Bcl2 - B cell leukemia/lymphoma 2 Gene

中文名称：B细胞白血病/淋巴瘤2

种属: Mus musculus

同用名: Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik

基因 ID: 12043 | 基因类型: protein coding

关于 Bcl2

Chromosome 1: 106,465,908-106,642,004 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 230 orthologues, 10 paralogues and is associated with 133 phenotypes. Ubiquitous expression in spleen adult (RPKM 4.5), limb E14.5 (RPKM 2.8) and 23 other tissues.

功能概要

该基因编码 B 细胞淋巴瘤 2 蛋白家族的一个成员。这个家族的成员调节多种细胞类型的细胞死亡，并且可以具有促凋亡或抗凋亡活性。该基因编码的蛋白质抑制线粒体介导的细胞凋亡。该蛋白是一种完整的线粒体外膜蛋白，作为信号通路的一部分，控制线粒体通透性以响应凋亡刺激。这种蛋白质也可能在神经元细胞存活和自噬中发挥作用。该基因的异常表达和染色体易位与许多组织中的癌症进展有关。交替剪接导致多个转录本变体。 [RefSeq 提供，2015 年 9 月]

This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated Apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and Autophagy. Abnormal expression and chromosomal translocations of this gene are associated with Cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Bcl2 基因产物(2)

mRNA	Protein	Name
NM_177410.3	NP_803129.2	apoptosis regulator Bcl-2 isoform 2
NM_009741.5	NP_033871.2	apoptosis regulator Bcl-2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	36812915	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	7834748	MGI
enables protein phosphatase 2A binding	IDA IDA: 通过直接分析推断	16717086	MGI
enables protein phosphatase binding	IDA IDA: 通过直接分析推断	12617961	MGI
enables transcription factor binding	IPI IPI: 通过物理相互作用推断	17382917	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of B cell apoptotic process	IDA IDA: 通过直接分析推断	8313913	MGI
acts upstream of or within B cell apoptotic process	IMP IMP: 通过突变表型推断	8372353	MGI
acts upstream of or within B cell differentiation	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within B cell homeostasis	IMP IMP: 通过突变表型推断	7650488	MGI
acts upstream of or within B cell lineage commitment	IMP IMP: 通过突变表型推断	8788039	MGI
acts upstream of or within CD8-positive, alpha-beta T cell lineage commitment	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of G1/S transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	12855558	MGI
acts upstream of T cell apoptotic process	IDA IDA: 通过直接分析推断	7751019	MGI
acts upstream of or within T cell apoptotic process	IMP IMP: 通过突变表型推断	8372353	MGI
acts upstream of or within T cell differentiation	IGI IGI: 通过遗传相互作用推断	9215624	MGI
acts upstream of or within T cell differentiation	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within T cell differentiation in thymus	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within T cell homeostasis	IGI IGI: 通过遗传相互作用推断	17591857	MGI
acts upstream of or within T cell homeostasis	IMP IMP: 通过突变表型推断	7650488	MGI
acts upstream of or within T cell lineage commitment	IMP IMP: 通过突变表型推断	8788039	MGI
acts upstream of or within actin filament organization	IMP IMP: 通过突变表型推断	9950951	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within apoptotic mitochondrial changes	IDA IDA: 通过直接分析推断	14707049	MGI
acts upstream of apoptotic process	IMP IMP: 通过突变表型推断	7840250	MGI
acts upstream of or within axon regeneration	IDA IDA: 通过直接分析推断	9009190	MGI
acts upstream of or within axonogenesis	IMP IMP: 通过突变表型推断	9009190	MGI
acts upstream of or within behavioral fear response	IMP IMP: 通过突变表型推断	16095731	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IDA IDA: 通过直接分析推断	14699151	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IGI IGI: 通过遗传相互作用推断	16672320	MGI
acts upstream of calcium ion transport into cytosol	IGI IGI: 通过遗传相互作用推断	15613488	MGI
acts upstream of cell growth	IMP IMP: 通过突变表型推断	12855558	MGI
acts upstream of cell migration	IMP IMP: 通过突变表型推断	15292044	MGI
acts upstream of or within cell morphogenesis	IDA IDA: 通过直接分析推断	18548006	MGI
acts upstream of or within cell morphogenesis	IMP IMP: 通过突变表型推断	10193316	MGI
acts upstream of or within cell population proliferation	IGI IGI: 通过遗传相互作用推断	10762311	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: 通过突变表型推断	15292044	MGI
acts upstream of or within cellular response to glucose starvation	IDA IDA: 通过直接分析推断	7595537	MGI
acts upstream of or within cellular response to hypoxia	IDA IDA: 通过直接分析推断	7595537	MGI
acts upstream of or within cochlear nucleus development	IMP IMP: 通过突变表型推断	11027399	MGI
acts upstream of dendritic cell apoptotic process	IDA IDA: 通过直接分析推断	17267035	MGI
acts upstream of or within developmental growth	IMP IMP: 通过突变表型推断	15818405	MGI
acts upstream of or within developmental pigmentation	IGI IGI: 通过遗传相互作用推断	11709185	MGI
acts upstream of or within developmental pigmentation	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within digestive tract morphogenesis	IMP IMP: 通过突变表型推断	7812968	MGI
acts upstream of or within ear development	IGI IGI: 通过遗传相互作用推断	11709185	MGI
acts upstream of or within ear development	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within endoplasmic reticulum calcium ion homeostasis	IGI IGI: 通过遗传相互作用推断	15613488	MGI
acts upstream of epithelial cell apoptotic process	IMP IMP: 通过突变表型推断	10200548	MGI
acts upstream of establishment of localization in cell	IGI IGI: 通过遗传相互作用推断	15613488	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IGI IGI: 通过遗传相互作用推断	12082633	MGI
acts upstream of or within focal adhesion assembly	IMP IMP: 通过突变表型推断	15292044	MGI
acts upstream of or within gland morphogenesis	IMP IMP: 通过突变表型推断	7812968	MGI
acts upstream of or within glomerulus development	IMP IMP: 通过突变表型推断	8623928	MGI
involved in hair follicle morphogenesis	IMP IMP: 通过突变表型推断	8402909	MGI
acts upstream of or within hematopoietic stem cell differentiation	IMP IMP: 通过突变表型推断	9028316	MGI
acts upstream of or within hemopoiesis	IMP IMP: 通过突变表型推断	7812968	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: 通过突变表型推断	9241272	MGI
acts upstream of or within immune system development	IMP IMP: 通过突变表型推断	7812968	MGI
acts upstream of or within intracellular calcium ion homeostasis	IDA IDA: 通过直接分析推断	7945396	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IGI IGI: 通过遗传相互作用推断	15983387	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress	IMP IMP: 通过突变表型推断	12855558	MGI
acts upstream of or within kidney development	IGI IGI: 通过遗传相互作用推断	9241272	MGI
acts upstream of or within kidney development	IMP IMP: 通过突变表型推断	7812968	MGI
acts upstream of or within leukocyte homeostasis	IMP IMP: 通过突变表型推断	9028316	MGI
acts upstream of lymphocyte apoptotic process	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within lymphocyte apoptotic process	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within lymphocyte homeostasis	IGI IGI: 通过遗传相互作用推断	11709185	MGI
acts upstream of or within lymphocyte homeostasis	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within lymphoid progenitor cell differentiation	IMP IMP: 通过突变表型推断	9028316	MGI
acts upstream of or within male gonad development	IGI IGI: 通过遗传相互作用推断	9241272	MGI
acts upstream of or within melanin metabolic process	IMP IMP: 通过突变表型推断	11709185	MGI
acts upstream of or within melanocyte differentiation	IGI IGI: 通过遗传相互作用推断	12086670	MGI
acts upstream of melanocyte differentiation	IMP IMP: 通过突变表型推断	16427619	MGI
acts upstream of or within melanocyte differentiation	IMP IMP: 通过突变表型推断	8758925	MGI
acts upstream of or within mesenchymal cell development	IMP IMP: 通过突变表型推断	8623928	MGI
acts upstream of or within metanephros development	IMP IMP: 通过突变表型推断	7840250	MGI
acts upstream of mitotic cell cycle	IDA IDA: 通过直接分析推断	9241272	MGI
acts upstream of motor neuron apoptotic process	IDA IDA: 通过直接分析推断	7472523	MGI
acts upstream of myeloid cell apoptotic process	IDA IDA: 通过直接分析推断	9202146	MGI
acts upstream of or within negative regulation of B cell apoptotic process	IDA IDA: 通过直接分析推断	8313913	MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: 通过直接分析推断	14660795	MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	12855558	MGI
acts upstream of or within negative regulation of T cell apoptotic process	IDA IDA: 通过直接分析推断	7751019	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	7834747	MGI
acts upstream of or within negative regulation of apoptotic process	IGI IGI: 通过遗传相互作用推断	7834747	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	7840250	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IDA IDA: 通过直接分析推断	11546872	MGI
involved in negative regulation of autophagy	IDA IDA: 通过直接分析推断	36812915	MGI
acts upstream of or within negative regulation of calcium ion transport into cytosol	IGI IGI: 通过遗传相互作用推断	15613488	MGI
acts upstream of or within negative regulation of cell growth	IMP IMP: 通过突变表型推断	12855558	MGI
acts upstream of or within negative regulation of cell migration	IMP IMP: 通过突变表型推断	15292044	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	8663032	MGI
acts upstream of or within negative regulation of dendritic cell apoptotic process	IDA IDA: 通过直接分析推断	17267035	MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process	IMP IMP: 通过突变表型推断	10200548	MGI
acts upstream of or within negative regulation of lymphocyte apoptotic process	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within negative regulation of mitotic cell cycle	IDA IDA: 通过直接分析推断	9241272	MGI
acts upstream of or within negative regulation of motor neuron apoptotic process	IDA IDA: 通过直接分析推断	7472523	MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process	IDA IDA: 通过直接分析推断	9202146	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IDA IDA: 通过直接分析推断	8625820	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	9153592	MGI
acts upstream of or within negative regulation of ossification	IMP IMP: 通过突变表型推断	9008714	MGI
acts upstream of or within negative regulation of osteoblast proliferation	IMP IMP: 通过突变表型推断	10193316	MGI
acts upstream of or within negative regulation of retinal cell programmed cell death	IMP IMP: 通过突变表型推断	10321489	MGI
acts upstream of neuron apoptotic process	IDA IDA: 通过直接分析推断	8625820	MGI
acts upstream of or within neuron apoptotic process	IGI IGI: 通过遗传相互作用推断	10762311	MGI
acts upstream of neuron apoptotic process	IMP IMP: 通过突变表型推断	9153592	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: 通过突变表型推断	7546744	MGI
acts upstream of neuron maturation	IMP IMP: 通过突变表型推断	9547242	MGI
acts upstream of or within oocyte development	IMP IMP: 通过突变表型推断	7628407	MGI
acts upstream of or within organ growth	IMP IMP: 通过突变表型推断	7812968	MGI
acts upstream of or within ossification	IMP IMP: 通过突变表型推断	10193316	MGI
acts upstream of osteoblast proliferation	IMP IMP: 通过突变表型推断	10193316	MGI
acts upstream of or within ovarian follicle development	IMP IMP: 通过突变表型推断	7628407	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	14660795	MGI
acts upstream of peptidyl-serine phosphorylation	IGI IGI: 通过遗传相互作用推断	15613488	MGI
acts upstream of or within peptidyl-threonine phosphorylation	IDA IDA: 通过直接分析推断	14660795	MGI
acts upstream of or within pigment granule organization	IMP IMP: 通过突变表型推断	8758925	MGI
involved in pigmentation	IMP IMP: 通过突变表型推断	8402909	MGI
acts upstream of or within positive regulation of catalytic activity	IMP IMP: 通过突变表型推断	17382917	MGI
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	11983915	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	8084613	MGI
acts upstream of or within positive regulation of developmental pigmentation	IGI IGI: 通过遗传相互作用推断	9241272	MGI
acts upstream of or within positive regulation of melanocyte differentiation	IMP IMP: 通过突变表型推断	16427619	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: 通过突变表型推断	11709185	MGI
acts upstream of or within positive regulation of neuron maturation	IMP IMP: 通过突变表型推断	9547242	MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IGI IGI: 通过遗传相互作用推断	15613488	MGI
acts upstream of or within positive regulation of skeletal muscle fiber development	IMP IMP: 通过突变表型推断	11146504	MGI
acts upstream of or within positive regulation of smooth muscle cell migration	IMP IMP: 通过突变表型推断	17382917	MGI
acts upstream of or within post-embryonic development	IGI IGI: 通过遗传相互作用推断	9241272	MGI
acts upstream of or within post-embryonic development	IMP IMP: 通过突变表型推断	7812968	MGI
acts upstream of or within protein dephosphorylation	IDA IDA: 通过直接分析推断	16717086	MGI
acts upstream of or within reactive oxygen species metabolic process	IMP IMP: 通过突变表型推断	9681465	MGI
acts upstream of or within regulation of apoptotic process	IGI IGI: 通过遗传相互作用推断	8918887	MGI
involved in regulation of autophagy	IMP IMP: 通过突变表型推断	22258505	MGI
acts upstream of or within regulation of catalytic activity	IMP IMP: 通过突变表型推断	9681465	MGI
acts upstream of or within regulation of cell cycle	IMP IMP: 通过突变表型推断	10200548	MGI
acts upstream of or within regulation of cell-matrix adhesion	IMP IMP: 通过突变表型推断	15292044	MGI
acts upstream of or within regulation of developmental pigmentation	IGI IGI: 通过遗传相互作用推断	15818405	MGI
acts upstream of or within regulation of gene expression	IMP IMP: 通过突变表型推断	12855558	MGI
acts upstream of or within regulation of glycoprotein biosynthetic process	IMP IMP: 通过突变表型推断	15292044	MGI
acts upstream of or within regulation of growth	IMP IMP: 通过突变表型推断	7812968	MGI
involved in regulation of mitochondrial membrane permeability	IDA IDA: 通过直接分析推断	9843949	MGI
involved in regulation of mitochondrial membrane potential	IDA IDA: 通过直接分析推断	9843949	MGI
acts upstream of or within regulation of nitrogen utilization	IGI IGI: 通过遗传相互作用推断	9241272	MGI
acts upstream of or within regulation of programmed cell death	IGI IGI: 通过遗传相互作用推断	16672320	MGI
acts upstream of or within regulation of protein localization	IMP IMP: 通过突变表型推断	9950951	MGI
acts upstream of or within regulation of protein stability	IMP IMP: 通过突变表型推断	14660795	MGI
involved in regulation of viral genome replication	IDA IDA: 通过直接分析推断	16950491	MGI
involved in release of cytochrome c from mitochondria	IDA IDA: 通过直接分析推断	9843949	MGI
acts upstream of or within renal system process	IMP IMP: 通过突变表型推断	8760259	MGI
acts upstream of or within response to UV-B	IMP IMP: 通过突变表型推断	10200548	MGI
acts upstream of or within response to acid chemical	IDA IDA: 通过直接分析推断	7675327	MGI
acts upstream of or within response to cytokine	IMP IMP: 通过突变表型推断	12855558	MGI
acts upstream of or within response to gamma radiation	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within response to glucocorticoid	IDA IDA: 通过直接分析推断	8313913	MGI
acts upstream of or within response to glucocorticoid	IMP IMP: 通过突变表型推断	8372353	MGI
acts upstream of or within response to hydrogen peroxide	IMP IMP: 通过突变表型推断	12855558	MGI
acts upstream of or within response to ischemia	IMP IMP: 通过突变表型推断	10488913	MGI
acts upstream of or within response to oxidative stress	IMP IMP: 通过突变表型推断	12855558	MGI
acts upstream of or within response to steroid hormone	IMP IMP: 通过突变表型推断	8170972	MGI
acts upstream of or within response to toxic substance	IMP IMP: 通过突变表型推断	10602483	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: 通过直接分析推断	9098922	MGI
acts upstream of retinal cell programmed cell death	IMP IMP: 通过突变表型推断	10321489	MGI
acts upstream of skeletal muscle fiber development	IMP IMP: 通过突变表型推断	11146504	MGI
acts upstream of smooth muscle cell migration	IMP IMP: 通过突变表型推断	17382917	MGI
acts upstream of or within spleen development	IGI IGI: 通过遗传相互作用推断	15818405	MGI
acts upstream of or within spleen development	IMP IMP: 通过突变表型推断	15818405	MGI
acts upstream of or within stem cell development	IMP IMP: 通过突变表型推断	8623928	MGI
acts upstream of or within thymus development	IGI IGI: 通过遗传相互作用推断	15818405	MGI
acts upstream of or within thymus development	IMP IMP: 通过突变表型推断	9241272	MGI
acts upstream of or within ureteric bud development	IMP IMP: 通过突变表型推断	8623928	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytoplasm	IDA IDA: 通过直接分析推断	36812915	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	7563251	MGI
located in cytosol	IDA IDA: 通过直接分析推断	8030757	MGI
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	8030757	MGI
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	15613488	MGI
located in intracellular anatomical structure	IDA IDA: 通过直接分析推断	9008714	MGI
located in membrane	IDA IDA: 通过直接分析推断	8030757	MGI
located in mitochondrial membrane	IDA IDA: 通过直接分析推断	11980919	MGI
located in mitochondrion	IDA IDA: 通过直接分析推断	7945396	MGI
located in myelin sheath	IDA IDA: 通过直接分析推断	7953633	MGI
located in nuclear membrane	IDA IDA: 通过直接分析推断	8030757	MGI
located in nucleus	IDA IDA: 通过直接分析推断	7945396	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bcl2 蛋白结构

bcl-2

0
100
200
236 a.a.

蛋白主名

其他名称

apoptosis regulator Bcl-2

重组 Bcl2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72101	BCL2 Protein, Mouse (His)	P10417-1 (G5-P205)	≥95%

相关产品

Approval

生物活性分子 (10)

目录号	产品名	作用方式	纯度	是否罕见病
HY-15531	Venetoclax		99.95%	是
HY-B0011	Docetaxel		99.94%	否
HY-B0318	Metronidazole		99.92%	是
HY-13407	Gossypol	Antagonist	99.67%	是
HY-17510	Gossypol (acetic acid)	Inhibitor	99.75%	是
HY-B0011A	Docetaxel Trihydrate		99.92%	否
HY-B0766	Bicyclol		99.91%	否
HY-118874	Oblimersen		/	否
HY-B0318A	Metronidazole hydrochloride		/	否
HY-B0011R	Docetaxel (Standard)		/	否

Clinical Phase

生物活性分子 (20)

目录号	产品名	作用方式	纯度	Phase
HY-105930	Lobaplatin		≥98.0%	Phase 4
HY-10087	Navitoclax	Inhibitor	99.97%	Phase 3
HY-10969	Obatoclax Mesylate		99.85%	Phase 3
HY-15464A	(R)-(-)-Gossypol acetic acid		98.93%	Phase 3
HY-N0867	13-Oxyingenol-13-dodecanoate		99.37%	Phase 3
HY-10969A	Obatoclax		≥99.0%	Phase 3
HY-50868	Bafetinib		99.77%	Phase 2
HY-129179	Lisaftoclax	Inhibitor	99.28%	Phase 2
HY-109185	Pelcitoclax		99.70%	Phase 2
HY-N0068	Solasodine		99.54%	Phase 2
HY-15464	(R)-(-)-Gossypol		98.82%	Phase 2
HY-138697	S65487		99.91%	Phase 2
HY-138697B	S65487 hydrochloride		99.67%	Phase 2
HY-123823	Nitroaspirin		/	Phase 2
HY-15464D	(S)-Gossypol (acetic acid)	Inhibitor	98.39%	Phase 2
HY-138697A	S65487 sulfate		98.08%	Phase 2
HY-13559	Atiprimod		/	Phase 2
HY-117288	S55746	Inhibitor	99.89%	Phase 1
HY-109184	Murizatoclax	Inhibitor	98.85%	Phase 1
HY-117288A	S55746 hydrochloride	Inhibitor	99.66%	Phase 1

Pre-clinical Phase

生物活性分子 (235)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-50907	ABT-737		99.96%	否
HY-107738	Guggulsterone		99.95%	否
HY-130604	DT2216		99.97%	否
HY-N2342	Procyanidin C1	Inducer	99.79%	否
HY-N0292	Oleuropein		99.05%	否
HY-N0674	Dehydrocorydaline		99.77%	否
HY-126477	NNK		99.98%	否
HY-N0087	Gambogic Acid		98.79%	否
HY-N0361	Dihydrocapsaicin		99.93%	否
HY-112416	AZD4320	Inhibitor	99.68%	否
HY-18628	UMI-77	Inhibitor	99.66%	否
HY-148026	Sonrotoclax	Inhibitor	99.61%	否
HY-125877	PROTAC Mcl1 degrader-1	Inhibitor	98.13%	否
HY-147081	AS 1411	Inhibitor	/	否
HY-118119	CAY10526	Inhibitor	99.40%	否
HY-126741	Azadirachtin		99.06%	否
HY-N3584	Paris saponin VII		99.96%	否
HY-125876	PROTAC Bcl2 degrader-1	Inhibitor	99.80%	否
HY-124284	Hexamethylene bisacetamide		99.56%	否
HY-15531S	Venetoclax-d8		99.76%	否
HY-N0265	Asperosaponin VI	Inhibitor	98.91%	否
HY-103243	TCPOBOP	Inhibitor	98.67%	否
HY-N0674A	Dehydrocorydaline chloride		99.72%	否
HY-N2897	Dihydrokaempferol		99.88%	否
HY-12020	TW-37	Inhibitor	99.27%	否
HY-33350	Clofilium tosylate		99.84%	否
HY-139309	PROTAC Bcl-xL degrader-2	Inhibitor	98.16%	否
HY-15191	Sabutoclax	Inhibitor	99.80%	否
HY-N0674B	Dehydrocorydaline (hydroxyl)		99.52%	否
HY-133557	XZ739		99.06%	否
HY-138832	BM-1244	Inhibitor	99.85%	否
HY-120882	BM-1197	Inhibitor	99.48%	否
HY-12011	HA14-1	Inhibitor	≥98.0%	否
HY-N3001	Isolinderalactone	Inhibitor	98.79%	否
HY-N6850	Calenduloside E		99.07%	否
HY-P1889	Bim BH3, Peptide IV		99.35%	否
HY-129700	MCL-1/BCL-2-IN-2	Inhibitor	99.12%	否
HY-16014	A-385358	Inhibitor	98.19%	否
HY-N1440	Koumine	Activator	99.97%	否
HY-129681	MCL-1/BCL-2-IN-1	Inhibitor	99.86%	否
HY-10087S	Navitoclax-d8	Inhibitor	99.71%	否
HY-157176	BAX-IN-1	Inhibitor	≥98.0%	否
HY-161100	BDM19	Inducer	98.09%	否
HY-N7930	Crenulatin		≥99.0%	否
HY-142209	ABBV-167	Inhibitor	97.33%	否
HY-100383	BH3I-1		≥98.0%	否
HY-132307	Mcl-1 inhibitor 6		98.40%	否
HY-119931	2-Hydroxychalcone		98.80%	否
HY-156278	FB49	Inhibitor	99.76%	否
HY-N1157	Thevetiaflavone		≥98.0%	否
HY-N6690	Destruxin B		99.86%	否
HY-P1527	Bim BH3		99.80%	否
HY-113471A	(S)-(-)-Perillic acid		≥95.0%	否
HY-118874A	Oblimersen sodium	Inhibitor	98.09%	否
HY-161254	ATPase-IN-3		99.89%	否
HY-169925	BM-962	Inhibitor	99.10%	否
HY-B0011S	Docetaxel-d9		≥98.0%	否
HY-N4238	Dehydrocorydaline nitrate		99.90%	否
HY-RS01415	BCL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-109617	4-(4-Fluorophenyl)benzoic acid		99.01%	否
HY-111329	JGB1741		99.05%	否
HY-119833	Rubone	Modulator	99.1%	否
HY-129179B	(Rac)-Lisaftoclax	Inhibitor	98.22%	否
HY-13408	(+)-Apogossypol	Inhibitor	/	否
HY-160921	Capeserod	Agonist	98.66%	否
HY-161276	BFC1108	Inducer	98.11%	否
HY-161410	WH244	Degrader	/	否
HY-N0307	Ciwujianoside B	Inhibitor	99.00%	否
HY-N2416	Taccalonolide A		99.29%	否
HY-P2343	BH3 hydrochloride	Activator	98.02%	否
HY-RS01431	BCL2L13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-15191B	(S)-Sabutoclax	Inhibitor	98.03%	否
HY-114310	VDR agonist 1		/	否
HY-128360	dMCL1-2	Inhibitor	/	否
HY-131247	Bcl-2-IN-2	Inhibitor	/	否
HY-135273	A-1211212		/	否
HY-155188	NWP-0476	Inhibitor	/	否
HY-100762	Mcl1-IN-11	Inhibitor	/	否
HY-100763	Mcl1-IN-12	Inhibitor	/	否
HY-146097	RMS5		/	否
HY-149918	Antiproliferative agent-23		/	否
HY-156620	Lacutoclax	Inhibitor	/	否
HY-19551	Apogossypolone		/	否
HY-B1559	Allethrin	Inducer	98.04%	否
HY-10087A1	Navitoclax dihydrochloride	Inhibitor	/	否
HY-101083	BDA-366	Antagonist	/	否
HY-101999	EM20-25		/	否
HY-115974	GRPR antagonist-1		/	否
HY-118925	Holothurin A	Inhibitor	/	否
HY-121934	BH3I-2'		/	否
HY-123034	CDKI-83		/	否
HY-123244	YC137		/	否
HY-124122	BPTQ		/	否
HY-125191	BRD1991	Inhibitor	/	否
HY-127130	Spicamycin		/	否
HY-129701	MCL-1/BCL-2-IN-3	Inhibitor	99.22%	否
HY-129702	MCL-1/BCL-2-IN-4	Inhibitor	/	否
HY-131188	PROTAC Bcl-xL degrader-1	Inhibitor	/	否
HY-131405	β-Eleostearic acid	Inhibitor	/	否
HY-133772	Venetoclax N-oxide		/	否
HY-13659	KRN5500		/	否
HY-13846	BM-1074		/	否
HY-143235	BRD4 Inhibitor-15		/	否
HY-143872	Bcl-2-IN-4	Inhibitor	/	否
HY-143873	Bcl-2-IN-5	Inhibitor	/	否
HY-144428	Bcl-2/Mcl-1-IN-2	Inhibitor	/	否
HY-144430	Bcl-2/Mcl-1-IN-1	Inhibitor	/	否
HY-144431	Bcl-2/Mcl-1-IN-3	Inhibitor	/	否
HY-144778	IDO1/TDO-IN-1		/	否
HY-144791	Bcl-2-IN-6		/	否
HY-144792	Bcl-2-IN-7		/	否
HY-145288	Antitumor agent-36		/	否
HY-145289	Antitumor agent-37		/	否
HY-146095	p53 Activator 2		/	否
HY-146253	CDK1/2/4-IN-1		/	否
HY-146444	Anticancer agent 56		/	否
HY-146471	EGFR-IN-51		/	否
HY-146472	EGFR-IN-52		/	否
HY-146817	Tubulin polymerization-IN-11		/	否
HY-147504	Anticancer agent 63		/	否
HY-147826	EGFR-IN-60		/	否
HY-147906	Anticancer agent 71		/	否
HY-147928	Apoptotic agent-2		/	否
HY-147929	Apoptotic agent-3		/	否
HY-149009	Bcl-2-IN-9		/	否
HY-149024	VEGFR-2-IN-23		/	否
HY-149436	CDK2/Bcl2-IN-1	Inhibitor	/	否
HY-149622	Bcl-2-IN-12	Inhibitor	/	否
HY-149623	Bcl-2-IN-13	Inhibitor	/	否
HY-149624	Bcl-2-IN-14	Inhibitor	/	否
HY-149625	Bcl-2-IN-15	Inhibitor	/	否
HY-149681	Beclin1-Bcl-2 interaction inhibitor 1	Inhibitor	/	否
HY-150540	Bcl-2-IN-10		/	否
HY-150596	CT1-3		/	否
HY-151428	Antitumor agent-78		/	否
HY-151429	Antitumor agent-77		/	否
HY-151443	HDAC-IN-47	Inhibitor	/	否
HY-153494	Rosomidnar	Inhibitor	/	否
HY-153494A	Rosomidnar sodium	Inhibitor	/	否
HY-153953	Bcl-2-IN-11	Inhibitor	/	否
HY-155242	VEGFR-2-IN-36		/	否
HY-156096	HDAC3-IN-2		/	否
HY-156877	Bcl-2-IN-16		/	否
HY-157343	GD3 Ganglioside		/	否
HY-157343A	GD3 Ganglioside sodium		/	否
HY-159513	Bcl-2/Mcl-1-IN-4	Inhibitor	/	否
HY-159668	DL002		/	否
HY-159817	Asaretoclax	Inhibitor	/	否
HY-160108	Bcl-2-IN-17	Inhibitor	/	否
HY-161415	BCL-xL/BCL-2 ligand 1		/	否
HY-161577	BFC1103		/	否
HY-161659	Apoptosis inducer 19		/	否
HY-161732	GQN-B37-E	Inhibitor	/	否
HY-161786	Bcl-2-IN-20		/	否
HY-162148	HNPMI	Inhibitor	99.57%	否
HY-162820	Bcl-2-IN-21	Inhibitor	/	否
HY-162826	Apoptosis inducer 27	Inducer	/	否
HY-162886	BSO-07	Activator	/	否
HY-163077	Anticancer agent 175	Inducer	/	否
HY-163308	Bcl-2-IN-18	Inhibitor	/	否
HY-163309	Bcl-2-IN-19	Inhibitor	/	否
HY-163435	Anticancer agent 201		/	否
HY-163527	FGFR-IN-13	Inhibitor	/	否
HY-163764	Bfl-1-IN-4		/	否
HY-167825	Barakol		/	否
HY-168171	ERK1/2 inhibitor 11		/	否
HY-168623	EGFR-IN-134		/	否
HY-168739	Topoisomerase I inhibitor 17		/	否
HY-169083	Bcl-2-IN-22	Inhibitor	/	否
HY-169096	DPP-21		/	否
HY-169124	Apoptosis inducer 28		/	否
HY-169265	BRD-K20733377	Inhibitor	/	否
HY-169266	BRD-K56819078	Inhibitor	/	否
HY-169267	BRD-K44839765	Inhibitor	/	否
HY-169412	MAPK-IN-3		/	否
HY-169431	VEGFR-2/AKT-IN-2		/	否
HY-170434	Bfl-1-IN-6		/	否
HY-170648	TS-IN-5		/	否
HY-170689	CG-3-246	Inhibitor	/	否
HY-18628S	UMI-77-d4	Inhibitor	/	否
HY-50907S	ABT-737-d8		99.11%	否
HY-B0011AS	Docetaxel-d5 trihydrate		/	否
HY-N0361S	Dihydrocapsaicin-d3		/	否
HY-N10091	2,3-Dihydro-3α-methoxynimbolide		/	否
HY-N1218	Stellasterol	Inhibitor	/	否
HY-N1930	(-)-Hinesol	Inducer	/	否
HY-N2741	Vitexin B-1	Inhibitor	/	否
HY-N3828	epi-Eriocalyxin A		/	否
HY-P10057	cpm-1285	Inducer	/	否
HY-P10058	cpm-1285m		/	否
HY-P1889A	Bim BH3, Peptide IV TFA		/	否
HY-P5324	Bad BH3 (mouse)		/	否
HY-P5325	Bid BH3 (80-99)		/	否
HY-P5327	r8 Bid BH3		/	否
HY-RS01416	Bcl2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01417	BCL2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01418	BCL2A1 Human Pre-designed siRNA Set A		/	否
HY-RS01419	Bcl2a1 Rat Pre-designed siRNA Set A		/	否
HY-RS01420	Bcl2a1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01421	BCL2L1 Human Pre-designed siRNA Set A		/	否
HY-RS01422	Bcl2l1 Mouse Pre-designed siRNA Set A		/	否
HY-RS01423	Bcl2l1 Rat Pre-designed siRNA Set A		/	否
HY-RS01424	BCL2L10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01425	Bcl2l10 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01426	Bcl2l10 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01427	BCL2L11 Human Pre-designed siRNA Set A		/	否
HY-RS01428	Bcl2l11 Mouse Pre-designed siRNA Set A		/	否
HY-RS01429	Bcl2l11 Rat Pre-designed siRNA Set A		/	否
HY-RS01430	BCL2L12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01432	BCL2L14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01433	BCL2L15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01434	BCL2L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01435	Bcl2l2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01436	Bcl2l2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-101083A	(Rac)-BDA-366	Inhibitor	/	否
HY-111244	DCB-3503		/	否
HY-115529	(-)BI97D6	Inducer	/	否
HY-116204	SKLB70326		/	否
HY-116532	YCW-E11	Inhibitor	/	否
HY-117136	AN-7		/	否
HY-12011A	(Rac)-HA14-1	Inhibitor	/	否
HY-122047	SW063058		/	否
HY-123020	CYD-2-88		/	否
HY-123715	Anticancer agent 255		/	否
HY-127057	Lambertianic acid		/	否
HY-136714	Bcl-2-IN-3	Inhibitor	/	否
HY-164468	Ch282-5	Inhibitor	/	否
HY-167881	MLS-0053105	Inhibitor	/	否
HY-171031	TFGF-18		/	否
HY-N15136	Isomorellinol	Inducer	/	否
HY-N8579	Eugenyl benzoate		/	否
HY-P10336	Serpinin	Agonist	/	否
HY-W751400	Solasodine hydrochloride		/	否
HY-18106	BM 957	Inhibitor	/	否
HY-P1733	BMf-BH3		/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Bcl2	NCBI	NCBI:596

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