2. Gene
  3. Brd4 - bromodomain containing 4 Gene

Brd4 - bromodomain containing 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含溴结构域 4

种属: Mus musculus

同用名: Brd5; MCAP; HUNK1; WI-11513

基因 ID: 57261 | 基因类型: protein coding

关于 Brd4

Chromosome 17: 32,415,248-32,503,696 reverse strand.GRCm39:CM001010.3

This gene has 12 transcripts (splice variants), 66 orthologues, 11 paralogues and is associated with 41 phenotypes. Ubiquitous expression in thymus adult (RPKM 17.8), spleen adult (RPKM 13.4) and 28 other tissues.

功能概要

该基因暂时命名为 bromodomain-containing 5 (Brd5)，并更名为 bromodomain-containing 4 (Brd4)。 [RefSeq 提供，2008 年 7 月]

This gene was temporarily named bromodomain-containing 5 (Brd5) and was renamed bromodomain-containing 4 (Brd4). [provided by RefSeq, Jul 2008]

Brd4 基因产物(3)

mRNA Protein Name
NM_198094.2 NP_932762.2 bromodomain-containing protein 4 isoform 2
NM_001286630.1 NP_001273559.1 bromodomain-containing protein 4 isoform 3
NM_020508.4 NP_065254.3 bromodomain-containing protein 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
16109376 MGI
enables GTP-dependent protein kinase activity IDA
IDA: 通过直接分析推断
22509028 MGI
enables RNA polymerase II C-terminal domain binding IPI
IPI: 通过物理相互作用推断
22509028 MGI
enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
IDA: 通过直接分析推断
22509028 MGI
enables RNA polymerase II CTD heptapeptide repeat kinase activity IMP
IMP: 通过突变表型推断
22509028 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
23154982 MGI
enables lysine-acetylated histone binding IDA
IDA: 通过直接分析推断
29379197 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16109376 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within chromosome segregation IMP
IMP: 通过突变表型推断
16339075 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: 通过突变表型推断
11997514 MGI
acts upstream of or within positive regulation of DNA binding IDA
IDA: 通过直接分析推断
16109376 MGI
involved in positive regulation of T-helper 17 cell lineage commitment IMP
IMP: 通过突变表型推断
28262505 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: 通过直接分析推断
22509028 MGI
acts upstream of or within protein phosphorylation IPI
IPI: 通过物理相互作用推断
16109376 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
16339075 MGI
located in condensed nuclear chromosome IDA
IDA: 通过直接分析推断
10938129 MGI
part of cyclin/CDK positive transcription elongation factor complex IDA
IDA: 通过直接分析推断
23752591 MGI
NOT located in nucleolus IDA
IDA: 通过直接分析推断
16109376 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10938129 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Brd4 蛋白结构

Bromo_Brdt_I_like

Bromo_Brdt_I_like: cd05497 (57 - 163)

Bromo_Brdt_II_like

Bromo_Brdt_II_like: cd05498 (353 - 454)

BET

BET: pfam17035 (609 - 673)

PHA03247

PHA03247: cl33720 (791 - 1229)

TPH

TPH: cl38442 (1263 - 1306)

BRD4_CDT

BRD4_CDT: pfam17105 (1357 - 1399)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1400 a.a.
蛋白主名 其他名称

bromodomain-containing protein 4

bromodomain-containing 5

fsh-like protein

mitotic chromosome-associated protein

Brd4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Brd4 Q9ESU6 RELA Homo sapiens Q04206
Pull Down
19103749
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-111916 ODM-207 Inhibitor 99.58% Phase 2
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
Pre-clinical Phase
生物活性分子 (121)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100972 ARV-771 Inhibitor 99.87% 否
HY-101838 dBET1 Inhibitor 99.24% 否
HY-136570 GSK778 Inhibitor 98.93% 否
HY-122826 ZXH-3-26 Inhibitor 98.90% 否
HY-12863 Pelabresib Inhibitor 99.95% 否
HY-14443 XMD8-92 Inhibitor 99.67% 否
HY-136571 GSK046 Inhibitor 99.65% 否
HY-123941 FKBP12 PROTAC dTAG-7 Inhibitor 99.07% 否
HY-100482 CPI-637 Inhibitor 99.94% 否
HY-114305 A1874 Inhibitor 99.70% 否
HY-107443 I-BET762 carboxylic acid Inhibitor 99.55% 否
HY-19999A PF-CBP1 hydrochloride Inhibitor 99.99% 否
HY-101519 BETd-260 Inhibitor 99.59% 否
HY-129937A GNE-987 Inhibitor 99.91% 否
HY-120028 GNE-207 Inhibitor 97.02% 否
HY-103632 PROTAC BRD9 Degrader-1 Inhibitor / 否
HY-123844 dBET57 Inhibitor 99.94% 否
HY-141438 SIM1 Inhibitor 99.57% 否
HY-133737 PROTAC BRD4 Degrader-5 Inhibitor 99.93% 否
HY-110374 NVS-CECR2-1 Inhibitor 99.40% 否
HY-125232 MS645 ≥98.0% 否
HY-101146 SF2523 Inhibitor 98.25% 否
HY-112429 HJB97 Inhibitor 98.05% 否
HY-126428 ZL0580 Modulator 99.26% 否
HY-120000 MS402 Inhibitor 99.62% 否
HY-138563 GSK973 Inhibitor 99.97% 否
HY-114204 GSK8814 Inhibitor 99.60% 否
HY-156828 MMH2 Degrader 98.03% 否
HY-112609 QCA570 Inhibitor 99.95% 否
HY-117491 BRD4 Inhibitor-10 Inhibitor 99.52% 否
HY-129917 KB02-JQ1 Inhibitor 99.17% 否
HY-111102 FL-411 Inhibitor 99.05% 否
HY-130622 LT052 Inhibitor 98.77% 否
HY-136920 CBP/p300-IN-8 Inhibitor 99.94% 否
HY-133131 PROTAC BRD4 Degrader-1 Inhibitor 99.12% 否
HY-114504 RVX-297 Inhibitor 95.00% 否
HY-161515 BRD4/NAMPT-IN-1 Inhibitor 99.45% 否
HY-107442 PROTAC BRD4-binding moiety 1 / 否
HY-112376 MZP-54 Inhibitor 98.16% 否
HY-112610 CF53 Inhibitor 99.78% 否
HY-148864 JQ1-TCO Inhibitor 99.95% 否
HY-156827 MMH1 Degrader 98.08% 否
HY-111875 SNIPER(BRD)-1 Inhibitor 99.43% 否
HY-114416 GS-626510 Inhibitor 99.80% 否
HY-111502 Y06036 Inhibitor 98.57% 否
HY-101121 NI-42 Inhibitor 99.53% 否
HY-147202 BRD4 Inhibitor-24 Inhibitor 99.27% 否
HY-146208 BRD4 Inhibitor-20 Inhibitor 99.00% 否
HY-160528 IBG3 Inhibitor 98.53% 否
HY-145260 BRD4/CK2-IN-1 Inhibitor 98.62% 否
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.91% 否
HY-142520 I-BET567 Inhibitor 99.49% 否
HY-158031 PLK1/BRD4-IN-5 Inhibitor 99.55% 否
HY-139148 UMB298 Inhibitor 99.11% 否
HY-129201 ZEN-2759 Inhibitor 99.45% 否
HY-145264 OARV-771 Inhibitor 98.33% 否
HY-148864A (Z)-JQ1-TCO Inhibitor 99.34% 否
HY-160557 PLK1/BRD4-IN-2 Inhibitor / 否
HY-160558 PLK1/BRD4-IN-3 Inhibitor 99.66% 否
HY-136857 BRD4 degrader-3 Degrader / 否
HY-111503 Y06137 Inhibitor 99.90% 否
HY-107425A cis-MZ 1 Degrader / 否
HY-114407 TD-428 Inhibitor / 否
HY-103297 OXFBD02 Inhibitor 98.04% 否
HY-110215 XD14 Inhibitor 95.02% 否
HY-161651 BRD4 ligand 6 / 否
HY-135236 OXFBD04 Inhibitor 98.99% 否
HY-146999 YM458 Inhibitor 99.16% 否
HY-111977 ZEN-3219 Inhibitor 99.75% 否
HY-100696 PNZ5 Inhibitor / 否
HY-133136 PROTAC BRD4 Degrader-2 Inhibitor / 否
HY-146660 BRD4 Inhibitor-18 Inhibitor / 否
HY-126325 BY27 Inhibitor / 否
HY-149806 Bromodomain IN-2 Inhibitor / 否
HY-149098 SJ1461 Inhibitor / 否
HY-136794 SB-284851-BT Inhibitor / 否
HY-163413 BRD4-BD1-IN-3 Inhibitor / 否
HY-169170 PARP1/BRD4-IN-3 Inhibitor / 否
HY-153519 WWL0245 Inhibitor / 否
HY-135558 PROTAC BRD4 Degrader-3 Inhibitor / 否
HY-169358 L134 Inhibitor / 否
HY-152213 BET-IN-13 Inhibitor / 否
HY-162240 SJH1-51B Degrader / 否
HY-150683 NC-III-49-1 Inhibitor / 否
HY-143300 BRD4-BD1-IN-2 Inhibitor / 否
HY-139294 PROTAC BRD4 Degrader-15 Inhibitor / 否
HY-150613 PARP1/BRD4-IN-2 Inhibitor / 否
HY-130612 PROTAC BRD2/BRD4 degrader-1 Inhibitor / 否
HY-163282 NB512 Inhibitor / 否
HY-157290 HL403 Inhibitor / 否
HY-161650 PROTAC BRD4 Degrader-26 Degrader / 否
HY-151972 BRD4 Inhibitor-25 Inhibitor / 否
HY-155680 BET BD2-IN-1 Inhibitor / 否
HY-147375 Bromodomain inhibitor-10 Inhibitor / 否
HY-142705 BRD4 D1-IN-2 Inhibitor / 否
HY-160662 BRD4-IN-5 Inhibitor / 否
HY-149100 PLK1-IN-6 Inhibitor / 否
HY-144338 PARP1/BRD4-IN-1 Inhibitor / 否
HY-163639 BRD4 degrader-2 Inhibitor / 否
HY-143328 PROTAC BRD4 Degrader-17 Degrader / 否
HY-161368 BRD-SF2 Degrader / 否
HY-147374 Bromodomain inhibitor-9 Inhibitor / 否
HY-143299 BRD4-BD1-IN-1 Inhibitor / 否
HY-143235 BRD4 Inhibitor-15 Inhibitor / 否
HY-143471 WNY0824 Inhibitor / 否
HY-157460 BRD4 Inhibitor-29 / 否
HY-131203 PROTAC BRD4 Degrader-6 Inhibitor / 否
HY-168634 SJ46421 Inhibitor / 否
HY-W265951 3-Methylcarbostyril Inhibitor / 否
HY-150684 GXH-II-052 Inhibitor / 否
HY-153945 BET-IN-15 Inhibitor / 否
HY-129937 (S)-GNE-987 Inhibitor / 否
HY-163638 BRD4 degrader-1 Degrader / 否
HY-104072 BRD4-IN-3 Inhibitor / 否
HY-158331 Gal-ARV-771 Degrader / 否
HY-132128 BRD4 Inhibitor-12 Inhibitor / 否
HY-132130 BRD4 Inhibitor-13 Inhibitor / 否
HY-136570A GSK778 hydrochloride Inhibitor / 否
HY-102044 BET-IN-2 Inhibitor / 否
HY-111979 ZEN-3411 Inhibitor / 否
HY-111978 ZEN-3862 Inhibitor 98.86% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Brd4 NCBI NCBI:23476
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