1. Gene
  2. Src - Rous sarcoma oncogene Gene

Src - Rous sarcoma oncogene Gene

中文名称:劳斯肉瘤致癌基因

种属: Mus musculus

同用名: pp60c-src

基因 ID: 20779 | 基因类型: protein coding

关于 Src

Chromosome 2: 157,260,364-157,313,782 forward strand.GRCm39:CM000995.3

This gene has 8 transcripts (splice variants), 261 orthologues, 32 paralogues and is associated with 54 phenotypes. Ubiquitous expression in duodenum adult (RPKM 49.), colon adult (RPKM 48.4) and 23 other tissues.

功能概要

该基因编码的蛋白可启动多种功能,包括连接蛋白结合活性; ephrin 受体结合活性;和支架蛋白结合活性。参与多个过程,包括白细胞介素6介导的信号通路;信号转导的正调控;和蛋白质不稳定。作用于多个过程的上游或内部,包括动物器官发育;细胞对生长因子刺激的反应;和信号转导的调节。位于几种细胞成分中,包括肌动蛋白细胞骨架;粘着斑;和荷叶边膜。以多种结构表达,包括中枢神经系统;早孕;泌尿生殖系统;直觉;和视网膜。用于研究 Williams-Beuren 综合症。该基因与结直肠癌相关的人类直系同源物(多个);导管原位癌;前列腺癌;血小板减少症;和 2 型糖尿病。与人类 Src 同源(SRC 原癌基因,非受体酪氨酸激酶)。 [由基因组资源联盟提供,2022 年 4 月]

Enables several functions, including connexin binding activity; Ephrin Receptor binding activity; and scaffold protein binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; positive regulation of signal transduction; and protein destabilization. Acts upstream of or within several processes, including animal organ development; cellular response to growth factor stimulus; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; focal adhesion; and ruffle membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and retina. Used to study Williams-Beuren syndrome. Human ortholog(s) of this gene implicated in colorectal Cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human Src (Src proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Src 基因产物(13)

mRNA Protein Name
NM_001412690.1 NP_001399619.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412691.1 NP_001399620.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001025395.3 NP_001020566.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412689.1 NP_001399618.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412693.1 NP_001399622.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412682.1 NP_001399611.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412683.1 NP_001399612.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_009271.4 NP_033297.2 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412687.1 NP_001399616.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412686.1 NP_001399615.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412684.1 NP_001399613.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412685.1 NP_001399614.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412688.1 NP_001399617.1 proto-oncogene tyrosine-protein kinase Src isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables connexin binding IPI
IPI: 通过物理相互作用推断
14699011 MGI
enables ephrin receptor binding IPI
IPI: 通过物理相互作用推断
12925710 MGI
enables kinase activity IMP
IMP: 通过突变表型推断
12808090 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7518772 MGI
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
8438166 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
11274221 MGI
enables protein kinase activity IMP
IMP: 通过突变表型推断
23100514 MGI
enables protein tyrosine kinase activity EXP
EXP: 通过实验结果推断
22759635 MGI
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
8910389 MGI
enables protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
12091389 MGI
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
12091389 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiotensin-activated signaling pathway IGI
IGI: 通过遗传相互作用推断
25017399 MGI
acts upstream of or within bone resorption IMP
IMP: 通过突变表型推断
19448635 MGI
involved in bone resorption IMP
IMP: 通过突变表型推断
14739300 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
16007215 MGI
acts upstream of or within cell migration IMP
IMP: 通过突变表型推断
15292044 MGI
acts upstream of or within cellular response to fluid shear stress IMP
IMP: 通过突变表型推断
24841674 MGI
acts upstream of or within cellular response to hydrogen peroxide IMP
IMP: 通过突变表型推断
23651497 MGI
involved in cellular response to peptide hormone stimulus IGI
IGI: 通过遗传相互作用推断
25017399 MGI
acts upstream of or within cellular response to platelet-derived growth factor stimulus IDA
IDA: 通过直接分析推断
17623777 MGI
acts upstream of or within cellular response to reactive oxygen species IDA
IDA: 通过直接分析推断
24190966 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IGI
IGI: 通过遗传相互作用推断
21829547 MGI
acts upstream of or within forebrain development IGI
IGI: 通过遗传相互作用推断
16162939 MGI
involved in interleukin-6-mediated signaling pathway IDA
IDA: 通过直接分析推断
25731159 MGI
involved in intestinal epithelial cell development IDA
IDA: 通过直接分析推断
25731159 MGI
acts upstream of or within intracellular signal transduction IGI
IGI: 通过遗传相互作用推断
23526378 MGI
acts upstream of or within odontogenesis IMP
IMP: 通过突变表型推断
23174213 MGI
acts upstream of or within oogenesis IMP
IMP: 通过突变表型推断
16007215 MGI
acts upstream of or within osteoclast development IGI
IGI: 通过遗传相互作用推断
23526378 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
12526740 MGI
involved in peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
27505886 MGI
involved in phosphorylation IMP
IMP: 通过突变表型推断
12091389 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
17045821 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
25731159 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
19920076 MGI
involved in positive regulation of glycolytic process IDA
IDA: 通过直接分析推断
35263589 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IGI
IGI: 通过遗传相互作用推断
17344476 MGI
acts upstream of or within positive regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: 通过突变表型推断
23651497 MGI
acts upstream of or within positive regulation of podosome assembly IDA
IDA: 通过直接分析推断
21525037 MGI
acts upstream of or within positive regulation of podosome assembly IGI
IGI: 通过遗传相互作用推断
21525037 MGI
acts upstream of or within positive regulation of protein localization to nucleus IGI
IGI: 通过遗传相互作用推断
17344476 MGI
acts upstream of or within positive regulation of protein processing IGI
IGI: 通过遗传相互作用推断
17344476 MGI
involved in protein destabilization IMP
IMP: 通过突变表型推断
25259869 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
11274221 MGI
acts upstream of or within regulation of cell projection assembly IGI
IGI: 通过遗传相互作用推断
11864995 MGI
involved in regulation of heart rate by cardiac conduction IGI
IGI: 通过遗传相互作用推断
25017399 MGI
acts upstream of or within regulation of intracellular estrogen receptor signaling pathway IMP
IMP: 通过突变表型推断
16007215 MGI
acts upstream of or within regulation of protein binding IDA
IDA: 通过直接分析推断
22027834 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IDA
IDA: 通过直接分析推断
11864995 MGI
acts upstream of or within uterus development IMP
IMP: 通过突变表型推断
16007215 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin filament IDA
IDA: 通过直接分析推断
17623777 MGI
located in caveola IDA
IDA: 通过直接分析推断
12091389 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
14699011 MGI
located in cytoskeleton IDA
IDA: 通过直接分析推断
12615910 MGI
located in focal adhesion IMP
IMP: 通过突变表型推断
22801373 MGI
located in membrane IMP
IMP: 通过突变表型推断
22801373 MGI
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
12615910 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
12615910 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12615910 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
17623777 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
12615910 MGI
located in podosome IDA
IDA: 通过直接分析推断
17893324 MGI
located in ruffle membrane IDA
IDA: 通过直接分析推断
17623777 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Src 蛋白结构

SH3_Src

SH3_Src: cd12008 (86 - 141)

SH2_Src_Src

SH2_Src_Src: cd10365 (145 - 245)

PTKc_Src

PTKc_Src: cd05071 (258 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 535 a.a.
蛋白主名 其他名称

proto-oncogene tyrosine-protein kinase Src

neuronal proto-oncogene tyrosine-protein kinase Src

p60-Src

proto-oncogene c-Src

重组 Src 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73423 Src Protein, Mouse (sf9, His-GST) P05480-2 (M1-L535) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Src NCBI NCBI:6714