2. Gene
  3. ACHE - acetylcholinesterase Gene

ACHE - acetylcholinesterase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：乙酰胆碱酯酶

种属: Rattus norvegicus

基因 ID: 83817 | 基因类型: protein coding

关于 ACHE

Primary_assembly 12: 19,407,360-19,413,651 reverse strand.mRatBN7.2:CM026985.1

This gene has 2 transcripts (splice variants), 234 orthologues, 27 paralogues and is associated with 38 phenotypes. Biased expression in Muscle (RPKM 131.4), Brain (RPKM 122.4) and 7 other tissues.

功能概要

该基因编码的蛋白可启动乙酰胆碱结合活性；乙酰胆碱酯酶活性；和胆碱结合活性。参与多个过程，包括乙酰胆碱分解代谢过程；神经发生的正向调节；和对胰岛素的反应。位于几种细胞成分中，包括内质网；神经细胞体；和突触膜。活跃于神经肌肉接头和突触间隙。急性应激障碍和钩端螺旋体病的生物标志物。该基因的人类直系同源物与阿尔茨海默病有关；癫痫;和重症肌无力。与人类 ACHE（乙酰胆碱酯酶（Cartwright 血型））同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables acetylcholine binding activity; acetylcholinesterase activity; and choline binding activity. Involved in several processes, including acetylcholine catabolic process; positive regulation of neurogenesis; and response to Insulin. Located in several cellular components, including endoplasmic reticulum; neuronal cell body; and synaptic membrane. Is active in neuromuscular junction and synaptic cleft. Biomarker of acute stress disorder and leptospirosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human AChE (acetylcholinesterase (Cartwright blood group)). [provided by Alliance of Genome Resources, Apr 2022]

ACHE 基因产物(1)

mRNA Protein Name
NM_172009.2 NP_742006.2 acetylcholinesterase precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetylcholine binding IDA
IDA: 通过直接分析推断
126256 RGD
enables acetylcholinesterase activity IDA
IDA: 通过直接分析推断
126256 RGD
enables choline binding IDA
IDA: 通过直接分析推断
1133098 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acetylcholine catabolic process IDA
IDA: 通过直接分析推断
126256 RGD
involved in acetylcholine metabolic process IMP
IMP: 通过突变表型推断
16628397 RGD
involved in brain development IEP
IEP: 通过表达模式推断
20147288 RGD
involved in choline metabolic process IDA
IDA: 通过直接分析推断
1133098 RGD
involved in choline metabolic process IMP
IMP: 通过突变表型推断
16628397 RGD
involved in positive regulation of axonogenesis IMP
IMP: 通过突变表型推断
12799140 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
12799140 RGD
involved in response to cadmium ion IEP
IEP: 通过表达模式推断
27491636 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
8293290 RGD
involved in response to insecticide IEP
IEP: 通过表达模式推断
7537966 RGD
involved in response to insulin IDA
IDA: 通过直接分析推断
19347982 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
20309727 RGD
involved in synapse assembly IMP
IMP: 通过突变表型推断
12799140 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
1133098 RGD
located in cell surface IDA
IDA: 通过直接分析推断
2731551 RGD
located in dendrite IDA
IDA: 通过直接分析推断
1133098 RGD
located in endoplasmic reticulum lumen IDA
IDA: 通过直接分析推断
1133098 RGD
located in membrane raft IDA
IDA: 通过直接分析推断
20147288 RGD
is active in neuromuscular junction IDA
IDA: 通过直接分析推断
26820598 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
1133098 RGD
located in nuclear envelope IDA
IDA: 通过直接分析推断
1133098 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16052514 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
3655326 RGD
located in presynaptic membrane IDA
IDA: 通过直接分析推断
3655326 RGD
is active in synaptic cleft IDA
IDA: 通过直接分析推断
26820598 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACHE 蛋白结构

COesterase

COesterase: pfam00135 (36 - 562)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 616 a.a.
蛋白主名 其他名称

acetylcholinesterase

glycolipid-anchored form of acetylcholinesterase

相关产品

Approval
生物活性分子 (21)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0034 Donepezil Hydrochloride Inhibitor 99.94% 是
HY-14566 Donepezil Inhibitor 99.91% 是
HY-76299 Galanthamine Inhibitor 99.96% 是
HY-17368 Rivastigmine Inhibitor 99.93% 是
HY-B1266 Physostigmine salicylate Inhibitor 99.37% 否
HY-17387 (-)-Huperzine A Inhibitor 99.74% 是
HY-B0207A Pyridostigmine bromide Inhibitor 99.93% 是
HY-111338 Tacrine Inhibitor 99.91% 是
HY-B1488 Tacrine hydrochloride Inhibitor 99.95% 否
HY-107922 Ethopropazine hydrochloride Inhibitor 99.66% 否
HY-B2244 Tacrine hydrochloride (hydrate) Inhibitor 99.98% 否
HY-A0009 Galanthamine hydrobromide Inhibitor 99.93% 是
HY-B0732 Itopride hydrochloride Inhibitor 99.85% 否
HY-B1200 Pralidoxime chloride Activator 99.73% 否
HY-B1738A Pralidoxime iodide Activator ≥98.0% 否
HY-B2155 Acotiamide monohydrochloride trihydrate Inhibitor 99.49% 是
HY-100919 Ambenonium chloride Inhibitor / 否
HY-114899 Azamethiphos Inhibitor 96.46% 否
HY-B0949A Protriptyline Inhibitor / 否
HY-B0732A Itopride Antagonist / 否
HY-B1738 Pralidoxime Activator / 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-N2320 Physostigmine hemisulfate Inhibitor ≥99.0% Phase 4
HY-127165 Velnacrine Inhibitor / Phase 3
HY-10399A Ladostigil hydrochloride Inhibitor 99.94% Phase 2
Pre-clinical Phase
生物活性分子 (189)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108477 TMPyP4 tosylate Inhibitor ≥98.0% 否
HY-138097 α-NETA Inhibitor ≥98.0% 否
HY-107569 Garcinol Inhibitor ≥99.0% 否
HY-N0285 Imperatorin Inhibitor 98.72% 否
HY-N0342 Scopoletin Inhibitor 99.89% 否
HY-N0528 Linarin Inhibitor 98.00% 否
HY-N0286 Isoimperatorin Inhibitor 99.61% 否
HY-16009 Buntanetap Inhibitor 99.25% 否
HY-N0226A Epiberberine chloride Inhibitor 99.02% 否
HY-N5077 Sinapine Inhibitor 99.96% 否
HY-N0810 Timosaponin AIII 99.73% 否
HY-N0450 Sinapine thiocyanate Inhibitor 99.74% 否
HY-B0815 Chlorpyrifos Inhibitor 99.88% 否
HY-N0740 Jatrorrhizine chloride Inhibitor 99.88% 否
HY-N0923 Corydaline Inhibitor 99.70% 否
HY-N4142 Cyanidin-3-O-galactoside chloride Inhibitor 99.20% 否
HY-N0825 Nodakenin Inhibitor 98.76% 否
HY-N2425 Rhodiosin Inhibitor 99.36% 否
HY-N2230 N-p-trans-Coumaroyltyramine Inhibitor 98.78% 否
HY-B0841 Acephate Inhibitor ≥98.0% 否
HY-N0702 Tenuifolin Inhibitor 99.24% 否
HY-W017423 (-)-Carvone Inhibitor 99.55% 否
HY-100620 RPR121056 Inhibitor 99.59% 否
HY-75247 Coumaran Inhibitor 99.54% 否
HY-103374 Phenserine Inhibitor 99.55% 否
HY-N0241 Rhodionin Inhibitor 98.78% 否
HY-W014700 Glycyl-L-glutamic acid Modulator ≥95.0% 否
HY-124957 β-NETA Inhibitor ≥98.0% 否
HY-17388 (±)-Huperzine A Inhibitor 98.73% 否
HY-P2616A Mca-YVADAP-Lys(Dnp)-OH TFA Chemical 98.85% 否
HY-B1881 Pirimiphos-methyl Inhibitor 98.00% 否
HY-B1093 Fenchlorphos Inhibitor 99.87% 否
HY-103373 PE154 Inhibitor 99.01% 否
HY-155140 BChE-IN-17 Inhibitor 99.07% 否
HY-N0801 Polygalacic acid Inhibitor 98.92% 否
HY-N6895 Violanthin Inhibitor 95.14% 否
HY-N5120 Dihydrowithaferin A Inhibitor ≥99.0% 否
HY-N7263 Galanthamine N-Oxide Inhibitor 99.90% 否
HY-126765 Territrem B Inhibitor ≥95.0% 否
HY-19651A Zanapezil Inhibitor 99.63% 否
HY-151368 AChE/BChE-IN-10 Inhibitor 99.67% 否
HY-19651B Zanapezil fumarate Inhibitor 99.63% 否
HY-N2192 Swertianolin Inhibitor 99.54% 否
HY-121072 ASS234 Inhibitor / 否
HY-N4191 Isorosmanol Inhibitor 98.08% 否
HY-105327 P11149 Inhibitor 99.23% 否
HY-N0226 Epiberberine Inhibitor 98.46% 否
HY-115910A Y13g dihydrochloride Inhibitor 99.89% 否
HY-107275 Ebeiedinone Inhibitor 99.51% 否
HY-122203A PCS1055 Inhibitor 98.02% 否
HY-119419 Pirimicarb Inhibitor 99.50% 否
HY-164130 AChE-IN-65 Inhibitor / 否
HY-N2284 Sophoflavescenol Inhibitor 98.15% 否
HY-110389 Pitofenone hydrochloride Inhibitor 99.88% 否
HY-N2176A (±)-Marmesin ≥95.0% 否
HY-N7993 Manghaslin Inhibitor ≥98.0% 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-151436 ZLMT-12 Inhibitor / 否
HY-131971 AChE/BChE-IN-1 Inhibitor / 否
HY-149233 hAChE-IN-1 Inhibitor / 否
HY-N10488 BChE-IN-11 Inhibitor / 否
HY-157437 AChE/BChE-IN-16 Inhibitor / 否
HY-151927 AChE-IN-28 Inhibitor / 否
HY-159116 AChE-IN-69 Inhibitor / 否
HY-157982 BChE-IN-28 Inhibitor / 否
HY-N10917 Xanthohumol I Inhibitor / 否
HY-158695 Dual AChE-MAO B-IN-4 Inhibitor / 否
HY-151562 AChE/BuChE/MAO-B-IN-1 Inhibitor / 否
HY-163441 BChE-IN-31 Inhibitor / 否
HY-146315 AChE/BChE-IN-6 Inhibitor / 否
HY-148412 Monarsen Inhibitor / 否
HY-152110 AChE/MAO-IN-2 Inhibitor / 否
HY-146959 K203 Activator / 否
HY-132903 eeAChE-IN-1 Inhibitor / 否
HY-157382 AChE-IN-51 Inhibitor / 否
HY-149272 tau/Aβ40 aggregation-IN-1 Inhibitor / 否
HY-143291 AChE-IN-9 Inhibitor / 否
HY-169163 BChE-IN-36 Inhibitor / 否
HY-155284 K1833 Inhibitor / 否
HY-147952 AChE-IN-20 Inhibitor / 否
HY-108048 Desoxypeganine Inhibitor / 否
HY-144272 AChE-IN-5 Inhibitor / 否
HY-162036 α-Amylase/α-Glucosidase-IN-7 Inhibitor / 否
HY-B0830S Isoprocarb-d3 Inhibitor / 否
HY-144775 AChE-IN-10 Inhibitor / 否
HY-161243 AChE-IN-56 Inhibitor / 否
HY-149273 hBChE-IN-1 Inhibitor / 否
HY-149300 SB-1436 Inhibitor / 否
HY-149090 AChE/BuChE/MAO-B-IN-2 / 否
HY-147846 AChE/PDE4-IN-1 Inhibitor / 否
HY-162639 α-Glucosidase-IN-68 Inhibitor / 否
HY-108048A Desoxypeganine hydrochloride Inhibitor / 否
HY-149087 MR2938 Inhibitor / 否
HY-158978 Multitarget AD inhibitor-2 Inhibitor / 否
HY-161842 AChE-IN-67 Inhibitor / 否
HY-157087 AChE/MAO-B-IN-4 Inhibitor / 否
HY-143465 BChE-IN-5 Inhibitor / 否
HY-127087 Isogarcinol Inhibitor / 否
HY-143252 CEase-IN-1 Inhibitor / 否
HY-163514 hAChE-IN-8 Inhibitor / 否
HY-157440 AChE/Aβ-IN-3 Inhibitor / 否
HY-N12388 AChE-IN-46 Inhibitor / 否
HY-N10781 Isograndifoliol Inhibitor / 否
HY-150728 AChE-IN-22 Inhibitor / 否
HY-114803 Kokusaginine Inhibitor / 否
HY-155085 hAChE-IN-3 Inhibitor / 否
HY-162606 MAO-A/B-IN-3 Inhibitor / 否
HY-158334 NDs-IN-1 Inhibitor / 否
HY-162933 AChE-IN-77 Inhibitor / 否
HY-151885 Dual AChE-MAO B-IN-3 Inhibitor / 否
HY-W795027 Anatoxin-a Inhibitor / 否
HY-146762 MAO-B-IN-7 Inhibitor / 否
HY-163537 AChE/BuChE-IN-5 Inhibitor / 否
HY-134006 Stemoninine Inhibitor / 否
HY-163909 AChE-IN-72 Inhibitor / 否
HY-149288 hAChE/hBACE-1-IN-2 Inhibitor / 否
HY-163126 AChE-IN-52 Inhibitor / 否
HY-132904 eeAChE-IN-2 Inhibitor / 否
HY-155366 hAChE-IN-6 Inhibitor / 否
HY-162338 BChE-IN-29 Inhibitor / 否
HY-159482 SBN-284 Inhibitor / 否
HY-152109 AChE/MAO-IN-1 Inhibitor / 否
HY-N2898 Artanin Inhibitor / 否
HY-W130236 Methylene Violet 3RAX Inhibitor / 否
HY-162812 H3R antagonist 4 Inhibitor / 否
HY-155714 AChE-IN-35 Inhibitor / 否
HY-161311 AChE/BChE-IN-18 Inhibitor / 否
HY-161150 AChE/BChE-IN-17 Inhibitor / 否
HY-159081 AChE/BChE-IN-20 Inhibitor / 否
HY-157981 AChE-IN-60 Inhibitor / 否
HY-162915 AChE-IN-75 Inhibitor / 否
HY-123887 Manumycin B Inhibitor / 否
HY-161156 BChE-IN-26 Inhibitor / 否
HY-157978 AChE-IN-59 Inhibitor / 否
HY-155713 AChE-IN-34 Inhibitor / 否
HY-144388 ChE/Aβ1-42-IN-1 Inhibitor / 否
HY-147939 AChE/BuChE-IN-3 Inhibitor / 否
HY-161512 hAChE/hBACE-1-IN-4 Inhibitor / 否
HY-149211 AChE/BChE-IN-12 Inhibitor / 否
HY-161142 Carbonic anhydrase/AChE-IN-1 Inhibitor / 否
HY-168603 AChE/CA I-IN-1 Inhibitor / 否
HY-162681 eeAChE-IN-3 Inhibitor / 否
HY-162693 AChE-IN-68 Inhibitor / 否
HY-157296 AChE-IN-47 Inhibitor / 否
HY-152232 BChE-IN-15 Inhibitor / 否
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / 否
HY-147938 AChE-IN-19 Inhibitor / 否
HY-149287 hAChE/hBACE-1-IN-1 Inhibitor / 否
HY-157532 AChE-IN-55 Inhibitor / 否
HY-146663A AChE/BChE-IN-3 hydrochloride Inhibitor / 否
HY-I1111S2 Fmoc-L-Val-OH-13C5,15N Inhibitor / 否
HY-158261 AChE-IN-63 Inhibitor / 否
HY-168241 Flucopride Inhibitor / 否
HY-144762 K027 Inhibitor / 否
HY-N12423 Bis-(-)-8-demethylmaritidine Inhibitor / 否
HY-162591 MR33317 Inhibitor / 否
HY-N10384 AChE-IN-17 Inhibitor / 否
HY-156372 AChE-IN-44 Inhibitor / 否
HY-168052 hAChE-IN-9 Inhibitor / 否
HY-122080 Memoquin Inhibitor / 否
HY-N11641 Methyl ganoderate A acetonide Inhibitor / 否
HY-49373 AChE-IN-64 Inhibitor / 否
HY-115919 AChE-IN-8 Inhibitor / 否
HY-169162 hBChE-IN-3 Inhibitor / 否
HY-149237 hAChE-IN-2 Inhibitor / 否
HY-145235 AChE-IN-4 / 否
HY-158092 ChEs/MAOs-IN-2 Inhibitor / 否
HY-149212 SD-6 Inhibitor / 否
HY-N8547A (Rac)-Sclerone Inhibitor / 否
HY-157441 AChE/Aβ-IN-4 Inhibitor / 否
HY-N10701 AChE/BChE-IN-11 Inhibitor / 否
HY-N12581 Kuwanon U Inhibitor / 否
HY-150545 AChE-IN-21 Inhibitor / 否
HY-161508 AChE/BChE-IN-19 Inhibitor / 否
HY-151260 AChE/BACE1/GSK3β-IN-1 Inhibitor / 否
HY-161507 hCAI/II-IN-8 Inhibitor / 否
HY-152111 AChE/MAO-B-IN-3 Inhibitor / 否
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / 否
HY-115910 Y13g Inhibitor / 否
HY-151152 AChE-IN-24 Inhibitor / 否
HY-115973 AChE-IN-11 Inhibitor / 否
HY-144389 hAChE/Aβ1-42-IN-1 Inhibitor / 否
HY-18039 WAY-361789 Agonist / 否
HY-169173 AL284 Inhibitor / 否
HY-161029 T14-A24 Inhibitor / 否
HY-N7346 Lucidadiol Inhibitor / 否
HY-101653 MHP 133 Inhibitor / 否
HY-W049312 7-Methoxytacrine Inhibitor / 否
HY-115650 TAE-1 Inhibitor 96.17% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ACHE NCBI NCBI:43
Canis familiaris ACHE NCBI NCBI:489828
Macaca fascicularis ACHE NCBI NCBI:102143626
Mus musculus ACHE NCBI NCBI:11423
Susscrofa domestica ACHE NCBI
Leporidae ACHE NCBI
Macaca mulatta ACHE NCBI NCBI:713370
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