YWHAE - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Gene

中文名称：酪氨酸 3-单加氧酶/色氨酸 5-单加氧酶激活蛋白 epsilon

种属: Homo sapiens

同用名: MDS; HEL2; MDCR; KCIP-1; 14-3-3E

关于 YWHAE

功能概要

该基因产物属于 14-3-3 蛋白家族，通过与含磷酸丝氨酸的蛋白结合来介导信号转导。这种高度保守的蛋白质家族存在于植物和哺乳动物中，并且这种蛋白质与小鼠直系同源物 100% 相同。它与 CDC25 磷酸酶、RAF1 和 IRS1 蛋白相互作用，表明它在与信号转导相关的多种生化活动中发挥作用，例如细胞分裂和胰岛素敏感性调节。它还与小细胞肺癌的发病机制有关。已发现该基因的两种转录变体，一种是蛋白质编码，另一种是非蛋白质编码。[RefSeq 提供，2008 年 8 月]

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of Insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung Cancer. Two transcript variants, one protein-coding and the Other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]