Kras - KRAS proto-oncogene, GTPase Gene

中文名称：KRAS 原癌基因，GTP 酶

种属: Rattus norvegicus

同用名: p21; Kras2; c-Ki-ras

关于 Kras

功能概要

该基因编码的蛋白可启动 GDP 绑定活动； GMP结合活性；和 LRR 域绑定活动。参与多个过程，包括 NF-kappaB 转录因子活性的正调控；细胞衰老的正向调节；和对皮质类固醇的反应。位于膜筏和线粒体中。用于研究细支气管肺泡腺癌；子宫内膜腺癌；肝细胞腺瘤；肝细胞癌；和肾纤维化。该基因的人类直系同源物与多种疾病有关，包括努南综合征（多种）；脑动静脉畸形;心面皮肤综合征（多发性）；胃肠系统癌症（多发性）；和血液系统癌症（多种）。与人类 KRAS 同源（KRAS 原癌基因，GTPase）。 [由基因组资源联盟提供，2022 年 4 月]

Enables GDP binding activity; GMP binding activity; and LRR domain binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cellular senescence; and response to corticosteroid. Located in membrane raft and mitochondrion. Used to study bronchiolo-alveolar adenocarcinoma; endometrial adenocarcinoma; hepatocellular adenoma; hepatocellular carcinoma; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system Cancer (multiple); and hematologic Cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]