1. Gene
  2. NCK1 - NCK adaptor protein 1 Gene

NCK1 - NCK adaptor protein 1 Gene

中文名称:NCK 衔接蛋白 1

种属: Homo sapiens

同用名: NCK; nck-1; NCKalpha

基因 ID: 4690 | 基因类型: protein coding

关于 NCK1

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:136,862,208-136,951,606 (from NCBI)

This gene has 12 transcripts (splice variants), 198 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 10.1), fat (RPKM 9.3) and 25 other tissues.

功能概要

由该基因编码的蛋白质是含有 Src 同源性 2 和 3 (SH2 和 SH3) 结构域的信号转导和转化蛋白质之一。它位于细胞质中,是一种衔接蛋白,参与将信号从受体酪氨酸激酶转导至下游信号受体,如 Ras。已发现编码不同亚型的选择性剪接转录物变体。[RefSeq 提供,2010 年 6 月]

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from Receptor Tyrosine Kinases to downstream signal recipients such as Ras. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]

NCK1 基因产物(3)

mRNA Protein Name
NM_001190796.3 NP_001177725.1 cytoplasmic protein NCK1 isoform 2
NM_001291999.2 NP_001278928.1 cytoplasmic protein NCK1 isoform 1
NM_006153.6 NP_006144.1 cytoplasmic protein NCK1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables eukaryotic initiation factor eIF2 binding IPI
IPI: 通过物理相互作用推断
11959995 GOA
enables molecular condensate scaffold activity IDA
IDA: 通过直接分析推断
26553976 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9346925 GOA
enables protein kinase inhibitor activity IDA
IDA: 通过直接分析推断
18835251 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
21707536 GOA
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
23358419 GOA
enables signaling adaptor activity IDA
IDA: 通过直接分析推断
16835242 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
12110186 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell activation IMP
IMP: 通过突变表型推断
12110186 GOA
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
18835251 GOA
involved in negative regulation of PERK-mediated unfolded protein response IDA
IDA: 通过直接分析推断
14676213 GOA
involved in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
IDA: 通过直接分析推断
14676213 GOA
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
21707536 GOA
involved in negative regulation of peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
14676213 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16835242 GOA
involved in positive regulation of T cell proliferation IMP
IMP: 通过突变表型推断
12110186 GOA
involved in positive regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
12110186 GOA
involved in positive regulation of cap-dependent translational initiation IDA
IDA: 通过直接分析推断
11959995 GOA
involved in positive regulation of cap-independent translational initiation IDA
IDA: 通过直接分析推断
11959995 GOA
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
14676213 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10026169 GOA
involved in positive regulation of translation in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
14676213 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
16835242 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
25468996 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
16835242 GOA
part of protein phosphatase type 1 complex IDA
IDA: 通过直接分析推断
16835242 GOA
located in ribosome IDA
IDA: 通过直接分析推断
11959995 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NCK1 蛋白结构

SH3_1

SH3_1: SH3 domain (8 - 53)

SH3_9

SH3_9: Variant SH3 domain (113 - 161)

SH3_1

SH3_1: SH3 domain (196 - 243)

SH2

SH2: SH2 domain (282 - 356)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
蛋白主名 其他名称

cytoplasmic protein NCK1

NCK tyrosine kinase

NCK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NCK1 P16333 KDR Homo sapiens P35968 16966330
种属内
NCK1 P16333 CHAF1A Homo sapiens Q13111 17474147
种属内
NCK1 P16333 RASA1 Homo sapiens P20936 21664272
种属内
NCK1 P16333 RASA1 Homo sapiens P20936 21664272
种属内
NCK1 P16333 TPX2 Homo sapiens Q9ULW0 17474147
种属内
NCK1 P16333 MET Homo sapiens P08581
FPS
24728074
种属内
NCK1 P16333 PAK2 Homo sapiens Q13177 16374509
种属内
NCK1 P16333 PAK2 Homo sapiens Q13177 16374509
种属内
NCK1 P16333 PAK2 Homo sapiens Q13177 32296183
种属内
NCK1 P16333 PAK2 Homo sapiens Q13177 33961781
种属内
NCK1 P16333 TNIK Homo sapiens Q9UKE5 33961781
种属内
NCK1 P16333 ABL2 Homo sapiens P42684
PLA
25241761
种属内
NCK1 P16333 ABL2 Homo sapiens P42684 33961781
种属内
NCK1 P16333 DAB2 Homo sapiens P98082 17474147
种属内
NCK1 P16333 PIK3AP1 Homo sapiens Q6ZUJ8-3 32296183
种属内
NCK1 P16333 DLGAP4 Homo sapiens Q9Y2H0-1 32296183
种属内
NCK1 P16333 CD3E Homo sapiens P07766 18955169
种属内
NCK1 P16333 CD3E Homo sapiens P07766
NMR
18955169
种属内
NCK1 P16333 KIT Homo sapiens P10721
FPS
24728074
种属内
NCK1 P16333 SHANK2 Homo sapiens Q9UPX8 17474147
种属内
NCK1 P16333 AGER Homo sapiens Q15109 17474147
种属内
NCK1 P16333 ASB16 Homo sapiens Q96NS5 17474147
种属内
NCK1 P16333 SHANK3 Homo sapiens Q9BYB0
Y2H
21988832
种属内
NCK1 P16333 NCKAP5 Homo sapiens O14513 17474147
种属内
NCK1 P16333 AIRE Homo sapiens O43918 17474147
种属内
NCK1 P16333 FYB1 Homo sapiens O15117 17474147
种属内
NCK1 P16333 MEPE Homo sapiens Q9NQ76 17474147
种属内
NCK1 P16333 SEMA7A Homo sapiens O75326 17474147
种属内
NCK1 P16333 PHACTR2 Homo sapiens O75167 17474147
种属内
NCK1 P16333 RAG1 Homo sapiens P15918 17474147
种属内
NCK1 P16333 DAG1 Homo sapiens Q14118 17474147
种属内
NCK1 P16333 TRAIP Homo sapiens Q9BWF2 17474147
种属内
NCK1 P16333 RIMS2 Homo sapiens Q9UQ26 17474147
种属内
NCK1 P16333 TULP1 Homo sapiens O00294 17474147
种属内
NCK1 P16333 ELK3 Homo sapiens P41970 17474147
种属内
NCK1 P16333 SLC23A1 Homo sapiens Q9UHI7 17474147
种属内
NCK1 P16333 TPSAB1 Homo sapiens Q15661 17474147
种属内
NCK1 P16333 ABCG5 Homo sapiens Q9H222 17474147
种属内
NCK1 P16333 NHSL2 Homo sapiens Q5HYW2 32296183
种属内
NCK1 P16333 GHR Homo sapiens P10912
PLA
25241761
种属内
NCK1 P16333 EGFR Homo sapiens P00533 8662998
种属内
NCK1 P16333 EGFR Homo sapiens P00533 24658140
种属内
NCK1 P16333 SOS1 Homo sapiens Q07889 10206341
种属内
NCK1 P16333 SOS1 Homo sapiens Q07889 33961781
种属内
NCK1 P16333 SOS1 Homo sapiens Q07889 17474147
种属内
NCK1 P16333 SOS2 Homo sapiens Q07890 33961781
种属内
NCK1 P16333 SOS2 Homo sapiens Q07890 17474147
种属内
NCK1 P16333 SP1 Homo sapiens P08047 17474147
种属内
NCK1 P16333 PNMA2 Homo sapiens Q9UL42 17474147
种属内
NCK1 P16333 CELSR3 Homo sapiens Q9NYQ7 17474147
种属内
NCK1 P16333 SYNJ2 Homo sapiens O15056 17474147
种属内
NCK1 P16333 ASAP2 Homo sapiens O43150 33961781
种属内
NCK1 P16333 ASAP2 Homo sapiens O43150 17474147
种属内
NCK1 P16333 WIPF1 Homo sapiens O43516 33961781
种属内
NCK1 P16333 WIPF1 Homo sapiens O43516 12620186
种属内
NCK1 P16333 ASAP1 Homo sapiens Q9ULH1 17474147
种属内
NCK1 P16333 LCP2 Homo sapiens Q13094 20562827
种属内
NCK1 P16333 LCP2 Homo sapiens Q13094 20562827
种属内
NCK1 P16333 LCP2 Homo sapiens Q13094
ITC
20562827
种属内
NCK1 P16333 LCP2 Homo sapiens Q13094 20562827
种属内
NCK1 P16333 NELFB Homo sapiens Q8WX92 17474147
种属内
NCK1 P16333 FLNB Homo sapiens O75369 17474147
种属内
NCK1 P16333 H1-4 Homo sapiens P10412 17474147
种属内
NCK1 P16333 ABI1 Homo sapiens Q8IZP0 33961781
种属内
NCK1 P16333 ABI1 Homo sapiens Q8IZP0 11418237
种属内
NCK1 P16333 NHSL3 Homo sapiens Q9P206 33961781
种属内
NCK1 P16333 TMPO Homo sapiens P42167 17474147
种属内
NCK1 P16333 STK38 Homo sapiens Q15208 31980649
种属内
NCK1 P16333 GAB1 Homo sapiens Q13480
FPS
24728074
种属内
NCK1 P16333 PIK3C2B Homo sapiens O00750 17474147
种属内
NCK1 P16333 PTPN4 Homo sapiens P29074 17474147
种属内
NCK1 P16333 DNM1 Homo sapiens Q05193 10206341
种属内
NCK1 P16333 DNM1 Homo sapiens Q05193 10206341
种属内
NCK1 P16333 CHN2 Homo sapiens P52757 32296183
种属内
NCK1 P16333 DLGAP4 Homo sapiens Q9Y2H0 17474147
种属内
NCK1 P16333 TRIM39 Homo sapiens Q9HCM9 17474147
种属内
NCK1 P16333 GAD1 Homo sapiens Q99259 17474147
种属内
NCK1 P16333 CBLB Homo sapiens Q13191 25218436
种属内
NCK1 P16333 GSTZ1 Homo sapiens O43708 17474147
种属内
NCK1 P16333 ISG20L2 Homo sapiens Q9H9L3 17474147
种属内
NCK1 P16333 NR5A1 Homo sapiens Q13285 39009827
种属内
NCK1 P16333 WASL Homo sapiens O00401 33961781
种属内
NCK1 P16333 WASL Homo sapiens O00401 26496610
种属内
NCK1 P16333 CDC27 Homo sapiens P30260 17474147
种属内
NCK1 P16333 NPHS1 Homo sapiens O60500 16525419
种属内
NCK1 P16333 NPHS1 Homo sapiens O60500 16525419
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NCK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70304 NCK1 Protein, Human (His) P16333-1 (M1-S377) ≥95%

NCK1 抗体

目录号 产品名 应用 反应物种
HY-P83549 NCK1 Antibody (YA3294) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Wiskott-Aldrich Syndrome

WAS

Eczema-Thrombocytopenia-Immunodeficiency Syndrome

Immunodeficiency 2

Aldrich Syndrome

Imd2

Wiskott-Aldrich Syndrome 1

Was1

Wiskott Syndrome

Wiskott Aldrich Syndrome

Eczema Thrombocytopenia Immunodeficiency Syndrome

Imd 2

Vaccinia
Agammaglobulinemia 4, Autosomal Recessive

Agammaglobulinemia 4

AGM4

Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect

B Cell Linker Protein Deficiency

B-Cell Linker Protein Deficiency

Blnk Deficiency

Agammaglobulinemia Autosomal Recessive Due To Blnk Defect

Agammaglobulinemia, Type 4, Autosomal Recessive

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Familial Nephrotic Syndrome

Congenital Nephrotic Syndrome

Nephrosis, Congenital

Finnish Congenital Nephrotic Syndrome

Frank-Ter Haar Syndrome

Ter Haar Syndrome

Borrone Dermatocardioskeletal Syndrome

FTHS

Autosomal Recessive Melnick-Needles Syndrome

Borrone Di Rocco Crovato Syndrome

Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay

Melnick-Needles Syndrome, Autosomal Recessive, Formerly

Frank Ter Haar Syndrome

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia

XLN

SCNX

Severe Congenital Neutropenia X-Linked

Neutropenia, Congenital, Severe, X-Linked

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus NCK1 MGD MGI:109601
Rattus norvegicus NCK1 RGD RGD:1310688
Canis familiaris NCK1 VGNC VGNC:52892
Bos taurus NCK1 VGNC VGNC:52804
Felis catus NCK1 VGNC VGNC:68427
Macaca mulatta NCK1 VGNC VGNC:110350
Others NCK1 NCBI