1. Gene
  2. Stat3 - signal transducer and activator of transcription 3 Gene

Stat3 - signal transducer and activator of transcription 3 Gene

中文名称:信号转导和转录激活因子 3

种属: Rattus norvegicus

基因 ID: 25125 | 基因类型: protein coding

关于 Stat3

Primary_assembly 10: 85,811,218-85,863,057 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 133 orthologues, 5 paralogues and is associated with 125 phenotypes. Biased expression in Heart (RPKM 347.1), Lung (RPKM 285.5) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 CCR5 趋化因子受体结合活性;糖皮质激素受体结合活性;和序列特异性 DNA 结合活性。参与多个过程,包括生长因子依赖性骨骼肌卫星细胞增殖的正调节;白细胞介素 6 产生的正向调节;和调节细胞生物合成过程。在对细胞因子刺激的细胞反应和对有机环状化合物的细胞反应的上游或内部起作用。位于线粒体内膜和细胞核。活跃于 Schaffer 侧支 - CA1 突触;谷氨酸能突触;和突触后密度。用于研究多种疾病,包括十二指肠溃疡;高尿酸血症;非酒精性脂肪肝病;肥胖;和短暂性脑缺血。结肠癌生物标志物;结直肠癌;心脏疾病;和癌前病变。该基因的人类直系同源物与多种疾病有关,包括自身免疫性疾病(多种);癌(多发性);高 IgE 反复感染综合征 1;生殖器官癌(多发性);和 2 型糖尿病。与人类 STAT3(信号转导和转录激活因子 3)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables CCR5 Chemokine Receptor binding activity; Glucocorticoid Receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of interleukin-6 production; and regulation of cellular biosynthetic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in mitochondrial inner membrane and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Biomarker of colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent Infection syndrome 1; reproductive organ Cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Apr 2022]

Stat3 基因产物(2)

mRNA Protein Name
NM_012747.2 NP_036879.1 signal transducer and activator of transcription 3
NM_012747.2 NP_036879.1 signal transducer and activator of transcription 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CCR5 chemokine receptor binding IPI
IPI: 通过物理相互作用推断
14674010 RGD
enables DNA binding IDA
IDA: 通过直接分析推断
8530402 RGD
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
16527988 RGD
enables nuclear glucocorticoid receptor binding IPI
IPI: 通过物理相互作用推断
20155810 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16055727 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16648019 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acute-phase response IEP
IEP: 通过表达模式推断
8530402 RGD
acts upstream of or within cellular response to cytokine stimulus IDA
IDA: 通过直接分析推断
19414010 RGD
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
19414010 RGD
involved in modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
22284190 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
22284190 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
22284190 RGD
involved in negative regulation of hydrogen peroxide biosynthetic process IMP
IMP: 通过突变表型推断
23590160 RGD
involved in positive regulation of ATP biosynthetic process IMP
IMP: 通过突变表型推断
23590160 RGD
involved in positive regulation of canonical NF-kappaB signal transduction IGI
IGI: 通过遗传相互作用推断
29702085 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
23608221 RGD
involved in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IMP
IMP: 通过突变表型推断
23869758 RGD
acts upstream of positive regulation of interleukin-6 production IGI
IGI: 通过遗传相互作用推断
29702085 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19538478 RGD
involved in postsynapse to nucleus signaling pathway IDA
IDA: 通过直接分析推断
22284190 RGD
involved in postsynapse to nucleus signaling pathway IEP
IEP: 通过表达模式推断
22284190 RGD
involved in regulation of cellular response to hypoxia IMP
IMP: 通过突变表型推断
19450559 RGD
involved in regulation of mitochondrial membrane permeability IMP
IMP: 通过突变表型推断
23590160 RGD
involved in response to cytokine IDA
IDA: 通过直接分析推断
18270592 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
17916759 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
17916759 RGD
involved in response to ischemia IMP
IMP: 通过突变表型推断
23884942 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
18339648 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
17911393 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18031608 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse EXP
EXP: 通过实验结果推断
22284190 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
22284190 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
22284190 RGD
located in cytosol IDA
IDA: 通过直接分析推断
23884942 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
22284190 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
22284190 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
22284190 RGD
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
23271731 RGD
located in nucleus IDA
IDA: 通过直接分析推断
19538478 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
10891587 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Stat3 蛋白结构

STAT_int

STAT_int: smart00964 (1 - 119)

STAT3_CCD

STAT3_CCD: cd16853 (138 - 317)

STAT3_DBD

STAT3_DBD: cd16847 (320 - 483)

SH2_STAT3

SH2_STAT3: cd10374 (553 - 714)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
蛋白主名 其他名称

signal transducer and activator of transcription 3

signal transducer and activator of transcription 3 (acute-phase response factor)

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stat3 NCBI NCBI:6774