Ar - androgen receptor Gene

中文名称：雄激素受体

种属: Mus musculus

同用名: Tfm

关于 Ar

功能概要

该基因编码含有锌指和 DNA 结合结构域的核激素受体。编码的蛋白质是雄激素信号的关键调节剂，雄激素是一类参与男性生殖发育的类固醇激素。该蛋白质通过转移到细胞核、形成二聚体并与目标基因启动子中的雄激素反应元件 (ARE) 结合来响应激素信号，这些元件随后被转录激活。该蛋白的活性受核受体亚家族 0 B 组成员 1（Nr0b1，也称为 Dax1）的负调控。该基因的突变导致雄性动物的生殖器女性化和不育。雌性动物的功能丧失也会导致生殖发育和功能出现问题。 [RefSeq 提供，2015 年 5 月]

This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid Hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male Animals. Loss of function in female Animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015]