HOXA1 - homeobox A1 Gene

中文名称：同源框 A1

种属: Homo sapiens

同用名: BSAS; HOX1; HOX1F

关于 HOXA1

功能概要

在脊椎动物中，编码称为同源盒基因的转录因子类的基因位于四个独立染色体上名为 A、B、C 和 D 的簇中。这些蛋白质的表达在胚胎发育过程中受到时空调控。该基因是 7 号染色体 A 簇的一部分，编码 DNA 结合转录因子，可调节基因表达、形态发生和分化。编码的蛋白质可能参与后脑节段在发育过程中沿前后轴放置在适当位置的过程。已发现该基因编码两种不同异构体的两种转录变体，其中只有一种异构体包含同源域区域。[RefSeq 提供，2008 年 7 月]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008]