride Inhibitor / 否
HY-W814315 Alectinib analog / 否
HY-111416 WY-135 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ALK NCBI NCBI:238
Canis familiaris ALK NCBI NCBI:483021
Macaca fascicularis ALK NCBI NCBI:102128455
Mus musculus ALK NCBI NCBI:11682
Macaca mulatta ALK NCBI NCBI:704823
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