2. Gene
  3. GMPS - guanine monophosphate synthase Gene

GMPS - guanine monophosphate synthase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鸟嘌呤单磷酸合酶

种属: Homo sapiens

同用名: GATD7

基因 ID: 8833 | 基因类型: protein coding

关于 GMPS

Cytogenetic location: 3q25.31 Genomic coordinates (GRCh38): 3:155,869,430-155,944,020 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues and is associated with 60 phenotypes. Broad expression in testis (RPKM 20.3), thyroid (RPKM 6.3) and 25 other tissues.

功能概要

在嘌呤核苷酸的从头合成中，IMP 是分支点代谢物，在该点途径分支为鸟嘌呤或腺嘌呤核苷酸的合成。在鸟嘌呤核苷酸途径中，有 2 种酶参与将 IMP 转化为 GMP，即 IMP 脱氢酶 (IMPD1) ，催化 IMP 氧化为 XMP；GMP 合成酶，催化 XMP 胺化为 GMP。[RefSeq 提供，2008 年 7 月]

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 Enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

GMPS 基因产物(1)

mRNA Protein Name
NM_003875.3 NP_003866.1 GMP synthase [glutamine-hydrolyzing]
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GMP synthase (glutamine-hydrolyzing) activity EXP
EXP: 通过实验结果推断
7706277 GOA
enables GMP synthase (glutamine-hydrolyzing) activity IDA
IDA: 通过直接分析推断
8089153 GOA
enables GMP synthase activity IDA
IDA: 通过直接分析推断
8081953 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within GMP biosynthetic process IDA
IDA: 通过直接分析推断
8089153 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
8089153 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GMPS 蛋白结构

GATase

GATase: Glutamine amidotransferase class-I (29 - 208)

NAD_synthase

NAD_synthase: NAD synthase (224 - 302)

GMP_synt_C

GMP_synt_C: GMP synthase C terminal domain (493 - 692)

  • 0
  • 200
  • 400
  • 600
  • 693 a.a.
蛋白主名 其他名称

GMP synthase [glutamine-hydrolyzing]

GMP synthase

关联疾病

疾病名称 别名
Thiopurines, Poor Metabolism Of, 1

Thiopurine S-Methyltransferase Deficiency

Tpmt Deficiency

Thiopurine Methyltransferase Deficiency

Thiopurine S Methyltranferase Deficiency

THPM1

Tpmtd

Poor Metabolism Of Thiopurines-1

6-Mercaptopurine Sensitivity

Thiopurines, Poor Metabolism Of

Poor Metabolism Of Thiopurines
Orotic Aciduria

Hereditary Orotic Aciduria

Orotidylic Pyrophosphorylase And Orotidylic Decarboxylase Deficiency

Uridine Monophosphate Synthase Deficiency

Umps Deficiency

Uridine Monophosphate Synthetase Deficiency

Orotic Aciduria I

Orotate Phosphoribosyltransferase And Orotidylic Decarboxylase Deficiency

Oprt And Odc Deficiency

Ump Synthase Deficiency

Orotic Aciduria Ii

Oroticaciduria 1

Orotic Aciduria Hereditary

Orotic Aciduria Type 1

Hereditary Orotic Aciduria Without Megaloblastic Anemia

Orotate Phosphoribosyltransferase And Omp Decarboxylase Deficiency

Ump Synthtase Deficiency

Umps

Orotidylic Decarboxylase Deficiency

Orotic Aciduria 1

ORAC1

Aciduria, Orotic

Hereditary Orotic Aciduria, Type 1

Orotic Aciduria Nos

Orotaciduric Anaemia

Orotic Aciduria Anaemia

Orotic Aciduria Megaloblastic Anaemia
Pyrimidine Metabolic Disorder

Disorder Of Pyrimidine Metabolism

Pyrimidine Metabolism Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B1730 Phensuximide 99.35% 否
Clinical Phase
生物活性分子 (14)
目录号 产品名 作用方式
纯度 Phase
HY-101952G Prostaglandin E2 (GMP) / Phase 4
HY-15162G Monomethyl auristatin E (GMP) / Phase 4
HY-B0166GL L-Ascorbic acid (GMP Like) 99.88% Phase 4
HY-10219G Rapamycin (GMP) Inhibitor / Phase 4
HY-50895G Gefitinib (GMP) / Phase 4
HY-18085G Quercetin (GMP) / Phase 4
HY-13631AG Exatecan mesylate (GMP) Inhibitor / Phase 3
HY-14649G Retinoic acid (GMP) Agonist / Phase 3
HY-50751G Linifanib (GMP) Inhibitor / Phase 3
HY-13740G Resiquimod (GMP) Agonist / Phase 2
HY-17500 Ataciguat Activator 99.40% Phase 2
HY-B0166G L-Ascorbic acid (GMP) / Phase 2
HY-10254G Mirdametinib (GMP) Inhibitor / Phase 2
HY-15150G Bemcentinib (GMP) Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (167)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10182 Laduviglusib 99.76% 否
HY-114180 RU.521 Inhibitor 99.95% 否
HY-100564A 2',3'-cGAMP sodium Activator 99.89% 否
HY-100564 2',3'-cGAMP Activator 99.95% 否
HY-110385 cGAMP disodium Activator 99.34% 否
HY-133916 G140 Inhibitor 99.17% 否
HY-12512 cGAMP Activator 99.22% 否
HY-128583 G150 Inhibitor 99.12% 否
HY-110382 Cyclic-di-GMP disodium Activator 99.23% 否
HY-N5134 5'-Guanylic acid 99.69% 否
HY-10583G Y-27632 dihydrochloride (GMP) Inhibitor / 否
HY-114182 PF-06928215 Inhibitor 99.69% 否
HY-10182G Laduviglusib (GMP) / 否
HY-107780B Cyclic-di-GMP diammonium Activator 99.07% 否
HY-101835 Decoyinine Inhibitor 99.96% 否
HY-111673 8-CPT-Cyclic AMP sodium 99.92% 否
HY-10431G SB-431542 (GMP) Inhibitor / 否
HY-137662 5'-Phosphoguanylyl-(3',5')-guanosine Control 95.77% 否
HY-113469A Cyclic GMP sodium 99.89% 否
HY-13012G RepSox (GMP) Inhibitor / 否
HY-15575G VcMMAE (GMP) / 否
HY-W010970 5'-Guanylic acid disodium salt ≥98.0% 否
HY-110385A cGAMP diammonium Activator 95.19% 否
HY-P0229 Ribonulease T1, Aspergillus oryzae / 否
HY-12379 NS-2028 Inhibitor 99.58% 否
HY-13257G Thiazovivin (GMP) Inhibitor / 否
HY-113469 Cyclic GMP Activator 99.43% 否
HY-114181 IRAK4-IN-4 Inhibitor 99.85% 否
HY-119611A Thioquinapiperifil dihydrochloride Inhibitor 99.22% 否
HY-149526 cGAS-IN-1 Inhibitor 98.29% 否
HY-12318G IBMX (GMP) Inhibitor / 否
HY-100933 MY-5445 Inhibitor 99.86% 否
HY-13027G DAPT (GMP) Inhibitor / 否
HY-10182R Laduviglusib (Standard) / 否
HY-114548 Ebselen oxide Inhibitor ≥98.0% 否
HY-123468 HA-1004 Inhibitor 99.03% 否
HY-160546 cGAS-IN-2 Inhibitor 99.67% 否
HY-P1179A Guanylin(human) TFA Activator 96.64% 否
HY-N5134R 5'-Guanylic acid (Standard) / 否
HY-107780 Cyclic-di-GMP Activator 98.18% 否
HY-10432G A 83-01 (GMP) Inhibitor / 否
HY-50723 3-Methylxanthine 99.62% 否
HY-15147G XAV-939 (GMP) Inhibitor / 否
HY-163668 MK-2118 Agonist / 否
HY-13912G IWP-2 (GMP) Inhibitor / 否
HY-119819 Psicofuranine Inhibitor ≥98.0% 否
HY-130530 AP-C5 98.14% 否
HY-15001G Stemregenin 1 (GMP) Antagonist / 否
HY-15764G A 419259 (GMP) / 否
HY-10219GL Rapamycin (GMP Like) Inhibitor 98.8% 否
HY-10475G AM580 (GMP) Agonist / 否
HY-113469B Cyclic GMP (TBAOH) 99.07% 否
HY-14648G Dexamethasone (GMP) Agonist / 否
HY-100164 SDZ-MKS 492 Inhibitor 99.77% 否
HY-110397G KP-457 (GMP) Inhibitor / 否
HY-112486G TA-316 (GMP) Agonist / 否
HY-115745 Calmodulin antagonist-1 Antagonist ≥98.0% 否
HY-50723R 3-Methylxanthine (Standard) / 否
HY-50723S 3-Methylxanthine-13C4,15N3 / 否
HY-B0185G Lidocaine (GMP) / 否
HY-P1179 Guanylin(human) Activator / 否
HY-164288 TDI-6570 Inhibitor 99.64% 否
HY-N5134S2 5'-Guanylic acid-15N5 dilithium ≥95.0% 否
HY-10182C Laduviglusib dihydrochloride / 否
HY-12071G LDN193189 (GMP) Inhibitor / 否
HY-13418G Dorsomorphin dihydrochloride (GMP) Inhibitor / 否
HY-15141G Staurosporine (GMP) Inhibitor / 否
HY-15582G Auristatin E (GMP) Inhibitor / 否
HY-78931G Boc-Dap-NE (GMP) / 否
HY-78932G Dap-NE (hydrochloride) (GMP) / 否
HY-10407G SU 5402 (GMP) Inhibitor / 否
HY-12186G 3-Deazaneplanocin A hydrochloride (GMP) Inhibitor / 否
HY-12323G ISX-9 (GMP) Activator / 否
HY-13319G JNK-IN-8 (GMP) Inhibitor / 否
HY-13526G YO-01027 (GMP) Inhibitor / 否
HY-14398GL Celecoxib (GMP Like) Inhibitor / 否
HY-15108G Purmorphamine (GMP) Agonist / 否
HY-15578G McMMAF (GMP) / 否
HY-15579BG MMAF sodium (GMP) Inhibitor / 否
HY-15579G MMAF (GMP) Inhibitor / 否
HY-15659G Wnt-C59 (GMP) Inhibitor / 否
HY-16700G PNU-159682 (GMP) Inhibitor / 否
HY-U00449G AGN 193109 (GMP) Antagonist / 否
HY-100374G Val-Cit-PAB-MMAE (GMP) / 否
HY-10181G Dasatinib (GMP) / 否
HY-10221G Vorinostat (GMP) Inhibitor / 否
HY-10320G Doramapimod (GMP) Inhibitor / 否
HY-106235 LB80317 Inhibitor / 否
HY-107780A Cyclic-di-GMP sodium Activator / 否
HY-112348 HA-1004 hydrochloride Inhibitor / 否
HY-119611 Thioquinapiperifil Inhibitor / 否
HY-119808 Terrein / 否
HY-12362G Val-cit-PAB-OH (GMP) / 否
HY-12519G Oltipraz (GMP) / 否
HY-128790S1 4-Methoxyestrone-13C6 / 否
HY-131833G Fmoc-Gly-Gly-Phe-OH (GMP) / 否
HY-131990G MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP) / 否
HY-134242 6-T-5'-GMP disodium / 否
HY-134242A 6-T-5'-GMP / 否
HY-134919 CU-76 Inhibitor / 否
HY-13506G M344 (GMP) Inhibitor / 否
HY-135110 Rp-8-Br-cGMPS sodium / 否
HY-14397G Indomethacin (GMP) Inhibitor / 否
HY-14398G Celecoxib (GMP) Inhibitor / 否
HY-153205G Aluminum hydroxide adjuvant (GMP) / 否
HY-153209G Adjuvant-4 (GMP) / 否
HY-155337 eIF4E-IN-6 / 否
HY-156087 Cholicamideβ Inducer / 否
HY-156087G Cholicamideβ (GMP) Inducer / 否
HY-15682G TTNPB (GMP) Agonist / 否
HY-15794G Nemorubicin (GMP) / 否
HY-162459 cGAS-IN-3 Inhibitor / 否
HY-16561G Resveratrol (GMP) / 否
HY-16910G WIKI4 (GMP) / 否
HY-170362 cGAS-IN-4 Inhibitor / 否
HY-17356G Fenofibrate (GMP) / 否
HY-17447AG Tranylcypromine hydrochloride (GMP) Inhibitor / 否
HY-19318G Fmoc-Val-Cit-PAB (GMP) / 否
HY-20336G Mc-Val-Cit-PABC-PNP (GMP) / 否
HY-42972G DBCO-acid (GMP) / 否
HY-44980G Fmoc-Gly-NH-CH2-acetyloxy (GMP) / 否
HY-45672G Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP) / 否
HY-78736G Val-Cit-PAB-OSBT (GMP) / 否
HY-78738G MC-Val-Cit-PAB (GMP) / 否
HY-78921AG Fmoc-3VVD-OH (GMP) / 否
HY-A0070AG Liothyronine (GMP) Agonist / 否
HY-B0377G Famotidine (GMP) Agonist / 否
HY-B0434G Ribavirin (GMP) Inhibitor / 否
HY-B0450AG Ciclopirox olamine (GMP) Inhibitor / 否
HY-B0497G Niclosamide (GMP) Inhibitor / 否
HY-E70441 Guanosine kinase / 否
HY-N5134S1 5'-Guanylic acid-13C10 dilithium / 否
HY-P5072 GRP (14-27) (human, porcine, canine) Agonist / 否
HY-RS05528 GMPS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W000423G DBCO-amine (GMP) / 否
HY-100224G SANT-1 (GMP) / 否
HY-100564BS 2',3'-cGAMP-d8 ammonium / 否
HY-101085G SKL2001 (GMP) Agonist / 否
HY-102022G α-Galactosylceramide (GMP) Inducer / 否
HY-10585AG Valproic acid (sodium) (GMP) / 否
HY-106110 OP-2507 / 否
HY-107614G 1-Oleoyl lysophosphatidic acid (sodium) (GMP) Agonist / 否
HY-107632G GYY4137 (GMP) / 否
HY-108548 Rp-8-Br-PET-cGMPS sodium / 否
HY-110382S 13C20,15N10-Cyclic di-GMP sodium Activator / 否
HY-111582G BBIQ (GMP) Agonist / 否
HY-12273G DMH-1 (GMP) / 否
HY-131764 2'-O-MB-cGMP sodium Inhibitor / 否
HY-131817 5'-GMPS / 否
HY-13441G (-)-Blebbistatin (GMP) Inhibitor / 否
HY-135110A Rp-8-Br-cGMPS / 否
HY-141432G NX-1607 (GMP) Inhibitor / 否
HY-14176G Compound E (GMP) Inhibitor / 否
HY-159642G TYRA-300 (GMP) Inhibitor / 否
HY-160197G Aluminum phosphate adjuvant (GMP) Activator / 否
HY-171020 8-Nitro-2'3'cGMP / 否
HY-50723S1 3-Methylxanthine-d3 / 否
HY-B0350AG Sodium butyrate (GMP) / 否
HY-B0764G Bucladesine (GMP) / 否
HY-N0729G Linoleic acid (GMP) / 否
HY-N5134S3 5'-Guanylic acid-d12 dilithium / 否
HY-N5134S4 5'-Guanylic acid-15N5,d12 dilithium / 否
HY-N5134S5 5'-Guanylic acid-13C10,15N5 dilithium / 否
HY-W010759 Inosine-5′-monophosphate disodium salt octahydrate ≥98.0% 否
HY-W507009 L-Arginyl-L-alanine / 否
HY-W654000 Cyclic GMP-13C,15N2 Activator / 否
HY-Y0320G Dimethyl sulfoxide (GMP) / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus GMPS VGNC VGNC:29443
Canis familiaris GMPS VGNC VGNC:41296
Macaca mulatta GMPS VGNC VGNC:73084
Mus musculus GMPS MGD MGI:2448526
Felis catus GMPS VGNC VGNC:62614
Rattus norvegicus GMPS RGD RGD:1310063
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