Tnf - tumor necrosis factor Gene

中文名称：肿瘤坏死因子

种属: Mus musculus

同用名: DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha

基因 ID: 21926 | 基因类型: protein coding

关于 Tnf

Chromosome 17: 35,418,357-35,420,983 reverse strand.GRCm39:CM001010.3

This gene has 2 transcripts (splice variants), 246 orthologues, 8 paralogues and is associated with 214 phenotypes. Broad expression in spleen adult (RPKM 4.1), thymus adult (RPKM 3.) and 16 other tissues.

功能概要

该基因编码属于肿瘤坏死因子 (TNF) 超家族的多功能促炎细胞因子。该家族的成员根据一级序列、功能和结构进行分类。这种蛋白质被合成为 II 型跨膜蛋白，据报道被切割成发挥不同生物学功能的产物。它在先天免疫反应和调节体内平衡中起着重要作用，但也与慢性炎症疾病有关。在小鼠中，该基因的缺陷与对细菌感染的反应缺陷、形成有组织的滤泡树突细胞网络和生发中心的缺陷以及缺乏原代 B 细胞滤泡有关。可变剪接导致多个转录本变体。 [RefSeq 提供，2013 年 6 月]

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to Bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Tnf 基因产物(2)

mRNA	Protein	Name
NM_013693.3	NP_038721.1	tumor necrosis factor isoform 1
NM_001278601.1	NP_001265530.1	tumor necrosis factor isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cytokine activity	IDA IDA: 通过直接分析推断	11588035	MGI
enables cytokine activity	IGI IGI: 通过遗传相互作用推断	16260493	MGI
enables death receptor agonist activity	IDA IDA: 通过直接分析推断	14985352	MGI
enables protease binding	IPI IPI: 通过物理相互作用推断	12135759	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	16702408	MGI
enables receptor ligand activity	IDA IDA: 通过直接分析推断	2989794	MGI
enables tumor necrosis factor receptor binding	IDA IDA: 通过直接分析推断	11588035	MGI
enables tumor necrosis factor receptor binding	IPI IPI: 通过物理相互作用推断	1645445	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of JNK cascade	IDA IDA: 通过直接分析推断	16260493	MGI
acts upstream of JNK cascade	IGI IGI: 通过遗传相互作用推断	16260493	MGI
acts upstream of or within JNK cascade	IGI IGI: 通过遗传相互作用推断	17015619	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	16183742	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: 通过突变表型推断	8879212	MGI
acts upstream of or within apoptotic signaling pathway	IDA IDA: 通过直接分析推断	8208546	MGI
acts upstream of or within cellular extravasation	IDA IDA: 通过直接分析推断	10528208	MGI
acts upstream of or within cellular response to amino acid stimulus	IDA IDA: 通过直接分析推断	20548288	MGI
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: 通过直接分析推断	19047410	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: 通过突变表型推断	29849090	MGI
involved in cellular response to type II interferon	IMP IMP: 通过突变表型推断	29849090	MGI
acts upstream of or within defense response	IMP IMP: 通过突变表型推断	8395024	MGI
acts upstream of or within defense response to Gram-positive bacterium	IGI IGI: 通过遗传相互作用推断	9834074	MGI
acts upstream of or within defense response to bacterium	IDA IDA: 通过直接分析推断	10899905	MGI
involved in endothelial cell apoptotic process	IDA IDA: 通过直接分析推断	26808574	MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis	IDA IDA: 通过直接分析推断	11241200	MGI
acts upstream of or within extracellular matrix organization	IDA IDA: 通过直接分析推断	15381731	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IGI IGI: 通过遗传相互作用推断	19498109	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IGI IGI: 通过遗传相互作用推断	12431371	MGI
acts upstream of or within glucose metabolic process	IDA IDA: 通过直接分析推断	12068289	MGI
acts upstream of or within humoral immune response	IMP IMP: 通过突变表型推断	8879212	MGI
acts upstream of or within inflammatory response	IGI IGI: 通过遗传相互作用推断	21148126	MGI
involved in inflammatory response to wounding	IDA IDA: 通过直接分析推断	27830702	MGI
acts upstream of interleukin-6 production	IDA IDA: 通过直接分析推断	11894098	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: 通过直接分析推断	17242187	MGI
acts upstream of or within leukocyte migration	IDA IDA: 通过直接分析推断	15034066	MGI
involved in macrophage activation involved in immune response	IMP IMP: 通过突变表型推断	29849090	MGI
involved in microglial cell activation	IDA IDA: 通过直接分析推断	22950459	MGI
acts upstream of or within multicellular organism development	IMP IMP: 通过突变表型推断	9368616	MGI
acts upstream of or within necroptotic signaling pathway	IGI IGI: 通过遗传相互作用推断	19498109	MGI
acts upstream of or within negative regulation of D-glucose import	IDA IDA: 通过直接分析推断	12068289	MGI
involved in negative regulation of alkaline phosphatase activity	IDA IDA: 通过直接分析推断	21689636	MGI
involved in negative regulation of amyloid-beta clearance	IGI IGI: 通过遗传相互作用推断	17255335	MGI
involved in negative regulation of endothelial cell proliferation	IDA IDA: 通过直接分析推断	26808574	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: 通过直接分析推断	26427354	MGI
involved in negative regulation of mitotic cell cycle	IDA IDA: 通过直接分析推断	26808574	MGI
acts upstream of or within negative regulation of myoblast differentiation	IMP IMP: 通过突变表型推断	23844157	MGI
involved in negative regulation of osteoblast differentiation	IDA IDA: 通过直接分析推断	21689636	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9305915	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	21689636	MGI
acts upstream of or within osteoclast differentiation	IGI IGI: 通过遗传相互作用推断	15485831	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	20080598	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12761567	MGI
acts upstream of or within positive regulation of JNK cascade	IDA IDA: 通过直接分析推断	16260493	MGI
acts upstream of or within positive regulation of JNK cascade	IGI IGI: 通过遗传相互作用推断	16260493	MGI
involved in positive regulation of amide metabolic process	IDA IDA: 通过直接分析推断	10411298	MGI
involved in positive regulation of amyloid-beta formation	IDA IDA: 通过直接分析推断	17255335	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	2989794	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: 通过遗传相互作用推断	7525730	MGI
involved in positive regulation of cellular metabolic process	IDA IDA: 通过直接分析推断	10411298	MGI
acts upstream of or within positive regulation of chronic inflammatory response to antigenic stimulus	IGI IGI: 通过遗传相互作用推断	9834074	MGI
involved in positive regulation of fever generation	IDA IDA: 通过直接分析推断	19940926	MGI
involved in positive regulation of gene expression	IDA IDA: 通过直接分析推断	17255335	MGI
involved in positive regulation of hair follicle development	IMP IMP: 通过突变表型推断	16702408	MGI
involved in positive regulation of heterotypic cell-cell adhesion	IDA IDA: 通过直接分析推断	26808574	MGI
acts upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin	IGI IGI: 通过遗传相互作用推断	9834074	MGI
acts upstream of or within positive regulation of interleukin-6 production	IDA IDA: 通过直接分析推断	11894098	MGI
involved in positive regulation of lipid metabolic process	IDA IDA: 通过直接分析推断	10411298	MGI
involved in positive regulation of neuron apoptotic process	IDA IDA: 通过直接分析推断	22950459	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	21689636	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	20080598	MGI
involved in positive regulation of protein localization to plasma membrane	IMP IMP: 通过突变表型推断	16547515	MGI
involved in positive regulation of synaptic transmission	IMP IMP: 通过突变表型推断	16547515	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9305915	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	18025219	MGI
acts upstream of or within positive regulation of translational initiation by iron	IDA IDA: 通过直接分析推断	11588035	MGI
acts upstream of or within positive regulation of type II interferon production	IGI IGI: 通过遗传相互作用推断	9834074	MGI
involved in positive regulation of vascular associated smooth muscle cell proliferation	IDA IDA: 通过直接分析推断	26808574	MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis	IDA IDA: 通过直接分析推断	11241200	MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis	IMP IMP: 通过突变表型推断	11241200	MGI
acts upstream of or within regulation of cell population proliferation	IDA IDA: 通过直接分析推断	11799106	MGI
acts upstream of or within regulation of immunoglobulin production	IDA IDA: 通过直接分析推断	12958312	MGI
acts upstream of or within regulation of inflammatory response	IDA IDA: 通过直接分析推断	24349514	MGI
involved in regulation of membrane lipid metabolic process	IDA IDA: 通过直接分析推断	10411298	MGI
involved in regulation of metabolic process	IGI IGI: 通过遗传相互作用推断	7715705	MGI
acts upstream of or within regulation of osteoclast differentiation	IDA IDA: 通过直接分析推断	12490655	MGI
acts upstream of or within regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	15169905	MGI
acts upstream of or within regulation of protein secretion	IDA IDA: 通过直接分析推断	19293336	MGI
acts upstream of or within regulation of reactive oxygen species metabolic process	IDA IDA: 通过直接分析推断	21052097	MGI
involved in regulation of synapse organization	IMP IMP: 通过突变表型推断	16547515	MGI
acts upstream of or within tumor necrosis factor-mediated signaling pathway	IDA IDA: 通过直接分析推断	3898078	MGI
involved in tumor necrosis factor-mediated signaling pathway	IDA IDA: 通过直接分析推断	10411298	MGI
acts upstream of type II interferon production	IGI IGI: 通过遗传相互作用推断	9834074	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	16282525	MGI
is active in extracellular region	IDA IDA: 通过直接分析推断	25049354	MGI
is active in extracellular space	IDA IDA: 通过直接分析推断	14985352	MGI
located in extracellular space	IDA IDA: 通过直接分析推断	1577194	MGI
located in intracellular anatomical structure	IDA IDA: 通过直接分析推断	19723499	MGI
located in membrane raft	IDA IDA: 通过直接分析推断	17010968	MGI
located in phagocytic cup	IDA IDA: 通过直接分析推断	16282525	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	15155767	MGI
located in recycling endosome	IDA IDA: 通过直接分析推断	16282525	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tnf 蛋白结构

TNF

0
100
200
235 a.a.

蛋白主名

其他名称

tumor necrosis factor

cachectin	tumor necrosis factor ligand 1f
tumor necrosis factor ligand superfamily member 2	tumor necrosis factor-alpha

重组 Tnf 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7090	TNF-alpha/TNFSF2 Protein, Mouse (156a.a)	P06804 (L80-L235)	≥95%
HY-P7090A	TNF-alpha/TNFSF2 Protein, Mouse (P. pastoris)	P06804 (S84-L235)	≥95%
HY-P7417	TNF-alpha/TNFSF2 Protein, Mouse (His)	P06804 (L80-L235)	≥95%
HY-P70571	TNF-alpha/TNFSF2 Protein, Mouse (147a.a)	P06804 (D89-L235)	≥95%
HY-P7417AF	Animal-Free TNF-alpha/TNFSF2 Protein, Mouse (His)	P06804 (L80-L235)	≥95%
HY-P700510	TNF-alpha/TNFSF2 Protein, Mouse (His-SUMO)	P06804 (G57-L235)	≥95%

相关产品

Approval

生物活性分子 (19)

目录号	产品名	作用方式	纯度	是否罕见病
HY-12085	Apremilast		99.91%	是
HY-103399	Trovafloxacin mesylate	Inhibitor	99.56%	否
HY-N0281	Daphnetin		99.86%	否
HY-B1077	Penfluridol		99.93%	否
HY-13682	Mifamurtide		≥99.0%	否
HY-A0170	Trovafloxacin	Inhibitor	98.99%	否
HY-N0066	Eucalyptol	Inhibitor	≥98.0%	否
HY-B1201	Tiratricol	Inhibitor	99.60%	是
HY-30235A	Benzydamine hydrochloride	Inhibitor	98.22%	否
HY-B0164	Mizolastine	Antagonist	99.82%	否
HY-B0446	Naphazoline hydrochloride		98.12%	否
HY-13682B	Mifamurtide sodium		98.19%	否
HY-B0513	Methylthiouracil	Inhibitor	≥98.0%	否
HY-111326A	Naphazoline nitrate		≥98.0%	否
HY-13682C	Mifamurtide TFA		≥98.0%	否
HY-B1615	Clenbuterol	Agonist	/	否
HY-111326	Naphazoline		/	否
HY-30235	Benzydamine	Inhibitor	/	否
HY-B0164A	Mizolastine dihydrochloride	Antagonist	/	否

抗体抑制剂 (6)

目录号	产品名	作用方式	纯度	是否罕见病
HY-P9970	Infliximab	Inhibitor	90.30%	否
HY-P9908	Adalimumab	Inhibitor	99.62%	否
HY-108847	Etanercept	Inhibitor	99.20%	否
HY-P9953	Certolizumab pegol	Inhibitor	99.30%	否
HY-P99111	Golimumab		99.71%	否
HY-P99796	Ozoralizumab	Inhibitor	99.80%	否

Clinical Phase

生物活性分子 (22)

目录号	产品名	作用方式	纯度	Phase
HY-N3021	D-chiro-Inositol	Inhibitor	≥98.0%	Phase 4
HY-N8277	Kdo2-Lipid A ammonium		99.00%	Phase 4
HY-114360AS1	Taurohyodeoxycholic acid-d4 sodium	Inhibitor	/	Phase 4
HY-11109	Resatorvid	Inhibitor	99.95%	Phase 3
HY-13743	Roquinimex	Inhibitor	99.69%	Phase 3
HY-13740	Resiquimod		99.95%	Phase 2
HY-16591	Birinapant		99.70%	Phase 2
HY-110133	JTE-607	Inhibitor	99.27%	Phase 2
HY-15509A	Semapimod tetrahydrochloride	Inhibitor	98.43%	Phase 2
HY-119307	Apratastat	Inhibitor	99.67%	Phase 2
HY-118250	GSK2245035		99.85%	Phase 2
HY-145726	ISIS 104838	Inhibitor	/	Phase 2
HY-105017	Evodenoson	Agonist	99.74%	Phase 2
HY-114766	Pumafentrine	Inhibitor	/	Phase 2
HY-U00179	CDC801	Inhibitor	98.94%	Phase 2
HY-10172	IMD-0354	Inhibitor	99.51%	Phase 1
HY-13518	Piceatannol		98.90%	Phase 1
HY-19717	DCVC	Inhibitor	99.83%	Phase 1
HY-107390A	AX-024 hydrochloride	Inhibitor	99.75%	Phase 1
HY-15507	VGX-1027	Inhibitor	99.76%	Phase 1
HY-N0803	Myrcene	Inhibitor	≥75.0%	Phase 1
HY-N8691	2',6'-Dihydroxy-4'-methoxydihydrochalcone	Inhibitor	/	Phase 1

抗体抑制剂 (16)

目录号	产品名	作用方式	纯度	Phase
HY-P99252	Itolizumab		95.00%	Phase 3
HY-P990070	Zigakibart	Inhibitor	98.37%	Phase 3
HY-P99499	Cetrelimab		≥99.0%	Phase 3
HY-P99578	Tanfanercept	Inhibitor	/	Phase 3
HY-P99692	Lenercept	Inhibitor	/	Phase 3
HY-P99772	Onfekafusp alfa		/	Phase 3
HY-P99670	Iscalimab	Inhibitor	99.64%	Phase 2
HY-P99315	Ruplizumab	Inhibitor	99.84%	Phase 2
HY-P99810	Quisovalimab		97.78%	Phase 2
HY-P99940	Remtolumab	Inhibitor	99.24%	Phase 2
HY-P9983	Lintuzumab		/	Phase 2
HY-P99704	Licaminlimab	Inhibitor	96.10%	Phase 2
HY-P99775	Placulumab	Inhibitor	/	Phase 2
HY-P99945	Revdofilimab	Activator	99.35%	Phase 1
HY-P99178	CTX-471		99.42%	Phase 1
HY-P99361	Enavatuzumab	Inhibitor	≥95.0%	Phase 1

Pre-clinical Phase

生物活性分子 (437)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13453	BAY 11-7082		99.98%	否
HY-N0822	Shikonin	Inhibitor	99.80%	否
HY-15648B	GSK-J4		99.64%	否
HY-108473	CU-CPT 4a	Inhibitor	99.34%	否
HY-P0224	N-Formyl-Met-Leu-Phe	Inhibitor	99.83%	否
HY-103490	Takinib		98.92%	否
HY-12326A	c-di-AMP disodium	Agonist	99.71%	否
HY-110203	R-7050	Antagonist	98.55%	否
HY-138682	STING-IN-2	Inhibitor	99.71%	否
HY-13812	QNZ	Inhibitor	99.50%	否
HY-123942	Diprovocim	Agonist	98.35%	否
HY-133122	UCB-9260	Inhibitor	99.96%	否
HY-P1860	TNF-α (31-45), human		99.77%	否
HY-122882	HOIPIN-8		99.89%	否
HY-109804	CORM-401	Inhibitor	98.27%	否
HY-13229	BOC-D-FMK	Inhibitor	≥95.0%	否
HY-N0633	Muscone	Inhibitor	≥98.0%	否
HY-126360	Oxazolone		≥98.0%	否
HY-N0029	Forsythoside B		99.99%	否
HY-100339	GSK583	Inhibitor	98.74%	否
HY-15648F	GSK-J4 hydrochloride	Inhibitor	98.83%	否
HY-100211	TAPI-2	Inhibitor	99.46%	否
HY-156798	ADS032		99.74%	否
HY-N0297	Sinensetin	Inhibitor	99.87%	否
HY-134471	TNF-α-IN-2	Inhibitor	98.75%	否
HY-N6796	Manumycin A		99.27%	否
HY-110353	CU-T12-9	Agonist	98.94%	否
HY-N0509	Astilbin		99.97%	否
HY-N0194	Asiatic acid		99.40%	否
HY-107737	1,2-DLPC	Activator	≥98.0%	否
HY-N0472	Geraniin	Inhibitor	99.84%	否
HY-147141	HS-276	Inhibitor	98.59%	否
HY-19744	T6167923	Inhibitor	99.08%	否
HY-N0405	Orientin	Inhibitor	99.73%	否
HY-107427	PF-3644022	Inhibitor	99.65%	否
HY-N0043	Ginsenoside Rd	Inhibitor	99.88%	否
HY-125402	GSK-843		99.18%	否
HY-111255	SPD304	Inhibitor	99.35%	否
HY-N0722	Neochlorogenic acid	Inhibitor	99.77%	否
HY-147045	UCB-5307	Inhibitor	97.37%	否
HY-148141	JPE-1375	Antagonist	99.94%	否
HY-N0619	Mulberroside A	Inhibitor	99.86%	否
HY-15511	Tyrphostin A9	Inhibitor	99.87%	否
HY-19975	RN-1734	Antagonist	99.86%	否
HY-142618	TNF-α-IN-6	Inhibitor	99.58%	否
HY-N6607	Tryptanthrin		99.89%	否
HY-14622	Necrostatin 2	Inhibitor	99.92%	否
HY-101448	TMI-1		99.59%	否
HY-150725	ODN 1585	Inducer	/	否
HY-103360	J-113863	Antagonist	≥99.0%	否
HY-N0042	Ginsenoside Rc		≥98.0%	否
HY-133807	Benpyrine	Inhibitor	99.74%	否
HY-101849	Fasentin		≥98.0%	否
HY-N1949	Homoplantaginin	Inhibitor	99.90%	否
HY-N7637	Tubuloside B	Inhibitor	99.95%	否
HY-32018	Cot inhibitor-2	Inhibitor	99.22%	否
HY-110177	SP-100030	Inhibitor	99.86%	否
HY-131249	MK2-IN-3	Inhibitor	99.58%	否
HY-107390	AX-024	Inhibitor	99.29%	是
HY-12700	RO5256390		98.75%	否
HY-156454	UCB-6876	Inhibitor	99.96%	否
HY-N0316	Mollugin		99.48%	否
HY-108642B	AMG-548 dihydrochloride	Inhibitor	99.91%	否
HY-103435	Vialinin A	Inhibitor	99.89%	否
HY-111255A	SPD304 dihydrochloride	Inhibitor	99.96%	否
HY-N0604	Ginsenoside Rh1	Inhibitor	≥98.0%	否
HY-125527	Resolvin D1		99.60%	否
HY-N0569	Madecassic acid	Inhibitor	99.23%	否
HY-N2350	Cynaropicrin	Inhibitor	99.79%	否
HY-P1832A	PTD-p65-P1 Peptide TFA		99.14%	否
HY-104073	CAY10602	Activator	98.65%	否
HY-124750	NecroX-7	Inhibitor	99.69%	否
HY-W010201	Citronellol		98.60%	否
HY-123984	LTβR-IN-1	Activator	99.79%	否
HY-12511	SKF-86002	Inhibitor	99.66%	否
HY-134911	HS-243	Inhibitor	99.88%	否
HY-N7056	4'-Hydroxychalcone	Inhibitor	99.66%	否
HY-130252	YQ128	Inhibitor	99.83%	否
HY-118922	IW927	Antagonist	99.04%	否
HY-P1847A	IKKγ NBD Inhibitory Peptide TFA		98.20%	否
HY-B0392	(S)-(+)-Rolipram		99.77%	否
HY-114360A	Taurohyodeoxycholic acid sodium	Inhibitor	99.60%	否
HY-160412	TNFα activity modulator 3	Inhibitor	98.30%	否
HY-N2086	Ethyl palmitate	Inhibitor	99.05%	否
HY-N4288	4-Methylesculetin	Inhibitor	98.21%	否
HY-152956	STING agonist-23	Agonist	99.16%	否
HY-N0613	Sauchinone	Inhibitor	99.88%	否
HY-N0041	Ginsenoside Rb3	Inhibitor	99.12%	否
HY-128348	PK68	Inhibitor	99.92%	否
HY-128686	KAG-308	Agonist	99.88%	否
HY-113402A	Gamma-glutamylcysteine TFA		95.20%	否
HY-116626	SM-7368	Inhibitor	99.77%	否
HY-139066	Punicic acid		≥98.0%	否
HY-12557	γ-Glutamylvaline		99.73%	否
HY-128598	MD2-TLR4-IN-1	Inhibitor	99.62%	否
HY-112275	TNF-α-IN-1	Inhibitor	99.42%	否
HY-113953	Z-Asp-CH2-DCB	Inhibitor	99.28%	否
HY-N2110	Phellopterin		99.94%	否
HY-N9965	2'-Fucosyllactose	Inhibitor	99.95%	否
HY-32015	Cot inhibitor-1	Inhibitor	98.45%	否
HY-100735	C 87	Inhibitor	98.06%	否
HY-124151	Adenosine-2'-monophosphate	Activator	99.91%	否
HY-132248	C5 Lenalidomide	Inhibitor	99.62%	否
HY-N0617	Sanggenon C		98.50%	否
HY-N1356	Reticuline	Inhibitor	98.91%	否
HY-N6246	Asperulosidic Acid	Inhibitor	99.72%	否
HY-135674	SR-318	Inhibitor	99.89%	否
HY-W082785A	L6H21		99.46%	否
HY-12326B	c-di-AMP diammonium	Agonist	99.36%	否
HY-131945	CU-115	Antagonist	99.55%	否
HY-N2055	Kaempferol 3-O-sophoroside		99.84%	否
HY-N2252	Licarin A	Inhibitor	98.48%	否
HY-102040	Hispidol	Inhibitor	98.70%	否
HY-19667A	BMS-561392 formate	Inhibitor	99.38%	否
HY-118694	TAPI-0	Inhibitor	98.01%	否
HY-120823	PF-05381941	Inhibitor	99.73%	否
HY-150725C	ODN 1585 sodium	Inducer	93.90%	否
HY-155998	NF-κB-IN-11	Inhibitor	98.42%	否
HY-N0358	1,4-Dicaffeoylquinic acid	Inhibitor	99.80%	否
HY-N6253	Pinoresinol	Inducer	98.35%	否
HY-N0506	Rosarin		99.94%	否
HY-N1987	Cucurbitacin IIb	Inducer	≥99.0%	否
HY-N3316	Martynoside	Antagonist	≥99.0%	否
HY-P2612A	WP9QY TFA	Antagonist	99.83%	否
HY-12326	c-di-AMP	Agonist	99.29%	否
HY-133807A	(Rac)-Benpyrine	Inhibitor	99.30%	否
HY-147263	Dovramilast	Inhibitor	99.83%	否
HY-N0907	Ginsenoside Rg6		99.13%	否
HY-N2855	Alphitolic acid		≥97.0%	否
HY-N3063	Pimaric acid		99.83%	否
HY-N4323	14-Deoxyandrographolide	Inhibitor	99.47%	否
HY-N9445	Lacto-N-neotetraose		99.71%	否
HY-110077	API-1		99.62%	否
HY-141582	Ceramide 3		≥98.0%	否
HY-N0857	Deoxyandrographolide	Activator	99.87%	否
HY-N0906	Ginsenoside Rk3	Inhibitor	98.85%	否
HY-N3807	Enniatin B1	Inhibitor	99.34%	否
HY-N6857	Armepavine	Inhibitor	99.53%	否
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA		99.21%	否
HY-101041	(E)-AG 556	Inhibitor	99.92%	否
HY-13740S	Resiquimod-d5		99.84%	否
HY-112389	p38 MAP Kinase Inhibitor III	Inhibitor	98.77%	否
HY-123194	SIRT2/6-IN-1	Inhibitor	98.44%	否
HY-129113	α-Chaconine	Inhibitor	99.04%	否
HY-145498	HDMAPP triammonium	Activator	≥90.0%	否
HY-148454	Necroptosis-IN-3	Inhibitor	99.77%	否
HY-162734	BRD5075	Inhibitor	98.03%	否
HY-N9315	Episappanol	Inhibitor	98.57%	否
HY-P3585	Epobis	Inhibitor	99.34%	否
HY-131707	LEO 39652	Inhibitor	99.51%	否
HY-150612	(R)-STU104	Inhibitor	99.91%	否
HY-110246	Quin C1		98.47%	否
HY-112456	IKK2-IN-4	Inhibitor	99.89%	否
HY-145726A	ISIS 104838 sodium		93.70%	否
HY-151966	TD1092		99.49%	否
HY-152959	STING agonist-26	Agonist	99.56%	否
HY-N1940	β-Anhydroicaritin	Inhibitor	99.09%	否
HY-N2205	Esculentoside H	Inhibitor	98.73%	否
HY-N3595	Cleomiscosin A	Inhibitor	99.15%	否
HY-N4285	Negletein	Inhibitor	≥99.0%	否
HY-N6073	Soyasapogenol A	Inhibitor	99.06%	否
HY-N6927	Isoforskolin	Inhibitor	≥98.0%	否
HY-P1860A	TNF-α (31-45), human TFA		/	否
HY-P2320	IDR-1	Inhibitor	99.01%	否
HY-150219A	ODN M326 sodium	Inhibitor	/	否
HY-157325	RIPK2-IN-5	Inhibitor	99.73%	否
HY-100376	CPI-1189	Inhibitor	98.49%	否
HY-106359A	Delmitide acetate	Inhibitor	98.55%	是
HY-108623	Atizoram	Inhibitor	96.3%	否
HY-117082	UTL-5g	Inhibitor	99.92%	否
HY-12085S	Apremilast-d5		98.63%	否
HY-122786	3-O-Methylviridicatin	Inhibitor	/	否
HY-125527S	Resolvin D1-d5		99.2%	否
HY-126114	Lupeol acetate	Inhibitor	≥98.0%	否
HY-129151	Ganoderic acid C1		≥95.0%	否
HY-133807B	(R)-Benpyrine		99.17%	否
HY-135808	BIZ 114	Inhibitor	≥98.0%	否
HY-147086	CAY10789		99.84%	否
HY-147506	NOD2 antagonist 1	Antagonist	99.57%	否
HY-147696	SMTIN-T140		99.58%	否
HY-151369	AV123	Inhibitor	99.60%	否
HY-151876	Glucocorticoid receptor modulator 1		99.79%	否
HY-153579	Anti-inflammatory agent 42	Inhibitor	≥98.0%	否
HY-160178	Glucocorticoid receptor agonist-3 Ala-Ala-Mal		99.72%	否
HY-160179	Glucocorticoid receptor agonist-4	Agonist	99.80%	否
HY-161016	TNF/IFN-γ-IN-1	Inhibitor	99.39%	否
HY-18754A	FR 167653	Inhibitor	99.87%	否
HY-N0569R	Madecassic acid (Standard)	Inhibitor	/	否
HY-N0619A	cis-Mulberroside A	Inhibitor	/	否
HY-N0811	Anemarsaponin B	Inhibitor	/	否
HY-P1875A	TNF-α (46-65), human TFA		99.20%	否
HY-P3149B	LEESGGGLVQPGGSMK acetate		99.01%	否
HY-P3203A	DSTYSLSSTLTLSK TFA		98.11%	否
HY-114531	Lomifylline		99.67%	否
HY-118157	3,5,7-Trimethoxyflavone		98.94%	否
HY-156060	NCI126224	Inhibitor	99.88%	否
HY-W013557	3-Hydroxyxanthone	Inhibitor	≥98.0%	否
HY-131340	LASSBio-1632	Inhibitor	/	否
HY-132195	RORγt inverse agonist 14	Inhibitor	/	否
HY-19667	BMS-561392	Inhibitor	/	否
HY-18862	PF-03715455	Inhibitor	/	否
HY-100211A	(R)-TAPI-2		/	否
HY-100702	SH-5		/	否
HY-101961	Tyrphostin AG 1288	Inhibitor	98.68%	否
HY-106359	Delmitide	Inhibitor	/	否
HY-108162A	Ataquimast	Inhibitor	/	否
HY-108641	SKF-86002 dihydrochloride	Inhibitor	/	否
HY-108642A	AMG-548 hydrochloride	Inhibitor	/	否
HY-108953	(S)-Quinolactacine A	Inhibitor	/	否
HY-111317	SIRT1 activator 3	Activator	/	否
HY-114221	Org 48762-0	Inhibitor	99.99%	否
HY-114592	M199		/	否
HY-114981	SRTCX1002	Activator	/	否
HY-115351	GW-3333	Inhibitor	/	否
HY-115913	PDE4-IN-6	Inhibitor	/	否
HY-115976	COX-2-IN-10	Inhibitor	/	否
HY-117356A	MRS2693 ammonium		/	否
HY-118101	15-Deoxy-Δ12,14-prostaglandin A1		/	否
HY-118250A	GSK2245035 maleate		/	否
HY-120041	ND-2158	Inhibitor	/	否
HY-120600	Sibiriline	Inhibitor	/	否
HY-121401	Myrtenal		/	否
HY-121996	Prostaglandin E2 Ethanolamide		/	否
HY-122292	Celastramycin A	Inhibitor	/	否
HY-122521	Sootepin D	Inhibitor	/	否
HY-123542	ONO-3403		/	否
HY-123736	Ro 32-7315	Inhibitor	/	否
HY-123936	SR12343	Inhibitor	/	否
HY-124003	Phytomonic acid		/	否
HY-126026	NF-κB-IN-17	Inhibitor	/	否
HY-126414	Methylenedihydrotanshinquinone		/	否
HY-128423AS	Tylvalosin-d9		/	否
HY-134950	(E)-C-HDMAPP ammonium	Activator	/	否
HY-136010	RIP2 Kinase Inhibitor 4	Inhibitor	/	否
HY-142069	KB-R7785	Inhibitor	/	否
HY-142958	NF-κB-IN-2		/	否
HY-14305	BMS-582949		/	否
HY-143410	Anti-inflammatory agent 16	Inhibitor	/	否
HY-144368	CO delivery molecule 1		/	否
HY-144727	Anti-inflammatory agent 11	Inhibitor	/	否
HY-144737	Anti-inflammatory agent 15	Inhibitor	/	否
HY-145492	Δ7(Z)-C14-HSL		/	否
HY-146419	Anti-inflammatory agent 20	Inhibitor	/	否
HY-146435	Anti-inflammatory agent 22	Inhibitor	/	否
HY-146483	Anti-Aβ agent 1A	Inhibitor	/	否
HY-146547	Anti-inflammatory agent 17	Inhibitor	/	否
HY-146723	IKKβ-IN-1	Inhibitor	/	否
HY-146765	AMS-17	Inhibitor	/	否
HY-147078	EJMC-1	Inhibitor	99.69%	否
HY-147697	LSD1-IN-21	Inhibitor	/	否
HY-147712	PKC-IN-4	Inhibitor	/	否
HY-147924	Keap1-Nrf2-IN-11	Inhibitor	/	否
HY-147950	PDE4-IN-10	Inhibitor	/	否
HY-148606	STING modulator-3	Inhibitor	/	否
HY-148908	TNF-α-IN-8		/	否
HY-149331	TNF-α-IN-11	Inhibitor	/	否
HY-149485	JNK2-IN-1	Inhibitor	/	否
HY-149816	Anti-inflammatory agent 41	Inhibitor	/	否
HY-149984	MAO-B-IN-21	Inhibitor	/	否
HY-150219	ODN M326	Agonist	/	否
HY-150725A	Biotin-labeled ODN 1585 sodium		/	否
HY-150725B	FITC-labeled ODN 1585 sodium	Inducer	/	否
HY-151188	DHU-Se1	Inhibitor	/	否
HY-152213	BET-IN-13	Inhibitor	/	否
HY-152957	STING agonist-24	Agonist	/	否
HY-152958	STING agonist-25	Agonist	/	否
HY-152961	STING agonist-28	Agonist	/	否
HY-153329	TNF-α-IN-9	Inhibitor	/	否
HY-153330	TNF-α-IN-10	Inhibitor	/	否
HY-153952	Immuno modulator-1	Inhibitor	/	否
HY-154698	Homouridine		/	否
HY-155027	DPP-4-IN-8	Inhibitor	/	否
HY-15509	Semapimod	Inhibitor	/	否
HY-155179	ZMF-23	Inhibitor	/	否
HY-155199	PDE1-IN-5	Inhibitor	/	否
HY-155243	12R-LOX-IN-1	Inhibitor	/	否
HY-155405	Anti-inflammatory agent 64	Inhibitor	/	否
HY-155753	Anti-inflammatory agent 50	Inhibitor	/	否
HY-155759	HMGB1-IN-2	Inhibitor	/	否
HY-155820	Anti-inflammatory agent 54	Inhibitor	/	否
HY-155821	Anti-inflammatory agent 55	Inhibitor	/	否
HY-156025	HCAR2 agonist 1		/	否
HY-15616	BMS-470539	Agonist	/	否
HY-156297	β5i-IN-1	Inhibitor	/	否
HY-156367	RIPK1-IN-16	Inhibitor	/	否
HY-157456	RIPK1-IN-19	Inhibitor	≥98.0%	否
HY-157546	VEGFR-2-IN-40	Inhibitor	/	否
HY-157809	Anti-inflammatory agent 74	Inhibitor	/	否
HY-157992	LM-021	Inhibitor	/	否
HY-159100	PVP-037	Agonist	/	否
HY-159516	Sabialimon P	Inhibitor	/	否
HY-159614	PG-PS	Activator	/	否
HY-159669	Stercobilin hydrochloride (mixture of isomers)	Inhibitor	/	否
HY-160027	TNF-alpha-IN-1	Inhibitor	/	否
HY-160180	Glucocorticoid receptor agonist-4 Ala-Ala-Mal		/	否
HY-160231	ssRNA42 sodium	Activator	/	否
HY-160433	TNF-α-IN-12	Inhibitor	/	否
HY-160434	TNF-α-IN-13	Inhibitor	/	否
HY-160435	TNF-α-IN-14	Inhibitor	/	否
HY-160436	TNF-α-IN-15	Inhibitor	/	否
HY-160437	TNF-α-IN-16	Inhibitor	/	否
HY-161240	MAO-B-IN-30	Inhibitor	98.53%	否
HY-161381	PDE4-IN-15	Inhibitor	/	否
HY-161520	Glucocorticoid receptor/NF-κB modulator-1		/	否
HY-161620	DW18134	Inhibitor	/	否
HY-161629	TLR8 agonist 7	Agonist	/	否
HY-161630	TLR8 agonist 8	Agonist	/	否
HY-161631	TLR8 agonist 9	Agonist	/	否
HY-161674	Monoamine Oxidase B inhibitor 4	Inhibitor	/	否
HY-161757	Anti-inflammatory agent 86		/	否
HY-161833	HSP90-IN-31	Inhibitor	/	否
HY-161901	BC-1293	Inhibitor	/	否
HY-161936	Z21115	Inhibitor	/	否
HY-161991	Caspase-3 activator 4		/	否
HY-162097	RIPK1-IN-20	Inhibitor	/	否
HY-162116	TLR7 agonist 18	Agonist	/	否
HY-162316	NF-κB-IN-15	Inhibitor	/	否
HY-162599	Spirohypertone B	Inhibitor	/	否
HY-162600	CDK8-IN-15	Inhibitor	/	否
HY-162641	AF-45	Inhibitor	/	否
HY-162649	TIC10g	Inhibitor	/	否
HY-162797	PDE4-IN-18	Inhibitor	/	否
HY-162850	DOR agonist 2		/	否
HY-162861	3-Methyl-chuangxinmycin	Inhibitor	/	否
HY-162963	PPARδ agonist 11	Agonist	/	否
HY-163102	IA-14069		/	否
HY-163280	JGB-1-155	Activator	/	否
HY-163368	HDAC6-IN-34	Inhibitor	/	否
HY-163670	TLR7 agonist 21	Inhibitor	/	否
HY-163673	Glucocorticoid receptor modulator 4	Modulator	/	否
HY-163747	VEGFR-2-IN-47	Inhibitor	/	否
HY-163748	GSK-3β inhibitor 17	Inhibitor	/	否
HY-163755	GPER activator 1		/	否
HY-163777	Talaroterphenyl A	Inhibitor	/	否
HY-163998	TLR4-IN-1		/	否
HY-164102	TNF-α-IN-18	Inhibitor	/	否
HY-167877	PS-166276	Inhibitor	/	否
HY-168130	TNF-α/IL-1β-IN-1	Inhibitor	/	否
HY-169004	CBT-295	Inhibitor	99.34%	否
HY-169103	Neuroprotective agent 5	Inhibitor	/	否
HY-18759	BMS-751324	Inhibitor	/	否
HY-19717S	DCVC-13C3,15N		/	否
HY-N0041R	Ginsenoside Rb3 (Standard)	Inhibitor	/	否
HY-N0066S	Eucalyptol-d6	Inhibitor	/	否
HY-N0803S	Myrcene-d6	Inhibitor	/	否
HY-N0976	1,11b-Dihydro-11b-hydroxymedicarpin		/	否
HY-N10009	Cudraflavone B		/	否
HY-N10047	7,8-Didehydrocimigenol	Inhibitor	/	否
HY-N10448	Sinulatumolin E	Inhibitor	/	否
HY-N10453	Sinulatumolin D		/	否
HY-N10454	Sinulatumolin C	Inhibitor	/	否
HY-N10835	Gnetumontanin B		/	否
HY-N1125	Triptobenzene H		/	否
HY-N11768	4-Methoxylonchocarpin	Inhibitor	/	否
HY-N11892	7-O-Methylaloesinol	Inhibitor	/	否
HY-N11996	Aloenin aglycone		/	否
HY-N12042	Taxamairin B	Inhibitor	/	否
HY-N12186	Sibiricine		/	否
HY-N12653	Exserohilone	Inhibitor	/	否
HY-N12743	Farobin A	Inhibitor	/	否
HY-N13114	8-Gingerdione		/	否
HY-N1326	Santamarine		/	否
HY-N3364	Lucidone	Inhibitor	/	否
HY-N3380	Linderaspirone A	Inhibitor	/	否
HY-N3421	Koaburaside	Inhibitor	/	否
HY-N3552	Catalposide	Inhibitor	≥98.0%	否
HY-N3625	Coronalolic acid	Inhibitor	/	否
HY-N4061	Hedycoronen A	Inhibitor	/	否
HY-N4275	Oleaside A		/	否
HY-N5054	(R)-5,7-Dimethoxyflavanone	Inhibitor	≥99.0%	否
HY-N6969A	Dicentrine hydrochloride	Antagonist	/	否
HY-N7699A	D-Trimannuronic acid	Activator	/	否
HY-N8371	Shizukaol B	Inhibitor	/	否
HY-N8413	Chlojaponilactone B	Inhibitor	/	否
HY-N8593	Undecane	Inhibitor	≥98.0%	否
HY-N8593S	Undecane-d24		/	否
HY-N8816	Stipuleanoside R2		/	否
HY-N8936	Narchinol B		/	否
HY-N9000	Loganic acid 6′-O-β-D-glucoside		/	否
HY-N9587	Tricin 7-O-β-D-glucopyranoside	Inducer	/	否
HY-N9699	8α-Hydroxyhirsutinolide	Inhibitor	/	否
HY-N9867	Gnetifolin E	Inhibitor	/	否
HY-P10241	Ac-LEHD-CHO	Inhibitor	/	否
HY-P10350	PapRIV	Agonist	/	否
HY-P10354	SPA4		/	否
HY-P1832	PTD-p65-P1 Peptide		/	否
HY-P1847	IKKγ NBD Inhibitory Peptide		/	否
HY-P2612	WP9QY	Antagonist	/	否
HY-P3149	LEESGGGLVQPGGSMK		/	否
HY-P3149A	LEESGGGLVQPGGSMK TFA		/	否
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2		/	否
HY-RS14784	TNF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14785	Tnf Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14786	TNF Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W010201R	Citronellol (Standard)		/	否
HY-W014049	N'-Nitro-D-arginine	Inhibitor	/	否
HY-W104821	Rosolic acid	Activator	/	否
HY-10320A	Doramapimod hydrochloride	Inhibitor	/	否
HY-108162	Ataquimast free base	Inhibitor	/	否
HY-110133A	JTE-607 free base	Inhibitor	/	否
HY-110343	DBM 1285 dihydrochloride	Inhibitor	/	否
HY-116426	IDT	Modulator	/	否
HY-117569	KF24345 free base	Inhibitor	/	否
HY-117622	ND-2110	Inhibitor	/	否
HY-118316	GSK223	Inhibitor	/	否
HY-118984	CRX-526	Antagonist	/	否
HY-119799	UK-500001	Inhibitor	/	否
HY-121200	Azadirone		/	否
HY-122566	SMU127		/	否
HY-12348	LEO 29102	Inhibitor	/	否
HY-123882	IRAK4-IN-29		/	否
HY-124388	PDE4-IN-20		/	否
HY-125980	LX-3	Inhibitor	/	否
HY-126211	KBH-A42	Inhibitor	/	否
HY-126758	Ludartin	Inhibitor	/	否
HY-137370	2-Hexynyl-5′-N-ethylcarboxamidoadenosine		/	否
HY-138063	Siegeskaurolic acid	Inhibitor	/	否
HY-156431	Anti-inflammatory agent 61	Inhibitor	/	否
HY-158650	10-OAHSA	Inhibitor	/	否
HY-162579	TLR7 agonist 22	Agonist	/	否
HY-163642	TNF-α agonistic 1		/	否
HY-163712	17-Epiestriol	Agonist	/	否
HY-16658C	Z-VA-DL-D-FMK	Inhibitor	/	否
HY-169118	EGR-1-IN-2	Inhibitor	/	否
HY-20070	BMS-566394	Inhibitor	/	否
HY-N1159	Teuclatriol	Inhibitor	/	否
HY-N11994	Aloeresin G	Inhibitor	/	否
HY-N12116	Maceneolignan A	Inhibitor	/	否
HY-N12905	Celastramycin A (isomer)	Inhibitor	/	否
HY-N13184	Giraldoid B	Inhibitor	/	否
HY-N8015S1	Octanal-d2	Inhibitor	/	否
HY-N9541	Chaetoglobosin Vb		/	否
HY-W015879S	2-Heptanol-d5	Inhibitor	/	否
HY-W030338	aPKC-IN-2		/	否
HY-W322573	(R)-Ketoprofen		/	否
HY-W505984	TPNA10168	Activator	/	否
HY-18754	FR 167653 free base	Inhibitor	/	否