1. Gene
  2. C3 - complement component 3 Gene

C3 - complement component 3 Gene

种属: Mus musculus

同用名: ASP; Plp; HSE-MSF

基因 ID: 12266 | 基因类型: protein coding

关于 C3

功能概要

This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the Complement System. The encoded preproprotein undergoes a multi-step processing to generate various functional Peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon Infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome. [provided by RefSeq, Mar 2015]

C3 基因产物(1)

mRNA Protein Name
NM_009778.3 NP_033908.2 complement C3 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11728339 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid-beta clearance IGI
IGI: 通过遗传相互作用推断
20199584 MGI
involved in amyloid-beta clearance IMP
IMP: 通过突变表型推断
22438044 MGI
acts upstream of or within complement activation IDA
IDA: 通过直接分析推断
18947875 MGI
acts upstream of or within complement activation IMP
IMP: 通过突变表型推断
25284781 MGI
involved in complement receptor mediated signaling pathway IMP
IMP: 通过突变表型推断
22632727 MGI
acts upstream of or within complement-dependent cytotoxicity IMP
IMP: 通过突变表型推断
25284781 MGI
involved in complement-mediated synapse pruning IMP
IMP: 通过突变表型推断
18083105 MGI
involved in neuron remodeling IMP
IMP: 通过突变表型推断
18083105 MGI
acts upstream of or within oviduct epithelium development IGI
IGI: 通过遗传相互作用推断
31604923 MGI
involved in positive regulation of activation of membrane attack complex IMP
IMP: 通过突变表型推断
15611275 MGI
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
15611275 MGI
acts upstream of or within positive regulation of phagocytosis IMP
IMP: 通过突变表型推断
11901193 MGI
involved in positive regulation of phagocytosis, engulfment IGI
IGI: 通过遗传相互作用推断
20199584 MGI
involved in positive regulation of phagocytosis, engulfment IMP
IMP: 通过突变表型推断
22438044 MGI
involved in positive regulation of receptor-mediated endocytosis IGI
IGI: 通过遗传相互作用推断
20199584 MGI
involved in positive regulation of receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
22438044 MGI
acts upstream of or within positive regulation of type IIa hypersensitivity IMP
IMP: 通过突变表型推断
11901193 MGI
acts upstream of or within response to bacterium IEP
IEP: 通过表达模式推断
23012479 MGI
acts upstream of or within retina development in camera-type eye IGI
IGI: 通过遗传相互作用推断
28057640 MGI
acts upstream of or within vascular associated smooth muscle cell differentiation IGI
IGI: 通过遗传相互作用推断
28057640 MGI
involved in vertebrate eye-specific patterning IMP
IMP: 通过突变表型推断
18083105 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
25284781 MGI
located in extracellular region IDA
IDA: 通过直接分析推断
19411110 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
18292556 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
23487775 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

complement C3

acylation stimulating protein

complement component 3d

complement factor 3

重组 C3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7863 Complement C3/C3a Protein, Mouse P01027-1 (S671-R748) ≥95%
HY-P78247 Complement C3 Protein, Mouse (HEK293, His) P01027-1 (I25-N1663) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens C3 NCBI NCBI:718
Canis familiaris C3 NCBI NCBI:476728
Macaca fascicularis C3 NCBI NCBI:102131458
Rattus norvegicus C3 NCBI NCBI:24232
Macaca mulatta C3 NCBI NCBI:703613