Kras - Kirsten rat sarcoma viral oncogene homolog Gene

中文名称：Kirsten 大鼠肉瘤病毒癌基因同系物

种属: Mus musculus

同用名: ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras

关于 Kras

功能概要

该基因编码的蛋白可启动 GTPase 活动。参与内分泌信号。作用于几个过程的上游或内部，包括前脑星形胶质细胞发育；化学突触传递的调节；和 Rac 蛋白信号转导的正调控。位于膜内。以多种结构表达，包括大脑；早期胚胎；眼睛;泌尿生殖系统；和直觉。用于研究多种疾病，包括努南综合征 3；癌（多发性）；幼年型粒单核细胞白血病；肺癌；和前列腺癌。该基因的人类直系同源物与多种疾病有关，包括努南综合征（多种）；脑动静脉畸形;心面皮肤综合征（多发性）；胃肠系统癌症（多发性）；和血液系统癌症（多种）。与人类 KRAS 同源（KRAS 原癌基因，GTPase）。 [由基因组资源联盟提供，2022 年 4 月]

Enables GTPase activity. Involved in endocrine signaling. Acts upstream of or within several processes, including forebrain astrocyte development; modulation of chemical synaptic transmission; and positive regulation of Rac protein signal transduction. Located in membrane. Is expressed in several structures, including brain; early embryo; eye; genitourinary system; and gut. Used to study several diseases, including Noonan syndrome 3; carcinoma (multiple); juvenile myelomonocytic leukemia; lung cancer; and prostate Cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system Cancer (multiple); and hematologic Cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]