1. Gene
  2. CREB3L1 - cAMP responsive element binding protein 3 like 1 Gene

CREB3L1 - cAMP responsive element binding protein 3 like 1 Gene

中文名称:cAMP 反应元件结合蛋白 3 like 1

种属: Homo sapiens

同用名: OI16; OASIS

基因 ID: 90993 | 基因类型: protein coding

关于 CREB3L1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,277,662-46,321,409 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues, 9 paralogues and is associated with 72 phenotypes. Broad expression in stomach (RPKM 29.2), colon (RPKM 23.7) and 16 other tissues.

功能概要

由该基因编码的蛋白质通常存在于内质网 (ER) 的膜中。然而,在对 ER 施加压力时,编码的蛋白质被切割,释放的细胞质转录因子结构域易位至细胞核。在那里它通过与 box-B 元件结合来激活目标基因的转录。[RefSeq 提供,2013 年 6 月]

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]

CREB3L1 基因产物(1)

mRNA Protein Name
NM_052854.4 NP_443086.1 cyclic AMP-responsive element-binding protein 3-like protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
27121396 GOA
enables SMAD binding IPI
IPI: 通过物理相互作用推断
25310401 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
27121396 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
16236796 GOA
located in membrane IDA
IDA: 通过直接分析推断
25310401 GOA
located in nucleus IDA
IDA: 通过直接分析推断
25310401 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CREB3L1 蛋白结构

bZIP_1

bZIP_1: bZIP transcription factor (288 - 350)

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  • 519 a.a.
蛋白主名 其他名称

cyclic AMP-responsive element-binding protein 3-like protein 1

BBF-2 homolog

CREB3L1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CREB3L1 Q96BA8 TMEM218 Homo sapiens A2RU14 29892012
种属内
CREB3L1 Q96BA8 TMEM218 Homo sapiens A2RU14 25416956
种属内
CREB3L1 Q96BA8 GPR25 Homo sapiens O00155 25416956
种属内
CREB3L1 Q96BA8 GPR25 Homo sapiens O00155 25416956
种属内
CREB3L1 Q96BA8 GPR25 Homo sapiens O00155 25416956
种属内
CREB3L1 Q96BA8 SLC30A8 Homo sapiens Q8IWU4 25416956
种属内
CREB3L1 Q96BA8 SLC30A8 Homo sapiens Q8IWU4 25416956
种属内
CREB3L1 Q96BA8 SLC30A8 Homo sapiens Q8IWU4 25416956
种属内
CREB3L1 Q96BA8 NRM Homo sapiens Q8IXM6 25416956
种属内
CREB3L1 Q96BA8 NRM Homo sapiens Q8IXM6 25416956
种属内
CREB3L1 Q96BA8 NRM Homo sapiens Q8IXM6 25416956
种属内
CREB3L1 Q96BA8 JAGN1 Homo sapiens Q8N5M9 25416956
种属内
CREB3L1 Q96BA8 JAGN1 Homo sapiens Q8N5M9 25416956
种属内
CREB3L1 Q96BA8 CCL4L1 Homo sapiens Q8NHW4 32296183
种属内
CREB3L1 Q96BA8 SLC35B4 Homo sapiens Q969S0 25416956
种属内
CREB3L1 Q96BA8 SLC35B4 Homo sapiens Q969S0 25416956
种属内
CREB3L1 Q96BA8 NINJ2 Homo sapiens Q9NZG7 32296183
种属内
CREB3L1 Q96BA8 MARCHF2 Homo sapiens Q9P0N8 32296183
种属内
CREB3L1 Q96BA8 TEX264 Homo sapiens Q9Y6I9 32296183
种属内
CREB3L1 Q96BA8 PRKAB2 Homo sapiens O43741 25416956
种属内
CREB3L1 Q96BA8 ORMDL1 Homo sapiens Q9P0S3 32296183
种属内
CREB3L1 Q96BA8 ADGRE2 Homo sapiens Q9UHX3 32296183
种属内
CREB3L1 Q96BA8 MGST2 Homo sapiens Q99735 32296183
种属内
CREB3L1 Q96BA8 TLCD1 Homo sapiens Q96CP7 32296183
种属内
CREB3L1 Q96BA8 CFHR5 Homo sapiens Q9BXR6 32296183
种属内
CREB3L1 Q96BA8 ARV1 Homo sapiens Q9H2C2 32296183
种属内
CREB3L1 Q96BA8 ARV1 Homo sapiens Q9H2C2 32296183
种属内
CREB3L1 Q96BA8 TNMD Homo sapiens Q9H2S6-2 32296183
种属内
CREB3L1 Q96BA8 LPAR3 Homo sapiens Q9UBY5 32296183
种属内
CREB3L1 Q96BA8 PGAP2 Homo sapiens Q9UHJ9-5 32296183
种属内
CREB3L1 Q96BA8 FAXDC2 Homo sapiens Q96IV6 32296183
种属内
CREB3L1 Q96BA8 MAN2B2 Homo sapiens Q9Y2E5 32296183
种属内
CREB3L1 Q96BA8 SLC35A4 Homo sapiens Q96G79 32296183
种属内
CREB3L1 Q96BA8 CNIH2 Homo sapiens Q6PI25 32296183
种属内
CREB3L1 Q96BA8 AQP10 Homo sapiens Q96PS8 32296183
种属内
CREB3L1 Q96BA8 ZDHHC15 Homo sapiens Q96MV8 32296183
种属内
CREB3L1 Q96BA8 TMEM208 Homo sapiens Q9BTX3 32296183
种属内
CREB3L1 Q96BA8 SLC39A2 Homo sapiens Q9NP94 32296183
种属内
CREB3L1 Q96BA8 SLC52A1 Homo sapiens Q9NWF4 32296183
种属内
CREB3L1 Q96BA8 SEMA4G Homo sapiens Q9NTN9-2 32296183
种属内
CREB3L1 Q96BA8 PLPPR2 Homo sapiens Q96GM1 32296183
种属内
CREB3L1 Q96BA8 FETUB Homo sapiens Q9UGM5 32296183
种属内
CREB3L1 Q96BA8 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
种属内
CREB3L1 Q96BA8 AGPAT4 Homo sapiens Q9NRZ5 32296183
种属内
CREB3L1 Q96BA8 TMEM14C Homo sapiens Q9P0S9 32296183
种属内
CREB3L1 Q96BA8 TMEM14A Homo sapiens Q9Y6G1 32296183
种属内
CREB3L1 Q96BA8 AGPAT3 Homo sapiens Q9NRZ7 32296183
种属内
CREB3L1 Q96BA8 CMTM7 Homo sapiens Q96FZ5 32296183
种属内
CREB3L1 Q96BA8 UBIAD1 Homo sapiens Q9Y5Z9 32296183
种属内
CREB3L1 Q96BA8 SLC39A9 Homo sapiens Q9NUM3 32296183
种属内
CREB3L1 Q96BA8 C11orf24 Homo sapiens Q96F05 32296183
种属内
CREB3L1 Q96BA8 NAT8 Homo sapiens Q9UHE5 32296183
种属内
CREB3L1 Q96BA8 NAT8 Homo sapiens Q9UHE5 32296183
种属内
CREB3L1 Q96BA8 FAM3C Homo sapiens Q92520 25416956
种属内
CREB3L1 Q96BA8 FAM3C Homo sapiens Q92520 25416956
种属内
CREB3L1 Q96BA8 TECR Homo sapiens Q9NZ01 32296183
种属内
CREB3L1 Q96BA8 TMEM222 Homo sapiens Q9H0R3 32296183
种属内
CREB3L1 Q96BA8 TMEM147 Homo sapiens Q9BVK8 32296183
种属内
CREB3L1 Q96BA8 TMEM147 Homo sapiens Q9BVK8 25416956
种属内
CREB3L1 Q96BA8 TMEM147 Homo sapiens Q9BVK8 25416956
种属内
CREB3L1 Q96BA8 TMEM147 Homo sapiens Q9BVK8 25416956
种属内
CREB3L1 Q96BA8 CFTR Homo sapiens P13569 35156780
种属内
CREB3L1 Q96BA8 SACM1L Homo sapiens Q9NTJ5 32296183
种属内
CREB3L1 Q96BA8 SACM1L Homo sapiens Q9NTJ5 32296183
种属内
CREB3L1 Q96BA8 MFSD5 Homo sapiens Q6N075 25416956
种属内
CREB3L1 Q96BA8 MFSD5 Homo sapiens Q6N075 25416956
种属内
CREB3L1 Q96BA8 MFSD5 Homo sapiens Q6N075 25416956
种属内
CREB3L1 Q96BA8 NAPB Homo sapiens Q9H115 32296183
种属内
CREB3L1 Q96BA8 ALG8 Homo sapiens Q9BVK2 32296183
种属内
CREB3L1 Q96BA8 UNC93B1 Homo sapiens Q9H1C4 32296183
种属内
CREB3L1 Q96BA8 GOLT1B Homo sapiens Q9Y3E0 32296183
种属内
CREB3L1 Q96BA8 CLN6 Homo sapiens Q9NWW5 32296183
种属内
CREB3L1 Q96BA8 GIMAP5 Homo sapiens Q96F15 32296183
种属内
CREB3L1 Q96BA8 VKORC1 Homo sapiens Q9BQB6 32296183
种属内
CREB3L1 Q96BA8 TIMMDC1 Homo sapiens Q9NPL8 32296183
种属内
CREB3L1 Q96BA8 TSPO Homo sapiens P30536 31515488
种属内
CREB3L1 Q96BA8 TSPO Homo sapiens P30536 25416956
种属内
CREB3L1 Q96BA8 AGPAT5 Homo sapiens Q9NUQ2 32296183
种属内
CREB3L1 Q96BA8 ERG28 Homo sapiens Q9UKR5 32296183
种属内
CREB3L1 Q96BA8 FXYD6 Homo sapiens Q9H0Q3 32296183
种属内
CREB3L1 Q96BA8 NEU1 Homo sapiens Q99519 32296183
种属内
CREB3L1 Q96BA8 CMTM3 Homo sapiens Q96MX0 32296183
种属内
CREB3L1 Q96BA8 STX8 Homo sapiens Q9UNK0 32296183
种属内
CREB3L1 Q96BA8 TMEM19 Homo sapiens Q96HH6 32296183
种属内
CREB3L1 Q96BA8 YIPF6 Homo sapiens Q96EC8 32296183
种属内
CREB3L1 Q96BA8 CIAO2A Homo sapiens Q9H5X1 32296183
种属内
CREB3L1 Q96BA8 INSIG2 Homo sapiens Q9Y5U4 32296183
种属内
CREB3L1 Q96BA8 CREB3L3 Homo sapiens Q68CJ9 23661758
种属内
CREB3L1 Q96BA8 C5 Homo sapiens P01031 25416956
种属内
CREB3L1 Q96BA8 C5 Homo sapiens P01031 25416956
种属内
CREB3L1 Q96BA8 RUSF1 Homo sapiens Q96GQ5 32296183
种属内
CREB3L1 Q96BA8 TMEM14B Homo sapiens Q9NUH8 32296183
种属内
CREB3L1 Q96BA8 SMCO4 Homo sapiens Q9NRQ5 32296183
种属内
CREB3L1 Q96BA8 TMEM234 Homo sapiens Q8WY98 25416956
种属内
CREB3L1 Q96BA8 TMEM234 Homo sapiens Q8WY98 25416956
种属内
CREB3L1 Q96BA8 DOLK Homo sapiens Q9UPQ8 32296183
种属内
CREB3L1 Q96BA8 SEC22A Homo sapiens Q96IW7 32296183
种属内
CREB3L1 Q96BA8 PEX16 Homo sapiens Q9Y5Y5 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CREB3L1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76284 CREB3L1 Protein, Human (HEK293, His) Q96BA8-1 (E396-S519) ≥95%

关联疾病

疾病名称 别名
Osteogenesis Imperfecta, Type Xvi

Osteogenesis Imperfecta Type 16

OI16

Oi, Type Xvi

Osteogenesis Imperfecta Type Xvi

Chromosome 11p11.2 Deletion Syndrome 91.3-Kb

Osteogenesis Imperfecta 16

Chromosome 11p11.2 Deletion Syndrome, 91.3-Kb

Myxofibrosarcoma

Fibromyxosarcoma

Fibromyxoid Sarcoma

Myxoid Malignant Fibrous Histiocytoma

Dermatofibrosarcoma Protuberans, Myxoid

Brittle Bone Disorder

Osteogenesis Imperfecta

Brittle Bone Disease

Fragilitas Ossium

Osteopsathyrosis

Lobstein Disease

Oi

Vrolik Disease

Lobstein'S Disease

Lobstein'S Syndrome

Vrolik'S Disease

Porak And Durante Disease

Glass Bone Disease

Osteogenesis Imperfecta, Dominant Perinatal Lethal

Osteogenesis Imperfecta, Recessive Perinatal Lethal

Brittle Bone Syndrome

Oi - [Osteogenesis Imperfecta]

Ossium Fragility

Osteitis Fragilitans

Bony Fragility

Blue Sclera With Fragility Of Bone And Deafness

White Blue Sclera - Fragility Of Bone - Deafness

Osteogenesis Imperfecta, Type Iii

Osteogenesis Imperfecta Type Iii

OI3

Oi, Type Iii

Osteogenesis Imperfecta Type 3

Oi Type Iii

Oi Type 3

Progressive Deforming Osteogenesis Imperfecta

Severe Osteogenesis Imperfecta

Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae

Progressively Deforming Osteogenesis Imperfecta With Normal Sclera

Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae

Progressively Deforming Oi

Osteogenesis Imperfecta 3

Oi-Iii

Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae

Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney

Dentinogenesis Imperfecta

Hereditary Opalescent Dentin

Dentinogenesis Imperfecta Without Osteogenesis Imperfecta

Dgi

Capdepont Teeth

Dgi Without Oi

Di

Non-Syndromic Dgi

Non-Syndromic Dentinogenesis Imperfecta

Opalescent Teeth Without Oi

Opalescent Teeth Without Osteogenesis Imperfecta

Opalescent Dentin

Small Cell Osteogenic Sarcoma

Small Cell Osteosarcoma

Round Cell Osteosarcoma

Osteosarcoma Small Cell

Osteogenesis Imperfecta, Type Xix

OI19

Osteogenesis Imperfecta Type 19

Osteogenesis Imperfecta Type Xix

Osteogenesis Imperfecta, Type 19

Osteogenesis Imperfecta 19

Keratosis Follicularis Spinulosa Decalvans

Kfsd

Keratosis Follicularis Spinulosa Decalvans Cum Ophiasi

Keratosis Follicularis Spinulosa Decalvans, X-Linked

Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant

Keratosis Pilaris Atrophicans

KPA

Burnett Schwartz Berberian Syndrome

Cole-Carpenter Syndrome

Cole Carpenter Syndrome

Bone Fragility Craniosynostosis Proptosis Hydrocephalus

Bone Fragility With Craniosynostosis, Ocular Proptosis, Hydrocephalus, And Distinctive Facial Features

Bone Fragility-Craniosynostosis-Proptosis-Hydrocephalus Syndrome

Sarcomatosis
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type

PLSD-T

PLSDT

Platyspondylic Dysplasia, Torrance Type

Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type

Thanatophoric Dysplasia, Torrance Variant

Platyspondylic Skeletal Dysplasia, Torrance Type

Torrance Type Platyspondylic Dysplasia

Platyspondylic Dysplasia, Torrance-Luton Type

Platyspondylic Lethal Skeletal Dysplasia Torrance Type

Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type

Thanatophoric Dysplasia Torrance Variant

Platyspondylic Chondrodysplasia, Torrance-Luton Type

Plsd-Tl

Dysplasia, Skeletal, Platyspondylic, Torrance Type

Conventional Osteosarcoma

Intracortical Osteosarcoma

Conventional Central Osteosarcoma

Intracortical Osteogenic Sarcoma

Medullary Osteosarcoma

Spindle Cell Liposarcoma
Pseudosarcomatous Fibromatosis

Nodular Fasciitis

Pseudosarcomatous Fasciitis

Fasciitis - Nodular

Fasciitis Nodular

Fibrosarcoma

Neoplasms, Fibrous Tissue

Fibrocytic Tumor

Fibrosarcoma Of Soft Tissue

Fibrous Tissue Neoplasm

Adult Fibrosarcoma
Osteogenesis Imperfecta, Type Xiv

Osteogenesis Imperfecta Type 14

OI14

Osteogenesis Imperfecta Type Xiv

Oi, Type Xiv

Osteogenesis Imperfecta 14

Oi Type Xiv

Oi-Xiv

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Bruck Syndrome

Osteogenesis Imperfecta With Congenital Joint Contractures

Osteogenesis Imperfecta-Congenital Joint Contractures Syndrome

Spondyloepiphyseal Dysplasia Congenita

SEDC

Sed Congenita

Spondyloepiphyseal Dysplasia, Congenital Type

Late Spondyloepiphyseal Dysplasia

Sed, Congenital Type

Congenital Spondyloepiphyseal Dysplasia

Spranger-Wiedemann Disease

Spondyloepiphyseal Dysplasia Congenital Type

Dysplasia, Spondyloepiphyseal, Congenita

Spondyloepiphyseal Dysplasia, Congenita

Spondyloepiphyseal Dysplasia Tarda, X-Linked

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma

Liposarcoma, Myxoid

Mrcls

Myxoliposarcoma

MXLIPO

Liposarcoma Myxoid

Liposarcoma

Osteogenesis Imperfecta, Type I

Osteogenesis Imperfecta Type I

OI1

Oi, Type I

Osteogenesis Imperfecta Tarda

Osteogenesis Imperfecta With Blue Sclerae

Osteogenesis Imperfecta Type 1

Adair-Dighton Syndrome

Mild Osteogenesis Imperfecta

Non-Deforming Osteogenesis Imperfecta

Oi Type 1

Van Der Hoeve Syndrome

Classic Non-Deforming Oi With Blue Sclerae

Osteogenesis Imperfecta 1

Oi-I

Osteopenic Non-Fracture Syndrome

Osteogenesis Imperfecta, Mild

Osteogenesis Imperfecta

Lobstein'S Disease

Osteochondrodysplasia

Skeletal Dysplasia

Chondrodystrophy

Congenital Anomaly Of Cartilage

Osteochondrodysplasias

Cartilage Development Disorder

Osteochondrodysplasia Syndrome

Dysplasia, Skeletal

Mucopolysaccharidosis Iv

Tooth Agenesis

Oligodontia

Hypodontia

Selective Tooth Agenesis

Tooth Agenesis, Selective

Familial Tooth Agenesis

Anodontia

Congenital Absence Of One Tooth

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CREB3L1 MGD MGI:1347062
Bos taurus CREB3L1 VGNC VGNC:27694
Felis catus CREB3L1 VGNC VGNC:61166
Rattus norvegicus CREB3L1 RGD RGD:1359613
Canis familiaris CREB3L1 VGNC VGNC:39597
Macaca mulatta CREB3L1 VGNC VGNC:71438
Others CREB3L1 NCBI