1. Gene
  2. Bcl2 - B cell leukemia/lymphoma 2 Gene

Bcl2 - B cell leukemia/lymphoma 2 Gene

中文名称:B细胞白血病/淋巴瘤2

种属: Mus musculus

同用名: Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik

基因 ID: 12043 | 基因类型: protein coding

关于 Bcl2

Chromosome 1: 106,465,908-106,642,004 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 230 orthologues, 10 paralogues and is associated with 133 phenotypes. Ubiquitous expression in spleen adult (RPKM 4.5), limb E14.5 (RPKM 2.8) and 23 other tissues.

功能概要

该基因编码 B 细胞淋巴瘤 2 蛋白家族的一个成员。这个家族的成员调节多种细胞类型的细胞死亡,并且可以具有促凋亡或抗凋亡活性。该基因编码的蛋白质抑制线粒体介导的细胞凋亡。该蛋白是一种完整的线粒体外膜蛋白,作为信号通路的一部分,控制线粒体通透性以响应凋亡刺激。这种蛋白质也可能在神经元细胞存活和自噬中发挥作用。该基因的异常表达和染色体易位与许多组织中的癌症进展有关。交替剪接导致多个转录本变体。 [RefSeq 提供,2015 年 9 月]

This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated Apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and Autophagy. Abnormal expression and chromosomal translocations of this gene are associated with Cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Bcl2 基因产物(2)

mRNA Protein Name
NM_177410.3 NP_803129.2 apoptosis regulator Bcl-2 isoform 2
NM_009741.5 NP_033871.2 apoptosis regulator Bcl-2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
36812915 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7834748 MGI
enables protein phosphatase 2A binding IDA
IDA: 通过直接分析推断
16717086 MGI
enables protein phosphatase binding IDA
IDA: 通过直接分析推断
12617961 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
17382917 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of B cell apoptotic process IDA
IDA: 通过直接分析推断
8313913 MGI
acts upstream of or within B cell apoptotic process IMP
IMP: 通过突变表型推断
8372353 MGI
acts upstream of or within B cell differentiation IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within B cell homeostasis IMP
IMP: 通过突变表型推断
7650488 MGI
acts upstream of or within B cell lineage commitment IMP
IMP: 通过突变表型推断
8788039 MGI
acts upstream of or within CD8-positive, alpha-beta T cell lineage commitment IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
12855558 MGI
acts upstream of T cell apoptotic process IDA
IDA: 通过直接分析推断
7751019 MGI
acts upstream of or within T cell apoptotic process IMP
IMP: 通过突变表型推断
8372353 MGI
acts upstream of or within T cell differentiation IGI
IGI: 通过遗传相互作用推断
9215624 MGI
acts upstream of or within T cell differentiation IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within T cell differentiation in thymus IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within T cell homeostasis IGI
IGI: 通过遗传相互作用推断
17591857 MGI
acts upstream of or within T cell homeostasis IMP
IMP: 通过突变表型推断
7650488 MGI
acts upstream of or within T cell lineage commitment IMP
IMP: 通过突变表型推断
8788039 MGI
acts upstream of or within actin filament organization IMP
IMP: 通过突变表型推断
9950951 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within apoptotic mitochondrial changes IDA
IDA: 通过直接分析推断
14707049 MGI
acts upstream of apoptotic process IMP
IMP: 通过突变表型推断
7840250 MGI
acts upstream of or within axon regeneration IDA
IDA: 通过直接分析推断
9009190 MGI
acts upstream of or within axonogenesis IMP
IMP: 通过突变表型推断
9009190 MGI
acts upstream of or within behavioral fear response IMP
IMP: 通过突变表型推断
16095731 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IDA
IDA: 通过直接分析推断
14699151 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IGI
IGI: 通过遗传相互作用推断
16672320 MGI
acts upstream of calcium ion transport into cytosol IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of cell growth IMP
IMP: 通过突变表型推断
12855558 MGI
acts upstream of cell migration IMP
IMP: 通过突变表型推断
15292044 MGI
acts upstream of or within cell morphogenesis IDA
IDA: 通过直接分析推断
18548006 MGI
acts upstream of or within cell morphogenesis IMP
IMP: 通过突变表型推断
10193316 MGI
acts upstream of or within cell population proliferation IGI
IGI: 通过遗传相互作用推断
10762311 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: 通过突变表型推断
15292044 MGI
acts upstream of or within cellular response to glucose starvation IDA
IDA: 通过直接分析推断
7595537 MGI
acts upstream of or within cellular response to hypoxia IDA
IDA: 通过直接分析推断
7595537 MGI
acts upstream of or within cochlear nucleus development IMP
IMP: 通过突变表型推断
11027399 MGI
acts upstream of dendritic cell apoptotic process IDA
IDA: 通过直接分析推断
17267035 MGI
acts upstream of or within developmental growth IMP
IMP: 通过突变表型推断
15818405 MGI
acts upstream of or within developmental pigmentation IGI
IGI: 通过遗传相互作用推断
11709185 MGI
acts upstream of or within developmental pigmentation IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within digestive tract morphogenesis IMP
IMP: 通过突变表型推断
7812968 MGI
acts upstream of or within ear development IGI
IGI: 通过遗传相互作用推断
11709185 MGI
acts upstream of or within ear development IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within endoplasmic reticulum calcium ion homeostasis IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of epithelial cell apoptotic process IMP
IMP: 通过突变表型推断
10200548 MGI
acts upstream of establishment of localization in cell IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: 通过遗传相互作用推断
12082633 MGI
acts upstream of or within focal adhesion assembly IMP
IMP: 通过突变表型推断
15292044 MGI
acts upstream of or within gland morphogenesis IMP
IMP: 通过突变表型推断
7812968 MGI
acts upstream of or within glomerulus development IMP
IMP: 通过突变表型推断
8623928 MGI
involved in hair follicle morphogenesis IMP
IMP: 通过突变表型推断
8402909 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: 通过突变表型推断
9028316 MGI
acts upstream of or within hemopoiesis IMP
IMP: 通过突变表型推断
7812968 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: 通过突变表型推断
9241272 MGI
acts upstream of or within immune system development IMP
IMP: 通过突变表型推断
7812968 MGI
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: 通过直接分析推断
7945396 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IGI
IGI: 通过遗传相互作用推断
15983387 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress IMP
IMP: 通过突变表型推断
12855558 MGI
acts upstream of or within kidney development IGI
IGI: 通过遗传相互作用推断
9241272 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
7812968 MGI
acts upstream of or within leukocyte homeostasis IMP
IMP: 通过突变表型推断
9028316 MGI
acts upstream of lymphocyte apoptotic process IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within lymphocyte apoptotic process IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within lymphocyte homeostasis IGI
IGI: 通过遗传相互作用推断
11709185 MGI
acts upstream of or within lymphocyte homeostasis IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within lymphoid progenitor cell differentiation IMP
IMP: 通过突变表型推断
9028316 MGI
acts upstream of or within male gonad development IGI
IGI: 通过遗传相互作用推断
9241272 MGI
acts upstream of or within melanin metabolic process IMP
IMP: 通过突变表型推断
11709185 MGI
acts upstream of or within melanocyte differentiation IGI
IGI: 通过遗传相互作用推断
12086670 MGI
acts upstream of melanocyte differentiation IMP
IMP: 通过突变表型推断
16427619 MGI
acts upstream of or within melanocyte differentiation IMP
IMP: 通过突变表型推断
8758925 MGI
acts upstream of or within mesenchymal cell development IMP
IMP: 通过突变表型推断
8623928 MGI
acts upstream of or within metanephros development IMP
IMP: 通过突变表型推断
7840250 MGI
acts upstream of mitotic cell cycle IDA
IDA: 通过直接分析推断
9241272 MGI
acts upstream of motor neuron apoptotic process IDA
IDA: 通过直接分析推断
7472523 MGI
acts upstream of myeloid cell apoptotic process IDA
IDA: 通过直接分析推断
9202146 MGI
acts upstream of or within negative regulation of B cell apoptotic process IDA
IDA: 通过直接分析推断
8313913 MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
14660795 MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
12855558 MGI
acts upstream of or within negative regulation of T cell apoptotic process IDA
IDA: 通过直接分析推断
7751019 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
7834747 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
7834747 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
7840250 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IDA
IDA: 通过直接分析推断
11546872 MGI
involved in negative regulation of autophagy IDA
IDA: 通过直接分析推断
36812915 MGI
acts upstream of or within negative regulation of calcium ion transport into cytosol IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within negative regulation of cell growth IMP
IMP: 通过突变表型推断
12855558 MGI
acts upstream of or within negative regulation of cell migration IMP
IMP: 通过突变表型推断
15292044 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
8663032 MGI
acts upstream of or within negative regulation of dendritic cell apoptotic process IDA
IDA: 通过直接分析推断
17267035 MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process IMP
IMP: 通过突变表型推断
10200548 MGI
acts upstream of or within negative regulation of lymphocyte apoptotic process IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within negative regulation of mitotic cell cycle IDA
IDA: 通过直接分析推断
9241272 MGI
acts upstream of or within negative regulation of motor neuron apoptotic process IDA
IDA: 通过直接分析推断
7472523 MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process IDA
IDA: 通过直接分析推断
9202146 MGI
acts upstream of or within negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
8625820 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
9153592 MGI
acts upstream of or within negative regulation of ossification IMP
IMP: 通过突变表型推断
9008714 MGI
acts upstream of or within negative regulation of osteoblast proliferation IMP
IMP: 通过突变表型推断
10193316 MGI
acts upstream of or within negative regulation of retinal cell programmed cell death IMP
IMP: 通过突变表型推断
10321489 MGI
acts upstream of neuron apoptotic process IDA
IDA: 通过直接分析推断
8625820 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
10762311 MGI
acts upstream of neuron apoptotic process IMP
IMP: 通过突变表型推断
9153592 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: 通过突变表型推断
7546744 MGI
acts upstream of neuron maturation IMP
IMP: 通过突变表型推断
9547242 MGI
acts upstream of or within oocyte development IMP
IMP: 通过突变表型推断
7628407 MGI
acts upstream of or within organ growth IMP
IMP: 通过突变表型推断
7812968 MGI
acts upstream of or within ossification IMP
IMP: 通过突变表型推断
10193316 MGI
acts upstream of osteoblast proliferation IMP
IMP: 通过突变表型推断
10193316 MGI
acts upstream of or within ovarian follicle development IMP
IMP: 通过突变表型推断
7628407 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
14660795 MGI
acts upstream of peptidyl-serine phosphorylation IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
14660795 MGI
acts upstream of or within pigment granule organization IMP
IMP: 通过突变表型推断
8758925 MGI
involved in pigmentation IMP
IMP: 通过突变表型推断
8402909 MGI
acts upstream of or within positive regulation of catalytic activity IMP
IMP: 通过突变表型推断
17382917 MGI
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11983915 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
8084613 MGI
acts upstream of or within positive regulation of developmental pigmentation IGI
IGI: 通过遗传相互作用推断
9241272 MGI
acts upstream of or within positive regulation of melanocyte differentiation IMP
IMP: 通过突变表型推断
16427619 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
11709185 MGI
acts upstream of or within positive regulation of neuron maturation IMP
IMP: 通过突变表型推断
9547242 MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within positive regulation of skeletal muscle fiber development IMP
IMP: 通过突变表型推断
11146504 MGI
acts upstream of or within positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
17382917 MGI
acts upstream of or within post-embryonic development IGI
IGI: 通过遗传相互作用推断
9241272 MGI
acts upstream of or within post-embryonic development IMP
IMP: 通过突变表型推断
7812968 MGI
acts upstream of or within protein dephosphorylation IDA
IDA: 通过直接分析推断
16717086 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
9681465 MGI
acts upstream of or within regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
8918887 MGI
involved in regulation of autophagy IMP
IMP: 通过突变表型推断
22258505 MGI
acts upstream of or within regulation of catalytic activity IMP
IMP: 通过突变表型推断
9681465 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: 通过突变表型推断
10200548 MGI
acts upstream of or within regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
15292044 MGI
acts upstream of or within regulation of developmental pigmentation IGI
IGI: 通过遗传相互作用推断
15818405 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
12855558 MGI
acts upstream of or within regulation of glycoprotein biosynthetic process IMP
IMP: 通过突变表型推断
15292044 MGI
acts upstream of or within regulation of growth IMP
IMP: 通过突变表型推断
7812968 MGI
involved in regulation of mitochondrial membrane permeability IDA
IDA: 通过直接分析推断
9843949 MGI
involved in regulation of mitochondrial membrane potential IDA
IDA: 通过直接分析推断
9843949 MGI
acts upstream of or within regulation of nitrogen utilization IGI
IGI: 通过遗传相互作用推断
9241272 MGI
acts upstream of or within regulation of programmed cell death IGI
IGI: 通过遗传相互作用推断
16672320 MGI
acts upstream of or within regulation of protein localization IMP
IMP: 通过突变表型推断
9950951 MGI
acts upstream of or within regulation of protein stability IMP
IMP: 通过突变表型推断
14660795 MGI
involved in regulation of viral genome replication IDA
IDA: 通过直接分析推断
16950491 MGI
involved in release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
9843949 MGI
acts upstream of or within renal system process IMP
IMP: 通过突变表型推断
8760259 MGI
acts upstream of or within response to UV-B IMP
IMP: 通过突变表型推断
10200548 MGI
acts upstream of or within response to acid chemical IDA
IDA: 通过直接分析推断
7675327 MGI
acts upstream of or within response to cytokine IMP
IMP: 通过突变表型推断
12855558 MGI
acts upstream of or within response to gamma radiation IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within response to glucocorticoid IDA
IDA: 通过直接分析推断
8313913 MGI
acts upstream of or within response to glucocorticoid IMP
IMP: 通过突变表型推断
8372353 MGI
acts upstream of or within response to hydrogen peroxide IMP
IMP: 通过突变表型推断
12855558 MGI
acts upstream of or within response to ischemia IMP
IMP: 通过突变表型推断
10488913 MGI
acts upstream of or within response to oxidative stress IMP
IMP: 通过突变表型推断
12855558 MGI
acts upstream of or within response to steroid hormone IMP
IMP: 通过突变表型推断
8170972 MGI
acts upstream of or within response to toxic substance IMP
IMP: 通过突变表型推断
10602483 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
9098922 MGI
acts upstream of retinal cell programmed cell death IMP
IMP: 通过突变表型推断
10321489 MGI
acts upstream of skeletal muscle fiber development IMP
IMP: 通过突变表型推断
11146504 MGI
acts upstream of smooth muscle cell migration IMP
IMP: 通过突变表型推断
17382917 MGI
acts upstream of or within spleen development IGI
IGI: 通过遗传相互作用推断
15818405 MGI
acts upstream of or within spleen development IMP
IMP: 通过突变表型推断
15818405 MGI
acts upstream of or within stem cell development IMP
IMP: 通过突变表型推断
8623928 MGI
acts upstream of or within thymus development IGI
IGI: 通过遗传相互作用推断
15818405 MGI
acts upstream of or within thymus development IMP
IMP: 通过突变表型推断
9241272 MGI
acts upstream of or within ureteric bud development IMP
IMP: 通过突变表型推断
8623928 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
36812915 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
7563251 MGI
located in cytosol IDA
IDA: 通过直接分析推断
8030757 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
8030757 MGI
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
15613488 MGI
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
9008714 MGI
located in membrane IDA
IDA: 通过直接分析推断
8030757 MGI
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
11980919 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
7945396 MGI
located in myelin sheath IDA
IDA: 通过直接分析推断
7953633 MGI
located in nuclear membrane IDA
IDA: 通过直接分析推断
8030757 MGI
located in nucleus IDA
IDA: 通过直接分析推断
7945396 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Bcl2 蛋白结构

bcl-2

bcl-2: TIGR00865 (10 - 235)

  • 0
  • 100
  • 200
  • 236 a.a.
蛋白主名 其他名称

apoptosis regulator Bcl-2

重组 Bcl2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72101 BCL2 Protein, Mouse (His) P10417-1 (G5-P205) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bcl2 NCBI NCBI:596