1. Gene
  2. Ar - androgen receptor Gene

Ar - androgen receptor Gene

中文名称:雄激素受体

种属: Rattus norvegicus

同用名: Tfm; Andr

基因 ID: 24208 | 基因类型: protein coding

关于 Ar

Primary_assembly X: 63,104,771-63,273,925 forward strand.mRatBN7.2:CM026994.1

This gene has 1 transcript (splice variant), 277 orthologues, 8 paralogues and is associated with 62 phenotypes. Biased expression in Adrenal (RPKM 352.8), Uterus (RPKM 74.9) and 7 other tissues.

功能概要

该基因编码的蛋白可启动多种功能,包括雄激素结合活性;雄激素受体结合活性;和核受体活性。参与多个过程,包括细胞对激素刺激的反应;交配;和转录调控,DNA 模板化。位于多个细胞成分中,包括轴突;树突;和核。用于研究高血压;骨质疏松症;前列腺癌;前列腺癌;和前列腺肥大。急性肾衰竭和雄激素不敏感综合征的生物标志物。该基因的人类直系同源物与多种疾病有关,包括注意力缺陷多动障碍;品行障碍;性发育障碍(多发);生殖器官癌(多发性);和脊髓性肌萎缩症(多发性)。与人类 AR(雄激素受体)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables several functions, including androgen binding activity; Androgen Receptor binding activity; and nuclear receptor activity. Involved in several processes, including cellular response to hormone stimulus; mating; and regulation of transcription, DNA-templated. Located in several cellular components, including axon; dendrite; and nucleus. Used to study hypertension; osteoporosis; prostate adenocarcinoma; prostate cancer; and prostatic hypertrophy. Biomarker of acute kidney failure and androgen insensitivity syndrome. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; disorder of sexual development (multiple); reproductive organ Cancer (multiple); and spinal muscular atrophy (multiple). Orthologous to human AR (Androgen Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ar 基因产物(1)

mRNA Protein Name
NM_012502.2 NP_036634.2 androgen receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables androgen binding IMP
IMP: 通过突变表型推断
2341409 RGD
enables chromatin binding IDA
IDA: 通过直接分析推断
3499428 RGD
enables nuclear androgen receptor binding IPI
IPI: 通过物理相互作用推断
9710597 RGD
enables nuclear receptor activity IDA
IDA: 通过直接分析推断
2341409 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12350225 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
17223690 RGD
enables ribonucleotide binding IDA
IDA: 通过直接分析推断
6193790 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10385402 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
11875111 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in androgen receptor signaling pathway IMP
IMP: 通过突变表型推断
2341409 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: 通过表达模式推断
2502458 RGD
involved in cellular response to steroid hormone stimulus IEP
IEP: 通过表达模式推断
2341409 RGD
involved in copulation IMP
IMP: 通过突变表型推断
15178162 RGD
involved in drinking behavior IMP
IMP: 通过突变表型推断
28776866 RGD
involved in liver regeneration IEP
IEP: 通过表达模式推断
2598758 RGD
involved in locomotion IMP
IMP: 通过突变表型推断
28776866 RGD
involved in male courtship behavior IMP
IMP: 通过突变表型推断
15178162 RGD
involved in male sex differentiation IMP
IMP: 通过突变表型推断
2341409 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10385402 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10385402 RGD
involved in positive regulation of hippocampal neuron apoptotic process IMP
IMP: 通过突变表型推断
18289534 RGD
involved in positive regulation of locomotion IMP
IMP: 通过突变表型推断
28776866 RGD
involved in positive regulation of penile erection IMP
IMP: 通过突变表型推断
21315100 RGD
involved in prostate gland growth IEP
IEP: 通过表达模式推断
3628973 RGD
involved in reproductive behavior IDA
IDA: 通过直接分析推断
20392832 RGD
involved in response to environmental enrichment IMP
IMP: 通过突变表型推断
28776866 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
10913783 RGD
involved in response to ethanol IDA
IDA: 通过直接分析推断
3678734 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
15596216 RGD
involved in response to muscle activity IEP
IEP: 通过表达模式推断
16286851 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
27602328 RGD
involved in response to steroid hormone IEP
IEP: 通过表达模式推断
2644508 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
10913783 RGD
involved in skeletal muscle hypertrophy IMP
IMP: 通过突变表型推断
7957162 RGD
involved in spermatogenesis IMP
IMP: 通过突变表型推断
15347734 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
12865346 RGD
located in cytosol IDA
IDA: 通过直接分析推断
3678734 RGD
located in dendrite IDA
IDA: 通过直接分析推断
12865346 RGD
located in nuclear matrix IDA
IDA: 通过直接分析推断
6466649 RGD
located in nucleus IDA
IDA: 通过直接分析推断
3678734 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ar 蛋白结构

Androgen_recep

Androgen_recep: cl27454 (5 - 442)

NR_DBD_AR

NR_DBD_AR: cd07173 (536 - 617)

NR_LBD_AR

NR_LBD_AR: cd07073 (654 - 899)

  • 0
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  • 902 a.a.
蛋白主名 其他名称

androgen receptor

androgen receptor (Testicular feminization), same as Tfm

dihydrotestosterone receptor

nuclear receptor subfamily 3 group C member 4

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ar NCBI NCBI:367
Canis familiaris Ar NCBI NCBI:403588
Macaca fascicularis Ar NCBI NCBI:102117720
Canis lupus familiaris Ar NCBI
Mus musculus Ar NCBI NCBI:11835
Susscrofa domestica Ar NCBI
Leporidae Ar NCBI
Macaca mulatta Ar NCBI NCBI:574293