KAT5 - lysine acetyltransferase 5 Gene

中文名称：赖氨酸乙酰转移酶 5

种属: Homo sapiens

同用名: TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1; NEDFASB

基因 ID: 10524 | 基因类型: protein coding

关于 KAT5

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,712,018-65,719,604 (from NCBI)

This gene has 17 transcripts (splice variants), 104 orthologues, 9 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 21.5), thyroid (RPKM 20.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质属于组蛋白乙酰转移酶 (HAT) 的 MYST 家族，最初作为 HIV-1 TAT 相互作用蛋白被分离出来。 HAT 通过乙酰化组蛋白和非组蛋白在调节染色质重塑、转录和其他核过程中发挥重要作用。这种蛋白质是一种组蛋白乙酰化酶，在 DNA 修复和细胞凋亡中起作用，并被认为在信号转导中发挥重要作用。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and Apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

KAT5 基因产物(4)

mRNA	Protein	Name
NM_001206833.2	NP_001193762.1	histone acetyltransferase KAT5 isoform 4
NM_006388.4	NP_006379.2	histone acetyltransferase KAT5 isoform 2
NM_182709.3	NP_874368.1	histone acetyltransferase KAT5 isoform 3
NM_182710.3	NP_874369.1	histone acetyltransferase KAT5 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	17360565	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	29335245	GOA
enables histone H2A acetyltransferase activity	IDA IDA: 通过直接分析推断	10966108	GOA
enables histone H2AK5 acetyltransferase activity	IDA IDA: 通过直接分析推断	26438602	GOA
enables histone H4 acetyltransferase activity	IDA IDA: 通过直接分析推断	10966108	GOA
enables histone H4K16 acetyltransferase activity	IDA IDA: 通过直接分析推断	33076429	GOA
enables histone acetyltransferase activity	IDA IDA: 通过直接分析推断	18397884	GOA
enables histone acetyltransferase activity	IMP IMP: 通过突变表型推断	17996965	GOA
enables peptide butyryltransferase activity	IDA IDA: 通过直接分析推断	29192674	GOA
enables peptide crotonyltransferase activity	IDA IDA: 通过直接分析推断	34608293	GOA
enables peptide-lysine-N-acetyltransferase activity	IDA IDA: 通过直接分析推断	17189187	GOA
enables protein binding	IDA IDA: 通过直接分析推断	32832608	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10966108	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	14966270	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IDA IDA: 通过直接分析推断	33076429	GOA
involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA IDA: 通过直接分析推断	14966270	GOA
involved in DNA repair-dependent chromatin remodeling	IDA IDA: 通过直接分析推断	25301942	GOA
involved in DNA repair-dependent chromatin remodeling	IMP IMP: 通过突变表型推断	10966108	GOA
involved in cellular response to estradiol stimulus	IDA IDA: 通过直接分析推断	23637611	GOA
involved in cellular response to glucose starvation	IDA IDA: 通过直接分析推断	34077757	GOA
involved in double-strand break repair	IDA IDA: 通过直接分析推断	26438602	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: 通过直接分析推断	27153538	GOA
involved in establishment of mitotic spindle orientation	IDA IDA: 通过直接分析推断	34608293	GOA
acts upstream of positive effect lipid droplet disassembly	IDA IDA: 通过直接分析推断	34077757	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	17360565	GOA
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: 通过直接分析推断	32832608	GOA
involved in negative regulation of interleukin-2 production	IDA IDA: 通过直接分析推断	17360565	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	17360565	GOA
involved in nucleotide-excision repair	IDA IDA: 通过直接分析推断	32034146	GOA
involved in peptidyl-lysine acetylation	IDA IDA: 通过直接分析推断	30704899	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	14966270	GOA
involved in positive regulation of aggrephagy	IDA IDA: 通过直接分析推断	31857589	GOA
involved in positive regulation of attachment of mitotic spindle microtubules to kinetochore	IDA IDA: 通过直接分析推断	30409912	GOA
involved in positive regulation of autophagy	IDA IDA: 通过直接分析推断	30704899	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: 通过直接分析推断	27153538	GOA
involved in positive regulation of innate immune response	IDA IDA: 通过直接分析推断	32817552	GOA
involved in positive regulation of mitotic sister chromatid segregation	IDA IDA: 通过直接分析推断	26829474	GOA
involved in positive regulation of myoblast differentiation	IDA IDA: 通过直接分析推断	26291311	GOA
involved in positive regulation of protein acetylation	IDA IDA: 通过直接分析推断	24012345	GOA
involved in positive regulation of regulatory T cell differentiation	IDA IDA: 通过直接分析推断	24835996	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	29335245	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	23637611	GOA
involved in positive regulation of triglyceride biosynthetic process	IDA IDA: 通过直接分析推断	29765047	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	18397884	GOA
involved in regulation of cell cycle	IMP IMP: 通过突变表型推断	27153538	GOA
involved in response to ionizing radiation	IDA IDA: 通过直接分析推断	18397884	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of NuA4 histone acetyltransferase complex	IDA IDA: 通过直接分析推断	10966108	GOA
part of Swr1 complex	IDA IDA: 通过直接分析推断	24463511	GOA
located in chromatin	IDA IDA: 通过直接分析推断	29335245	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	25301942	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	26829474	GOA
located in mitotic spindle pole	IDA IDA: 通过直接分析推断	34608293	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	16387653	GOA
part of nucleosome	IDA IDA: 通过直接分析推断	27153538	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17996965	GOA
part of piccolo histone acetyltransferase complex	IDA IDA: 通过直接分析推断	14966270	GOA
is active in site of double-strand break	IDA IDA: 通过直接分析推断	27153538	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KAT5 蛋白结构

Tudor-knot

MOZ_SAS

0
100
200
300
400
513 a.a.

蛋白主名

其他名称

histone acetyltransferase KAT5

60 kDa Tat-interactive protein

重组 KAT5 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71707	KAT5 Protein, Human (His)	Q92993 (E3-W513)	≥95%

关联疾病

疾病名称

别名

Neurodevelopmental Disorder With Dysmorphic Facies, Sleep Disturbance, And Brain Abnormalities

NEDFASB

Genitourinary Tract Anomalies

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome	Broad Thumb-Hallux Syndrome
Chromosome 16p13.3 Deletion Syndrome	Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion
Rubinstein Syndrome	Broad Thumbs-Halluces Syndrome
Rsts	Rubinstein-Taybi Deletion Syndrome
Rsts Deletion Syndrome	Proximal Chromosome 16p13.3 Deletion Syndrome
16p13.3 Deletion Syndrome	Broad Thumbs And Great Toes, Characteristic Facies, And Intellectual Disability
Rts

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-102058	WM-1119	Inhibitor	99.57%	否
HY-110127	NU9056		98.81%	否
HY-123604	TH1834		99.60%	否
HY-123604A	TH1834 dihydrochloride		99.68%	否
HY-RS07080	KAT5 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	KAT5	VGNC	VGNC:42211
Mus musculus	KAT5	MGD	MGI:1932051
Macaca mulatta	KAT5	VGNC	VGNC:73955
Rattus norvegicus	KAT5	RGD	RGD:621061
Bos taurus	KAT5	VGNC	VGNC:30400
Felis catus	KAT5	VGNC	VGNC:67665
Others	KAT5	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4