2. Gene
  3. Bche - butyrylcholinesterase Gene

Bche - butyrylcholinesterase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：丁酰胆碱酯酶

种属: Mus musculus

同用名: C730038G20Rik

基因 ID: 12038 | 基因类型: protein coding

关于 Bche

Chromosome 3: 73,543,141-73,615,748 reverse strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 130 orthologues, 25 paralogues and is associated with 2 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 7.4), liver E18 (RPKM 6.) and 21 other tissues.

功能概要

该基因编码的蛋白可启动乙酰胆碱酯酶活性。预计参与多个过程，包括乙酰胆碱分解代谢过程；成神经细胞分化；和对叶酸的反应。位于内质网和核包膜腔内。以多种结构表达，包括肾上腺；消化系统；耳朵;肝;和神经系统。该基因的人类直系同源物与阿尔茨海默病有关；冠状动脉疾病（多发性）；糖尿病（多发性）；癫痫;和遗传性代谢紊乱。与人类 BCHE（丁酰胆碱酯酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables acetylcholinesterase activity. Predicted to be involved in several processes, including acetylcholine catabolic process; neuroblast differentiation; and response to folic acid. Located in endoplasmic reticulum and nuclear envelope lumen. Is expressed in several structures, including adrenal gland; alimentary system; ear; liver; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); diabetes mellitus (multiple); epilepsy; and inherited metabolic disorder. Orthologous to human BChE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Apr 2022]

Bche 基因产物(1)

mRNA Protein Name
NM_009738.3 NP_033868.3 cholinesterase precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetylcholinesterase activity IDA
IDA: 通过直接分析推断
17212694 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
8651510 MGI
located in nuclear envelope lumen IDA
IDA: 通过直接分析推断
8651510 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bche 蛋白结构

COesterase

COesterase: pfam00135 (30 - 550)

AChE_tetra

AChE_tetra: pfam08674 (565 - 599)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 603 a.a.
蛋白主名 其他名称

cholinesterase

acylcholine acylhydrolase

butyrylcholine esterase

choline esterase II

pseudocholinesterase

重组 Bche 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72859 Butyrylcholinesterase/BCHE Protein, Mouse (HEK293, His) Q03311 (H28-L603) ≥95%

相关产品

Approval
生物活性分子 (8)
目录号 产品名 作用方式
纯度 是否罕见病
HY-17368 Rivastigmine Inhibitor 99.93% 是
HY-B1488 Tacrine hydrochloride Inhibitor 99.95% 否
HY-107922 Ethopropazine hydrochloride Inhibitor 99.66% 否
HY-B2244 Tacrine hydrochloride (hydrate) Inhibitor 99.98% 否
HY-B1542A Benactyzine hydrochloride Inhibitor 99.02% 否
HY-B1239 Drofenine hydrochloride Inhibitor 98.10% 否
HY-100919 Ambenonium chloride Inhibitor / 否
HY-16183 Echothiopate iodide Inhibitor / 否
Pre-clinical Phase
生物活性分子 (105)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107569 Garcinol Inhibitor ≥99.0% 否
HY-N0285 Imperatorin Inhibitor 98.72% 否
HY-N0226A Epiberberine chloride Inhibitor 99.02% 否
HY-103373 PE154 Inhibitor 99.01% 否
HY-155140 BChE-IN-17 Inhibitor 99.07% 否
HY-N0226 Epiberberine Inhibitor 98.46% 否
HY-N7263 Galanthamine N-Oxide Inhibitor 99.90% 否
HY-107275 Ebeiedinone Inhibitor 99.51% 否
HY-151368 AChE/BChE-IN-10 Inhibitor 99.67% 否
HY-121072 ASS234 Inhibitor / 否
HY-N2284 Sophoflavescenol Inhibitor 98.15% 否
HY-162340 Z32439948 Inhibitor / 否
HY-151436 ZLMT-12 Inhibitor / 否
HY-131971 AChE/BChE-IN-1 Inhibitor / 否
HY-108048 Desoxypeganine Inhibitor / 否
HY-N2960 Broussonin A Inhibitor / 否
HY-155366 hAChE-IN-6 Inhibitor / 否
HY-159081 AChE/BChE-IN-20 Inhibitor / 否
HY-158092 ChEs/MAOs-IN-2 Inhibitor / 否
HY-W130236 Methylene Violet 3RAX Inhibitor / 否
HY-149287 hAChE/hBACE-1-IN-1 Inhibitor / 否
HY-121191 Bisnorcymserine Inhibitor / 否
HY-161156 BChE-IN-26 Inhibitor / 否
HY-N10489 BChE-IN-12 Inhibitor / 否
HY-161512 hAChE/hBACE-1-IN-4 Inhibitor / 否
HY-146315 AChE/BChE-IN-6 Inhibitor / 否
HY-149087 MR2938 Inhibitor / 否
HY-N10490 Blestrin D Inhibitor / 否
HY-168052 hAChE-IN-9 Inhibitor / 否
HY-163537 AChE/BuChE-IN-5 Inhibitor / 否
HY-149993 hBChE-IN-2 Inhibitor / 否
HY-108048A Desoxypeganine hydrochloride Inhibitor / 否
HY-151405 Z164597606 Inhibitor / 否
HY-157978 AChE-IN-59 Inhibitor / 否
HY-162036 α-Amylase/α-Glucosidase-IN-7 Inhibitor / 否
HY-162693 AChE-IN-68 Inhibitor / 否
HY-156031 BChE-IN-19 Inhibitor / 否
HY-152232 BChE-IN-15 Inhibitor / 否
HY-157382 AChE-IN-51 Inhibitor / 否
HY-149243 BChE-IN-16 Inhibitor / 否
HY-163441 BChE-IN-31 Inhibitor / 否
HY-161508 AChE/BChE-IN-19 Inhibitor / 否
HY-146687 BuChE-IN-4 Inhibitor / 否
HY-157384 BChE-IN-22 Inhibitor / 否
HY-N10486 BChE-IN-10 Inhibitor / 否
HY-150585 BuChE-IN-5 Inhibitor / 否
HY-169162 hBChE-IN-3 Inhibitor / 否
HY-N10781 Isograndifoliol Inhibitor / 否
HY-163514 hAChE-IN-8 Inhibitor / 否
HY-162671 BuChE-IN-12 Inhibitor / 否
HY-162639 α-Glucosidase-IN-68 Inhibitor / 否
HY-169234 BChE-IN-35 Inhibitor / 否
HY-143465 BChE-IN-5 Inhibitor / 否
HY-149273 hBChE-IN-1 Inhibitor / 否
HY-N10701 AChE/BChE-IN-11 Inhibitor / 否
HY-150545 AChE-IN-21 Inhibitor / 否
HY-152632 BuChE-IN-7 Inhibitor / 否
HY-157437 AChE/BChE-IN-16 Inhibitor / 否
HY-159482 SBN-284 Inhibitor / 否
HY-144762 K027 Inhibitor / 否
HY-161842 AChE-IN-67 Inhibitor / 否
HY-157981 AChE-IN-60 Inhibitor / 否
HY-163883 BChE-IN-34 Inhibitor / 否
HY-161643 S21-1011 Inhibitor / 否
HY-146669 BChE-IN-6 Inhibitor / 否
HY-146663A AChE/BChE-IN-3 hydrochloride Inhibitor / 否
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / 否
HY-169163 BChE-IN-36 Inhibitor / 否
HY-151562 AChE/BuChE/MAO-B-IN-1 Inhibitor / 否
HY-158978 Multitarget AD inhibitor-2 Inhibitor / 否
HY-161331 S16–1029 Inhibitor / 否
HY-N10488 BChE-IN-11 Inhibitor / 否
HY-162338 BChE-IN-29 Inhibitor / 否
HY-149090 AChE/BuChE/MAO-B-IN-2 / 否
HY-149288 hAChE/hBACE-1-IN-2 Inhibitor / 否
HY-155284 K1833 Inhibitor / 否
HY-158334 NDs-IN-1 Inhibitor / 否
HY-162812 H3R antagonist 4 Inhibitor / 否
HY-155085 hAChE-IN-3 Inhibitor / 否
HY-161507 hCAI/II-IN-8 Inhibitor / 否
HY-146251 BuChE-IN-6 Inhibitor / 否
HY-127087 Isogarcinol Inhibitor / 否
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / 否
HY-159143 BChE-IN-33 Inhibitor / 否
HY-147939 AChE/BuChE-IN-3 Inhibitor / 否
HY-149211 AChE/BChE-IN-12 Inhibitor / 否
HY-153432 TRV-7019 99.64% 否
HY-162681 eeAChE-IN-3 Inhibitor / 否
HY-149272 tau/Aβ40 aggregation-IN-1 Inhibitor / 否
HY-144446 BuChE-IN-1 Inhibitor / 否
HY-N10917 Xanthohumol I Inhibitor / 否
HY-163909 AChE-IN-72 Inhibitor / 否
HY-163746 BuChE-IN-11 Inhibitor / 否
HY-N12581 Kuwanon U Inhibitor / 否
HY-149300 SB-1436 Inhibitor / 否
HY-149212 SD-6 Inhibitor / 否
HY-161150 AChE/BChE-IN-17 Inhibitor / 否
HY-161453 BChE-IN-32 Inhibitor / 否
HY-N7708 Lycodoline Inhibitor / 否
HY-157982 BChE-IN-28 Inhibitor / 否
HY-158696 BChE/MAO-B-IN-1 Inhibitor / 否
HY-158261 AChE-IN-63 Inhibitor / 否
HY-B1542 Benactyzine Inhibitor / 否
HY-N7346 Lucidadiol Inhibitor / 否
HY-W049312 7-Methoxytacrine Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bche NCBI NCBI:590
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