1. Gene
  2. Egfr - epidermal growth factor receptor Gene

Egfr - epidermal growth factor receptor Gene

中文名称:表皮生长因子受体

种属: Mus musculus

同用名: Wa5; wa2; Erbb; Errp; wa-2; Errb1; 9030024J15Rik

基因 ID: 13649 | 基因类型: protein coding

关于 Egfr

Chromosome 11: 16,702,203-16,868,158 forward strand.GRCm39:CM001004.3

This gene has 5 transcripts (splice variants), 283 orthologues, 53 paralogues and is associated with 180 phenotypes. Broad expression in liver adult (RPKM 26.7), liver E18 (RPKM 8.7) and 15 other tissues.

功能概要

该基因编码的蛋白可启动表皮生长因子结合活性和表皮生长因子激活受体活性。参与细胞对氨基酸刺激的反应和成纤维细胞增殖的正调节。作用于多个过程的上游或内部,包括动物器官发育;表皮生长因子受体信号通路;和蛋白质自身磷酸化。位于几种细胞成分中,包括基底外侧质膜;内吞囊泡;和细胞质的核周区。以多种结构表达,包括消化系统;脑;外皮系统;肢;和呼吸系统。用于研究冠状病毒感染性疾病和主动脉瓣疾病。该基因的人类直系同源物与多种疾病有关,包括结直肠癌;肺非小细胞癌(多发性);胰腺癌;前列腺癌;和肺结核。与人类 EGFR(表皮生长因子受体)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in cellular response to amino acid stimulus and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; epidermal growth factor receptor signaling pathway; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and respiratory system. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

Egfr 基因产物(2)

mRNA Protein Name
NM_207655.2 NP_997538.1 epidermal growth factor receptor isoform 1 precursor
NM_007912.4 NP_031938.1 epidermal growth factor receptor isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables epidermal growth factor binding IDA
IDA: 通过直接分析推断
7678348 MGI
enables epidermal growth factor receptor activity IDA
IDA: 通过直接分析推断
6248866 MGI
enables epidermal growth factor receptor activity IGI
IGI: 通过遗传相互作用推断
16357442 MGI
enables epidermal growth factor receptor activity IMP
IMP: 通过突变表型推断
18701712 MGI
enables kinase activity IDA
IDA: 通过直接分析推断
12808090 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11274221 MGI
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
15383614 MGI
enables protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
11823423 MGI
enables transmembrane receptor protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7752576 MGI
enables transmembrane receptor protein tyrosine kinase activity IGI
IGI: 通过遗传相互作用推断
28783046 MGI
enables transmembrane receptor protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
12399441 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERBB2-EGFR signaling pathway IDA
IDA: 通过直接分析推断
8702723 MGI
involved in ERBB2-EGFR signaling pathway IMP
IMP: 通过突变表型推断
18701712 MGI
acts upstream of or within cell morphogenesis IGI
IGI: 通过遗传相互作用推断
17686994 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
18656477 MGI
involved in cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
22711986 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: 通过直接分析推断
8702723 MGI
acts upstream of or within cerebral cortex cell migration IMP
IMP: 通过突变表型推断
7618084 MGI
acts upstream of or within digestive tract morphogenesis IMP
IMP: 通过突变表型推断
7618084 MGI
acts upstream of or within embryonic placenta development IMP
IMP: 通过突变表型推断
7618084 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
14712229 MGI
involved in epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
6248866 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
7641815 MGI
involved in epidermal growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
28783046 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
17686994 MGI
involved in epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
12399441 MGI
acts upstream of or within epidermis development IMP
IMP: 通过突变表型推断
7618084 MGI
acts upstream of epithelial cell proliferation IMP
IMP: 通过突变表型推断
7618084 MGI
acts upstream of or within eyelid development in camera-type eye IGI
IGI: 通过遗传相互作用推断
9030684 MGI
acts upstream of or within hair follicle development IGI
IGI: 通过遗传相互作用推断
9030684 MGI
acts upstream of or within hair follicle development IMP
IMP: 通过突变表型推断
7618084 MGI
acts upstream of or within morphogenesis of an epithelial fold IMP
IMP: 通过突变表型推断
7618084 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
23457600 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
11823423 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
14712229 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
7641815 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
7618084 MGI
involved in positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
20208556 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: 通过直接分析推断
15314156 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
11818567 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
11940581 MGI
acts upstream of or within salivary gland morphogenesis IMP
IMP: 通过突变表型推断
10521784 MGI
acts upstream of or within signal transduction IDA
IDA: 通过直接分析推断
11940581 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
7723235 MGI
located in cell surface IDA
IDA: 通过直接分析推断
23918928 MGI
located in endocytic vesicle IDA
IDA: 通过直接分析推断
10534613 MGI
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
10534613 MGI
located in nucleus IDA
IDA: 通过直接分析推断
20208556 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
20208556 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
6248866 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
7641815 MGI
is active in plasma membrane IGI
IGI: 通过遗传相互作用推断
28783046 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Egfr 蛋白结构

Recep_L_domain

Recep_L_domain: pfam01030 (56 - 167)

Furin-like

Furin-like: pfam00757 (183 - 334)

Recep_L_domain

Recep_L_domain: pfam01030 (361 - 480)

GF_recep_IV

GF_recep_IV: pfam14843 (504 - 635)

TM_ErbB1

TM_ErbB1: cd12093 (633 - 678)

PTKc_EGFR

PTKc_EGFR: cd05108 (705 - 1017)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1210 a.a.
蛋白主名 其他名称

epidermal growth factor receptor

avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

waved 2

重组 Egfr 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72988 EGFR Protein, Mouse (HEK293, Fc) Q01279 (L25-S647) ≥95%
HY-P72989 EGFR Protein, Mouse (HEK293, His) Q01279 (L25-S647) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Egfr NCBI NCBI:1956
Canis familiaris Egfr NCBI NCBI:404306
Macaca fascicularis Egfr NCBI NCBI:102138724
Rattus norvegicus Egfr NCBI NCBI:24329
Macaca mulatta Egfr NCBI NCBI:613027