Stat3 - signal transducer and activator of transcription 3 Gene

中文名称：信号转导和转录激活因子 3

种属: Mus musculus

同用名: Aprf; 1110034C02Rik

关于 Stat3

功能概要

该基因编码的蛋白质是 STAT 蛋白质家族的成员。响应于细胞因子和生长因子，STAT 家族成员被受体相关激酶磷酸化，然后形成同二聚体或异二聚体，转移到细胞核，在那里它们充当转录激活剂。该蛋白通过响应各种细胞因子和生长因子（包括 IFN、EGF、IL5、IL6、HGF、LIF 和 BMP2）的磷酸化而被激活。该蛋白介导多种基因响应细胞刺激的表达，因此在细胞生长和细胞凋亡等许多细胞过程中起着关键作用。小 GTPase Rac1 已被证明可以结合并调节这种蛋白质的活性。 PIAS3蛋白是该蛋白的特异性抑制剂。可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2015 年 9 月]

The protein encoded by this gene is a member of the STAT protein family. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various Cytokines and Growth Factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and Apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]